Quetiapine, Olanzapine and Haloperidol Affect Human Plasma Lipid Peroxidation in vitro

AbstractMany selenoorganic compounds play an important role in biochemical processes and act as antioxidants, enzyme inhibitors or drugs. The effects of a new selenocompound — bis(2-aminophenyl)-diselenide on oxidative/nitrative changes in human plasma proteins induced by peroxynitrite (ONOO−) were studied in vitro and compared with the those of ebselen, a well-known antioxidant. We also studied the role of the tested selenocompounds in peroxynitrite-induced plasma lipid peroxidation. Exposure of the plasma to peroxynitrite (0.1 mM) resulted in an increase in the level of carbonyl groups and nitrotyrosine residues in plasma proteins (estimated using the ELISA method and Western blot analysis). In the presence of different concentrations (0.025–0.1 mM) of the tested selenocompounds, 0.1 mM peroxynitrite caused a distinct decrease in the level of carbonyl group formation and tyrosine nitration in plasma proteins. Moreover, these selenocompounds also inhibited plasma lipid peroxidation induced by ONOO−1 (0.1 mM). The obtained results indicate that in vitro bis(2-aminophenyl)-diselenide and ebselen have very similar protective effects against peroxynitrite-induced oxidative/nitrative damage to human plasma proteins and lipids.

Download Full-text

P.3.d.023 The effects of quetiapine and haloperidol on human plasma lipid peroxidation in vitro

European Neuropsychopharmacology ◽

10.1016/s0924-977x(08)70684-9 ◽

2008 ◽

Vol 18 ◽

pp. S461-S462

Author(s):

A. Dietrich-Muszalska ◽

J. Rabe-Jablonska ◽

B. Kontek

Keyword(s):

Lipid Peroxidation ◽

Human Plasma ◽

Plasma Lipid ◽

Plasma Lipid Peroxidation

Download Full-text

The extract from hop cones in plasma protects against changes following exposure to peroxynitrite

Open Life Sciences ◽

10.2478/s11535-011-0078-9 ◽

2011 ◽

Vol 6 (6) ◽

pp. 990-996 ◽

Cited By ~ 2

Author(s):

Beata Olas ◽

Joanna Kołodziejczyk-Czepas ◽

Barbara Wachowicz ◽

Dariusz Jędrejek ◽

Anna Stochmal ◽

...

Keyword(s):

Human Plasma ◽

Plasma Lipid ◽

Humulus Lupulus ◽

Raw Material ◽

Brewing Industry ◽

Coagulation Activity ◽

Medicinal Properties ◽

Plasma Lipid Peroxidation ◽

Antioxidative Action

AbstractHumulus lupulus (Cannabaceae) is well known throughout the world as a raw material in the brewing industry. The antioxidative action of hop cones is poorly understood, therefore the aim of our present study was to investigate in vitro changes in human plasma induced by peroxynitrite in the presence of the highly purified extract from hop cones (Humulus lupulus). The aim of our study was also to explain the effect of the extract from hop cones on coagulation activity of human plasma treated with peroxynitrite. The action of the extract from hop cones was compared with the properties of a well-characterized commercial monomeric polyphenol — resveratrol (3,4′,5-trihydroxystilbene). The tested plant extract, like resveratrol, significantly inhibited protein carbonylation and nitration in plasma treated with ONOO−(0.1 mM). The extract from hop cones, like resveratrol, also caused a distinct reduction of plasma lipid peroxidation induced by ONOO−. Moreover, the tested extract modulated the coagulation properties of plasma treated with peroxynitrite. It seems that antioxidative activities of the highly purified extract from hop cones may be responsible for its medicinal properties.

Download Full-text

Polyphenols from Berries ofAronia melanocarpaReduce the Plasma Lipid Peroxidation Induced by Ziprasidone

Schizophrenia Research and Treatment ◽

10.1155/2014/602390 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Anna Dietrich-Muszalska ◽

Justyna Kopka ◽

Bogdan Kontek

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Healthy Subjects ◽

Plasma Lipid ◽

Thiobarbituric Acid ◽

Tbars Level ◽

Polyphenol Compounds ◽

Aronia Melanocarpa ◽

Plasma Lipid Peroxidation

Background. Oxidative stress in schizophrenia may be caused partially by the treatment of patients with antipsychotics. The aim of the study was to establish the effects of polyphenol compounds derived from berries ofAronia melanocarpa(Aronox) on the plasma lipid peroxidation induced by ziprasidonein vitro.Methods. Lipid peroxidation was measured by the level of thiobarbituric acid reactive species (TBARS). The samples of plasma from healthy subjects were incubated with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) alone and with Aronox (5 ug/ml; 50 ug/ml).Results. We observed a statistically significant increase of TBARS level after incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) (after 24 h incubation:P=7.0× 10−4,P=1.6× 10−3, andP=2.7× 10−3, resp.) and Aronox lipid peroxidation caused by ziprasidone was significantly reduced. After 24-hour incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) in the presence of 50 ug/ml Aronox, the level of TBARS was significantly decreased:P=6.5× 10−8,P=7.0× 10−6, andP=3.0× 10−5, respectively.Conclusion. Aronox causes a distinct reduction of lipid peroxidation induced by ziprasidone.

Download Full-text

Copper-Manganese Interactions Concerning Red-Cell and Plasma Lipid Peroxidation

Free Radical Research Communications ◽

10.3109/10715768809066927 ◽

1988 ◽

Vol 5 (3) ◽

pp. 177-184 ◽

Cited By ~ 1

Author(s):

A. C. Fernandes ◽

C. F. Manso

Keyword(s):

Lipid Peroxidation ◽

Plasma Lipid ◽

Red Cell ◽

Copper Manganese ◽

Plasma Lipid Peroxidation

Download Full-text

Plasma Lipid Peroxidation as a Marker for Seminal Oxidative Stress in Stallion

Journal of Agricultural Science ◽

10.5539/jas.v11n6p401 ◽

2019 ◽

Vol 11 (6) ◽

pp. 401

Author(s):

Patricia Wolkmer ◽

Andressa M. G. Stumm ◽

Luiz F. K. Borges ◽

Eduarda P. T. Ferreira ◽

Bruna Favaretto ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Seminal Plasma ◽

Plasma Lipid ◽

Thiobarbituric Acid ◽

Thiobarbituric Acid Reactive Substances ◽

Semen Collection ◽

Semen Storage ◽

Plasma Lipid Peroxidation ◽

Antioxidant Enzyme Catalase

This experiment aims to evaluate the correlation between lipid peroxidation levels in serum and seminal plasma in equines. Also, it investigates the lipid peroxidation in extended semen samples and its effects and sperm motility during a 72 hr refrigeration period. Blood and semen were collected from fertile Crioulo stallions. Serum and seminal plasma lipid peroxidation levels were analyzed by thiobarbituric acid reactive substances (TBARS) immediately after semen collection. After addition of extender (hour = 0), diluted semen was refrigerated and stored at 5 °C. Semen analyses, TBARS and catalase activity were performed in extended semen at 0, 24, 48, and 72 hours. We noted that levels of plasma lipid peroxidation can be used as an indicative of seminal oxidative stress. Also, lipid peroxidation does not increase substantially during semen storage. Lipid peroxidation and the antioxidant enzyme catalase do not seem to be the major cause of loss and motility and consequently reduction in fertility in stallion semen during storage for 72 h at 5 °C.

Download Full-text