scholarly journals A case of canine epitheliotropic lymphoma (mycosis fungoides)

2018 ◽  
Vol 52 (4) ◽  
pp. 286
Author(s):  
M. N. SARIDOMICHELAKIS (Μ. Ν. ΣΑΡΙΔΟΜΙΧΕΛΑΚΗΣ) ◽  
C. K. KOUTINAS (X.K. ΚΟΥΤΙΝΑΣ) ◽  
A. F. KOUTINAS (Α. Φ. ΚΟΥΤΙΝΑΣ)
Keyword(s):  
Mycosis Fungoides ◽  
Combination Chemotherapy ◽  
Clinical Picture ◽  
Initial Treatment ◽  
Lymphocytic Infiltration ◽  
Skin Lesions ◽  
Substantial Improvement ◽  
Short Period ◽  
History Of ◽  
Pruritic Skin

The clinical picture, diagnosis and treatment of a dog with epitheliotropic lymphoma are presented. The dog (male, mongrel, 13-year old) was admitted to our Clinic with a 5-month history of non-pruritic skin lesions. At clinical examination a multifocal to diffuse exfoliative erythrodermia was the most striking finding. Diagnosis of epitheliotropic lymphoma was based on cutaneous histopathology, revealing a dense dermal and epidermal lymphocytic infiltration and Pautrie microabcess formation. Initial treatment with isotretinoin had a poor impact on skin lesions that progressed to the macular stage. On the contrary, combination chemotherapy with Lasparaginase and isotretinoin resulted in substantial improvement. The animal died, following a short period of depression and inappetance, 15 months after the first appearance of skin lesions and 10 months after diagnosis.

scholarly journals Bullous Systemic Lupus Erythematosus Associated with Esophagitis Dissecans Superficialis

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Meera Yogarajah ◽  
Bhradeev Sivasambu ◽  
Eric A. Jaffe
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Skin Lesions ◽  
Esophageal Mucosa ◽  
Systemic Lupus ◽  
Neck Lymph Node ◽  
The Face ◽  
History Of ◽  
The Right ◽  
Pruritic Skin

Bullous systemic lupus erythematosus is one of the rare autoantibody mediated skin manifestation of systemic lupus erythematosus (SLE) demonstrating subepidermal blistering with neutrophilic infiltrate histologically. We present a case of a 40-year-old Hispanic female who presented with a several months’ history of multiple blistering pruritic skin lesions involving the face and trunk, a photosensitive rash over the face and neck, swelling of the right neck lymph node, and joint pain involving her elbows and wrist. Her malady was diagnosed as bullous systemic lupus erythematosus based on the immunological workup and biopsy of her skin lesions. The patient also complained of odynophagia and endoscopy revealed esophagitis dissecans superficialis which is a rare endoscopic finding characterized by sloughing of the esophageal mucosa. The bullous disorders typically associated with esophagitis dissecans superficialis are pemphigus and rarely bullous pemphigoid. However, this is the first reported case of bullous systemic lupus erythematosus associated with esophagitis dissecans superficialis.

scholarly journals A case of Trixacarus caviae mange in a guinea pig (Caviaporcellus)

2018 ◽  
Vol 53 (4) ◽  
pp. 352 ◽  
Author(s):  
M. PERRAKI (Μ. ΠΕΡΡΑΚΗ) ◽  
M. SARIDOMICHELAKIS (Μ. ΣΑΡΙΔΟΜΙΧΕΛΑΚΗΣ) ◽  
C. KOUTINAS (X. ΚΟΥΤΙΝΑΣ) ◽  
A. KOUTINAS (Α. ΚΟΥΤΙΝΑΣ) ◽  
M. PAPAZACHARIADOU (Μ. ΠΑΠΑΖΑΧΑΡΙΑΔΟΥ)
Keyword(s):  
Guinea Pig ◽  
Subcutaneous Administration ◽  
Skin Lesions ◽  
The Body ◽  
Cavia Porcellus ◽  
The Past ◽  
Superficial Skin ◽  
Animal Medicine ◽  
History Of ◽  
Pruritic Skin

