Second Primary Cancer in Patients with Colorectal Cancer after a Curative Resection

2009 ◽  
Vol 26 (5) ◽  
pp. 400-405 ◽  
Author(s):  
Shingo Noura ◽  
Masayuki Ohue ◽  
Yosuke Seki ◽  
Koji Tanaka ◽  
Masaaki Motoori ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Curative Resection ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer

scholarly journals Machine Learning in Prediction of Second Primary Cancer and Recurrence in Colorectal Cancer

2020 ◽  
Vol 17 (3) ◽  
pp. 280-291
Author(s):  
Wen-Chien Ting ◽  
Yen-Chiao Angel Lu ◽  
Wei-Chi Ho ◽  
Chalong Cheewakriangkrai ◽  
Horng-Rong Chang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Machine Learning ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer

The incidence of second primary cancer in male and female patients with initial colorectal cancer

2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Yanyan Chen ◽  
Chao Han ◽  
Yadi Huang ◽  
Chao Liu ◽  
Siqi Sheng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Male And Female ◽  
Female Patients

scholarly journals Second primary cancers and recurrence in patients after resection of colorectal cancer: An integrated analysis of trials by Japan Clinical Oncology Group: JCOG1702A

2020 ◽  
Author(s):  
Kiyo Tanaka ◽  
Gakuto Ogawa ◽  
Junki Mizusawa ◽  
Tomohiro Kadota ◽  
Kenichi Nakamura ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
General Population ◽  
Cumulative Incidence ◽  
National Database ◽  
Integrated Analysis ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Surveillance Strategy ◽  
Second Primary Cancers

Abstract Background Improvements in early detection and treatment have resulted in an increasing number of long-term survivors of colorectal cancer (CRC). For the survivors, second primary cancer and recurrence are important issues; however, evidence for an appropriate surveillance strategy remains limited. This study aimed to investigate the frequency and timing of second primary cancer in patients after surgery for exploring an appropriate surveillance strategy by using an integrated analysis of three large-scale randomized controlled trials in Japan. Methods The eligibility criteria of three trials included histologically confirmed CRC and having received surgery. The timing, site and frequency of second primary cancers and recurrence were investigated. Risk factors associated with second primary cancers were also examined. The standardized incidence ratio (SIR) of second primary cancers compared with the national database of the Japan Cancer Registry was estimated. Results A total of 2824 patients were included in this study. The cumulative incidence of second primary cancer increased over time. The SIR of any second primary cancer was 1.07 (95% CI: 0.94–1.21). The SIR for second primary cancers of colon was 1.09 (95% CI: 0.79–1.47). The cumulative incidence of recurrence almost reached plateau at 3 years. Conclusions A common surveillance strategy for the general population can be applied even for curatively resected CRC patients, as the risk of second primary cancers was almost the same as that of the general population.

Second primary cancers and recurrence in patients after resection of colorectal cancer: An integrated analysis of trials by Japan Clinical Oncology Group: JCOG0205, JCOG0212, JCOG0404 (JCOG1702A).

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 561-561
Author(s):  
Kiyo Tanaka ◽  
Gakuto Ogawa ◽  
Junki Mizusawa ◽  
Junko Eba ◽  
Hiroshi Katayama ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Cumulative Incidence ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Surveillance Strategy ◽  
Second Primary Cancers ◽  
Over Time

561 Background: Improvements in early detection and treatment have resulted in an increasing number of long-term survivors of colorectal cancer (CRC). For the survivors, Second primary cancers and recurrence are important issues, but the evidence for appropriate surveillance strategy is limited. The aim of this study was to investigate the frequency and the timing of second primary cancers and recurrence in patients (pts) after surgery using 3 randomized trials (J0205, J0212 and J0404) conducted by Colorectal Cancer Study Group of JCOG. Methods: Eligibility criteria included histologically proven CRC and having received surgery. The timing, site and frequency of second primary cancer and recurrence were investigated. Risk factors associated with the events were explored. Standardized incidence ratio (SIR) about second primary cancer compared with national database of Japan Cancer Registry was estimated. Results: A total of 2,824 pts with a median follow-up time of 6 years were included. Median age was 62 years old (23-75), male/female was 58%/42%, and stage 0/I/II/III/IV was 0.2%/8.7%/25.4%/64.8%/0.9%. Pts with 5-FU based adjuvant chemotherapy were 63%. Cumulative incidence of second primary cancer increased constantly over time (Table). Among 240 pts, the most common site was lung (37), stomach (35) and colon (32). In multivariable analysis, age (over 64 years old) and sex (male) were risk factors (age HR: 1.60 (95% CI: 1.24-2.07), sex HR: 1.36 (95% CI: 1.04-1.78)). The SIR of any second primary cancers was 1.07 (95% CI: 0.94-1.21). The SIR for second primary cancers of colon was 1.09 (95% CI: 0.79-1.47). On the other hand, cumulative incidence of recurrence almost reached at 3 years. Conclusions: Common surveillance strategy can be applied even for curatively resected CRC pts after 3 years from surgery, because the risk of second primary cancer was almost same as general population over time. The necessity of intensive follow-up to detect recurrence decreases after 3 years. [Table: see text]

