Antibacterial Activities of Tosufloxacin against Anaerobic Bacteria and the Electron Micrograph of Its Bactericidal Effects

Chemotherapy ◽  
1997 ◽  
Vol 43 (3) ◽  
pp. 153-158 ◽  
Author(s):  
Masahiro Takahata ◽  
Takeshi Nishino
Keyword(s):  
Anaerobic Bacteria ◽  
Antibacterial Activities ◽  
Electron Micrograph ◽  
Bactericidal Effects

scholarly journals Bactericidal and Morphological Effects of NE-2001, a Novel Synthetic Agent Directed against Helicobacter pylori

2005 ◽  
Vol 49 (8) ◽  
pp. 3468-3473 ◽  
Author(s):  
Guofei Dai ◽  
Ni Cheng ◽  
Lei Dong ◽  
Mutsumi Muramatsu ◽  
Shudong Xiao ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Anaerobic Bacteria ◽  
Antibacterial Activities ◽  
Clinical Isolates ◽  
Synthetic Compound ◽  
Morphological Alterations ◽  
Transmission Electron Microcopy ◽  
Transmission Electron ◽  
Bactericidal Effects ◽  
Aerobic And Anaerobic

ABSTRACT The antibacterial activities of NE-2001 were tested against 24 clinical isolates of Helicobacter pylori and compared with those of amoxicillin, clarithromycin, metronidazole, and furazolidone. The MIC50 and MIC90 of this synthetic compound on the isolates were 8 and 16 μg/ml, respectively. This action was highly selective against Helicobacter pylori; there was a >4-fold difference between the concentration of NE-2001 required to inhibit the growth of Helicobacter pylori and that required to inhibit the growth of common aerobic and anaerobic bacteria. Exposure of Helicobacter pylori (ATCC43504) to NE-2001 at the MIC (4 μg/ml), or at a greater concentration, resulted in an extensive loss of viability. The phenomenon was also observed at pH levels between 3.0 and 7.0. When two clinical Helicobacter pylori strains were successively cultured at subinhibitory concentrations of NE-2001, no significant changes in the bactericidal effects were found. The morphological alterations of Helicobacter pylori cells (ATCC43504), exposed to NE-2001 at various concentrations for 6 h, were observed using transmission electron microcopy. The bacterium displayed features such as swelling, vacuole-like structures in the cytoplasm, and cell destruction following exposure to NE-2001. The efficacy of NE-2001 was maintained when evaluated in eight clinical isolates resistant to metronidazole and five isolates resistant to both metronidazole and clarithromycin (MIC ranging between 4 and 16 μg/ml). The above-described results suggest that NE-2001 may have the potential to be developed as a candidate agent for the treatment of Helicobacter pylori infection.

Preparation of Fine Ag2WO4 Antibacterial Powders and Its Application in the Sanitary Ceramics

2011 ◽  
Vol 284-286 ◽  
pp. 1321-1325 ◽  
Author(s):  
Qian Ping Wang ◽  
Xiang Xiong Guo ◽  
Wei Hua Wu ◽  
Shu Xian Liu
Keyword(s):  
Antibacterial Activities ◽  
Antimicrobial Action ◽  
Precipitation Method ◽  
Homogeneous Precipitation ◽  
Antibacterial Mechanism ◽  
Homogeneous Precipitation Method ◽  
Bactericidal Effects

Superfine Ag2WO4 antibacterial powders, which are prepared by supersonic assisted homogeneous precipitation method, is added 1.0-1.5wt.% to sanitary ceramics, having 90% antimicrobial action, and achieve good bactericidal effects. The antibacterial ceramics with Ag2WO4 were soaked into acid and alkali for 3 months, and antibacterial activities had little change, keeping good antimicrobial durability. Finally, the antibacterial mechanism of Ag2WO4 ceramics is advanced.

scholarly journals Chemical Analysis and Study of Phenolics, Antioxidant Activity, and Antibacterial Effect of the Wood and Bark ofMaclura tinctoria(L.) D. Don ex Steud.