A male, peruvian, 1.5-years old, guinea pig {Cavia porcellus) was admitted to the Clinic of Companion Animal Medicine with a history of intensively pruritic skin lesions lasting for the past two months. Physical examination disclosed hypotrichosis, erythema, hyperpigmentation, scales, crusts, ulcers and papules in a focal to diffuse pattern on both the dorsal and ventral aspects of the body trunk. Whenever the handling of the animal was attempted, it started vocalizing, cycling and rolling in a frenzy manner. Pruritic papules were also observed on some parts of the glabrous skin of the owner. The diagnosis of Trixacarus caviae mange was based on the observation of the parasite in superficial skin scrapings. The subcutaneous administration of three weekly ivermectin injections, at the dose of 0.4 mg/Kg BW, resulted in the disappearance of the lesions and pruritus within a six-week period.

scholarly journals Porokeratotic Eccrine Ostial and Dermal Duct Nevus

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Mona Masoumeh Naraghi ◽  
Azita Nikoo ◽  
Azadeh Goodarzi
Keyword(s):  
Granular Layer ◽  
Clinical Presentation ◽  
Late Onset ◽  
Skin Lesions ◽  
Pathologic Examination ◽  
Lateral Ankle ◽  
History Of ◽  
Characteristic Features ◽  
Blaschko’S Lines ◽  
Pruritic Skin

PEODDN is a rare benign cutaneous disorder that clinically resembles comedo nevus but favors the palms and soles, where pilosebaceous follicles are absent. Widespread involvement along Blaschko’s lines can also occur. It is a disorder of keratinization involving the intraepidermal eccrine duct (acrosyringium) and is characterized by eccrine hamartoma and cornoid lamellation in pathology. The patient is a 29-year-old man with an 8-year history of pruritic skin lesions on his right lateral ankle. In the pathologic examination, multiple small epidermal invagination with overlying parakeratotic cornoid lamellation, loss of granular layer, and few dyskeratotic cells at the base of epidermal invagination are revealed. After clinic-pathologic correlation, the diagnosis of porokeratotic eccrine ostial and dermal duct nevus (PEODDN) was made. Late-onset and rare clinical presentation as pruritic lesion are the characteristic features that make this patient an extraordinary presentation of PEODDN.

scholarly journals Concomitant B Hairy Cell Leukemia and Mycosis Fungoides in an Elderly Man

2017 ◽  
Vol 9 (1) ◽  
pp. 103-107
Author(s):  
Eric Wong ◽  
Muhammad N. Mahmood ◽  
Thomas G. Salopek
Keyword(s):  
Mycosis Fungoides ◽  
Hairy Cell Leukemia ◽  
Lymphoproliferative Disorder ◽  
Skin Lesions ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Acneiform Eruption ◽  
History Of ◽  
Low Prevalence ◽  
New Onset

The development of both a T- and B-cell lymphoproliferative disorder in one patient is an unlikely coincidence due to the low prevalence of each malignancy. We report a 65-year-old man with a previously documented history of B hairy cell leukemia, who presented with a new-onset acneiform eruption of his scalp, face, trunk, back, and extremities. Routine pathology of the skin lesions with immunohistochemical stains and molecular studies were consistent with a folliculotropic mycosis fungoides. B hairy cell leukemia and mycosis fungoides occurring in the same patient seems to be a rare phenomenon with only 5 cases reported in the literature.

scholarly journals Childhood Hypopigmented Mycosis Fungoides: A Rare Diagnosis

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Cláudia Patraquim ◽  
Maria Miguel Gomes ◽  
Carla Garcez ◽  
Filipa Leite ◽  
Tereza Oliva ◽  
...  
Keyword(s):  
Skin Biopsy ◽  
Mycosis Fungoides ◽  
Narrow Band ◽  
Skin Lesions ◽  
Ultraviolet B ◽  
Topical Corticosteroids ◽  
Cutaneous Lymphomas ◽  
History Of ◽  
Clinical Variants ◽  
Rare Diagnosis

Primary cutaneous lymphomas (PCL) are rare in pediatrics. Mycosis fungoides (MF) is the most frequent PCL diagnosed in childhood. There are various clinical variants of MF, including the hypopigmented MF (HMF). We present a 5-year-old boy with an 18-month history of progressive, generalized, nonpruritic hypopigmented lesions with central lacy erythema. He had no improvement with emollients. Skin biopsy showed typical features of HMF. He was treated with topical corticosteroids and tacrolimus and narrow-band ultraviolet B (NBUVB) phototherapy, with good response. HMF may mimic multiple skin disorders. Unusual hypopigmented skin lesions should be biopsied. Though phototherapy is effective, recurrence is common.

