Evaluation of a Self-Administered Computerized Cognitive Battery in an Older Population

Objective: The aim of this study is to assess the utility of the Cogstate self-administered computerized neuropsychological battery in a large population of older men. Methods: We invited 7,167 men (mean age of 75 years) from the Health Professionals Follow-up Study, a prospective cohort of male health professionals. We considered individual Cogstate scores and composite scores measuring psychomotor speed and attention, learning and working memory and overall cognition. Multivariate linear regression was used to assess the association between risk factors measured 4 and 28 years prior to cognitive testing and each outcome. Results: The 1,866 men who agreed to complete Cogstate testing were similar to the 5,301 non-responders. Many expected risk factors were associated with Cogstate scores in multivariate adjusted models. Increasing age was significantly associated with worse performance on all outcomes (p < 0.001). For risk factors measured 4 years prior to testing and overall cognition, a history of hypertension was significantly associated with worse performance (mean difference of -0.08 standard units (95% CI -0.16, 0.00)) and higher consumption of nuts was significantly associated with better performance (>2 servings/week vs. <1 serving/month: 0.15 (0.03, 0.27)). Conclusions: The self-administered Cogstate battery showed significant associations with several risk factors known to be associated with cognitive function. Future studies of cognitive aging may benefit from the numerous advantages of self-administered computerized testing.

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Prevalences and Risk Factors of Electrocardiographic Abnormalities in Chinese Adults: a cross-sectional study

10.21203/rs.3.rs-28222/v1 ◽

2020 ◽

Author(s):

Liping Yu ◽

Xiaojun Ye ◽

Zhaojun Yang ◽

Wenying Yang ◽

Bo Zhang

Keyword(s):

Risk Factors ◽

Large Population ◽

Cerebrovascular Diseases ◽

Cvd Risk Factors ◽

Chinese Adults ◽

Cvd Risk ◽

Bundle Branch Block ◽

St Depression ◽

History Of ◽

Ecg Abnormalities

Abstract Background: Electrocardiogram (ECG) is widely used to screen cardiac diseases. To date, no large population study has provided estimates of the prevalences of ECG findings in China. We aim to investigate the prevalences and risk factors of ECG abnormalities in the general population of Chinese adults.Methods: ECG data were obtained from 34965 participants in the 2007-2008 China National Diabetes and Metabolic Disorders Study. ECG abnormalities were classified according to the Minnesota coding (MC) criteria. Prevalences of variant ECG abnormalities were calculated. The associations between ECG abnormalities and gender, age and other risk factors for cardiovascular diseases (CVD) were analyzed by multivariate logistic regression test.Results: The prevalences of major arrhythmias were 1.70%, 2.37% and 1.04% in the whole population, men and women, respectively. Atrial fibrillation/flutter was found in 0.35% of men and 0.20% of women. ST depression and T abnormalities accounted for 10.96%, 7.54% and 14.32% in the whole population, men and women, respectively. Independent of gender and other CVD risk factors, the older age significantly increased the risk of having atrial fibrillation/flutter, complete left bundle branch block, complete right bundle branch block, sinus tachycardia, atrial/junctional/ventricular premature beats, ST depression and T abnormalities, tall R wave left, left/right atrial hypertrophy, left axis deviation and low voltage. Hypertension, overweight, obesity and hypercholesterolemia all independently increased the odds ratios of having ST depression and T abnormalities. History of cardiovascular/cerebrovascular diseases was positively associated with major arrhythmias, ST depression and T abnormalities and tall R wave left.Conclusions: This study provides estimates of the prevalences of ECG findings in a large population of Chinese adults. Gender, age, CVD risk factors and history of cardiovascular/cerebrovascular diseases had important impact on ECG abnormalities.# Liping Yu and Xiaojun Ye contributed equally to this work.