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
K. C. Lamounier ◽  
L. C. S. Cunha ◽  
S. A. L. de Morais ◽  
F. J. T. de Aquino ◽  
R. Chang ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Effect ◽  
Anaerobic Bacteria ◽  
Tectona Grandis ◽  
Antibacterial Activities ◽  
High Potential ◽  
Total Phenols ◽  
Wood Extracts ◽  
Resistance Rates ◽  
Aerobic And Anaerobic

Maclura tinctoria(L.) D. Don ex Steud. has one of the highest qualities among the coefficients for Brazilian woods (up to 9.6) and resistance rates equivalent to Indian teak (Tectona grandis). In this study, the macromolecular constituents and total phenols compounds as well as the antioxidant and antibacterial activities of this wood were evaluated. Total phenols and proanthocyanidin levels were higher in wood when compared with bark levels. The antioxidant activity of wood extracts (IC50= 18.7 μg/mL) was more effective than that of bark extracts (IC50= 20.9 μg/mL). Wood and bark extracts revealed a high potential for inhibition of aerobic and anaerobic bacteria. The bark extracts were the most active (MIC from 20 to 60 μg/mL). Both antioxidant activity and high potential for bacteria inhibition turn these extracts promising for drug formulations, especially as antibacterial agent.

scholarly journals In Vitro and In Vivo Antibacterial Activities of TAK-083, an Agent for Treatment of Helicobacter pyloriInfection

2001 ◽  
Vol 45 (9) ◽  
pp. 2455-2459 ◽  
Author(s):  
Tsuneo Kanamaru ◽  
Yoshitaka Nakano ◽  
Yukio Toyoda ◽  
Ken-Ichiro Miyagawa ◽  
Mayumi Tada ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Anaerobic Bacteria ◽  
Antibacterial Activities ◽  
Mongolian Gerbils ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
H Pylori ◽  
Aerobic And Anaerobic

ABSTRACT The antibacterial activity of TAK-083 was tested against 54 clinical isolates of Helicobacter pylori and was compared with those of amoxicillin, clarithromycin, and metronidazole. The growth-inhibitory activity of TAK-083 was more potent than that of amoxicillin, clarithromycin, or metronidazole (the MICs at which 90% of the strains are inhibited were 0.031, 0.125, 64, and 8 μg/ml, respectively). The antibacterial activity of TAK-083 was highly selective against H. pylori; there was a >30-fold difference between the concentration of TAK-083 required to inhibit the growth of H. pylori and that required to inhibit the growth of common aerobic and anaerobic bacteria. Exposure ofH. pylori strains to TAK-083 at the MIC or at a greater concentration resulted in an extensive loss of viability. When four H. pylori strains were successively subcultured in the medium containing subinhibitory concentrations of TAK-083, no significant change in the MICs of this compound was observed. TAK-083 strongly inhibited the formation of tryptophanyl-tRNA in H. pylori while exhibiting little effect on the same system in eukaryotes. TAK-083 was efficacious in the treatment of gastric infection caused by H. pylori in Mongolian gerbils. The results presented here indicate that TAK-083 is a promising candidate for the treatment of H. pylori infection.

scholarly journals In VitroPotential of Lycosin-I as an Alternative Antimicrobial Drug for Treatment of Multidrug-Resistant Acinetobacter baumannii Infections

2014 ◽  
Vol 58 (11) ◽  
pp. 6999-7002 ◽  
Author(s):  
Ling Wang ◽  
Yong-Jun Wang ◽  
Yin-Yin Liu ◽  
Hui Li ◽  
Ling-Xia Guo ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Antibacterial Activities ◽  
Multidrug Resistant ◽  
Antimicrobial Drug ◽  
High Salt ◽  
Content Type ◽  
Bactericidal Effects

ABSTRACTThe resistance of multidrug-resistantAcinetobacter baumannii(MDRAB) isolates to most traditional antibiotics results in huge challenges for infection therapy. We investigated thein vitroactivities of bothl- andd-lycosin-I against MDRAB. These two compounds displayed high antibacterial activities and rapid bactericidal effects against MDRAB. Moreover, the compounds retained their activity even at high salt (Mg2+or Ca2+) concentrations. These results demonstrate the potential of lycosin-I to be developed as a new antibiotic.