scholarly journals Occurrence of second primary cancer after curative resection of cholangiocarcinoma: a report of 5 cases

2017 ◽  
Vol 4 (4) ◽  
pp. 1455
Author(s):  
Hao Long ◽  
Menghao Wang ◽  
Jianping Gong ◽  
Lan Hu
Keyword(s):  
Curative Resection ◽  
Early Stage ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Second Primary Cancers ◽  
History Of ◽  
Well Differentiated ◽  
Operative Excision ◽  
History Of Cancer

The second primary cancer, a new cancer subsequent to the initial cancer, usually occurs in a person who has a history of cancer or the patient treated with curative resection. Although the pathogenesis of second primary cancer is unclear, it is always found that occurrence of second primary cancer is related to the age and family history. In our 5 cases’ reports, second primary cancer occurs after curative resection of cholangiocarcinoma. And most of the second primary cancers belong to well differentiated adenocarcinomas which grow slowly and never metastasize distally in early stage. Therefore, operative excision is the most effective treatment. At the same time, conventional examination after operation could improve early diagnosis and timely surgical treatment.

Aspirin and risks of non-colorectal second primary cancer in patients with prior colorectal cancer.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 1564-1564
Author(s):  
Yu-Ting Lee ◽  
Chung-Jen Teng ◽  
Jin-Hwang Liu ◽  
Tzeon-Jye Chiou ◽  
Po-Min Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer

scholarly journals 239Incidence and potential risk factors of a second primary cancer among 217,702 colorectal cancer survivors

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Yingju Tseng ◽  
Linda Liang ◽  
Stefanie J Klug
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Cancer Survivors ◽  
Potential Risk ◽  
Tumour Size ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer ◽  
Increased Risk ◽  
Potential Risk Factors

Abstract Background Survival of colorectal cancer (CRC) has improved markedly but risk of an independent second primary cancer (SPC) increases. We determined incidence and potential risk factors of SPC following CRC. Methods We obtained data from 217,202 CRC cases (ICD-10 C18-C20, aged ≥20 years) diagnosed between 1990-2013 from the German Centre for Cancer Registry Data. Cancers arising in a distinct site (excluding non-melanoma skin cancer) and/or of a different histology group were classified as SPCs. Standardised incidence ratios (SIR) and 95% confidence intervals compared the excess risk to the general population, stratified by age, sex and CRC sub-site. Cox proportional hazards models identified potential risk factors of SPC. Results Following CRC (median age 70 years), 18,751 SPCs occurred (8.63%; median age 69 years). SPC incidence increased by 36% in males (SIR: 1.36 [1.34-1.38]), 46% in females (SIR: 1.46 [1.43-1.49]) and doubled for cases <65 years (SIR: 2.08 [1.99-2.17]). Common SPC sites following colon cancer included the small intestine, stomach, liver, pancreas, bladder and kidney. Common male-specific sites included prostate and in females: breast, uterus and ovary. Similar sites were observed following rectal cancer, particularly in cases <65 years. Age, male sex and tumour size (T1, T2) were potential risk factors of SPC. Therapy of CRC (including radiotherapy) did not demonstrate an elevated risk. Conclusions CRC survivors have an increased risk of SPC, particularly due to age, sex and tumour size. Key messages Colorectal cancer survivors have an increased risk of a SPC. Age, sex and tumour size are associated risk factors.

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