scholarly journals Linear lichen planus associated with primary aldosteronism

2021 ◽  
Vol 12 (4) ◽  
pp. 468-469
Author(s):  
Natsuko Matsumura ◽  
Toshiyuki Yamamoto
Keyword(s):  
T Lymphocytes ◽  
Lichen Planus ◽  
Primary Aldosteronism ◽  
Histopathological Examination ◽  
Metastatic Cancer ◽  
Lymphocytic Infiltration ◽  
Skin Lesions ◽  
Unknown Etiology ◽  
Cd8 T Lymphocytes ◽  
History Of

Sir, Lichen planus (LP) is categorized as a chronic inflammatory skin disease of unknown etiology that involves immune reactions. It is characterized by flat-topped, polygonal, violaceous papules and plaques. It has various clinical presentations, such as classical LP, hypertrophic LP, LP pigmentosus, and linear LP (LLP). Primary aldosteronism (PA) is known to pose a higher risk of causing multiple autoimmune diseases [1]. Herein, we report a case with LLP and PA present at the same time. A 72-year-old Japanese female presented herself to our hospital with a three-month history of slightly itchy skin lesions on the lower right leg. A physical examination revealed flat-topped plaques on the lower right limb extending from the middle of the leg to the dorsum of the foot (Fig. 1a). There was no oral or nail involvement. The patient had a history of hypertension from the age of 62 years and was diagnosed with PA afterward. The patient had been treated with an antihypertensive drug since then without change in internal medication. The patient had no history of a preceding trauma, dental metal fillings, hepatitis, metastatic cancer, or any other infections. A histopathological examination of a skin biopsy from a lesion on the right leg revealed hyperkeratosis, a saw-tooth appearance of the epidermis, and severe liquefaction degeneration. A band-like lymphocytic infiltration was present in the upper dermis (Figs. 2a and 2b), as well as lichenoid infiltration into the dermis composed of CD4+ and CD8+ T lymphocytes. Predominantly, CD8+ T lymphocytes infiltrated into the epidermis (Figs. 2c and 2d). Clinical and histological findings confirmed the diagnosis of LPP.

Stepping up detection, response, preparedness and readiness measures for “COVID-19”- A Pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1042-1047
Author(s):  
Khushbu Balsara ◽  
Deepankar Shukla
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Clinical History ◽  
Frontline Workers ◽  
Diagnostic Assays ◽  
Care Workers ◽  
Short Period ◽  
History Of ◽  
Detection Response ◽  
Care Worker

In a very short period of time, “COVID-19” has seized the consciousness globally by making remarkable changes in our day to day living and has superintended as a public health emergency globally. It has high radar of transmission, affecting an individual at work to frontline workers. The measures and planning for a response plays a key role from drawing up an emergency committee and this follows an equation which broadly deals with epidemiological to clinical history of the patient, management steps from isolation, screening, diagnostic assays for identification and treatment. The application of an organized plan with secure structure aids in better performance, increases efficacy of management and saves time. Also saves time for a health care worker to g through routine levels of channels of administration if already a familiar way of operation is known for such situations. Thus, planning and developing a ‘blueprint of approach’ towards management of patient while facing such situation is a must. This review provides an insight to the measures for detection, response and preparedness of the hospital and health care workers should largely be inclusive of; also highlights the measures to be taken at every step after coming in contact with a positive case of “COVID-19”.

“The last chord of the Silver Age”: science and culture in Crimea in 1920

2020 ◽  
Vol 2020 (10-4) ◽  
pp. 4-14
Author(s):  
Vladimir Kalinovsky ◽  
Alexander Puchenkov
Keyword(s):  
Civil War ◽  
The South ◽  
Silver Age ◽  
Russian Culture ◽  
Short Period ◽  
The Crimea ◽  
Science And Culture ◽  
History Of ◽  
Russian Intelligentsia

This article is devoted to the development of science and culture in the short period of the Wrangel Crimea - 1920. At this time, the brightest figures of Russian culture of that time worked on the territory of the small Peninsula: O. E. Mandelstam, M. A. Voloshin, B.D. Grekov, G.V. Vernadsky, V.I. Vernadsky and others. The article provides an overview of the life and activities of the Russian intelligentsia in 1920 in the Crimea, based on materials of periodicals as the most important source for studying the history of the Civil war in the South of Russia whose value is to be fully evaluated.

