Total Serum Immunoglobulins and Atopic Symptoms in Patients with Vitiligo

Dermatology ◽  
1994 ◽  
Vol 189 (1) ◽  
pp. 27-31 ◽  
Author(s):  
C. Chatain ◽  
J. Ring ◽  
K.U. Schallreuter
Keyword(s):  
Total Serum ◽  
Serum Immunoglobulins

scholarly journals Serum immunoglobulins and anti-pneumococcal antibody levels in patients with bronchiectasis of unknown aetiology

2020 ◽  
Vol 19 (2) ◽  
pp. 200-207
Author(s):  
Mustafa Norhazlin ◽  
Asrul Abdul Wahab ◽  
Mohd Faisal Abdul Hamid ◽  
Hamzaini Abdul Hamid ◽  
Husyairi Harunarashid
Keyword(s):  
Streptococcus Pneumoniae ◽  
Specific Antibody ◽  
Capsular Polysaccharide ◽  
Medical Science ◽  
Asian Population ◽  
Immunoglobulin Therapy ◽  
Female Gender ◽  
Total Serum ◽  
Capsular Polysaccharides ◽  
Serum Immunoglobulins

Background: Bronchiectasis is a chronic condition which can result in significant physical and social morbidity. The exact prevalence in Malaysia is unknown although several studies have shown a higher prevalence in the Asian population. Several causative factors have been identified but there are many patients with unknown aetiologies. This study looks into the level of serum immunoglobulins and antipenumococcal antibody in bronchiectasis patients where they were not part of prior routine investigations. Methodology: Four hundred fifteen bronchiectasis patients were screened and 26 patients who fulfilled the inclusion and exclusion criteria were enrolled for this study. The serum immunoglobulins (IgG, IgA and IgM) concentrations were measured using nephelometry and interpreted according to age-matched reference range. The integrity of antibody production against specific antibody to capsular polysaccharides of Streptococcus pneumoniae were assessed using ELISA method and the level of ≥ 10mg/L is considered as reactive. Results: The twenty six bronchiectasis patients have the mean age of 62 years and a predilection of female gender. Majority of patients presented with typical bronchiectasis symptoms which were further supported by radiological findings. One of 26 patients (4%) had low total serum IgG level. The vaccinated group has higher anti-pneumococcal capsular polysaccharide antibody level (median: 224.2 mg/L) compared to the unvaccinated group (median: 100.4 mg/L). However there is no statistical difference between the anti-PCP levels of both groups (p> 0.05). All of the selected patients had reactive specific antibody to capsular polysaccharides of Streptococcus pneumoniae regardless of the vaccination status, which may reflect the natural acquisition of anti-pneumococcal immunity. Conclusion: Although immunoglobulin deficiency is an uncommon aetiological cause of bronchiectasis, the immunoglobulin parameters can be helpful in selecting patients who should receive the appropriate treatment of immunoglobulin therapy for the prevention of subsequent complications and better quality of life. Bangladesh Journal of Medical Science Vol.19(2) 2020 p.200-207

scholarly journals Experimental splenectomies and malaria in mice

2009 ◽  
Vol 24 (6) ◽  
pp. 437-441 ◽  
Author(s):  
Róbson Miguel de Araújo Negreiros ◽  
Fabiano Hiromichi Makimoto ◽  
Linda Luciana Oliveira Santana ◽  
Luís Carlos de Lima Ferreira ◽  
Gerson Suguiyama Nakajima ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Plasmodium Berghei ◽  
Blood Cells ◽  
Total Serum ◽  
Splenic Trauma ◽  
Female Mice ◽  
Serum Immunoglobulins ◽  
Elisa Technique ◽  
Dot Elisa

PURPOSE: To evaluate the importance of spleen in malaric infection in murino model, comparing the parasitemia and the titles of imunoglobulins in the different groups. METHODS: It was used female mice non-isogenic, in inoculated with Plasmodium berghei, cepa ANKA, intraperitoneally. The parasitemia was analyzed in 23rd, 25th, 27th and 32nd day of the experiment, being the stained blood' exam colored by Giemsa. The titles of the total serum immunoglobulins IgM and IgG were analyzed by Dot-ELISA technique, at 6th, 22nd and 32nd day, when the animals were sacrificed. RESULTS: The parasitemia was gradual in all the inoculated groups. In the end of the experiment, the animals with partial parasitemia present superior parasitemia, but next to the non-splenectomized, while the asplenics present difference bigger than the double. The levels of total serum IgM and IgG didin´t have significant changes with the removal partial or total splenic. CONCLUSION: The techniques conservatives in splenic trauma are possible and necessary. The importance of remaining spleen in the clearance of red blood cells parasitized by Plasmodium berghei showed being efficient, in order to avoid serious complications resulting of the malaria in mice.

