Platelet Contribution to Cancer Cell Growth and Migration: The Role of Platelet Growth Factors

1988 ◽  
Vol 18 (1) ◽  
pp. 18-28 ◽  
Author(s):  
Andreina Poggi ◽  
Elisa Vicenzi ◽  
Vittoria Cioce ◽  
Åke Wasteson
Keyword(s):  
Growth Factors ◽  
Cell Growth ◽  
Cancer Cell ◽  
Cancer Cell Growth ◽  
Cell Growth And Migration ◽  
And Migration

scholarly journals p66α Suppresses Breast Cancer Cell Growth and Migration by Acting as Co-Activator of p53

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3593
Author(s):  
Qun Zhang ◽  
Yihong Zhang ◽  
Jie Zhang ◽  
Dan Zhang ◽  
Mengying Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Tumor Suppressor ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Target Genes ◽  
Cancer Cell Growth ◽  
Cell Growth And Migration ◽  
Breast Cancer Cell Growth ◽  
And Migration

p66α is a GATA zinc finger domain-containing transcription factor that has been shown to be essential for gene silencing by participating in the NuRD complex. Several studies have suggested that p66α is a risk gene for a wide spectrum of diseases such as diabetes, schizophrenia, and breast cancer; however, its biological role has not been defined. Here, we report that p66α functions as a tumor suppressor to inhibit breast cancer cell growth and migration, evidenced by the fact that the depletion of p66α results in accelerated tumor growth and migration of breast cancer cells. Mechanistically, immunoprecipitation assays identify p66α as a p53-interacting protein that binds the DNA-binding domain of p53 molecule predominantly via its CR2 domain. Depletion of p66α in multiple breast cells results in decreased expression of p53 target genes, while over-expression of p66α results in increased expression of these target genes. Moreover, p66α promotes the transactivity of p53 by enhancing p53 binding at target promoters. Together, these findings demonstrate that p66α is a tumor suppressor by functioning as a co-activator of p53.

scholarly journals Inhibitory effects of norcantharidin against human lung cancer cell growth and migration

2010 ◽  
Vol 62 (4) ◽  
pp. 349-355 ◽  
Author(s):  
Jinling Luan ◽  
Huiying Duan ◽  
Qian Liu ◽  
Kazumi Yagasaki ◽  
Guoying Zhang
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Inhibitory Effects ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Cell Growth And Migration ◽  
And Migration
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