Long-Term Functional, Cosmetic and Sexual Outcomes of Hypospadias Correction Performed in Childhood

2015 ◽  
Vol 95 (2) ◽  
pp. 137-141 ◽  
Author(s):  
S. Thiry ◽  
T. Saussez ◽  
S. Dormeus ◽  
B. Tombal ◽  
F.X. Wese ◽  
...  
Keyword(s):  
Hypospadias Repair ◽  
Single Item ◽  
Mean Values ◽  
Sexual Outcomes ◽  
High Satisfaction ◽  
Number Of Patients ◽  
Overall Evaluation ◽  
Long Term Impact ◽  
Hypospadias Surgery

Objective: Hypospadias surgery, especially when performed early in life, may have a significant impact on the urinary and sexual functions in an adult. Because the literature is still limited, this paper assesses long-term functional, cosmetic and sexual results of hypospadias repair performed in childhood. Patients and Methods: The study includes 275 patients older than 12 years treated for a hypospadias by an Onlay, Mathieu, Duplay, or Duckett's technique between January 1990 and December 2000. Flowmetry results were retrospectively obtained from patients' charts. The Paediatric Penile Perception Score (PPPS), the Hypospadias Objective Scoring Evaluation (HOSE) and the IIEF-5 score (when older than 16 years old) questionnaires were used to assess cosmetic and sexual results. The PPPS is designed to assess both penile self-perception with regard to meatus, glans, skin and general appearance. The HOSE is a five-point scoring system designed to allow an objective appraisal of the outcome of hypospadias repair, based on evaluating meatal location, meatal shape, urinary stream, straightness of erection, and the presence and complexity of any complicating urethral fistula. Results: Qmax were within age-adjusted references, independent of the surgical technique, with median (range) Qmax of 18.8 ml/s (range 3-45, n = 136). Patients expressed a high satisfaction for every single item of the penile perception scale (PPPS), with mean values between 2 (satisfied) and 3 (very satisfied). Eighty-two percent were satisfied or very satisfied of the overall evaluation of penile appearance. Eighty-one percent of patients had a normal erectile function (IIEF-5 >22; n = 35/43). Conclusions: Taking into account the limitation of a small number of patients resulting from a low 21% questionnaire's response rate, the results of this study align with previous reports from the literature and confirms that hypospadias repair using standard techniques results in acceptable functional, cosmetic and sexual outcomes. This study highlights the need of developing a set of standard approved outcomes assessments tools for evaluating the long-term impact of hypospadias repair performed in infancy.

Rectosigmoid vaginoplasty in patients with vaginal agenesis: sexual and psychosocial outcomes

Sexual Health ◽  
2011 ◽  
Vol 8 (3) ◽  
pp. 427 ◽  
Author(s):  
Ljiljana D. Labus ◽  
Miroslav L. Djordjevic ◽  
Dusan S. Stanojevic ◽  
Marta R. Bizic ◽  
Borko Z. Stojanovic ◽  
...  
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Psychosocial Adjustment ◽  
Severe Depression ◽  
Vaginal Agenesis ◽  
Symptoms Of Depression ◽  
High Satisfaction ◽  
Number Of Patients ◽  
The Right

Background The main goal in women with Mayer–Rokitansky–Küster–Hauser syndrome (vaginal agenesis) is creation of a neovagina that will satisfy the patient’s desire. We evaluated sexual and psychosocial adjustment in patients who underwent rectosigmoid vaginoplasty because of vaginal agenesis. Methods: A total of 36 women, aged 21 to 38 years (mean = 26) who underwent rectosigmoid vaginoplasty from 1997 to 2006 were evaluated. Sexual and psychosocial appraisal included the Female Sexual Function Index (FSFI), Beck’s Depression Inventory (BDI), and standardised questionnaires about postoperative satisfaction, social and sexual adjustment. Results: Mean FSFI score was 28.9 (range = 11.5–35.7) with a cut-off score of 26.55 for sexual dysfunction. Out of the 36 women, 10 (27, 8%) had sexual dysfunction. Mean BDI score was 7.55 (cut-off score = 0–9 for non-depression). Twenty-eight women (77.8%) were without symptoms of depression, six women (BDI range = 10–29) had moderate and two women had severe depression (BDI = 42). There were a significant number of patients (P < 0.01) with a high satisfaction score in FSFI and low BDI results. Thirty-two (88.9%) of the patients believed that surgery was done at the right time and the main postoperative support came from their family. Thirty-four (94.4%) of the patients reported satisfactory femininity, with a heterosexual orientation. Thirty patients (83. 3%) were very satisfied with the surgery, while 34 considered surgery as the best treatment. Conclusions: The sexual function and psychosocial status of these patients should be followed long-term to estimate their quality of life.