scholarly journals Nanomaterials for the Photothermal Killing of Bacteria

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1123 ◽  
Author(s):  
Sibidou Yougbaré ◽  
Chinmaya Mutalik ◽  
Dyah Ika Krisnawati ◽  
Heny Kristanto ◽  
Achmad Jazidie ◽  
...  
Keyword(s):  
Human Health ◽  
Structural Properties ◽  
Near Infrared ◽  
Antibacterial Activities ◽  
Multidrug Resistant ◽  
Clinical Applications ◽  
Light Irradiation ◽  
Nir Light ◽  
Current Trends ◽  
Bactericidal Effects

An upsurge in the multidrug-resistant (MDR) bacterial pestilence is a global cause for concern in terms of human health. Lately, nanomaterials with photothermal effects have assisted in the efficient killing of MDR bacteria, attributable to their uncommon plasmonic, photocatalytic, and structural properties. Examinations of substantial amounts of photothermally enabled nanomaterials have shown bactericidal effects in an optimized time under near-infrared (NIR) light irradiation. In this review, we have compiled recent advances in photothermally enabled nanomaterials for antibacterial activities and their mechanisms. Photothermally enabled nanomaterials are classified into three groups, including metal-, carbon-, and polymer-based nanomaterials. Based on substantial accomplishments with photothermally enabled nanomaterials, we have inferred current trends and their prospective clinical applications.

scholarly journals High-Level Antimicrobial Efficacy of Representative Mediterranean Natural Plant Extracts against Oral Microorganisms

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Lamprini Karygianni ◽  
Manuel Cecere ◽  
Alexios Leandros Skaltsounis ◽  
Aikaterini Argyropoulou ◽  
Elmar Hellwig ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Present Report ◽  
Treatment Options ◽  
Anaerobic Bacteria ◽  
Fusobacterium Nucleatum ◽  
Oral Diseases ◽  
Parvimonas Micra ◽  
Bactericidal Effects ◽  
High Level ◽  
Oral Microorganisms

Nature is an unexplored reservoir of novel phytopharmaceuticals. Since biofilm-related oral diseases often correlate with antibiotic resistance, plant-derived antimicrobial agents could enhance existing treatment options. Therefore, the rationale of the present report was to examine the antimicrobial impact of Mediterranean natural extracts on oral microorganisms. Five different extracts fromOlea europaea, mastic gum, andInula viscosawere tested against ten bacteria and oneCandida albicansstrain. The extraction protocols were conducted according to established experimental procedures. Two antimicrobial assays—the minimum inhibitory concentration (MIC) assay and the minimum bactericidal concentration (MBC) assay—were applied. The screened extracts were found to be active against each of the tested microorganisms.O. europaeapresented MIC and MBC ranges of 0.07–10.00 mg mL−1and 0.60–10.00 mg mL−1, respectively. The mean MBC values for mastic gum andI. viscosawere 0.07–10.00 mg mL−1and 0.15–10.00 mg mL−1, respectively. Extracts were less effective againstC. albicansand exerted bactericidal effects at a concentration range of 0.07–5.00 mg mL−1on strict anaerobic bacteria (Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and Parvimonas micra). Ethyl acetateI. viscosaextract and total mastic extract showed considerable antimicrobial activity against oral microorganisms and could therefore be considered as alternative natural anti-infectious agents.

Light Optical Diffraction Studies of Macromolecular Ultrastructure

1970 ◽  
Vol 28 ◽  
pp. 258-259
Author(s):  
Glen B. Haydon
Keyword(s):  
High Resolution ◽  
Diffraction Analysis ◽  
Diffraction Pattern ◽  
Electron Micrographs ◽  
Optical Diffraction ◽  
Electron Micrograph ◽  
Its Analysis ◽  
Resolution Electron ◽  
Diffraction Patterns

Analysis of light optical diffraction patterns produced by electron micrographs can easily lead to much nonsense. Such diffraction patterns are referred to as optical transforms and are compared with transforms produced by a variety of mathematical manipulations. In the use of light optical diffraction patterns to study periodicities in macromolecular ultrastructures, a number of potential pitfalls have been rediscovered. The limitations apply to the formation of the electron micrograph as well as its analysis.(1) The high resolution electron micrograph is itself a complex diffraction pattern resulting from the specimen, its stain, and its supporting substrate. Cowley and Moodie (Proc. Phys. Soc. B, LXX 497, 1957) demonstrated changing image patterns with changes in focus. Similar defocus images have been subjected to further light optical diffraction analysis.

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