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Prevalences and Associated Factors of Electrocardiographic Abnormalities in Chinese Adults: A Cross-sectional Study

10.21203/rs.3.rs-28222/v3 ◽

2020 ◽

Author(s):

Liping Yu ◽

Xiaojun Ye ◽

Zhaojun Yang ◽

Wenying Yang ◽

Bo Zhang

Keyword(s):

Risk Factors ◽

Large Population ◽

Cerebrovascular Diseases ◽

Cvd Risk Factors ◽

Chinese Adults ◽

Cvd Risk ◽

Bundle Branch Block ◽

St Depression ◽

History Of ◽

Ecg Abnormalities

Abstract Background: Electrocardiogram (ECG) is widely used to screen cardiac diseases. To date, no large population study has provided estimates of the prevalences of ECG findings in China. We aim to investigate the prevalences and associated factors of ECG abnormalities in a general population of Chinese adults. Methods: ECG data were obtained from 34,965 participants in the 2007-2008 China National Diabetes and Metabolic Disorders Study. ECG abnormalities were classified according to the Minnesota coding (MC) criteria. Prevalences of variant ECG abnormalities were calculated. The associations between ECG abnormalities and gender, age and other risk factors for cardiovascular diseases (CVD) were analyzed by multivariate logistic regression test. Results: The prevalences of major arrhythmias were 1.70%, 2.37% and 1.04% in the whole population, men and women, respectively. Atrial fibrillation/flutter was found in 0.35% of men and 0.20% of women. ST depression and T abnormalities accounted for 10.96%, 7.54% and 14.32% in the whole population, men and women, respectively. Independent of gender and other CVD risk factors, older age significantly increased the odds of having atrial fibrillation/flutter, complete left bundle branch block, complete right bundle branch block, sinus tachycardia, atrial/junctional/ventricular premature beats, ST depression and T abnormalities, tall R wave left, left/right atrial hypertrophy, left axis deviation and low voltage. Hypertension, overweight, obesity and hypercholesterolemia all independently increased the odds of having ST depression and T abnormalities. History of cardiovascular/cerebrovascular diseases was positively associated with major arrhythmias, ST depression and T abnormalities and tall R wave left. Conclusions: This study provides estimates of the prevalences of ECG findings in a large population of Chinese adults. Gender, age, CVD risk factors and history of cardiovascular/cerebrovascular diseases were significantly associated with ECG abnormalities.

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Preseason Symptom Reporting and Cognition in Middle School Athletes with Past Concussions

International Journal of Sports Medicine ◽

10.1055/a-1538-0075 ◽

2022 ◽

Author(s):

Grant L. Iverson ◽

Paul D. Berkner ◽

Ross Zafonte ◽

Bruce Maxwell ◽

Douglas P. Terry

Keyword(s):

Visual Memory ◽

Cognitive Testing ◽

Symptom Reporting ◽

Symptom Scale ◽

Health History ◽

School Sports ◽

History Of ◽

Concussion History ◽

Composite Scores ◽

The Impact

AbstractThis study examined the association between past concussions and current preseason symptom reporting and cognitive performance in 9,257 youth ages 11–13. Participants completed neurocognitive testing prior to participating in a school sports between 2009 and 2019. We stratified the sample by gender and number of prior concussions and assessed group differences on the Post-Concussion Symptom Scale total score and the ImPACT cognitive composite scores. Those with≥2 prior concussions reported more symptoms than those with 0 concussions (d=0.43–0.46). Multiple regressions examining the contribution of concussion history and developmental/health history to symptom reporting showed the most significant predictors of symptoms scores were (in descending order): treatment for a psychiatric condition, treatment for headaches, history of learning disability (in boys only), history of attention-deficit/hyperactivity disorder, and age. Concussion history was the weakest statistically significant predictor in boys and not significant in girls. Cognitively, boys with 1 prior concussion had worse speed those with 0 concussions (d=0.11), and girls with≥2 prior concussions had worse verbal/visual memory than girls with 0 concussions (ds=0.38–0.39). In summary, youth with≥2 prior concussions reported more symptoms than those with no concussions. Boys with multiple concussions performed similarly on cognitive testing, while girls had worse memory scores.

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Prevalences and associated factors of electrocardiographic abnormalities in Chinese adults: a cross-sectional study

BMC Cardiovascular Disorders ◽

10.1186/s12872-020-01698-5 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Liping Yu ◽

◽

Xiaojun Ye ◽

Zhaojun Yang ◽

Wenying Yang ◽

...