A Rare Case of Spinal Leprosy Mimicking Spinal Tuberculosis

2019 ◽  
pp. 33
Author(s):  
K Thuraikumar ◽  
V Naveen ◽  
Mustaqim A ◽  
Arieff AA ◽  
K Shri ◽  
...  
Keyword(s):  
Back Pain ◽  
Soft Tissue ◽  
Histopathological Examination ◽  
Posterior Instrumentation ◽  
Spinal Tuberculosis ◽  
Previous History ◽  
Skin Lesions ◽  
Titanium Implants ◽  
Paravertebral Abscess ◽  
History Of

Introduction: Spinal tuberculosis is the most common manifestation of extrapulmonar y tuberculosis. A combination of leprosy and tuberculosis is a rare entity.Case report: A 44-year-old male patient working as a laborer presented to our hospital with complaints of severe back pain and swelling over the back, difficulty in walking, associated with constitutional symptoms. On admission, he was febrile and had leukocytosis. Initial spine X-ray showed end plate destruction and increase in soft tissue shadow at the level of T8-T9. CT spine revealed thoracic paravertebral collection extending from T7 to T9 levels, suggest ive of tuberculous spondylitis with cold abscess. Patient refused a transpedicular biopsy and was started on anti-tubercular therapy. Two weeks after commencement of treatment, he developed worsening back pain and weakness of the lower extremities. MRI spine showed a paravertebral abscess and posterior soft tissue edema involving level of T7 to T11. Patient underwent a posterior decompression, debridement and posterior instrumentation. He was discharged well, there was improvement of his lower limb power. Upon clinic review, he complained of multiple hyperpigmented, painless, nonpruritic skin lesions over the trunk and back. No previous history of eczema, psoriasis and Tinea corporis. Given the history of allergy, initial impression was hypersensitivity reaction towards the titanium implants, and he was started on anti-histamines. However, there was no improvements seen. Histopathological examination of skin lesions revealed presence of granuloma within the dermis layer, composed of epitheloid, histiocytes, lymphocytes and plasma cells. Wade-Fite stain for Mycobacterium leprae is positive. Slit skin smear shows multibacillary leprosy. Patient was started on multidrug therapy (rifampicin, clofazimine and dapsone) for 1 year. He has recovered well.International Journal of Human and Health Sciences Supplementary Issue: 2019 Page: 33

scholarly journals Case report: Manual therapies promote resolution of persistent post-concussion symptoms in a 24-year-old athlete

2021 ◽  
Vol 9 ◽  
pp. 2050313X2095222
Author(s):  
Susan Vaughan Kratz
Keyword(s):  
Case Report ◽  
Symptom Severity ◽  
Impact Test ◽  
Manual Therapies ◽  
Symptom Checklist ◽  
Post Concussion Syndrome ◽  
Persistent Symptoms ◽  
Short Period ◽  
History Of ◽  
Headache Impact

This case report illustrates the treatment outcomes of a collegiate athlete presenting with an 18-month history of post-concussion syndrome who received a series of mixed manual therapies in isolation of other therapy. Persistent symptoms were self-reported as debilitating, contributing to self-removal from participation in school, work, and leisure activities. Patient and parent interviews captured the history of multiple concussions and other sports-related injuries. Neurological screening and activities of daily living were baseline measured. Post-Concussion Symptom Checklist and Headache Impact Test-6™ were utilized to track symptom severity. Treatments applied included craniosacral therapy, manual lymphatic drainage, and glymphatic techniques. Eleven treatment sessions were administered over 3 months. Results indicated restoration of oxygen saturation, normalized pupil reactivity, and satisfactory sleep. Post-concussion syndrome symptom severity was reduced by 87% as reflected by accumulative Post-Concussion Symptom Checklist scores. Relief from chronic headaches was achieved, reflected by Headache Impact Test-6 scores. Restoration of mood and quality of life were reported. A 6-month follow-up revealed symptoms remained abated with full re-engagement of daily activities. The author hypothesized that post-concussion syndrome symptoms were related to compression of craniosacral system structures and lymphatic fluid stagnation that contributed to head pressure pain, severe sleep deprivation, and multiple neurological and psychological symptoms. Positive outcomes over a relatively short period of time without adverse effects suggest these therapies may offer viable options for the treatment of post-concussion syndrome.

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