Radiocarbon in the Atmosphere of the Žlkovce Monitoring Station of the Bohunice NPP: 25 Years of Continuous Monthly Measurements

Radiocarbon ◽  
2015 ◽  
Vol 57 (3) ◽  
pp. 355-362 ◽  
Author(s):  
P P Povinec ◽  
A Šivo ◽  
M Ješkovský ◽  
I Svetlik ◽  
M Richtáriková ◽  
...  
Keyword(s):  
Nuclear Power ◽  
Fossil Fuel ◽  
Monitoring Station ◽  
Monitoring Site ◽  
Short Term ◽  
Mean Values ◽  
Tree Ring Data ◽  
Clean Air ◽  
Long Term Impact

Radiocarbon variations in the atmosphere have been observed at the Žlkovce monitoring station of the Bohunice nuclear power plant (NPP), situated only 5 km ESE from the NPP. The observed 14C levels provide unique evidence of a decreasing long-term impact of the Bohunice NPP on the region. Simultaneously, decreasing emissions of fossil fuel carbon dioxide in the atmosphere of the monitoring site have been found. The observed Δ14C variations with time have attenuating amplitudes and decreasing mean values, showing maxima in summer and minima in winter, the latter primarily caused by increased emission of fossil CO2 in winter months. Sporadic short-term releases of 14C from the Bohunice NPP were observed at the Žlkovce station. The annual atmospheric Δ14C variations compared with tree-ring data collected at the Žlkovce village show reasonable agreement. The observed Δ14C levels after 2005 are close to the European clean-air levels as measured at the Jungfraujoch (3450 m asl) monitoring station.

Long-Term Psychological and Sexual Outcomes of Severe Penile Hypospadias Repair

2011 ◽  
Vol 8 (5) ◽  
pp. 1529-1539 ◽  
Author(s):  
Andras Kiss ◽  
Balint Sulya ◽  
A. Marcell Szász ◽  
Imre Romics ◽  
Zsolt Kelemen ◽  
...  
Keyword(s):  
Hypospadias Repair ◽  
Sexual Outcomes

scholarly journals Long Term Impact on Lung Function of Patients With Moderate and Severe COVID-19. A Prospective Cohort Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Sonia Qureshi ◽  
Nosheen Nasir ◽  
Naveed Rashid ◽  
Naveed Ahmed ◽  
Zoya Haq ◽  
...  
Keyword(s):  
Cohort Study ◽  
Lung Function ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Ethical Review ◽  
Vital Functions ◽  
Number Of Patients ◽  
Long Term Impact ◽  
The Impact

Background: In Pakistan, the cases of COVID-19 have declined from 6000 per day in June to 600 in September 2020. A significant number of patients continue to recover from the disease, however, little is known about the lung function capacity among survivors. We aim to determine the long-term impact on lung function capacity in patients who have survived moderate or severe COVID-19 disease in a resource-poor setting.Methods: This prospective cohort study will be conducted at Aga Khan University Hospital (AKUH), Karachi Pakistan. Patients 15 years and above who have survived an episode of moderate or severe COVID-19, have reverse transcriptase-polymerase chain reaction (RT-PCR) positive for COVID 19 (nasopharyngeal or oropharyngeal) will be included. Patients with a pre-existing diagnosis of obstructive or interstitial lung disease, lung fibrosis, lung cancers, connective tissue disorders, autoimmune conditions affecting the lungs, underlying heart disease, history of syncope and those who refuse to participate will be excluded from the study. Pulmonary function will be assessed using spirometry and diffusion lung capacity for carbon monoxide (DLCO) at 3- and 6-months interval from the time of discharge from the hospital. Additionally, a chest X-ray and CT-chest will be performed if clinically indicated after consultation with the study pulmonologist or Infectious Disease (ID) physician. Echocardiogram (ECHO) will be performed to look for pulmonary hypertension at the 3 month visit and repeated at 6 months in case any abnormality is identified in the initial ECHO. Data analysis will be performed using standard statistical software. The study was approved by the Ethical Review Committee (ERC) of the institution (ERC reference number 2020-4735-11311).Strengths and Limitations of the Study: This cohort study will provide evidence on the long-term impact on lung function among COVID-19 survivors with moderate to severe disease. Such data will be key in understanding the impact of the disease on vital functions and will help devise rehabilitative strategies to best overcome the effects of disease. However, this will be a single-center, study recruiting only a limited number of COVID-19 survivors.