Two Different UGT1A1 Mutations causing Crigler–Najjar Syndrome types I and II in an Iranian Family

2015 ◽  
Vol 24 (4) ◽  
pp. 523-526 ◽  
Author(s):  
Yoshihiro Maruo ◽  
Mahdiyeh Behnam ◽  
Shinichi Ikushiro ◽  
Sayuri Nakahara ◽  
Narges Nouri ◽  
...  
Keyword(s):  
Serum Bilirubin ◽  
Total Serum Bilirubin ◽  
Total Serum ◽  
Compound Heterozygous ◽  
Type I ◽  
Syndrome Type ◽  
Type Ii ◽  
Wild Type ◽  
Iranian Family ◽  
Udp Glucuronosyltransferase

Background: Crigler–Najjar syndrome type I (CN-1) and type II (CN-2) are rare hereditary unconjugated hyperbilirubinemia disorders. However, there have been no reports regarding the co-existence of CN-1 and CN-2 in one family. We experienced a case of an Iranian family that included members with either CN-1 or CN-2. Genetic analysis revealed a mutation in the bilirubin UDP-glucuronosyltransferase (UGT1A1) gene that resulted in residual enzymatic activity.Case report: The female proband developed severe hyperbilirubinemia [total serum bilirubin concentration (TB) = 34.8 mg/dL] with bilirubin encephalopathy (kernicterus) and died after liver transplantation. Her family history included a cousin with kernicterus (TB = 30.0 mg/dL) diagnosed as CN-1. Her great grandfather (TB unknown) and uncle (TB = 23.0 mg/dL) developed jaundice, but without any treatment, they remained healthy as CN-2. Results: The affected cousin was homozygous for a novel frameshift mutation (c.381insGG, p.C127WfsX23). The affected uncle was compound heterozygous for p.C127WfsX23 and p.V225G linked with A(TA)7TAA. p.V225G-UGT1A1 reduced glucuronidation activity to 60% of wild-type. Thus, linkage of A(TA)7TAA and p.V225G might reduce UGT1A1 activity to 18%–36 % of the wild-type. Conclusion: Genetic and in vitro expression analyses are useful for accurate genetic counseling for a family with a history of both CN-1 and CN-2. Abbreviations: CN-1: Crigler–Najjar syndrome type I; CN-2: Crigler–Najjar syndrome type II; GS: Gilbert syndrome; UGT1A1: bilirubin UDP-glucuronosyltransferase; WT: Wild type; TB: total serum bilirubin.

The Reference Intervals Used in Pediatric Medical Analysis Laboratories to Interpret the Results Analysis for Total Serum Calcium

2017 ◽  
Vol 68 (2) ◽  
pp. 243-245
Author(s):  
Elisabeta Antonescu ◽  
Maria Totan ◽  
Gheorghe Cornel Boitor ◽  
Julianna Szakacs ◽  
Sinziana Calina Silisteanu ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Colorimetric Method ◽  
Age Groups ◽  
Essential Element ◽  
Reference Intervals ◽  
Total Serum ◽  
Electronic Archive ◽  
Total Serum Calcium ◽  
Analysis Laboratory ◽  
Medical Analysis

Medical analysis laboratory must establish its own reference intervals depending on the facilities they are working with, the working substances and protocols. These reference intervals must be obtained depending on age groups in order to accurately interpret the results of the analyzes performed. The study is a retrospective one using 3217 data from the electronic archive of the S.C. Vladutiu&Garabedian S.R.L. Clinic in Medias. Total serum calcium was determined by the colorimetric method on the Konelab analyzer. Processing of the collected data was done using the Hoffmann method, considering 5% up to 95% of the values in the database, the values being randomly selected. For comparison, data from the literature was used. In children under 1 year old, it was not possible to calculate the reference intervals since data was insufficient. In the other age groups, reference intervals obtained in the current study were similar to the studied literature. Reference intervals established for calcium can provide important guidance for the reasonable supplementation of this essential element in children.

Genome-Wide Association and Transcriptome Analysis Reveals Total Serum Ghrelin to Be Linked with GFRAL

2020 ◽  
Author(s):  
Dirk Alexander Wittekind ◽  
Markus Scholz ◽  
Jürgen Kratzsch ◽  
Markus Loeffler ◽  
Katrin Horn ◽  
...  
Keyword(s):  
Transcriptome Analysis ◽  
Genome Wide Association ◽  
Total Serum ◽  
Genome Wide ◽  
Serum Ghrelin
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