scholarly journals The protective effects of selenoorganic compounds against peroxynitrite-induced changes in plasma proteins and lipids

2006 ◽  
Vol 11 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Paweł Nowak ◽  
Joanna Saluk-Juszczak ◽  
Beata Olas ◽  
Joanna Kołodziejczyk ◽  
Barbara Wachowicz
Keyword(s):  
Lipid Peroxidation ◽  
Human Plasma ◽  
Plasma Proteins ◽  
Enzyme Inhibitors ◽  
Group Formation ◽  
Plasma Lipid ◽  
Protective Effects ◽  
Induced Changes ◽  
Plasma Lipid Peroxidation

AbstractMany selenoorganic compounds play an important role in biochemical processes and act as antioxidants, enzyme inhibitors or drugs. The effects of a new selenocompound — bis(2-aminophenyl)-diselenide on oxidative/nitrative changes in human plasma proteins induced by peroxynitrite (ONOO−) were studied in vitro and compared with the those of ebselen, a well-known antioxidant. We also studied the role of the tested selenocompounds in peroxynitrite-induced plasma lipid peroxidation. Exposure of the plasma to peroxynitrite (0.1 mM) resulted in an increase in the level of carbonyl groups and nitrotyrosine residues in plasma proteins (estimated using the ELISA method and Western blot analysis). In the presence of different concentrations (0.025–0.1 mM) of the tested selenocompounds, 0.1 mM peroxynitrite caused a distinct decrease in the level of carbonyl group formation and tyrosine nitration in plasma proteins. Moreover, these selenocompounds also inhibited plasma lipid peroxidation induced by ONOO−1 (0.1 mM). The obtained results indicate that in vitro bis(2-aminophenyl)-diselenide and ebselen have very similar protective effects against peroxynitrite-induced oxidative/nitrative damage to human plasma proteins and lipids.

Epicatechin Inhibits Human Plasma Lipid Peroxidation Caused by Haloperidol In Vitro

2011 ◽  
Vol 37 (3) ◽  
pp. 557-562 ◽  
Author(s):  
Anna Dietrich-Muszalska ◽  
Bogdan Kontek ◽  
Beata Olas ◽  
Jolanta Rabe-Jabłońska
Keyword(s):  
Lipid Peroxidation ◽  
Human Plasma ◽  
Plasma Lipid ◽  
Plasma Lipid Peroxidation

scholarly journals Quetiapine, Olanzapine and Haloperidol Affect Human Plasma Lipid Peroxidation in vitro

2011 ◽  
Vol 63 (4) ◽  
pp. 197-201 ◽  
Author(s):  
Anna Dietrich-Muszalska ◽  
Bogdan Kontek ◽  
Jolanta Rabe-Jabłońska
Keyword(s):  
Lipid Peroxidation ◽  
Human Plasma ◽  
Plasma Lipid ◽  
Plasma Lipid Peroxidation

The extract from hop cones in plasma protects against changes following exposure to peroxynitrite

2011 ◽  
Vol 6 (6) ◽  
pp. 990-996 ◽  
Author(s):  
Beata Olas ◽  
Joanna Kołodziejczyk-Czepas ◽  
Barbara Wachowicz ◽  
Dariusz Jędrejek ◽  
Anna Stochmal ◽  
...  
Keyword(s):  
Human Plasma ◽  
Plasma Lipid ◽  
Humulus Lupulus ◽  
Raw Material ◽  
Brewing Industry ◽  
Coagulation Activity ◽  
Medicinal Properties ◽  
Plasma Lipid Peroxidation ◽  
Antioxidative Action

AbstractHumulus lupulus (Cannabaceae) is well known throughout the world as a raw material in the brewing industry. The antioxidative action of hop cones is poorly understood, therefore the aim of our present study was to investigate in vitro changes in human plasma induced by peroxynitrite in the presence of the highly purified extract from hop cones (Humulus lupulus). The aim of our study was also to explain the effect of the extract from hop cones on coagulation activity of human plasma treated with peroxynitrite. The action of the extract from hop cones was compared with the properties of a well-characterized commercial monomeric polyphenol — resveratrol (3,4′,5-trihydroxystilbene). The tested plant extract, like resveratrol, significantly inhibited protein carbonylation and nitration in plasma treated with ONOO−(0.1 mM). The extract from hop cones, like resveratrol, also caused a distinct reduction of plasma lipid peroxidation induced by ONOO−. Moreover, the tested extract modulated the coagulation properties of plasma treated with peroxynitrite. It seems that antioxidative activities of the highly purified extract from hop cones may be responsible for its medicinal properties.

scholarly journals Polyphenols from Berries ofAronia melanocarpaReduce the Plasma Lipid Peroxidation Induced by Ziprasidone

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Anna Dietrich-Muszalska ◽  
Justyna Kopka ◽  
Bogdan Kontek
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Healthy Subjects ◽  
Plasma Lipid ◽  
Thiobarbituric Acid ◽  
Tbars Level ◽  
Polyphenol Compounds ◽  
Aronia Melanocarpa ◽  
Plasma Lipid Peroxidation

Background. Oxidative stress in schizophrenia may be caused partially by the treatment of patients with antipsychotics. The aim of the study was to establish the effects of polyphenol compounds derived from berries ofAronia melanocarpa(Aronox) on the plasma lipid peroxidation induced by ziprasidonein vitro.Methods. Lipid peroxidation was measured by the level of thiobarbituric acid reactive species (TBARS). The samples of plasma from healthy subjects were incubated with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) alone and with Aronox (5 ug/ml; 50 ug/ml).Results. We observed a statistically significant increase of TBARS level after incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) (after 24 h incubation:P=7.0× 10−4,P=1.6× 10−3, andP=2.7× 10−3, resp.) and Aronox lipid peroxidation caused by ziprasidone was significantly reduced. After 24-hour incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) in the presence of 50 ug/ml Aronox, the level of TBARS was significantly decreased:P=6.5× 10−8,P=7.0× 10−6, andP=3.0× 10−5, respectively.Conclusion. Aronox causes a distinct reduction of lipid peroxidation induced by ziprasidone.

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