scholarly journals Investigating the relationship between the long-term exposure to air pollution and the frequency of depression in Shiraz during 2010-2017

2021 ◽  
Vol 8 (1) ◽  
pp. 9-14
Author(s):  
Leila Keshtgar ◽  
Samaneh Shahsavani ◽  
Ahmad Maghsoudi ◽  
Amir Anushiravani ◽  
Foroozandeh Zaravar ◽  
...  
Keyword(s):  
Air Pollution ◽  
Significant Relationship ◽  
Hospital Admissions ◽  
Environmental Pollutants ◽  
University Hospital ◽  
Mean Values ◽  
Number Of Patients ◽  
Background Exposure ◽  
The Relationship

Background: Exposure to environmental pollutants which have entered the atmosphere due to human and industrial activities results in harmful and unwanted effects on human health. The undesired effects of air pollution on mental disorders, mortality, and psychological disorders have been proven. Depression is a common mental health problem in today’s societies which impacts the quality of life. The objective of this study was to determine the relation between exposure to air pollution and frequency of depression in Shiraz (Southern Iran). Methods: Archived documents of 2658 patients diagnosed with major depressive disorder (MDD) from a psychiatric university hospital were reviewed. The concentrations of five air pollutants including CO, NOX, O3 , PM10, and NO2 were determined daily in two air quality monitory stations in downtown Shiraz (Imam Hossein Square) and Kazeroon Gate. The data relevant to these five pollutants were gathered every day for 83 months, from 2010 to 2017, and for more precision, the mean values were used. The relationship between the concentration of each pollutant in the air and the number of patients referring to hospital was determined using the Spearman’s correlation coefficient. Results: There was a direct and significant relationship between all pollutants and the number of hospital admissions in each month (P<0.05) except for CO which did not show a significant relationship with hospital admission due to depression (P>0.05). Conclusion: The results of this study indicated a positive relationship between air pollution and depression. Of course, to prove this relationship, it is essential to conduct a number of studies with appropriate methodology and design.

The Attitudes Towards Depression Of General Practitioners Can Be Improved By An Educational Program

2016 ◽  
Vol 33 (S1) ◽  
pp. S434-S434
Author(s):  
M.Á. Álvarez de Mon ◽  
R. Manzanera ◽  
G. Lahera ◽  
J. Saiz-Ruiz ◽  
M. Alvarez de Mon
Keyword(s):  
General Practitioners ◽  
Educational Program ◽  
Short Term ◽  
Positive Effects ◽  
Number Of Patients ◽  
Short And Long Term ◽  
Quality Of Medical Care ◽  
Competing Interest ◽  
Long Term Impact

BackgroundContinuous education of physicians is critical for the quality of medical care.ObjectivesTo investigate the attitudes of general practitioners towards depression and to evaluate the short- and long-term impact of a specific designed postgraduate university program in depression.MethodIn this prospective, interventional study participated 1322-certificated Family Practice specialist. They filled out the Depression Attitude Questionnaire (DAQ) Spanish validated version before starting the educational intervention; an official approved 12 ECTS postgraduate university program. The participant refilled the questionnaires at the end of the course and 6 months later.ResultsA total of 885 females and 420 males (mean 48 years) and with a mean clinical experience of 25 years participated in this study. Short-term after training, PGs positively significant (P < 0.05) changed their attitudes in the management of depression in 18 out 20 items of the DAQ. There were not significant changes in only item 1 related to the number of patients presenting depressive symptoms seen in the last 5 years and the knowledge of the underlying biochemical abnormality. In the long-term, the positive effects observed in the short-term did not significantly change. However, in item 1 a significantly increase was observed. The effectiveness of the intervention was related nor to the to the age and sex of the physician nor to the years of medical practice.ConclusionsA specific designed educational program can improve the attitudes in depression of GPs. Years of clinical practice are not a limitation for improving the medical attitudes of General practitioners in mental health.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Association Between Sharp's Radiographic Index and Acute Phase Reactants in Rheumatoid Arthritis

2008 ◽  
Vol 27 (4) ◽  
pp. 447-453
Author(s):  
Irena Kafeđiska ◽  
Dejan Spasovski ◽  
Todor Gruev ◽  
Nada Marina ◽  
Mane Grličkov ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Acute Phase ◽  
Time Intervals ◽  
Acute Phase Reactants ◽  
Disease Evolution ◽  
Course Of Disease ◽  
Mean Values ◽  
Early Ra ◽  
Number Of Patients

Association Between Sharp's Radiographic Index and Acute Phase Reactants in Rheumatoid ArthritisThe aim of this study was to evaluate the activity of rheumatoid arthritis (RA) by hand radiography (Sharp's radiographic index), and assessment of acute phase reactants - erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and rheumatoid factor (RF), and to determine their value as prognostic markers for disease outcome in patients with early RA treated with disease modifying antirheumatic drugs (DMARDs)-Methotrexate (MTH); to register and quantify clinical, radiographic and laboratorial differences in certain time intervals in a group of patients treated with immunomodulation therapy with MTH; to determine which of the acute phase reactants would be the most useful marker for evaluation of disease activity in long-term follow-up in RA patients; to select high-risk groups with aggressive course of disease, in order to emphasize the necessity of early and aggressive treatment. Thirty patients with early RA (disease evolution up to 1 year) were evaluated in several time intervals. The score of the Sharp's index showed greater radiographic progression of the joint damage of hands in time intervals between 0-time and 12 months (p=0.0167) and between 0-time and 18 months (p=0.0089). Statistical analysis showed differences in values of CRP in four time intervals (p=0.00002). Considering CRP, there were statistically significant differences among mean values in four time intervals (p=0.0428) (standard deviations showed greater variations). There were no statistically significant differences among mean values of RF in four time intervals (p=0.573). At 0-time in 3 (10%) patients progression of the Sharp's index was found, after 6 months in 13 (39%) patients, while after 12 and 18 months progression of the Sharp's index was found in an identical number of patients, 15 (50%). In most patients high values of CRP and RF were found. Progression of the radiographic damage is especially expressed in patients with high values of ESR, CRP, RF and existence of previous erosions of hands, which are predictors for aggressive course of disease. CRP is the most useful marker for the evaluation of RA activity in the long-term followup of RA patients.

Crisis Phones - Suicide Prevention Versus Suggestion/Contagion Effects

Crisis ◽  
2015 ◽  
Vol 36 (3) ◽  
pp. 220-224 ◽  
Author(s):  
Steven Stack
Keyword(s):  
Suicide Prevention ◽  
Contagion Effects ◽  
Long Term Impact

Abstract. Background: There has been no systematic work on the short- or long-term impact of the installation of crisis phones on suicides from bridges. The present study addresses this issue. Method: Data refer to 219 suicides from 1954 through 2013 on the Skyway Bridge in St. Petersburg, Florida. Six crisis phones with signs were installed in July 1999. Results: In the first decade after installation, the phones were used by 27 suicidal persons and credited with preventing 26 or 2.6 suicides a year. However, the net suicide count increased from 48 in the 13 years before installation of phones to 106 the following 13 years or by 4.5 additional suicides/year (t =3.512, p < .001). Conclusion: Although the phones prevented some suicides, there was a net increase after installation. The findings are interpreted with reference to suggestion/contagion effects including the emergence of a controversial bridge suicide blog.

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