Keyword(s):

Risk Factors ◽

Large Population ◽

Cerebrovascular Diseases ◽

Cvd Risk Factors ◽

Chinese Adults ◽

Cvd Risk ◽

Bundle Branch Block ◽

St Depression ◽

History Of ◽

Ecg Abnormalities

Abstract Background Electrocardiogram (ECG) is widely used to screen cardiac diseases. To date, no large population study has provided estimates of the prevalences of ECG findings in China. We aim to investigate the prevalences and associated factors of ECG abnormalities in a general population of Chinese adults. Methods ECG data were obtained from 34,965 participants in the 2007–2008 China National Diabetes and Metabolic Disorders Study. ECG abnormalities were classified according to the Minnesota coding (MC) criteria. Prevalences of variant ECG abnormalities were calculated. The associations between ECG abnormalities and gender, age and other risk factors for cardiovascular diseases (CVD) were analyzed by multivariate logistic regression test. Results The prevalences of major arrhythmias were 1.70, 2.37 and 1.04% in the whole population, men and women, respectively. Atrial fibrillation/flutter was found in 0.35% of men and 0.20% of women. ST depression and T abnormalities accounted for 10.96, 7.54 and 14.32% in the whole population, men and women, respectively. Independent of gender and other CVD risk factors, older age significantly increased the odds of having atrial fibrillation/flutter, complete left bundle branch block, complete right bundle branch block, sinus tachycardia, atrial/junctional/ventricular premature beats, ST depression and T abnormalities, tall R wave left, left/right atrial hypertrophy, left axis deviation and low voltage. Hypertension, overweight, obesity and hypercholesterolemia all independently increased the odds of having ST depression and T abnormalities. History of cardiovascular/cerebrovascular diseases was positively associated with major arrhythmias, ST depression and T abnormalities and tall R wave left. Conclusions This study provides estimates of the prevalences of ECG findings in a large population of Chinese adults. Gender, age, CVD risk factors and history of cardiovascular/cerebrovascular diseases were significantly associated with ECG abnormalities.

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Prevalences and Associated Factors of Electrocardiographic Abnormalities in Chinese Adults: A Cross-sectional Study

10.21203/rs.3.rs-28222/v2 ◽

2020 ◽

Author(s):

Liping Yu ◽

Xiaojun Ye ◽

Zhaojun Yang ◽

Wenying Yang ◽

Bo Zhang

Keyword(s):

Risk Factors ◽

Large Population ◽

Cerebrovascular Diseases ◽

Cvd Risk Factors ◽

Chinese Adults ◽

Cvd Risk ◽

Bundle Branch Block ◽

St Depression ◽

History Of ◽

Ecg Abnormalities

Abstract Background: Electrocardiogram (ECG) is widely used to screen cardiac diseases. To date, no large population study has provided estimates of the prevalences of ECG findings in China. We aim to investigate the prevalences and associated factors of ECG abnormalities in a general population of Chinese adults. Methods: ECG data were obtained from 34,965 participants in the 2007-2008 China National Diabetes and Metabolic Disorders Study. ECG abnormalities were classified according to the Minnesota coding (MC) criteria. Prevalences of variant ECG abnormalities were calculated. The associations between ECG abnormalities and gender, age and other risk factors for cardiovascular diseases (CVD) were analyzed by multivariate logistic regression test. Results: The prevalences of major arrhythmias were 1.70%, 2.37% and 1.04% in the whole population, men and women, respectively. Atrial fibrillation/flutter was found in 0.35% of men and 0.20% of women. ST depression and T abnormalities accounted for 10.96%, 7.54% and 14.32% in the whole population, men and women, respectively. Independent of gender and other CVD risk factors, older age significantly increased the odds of having atrial fibrillation/flutter, complete left bundle branch block, complete right bundle branch block, sinus tachycardia, atrial/junctional/ventricular premature beats, ST depression and T abnormalities, tall R wave left, left/right atrial hypertrophy, left axis deviation and low voltage. Hypertension, overweight, obesity and hypercholesterolemia all independently increased the odds of having ST depression and T abnormalities. History of cardiovascular/cerebrovascular diseases was positively associated with major arrhythmias, ST depression and T abnormalities and tall R wave left. Conclusions: This study provides estimates of the prevalences of ECG findings in a large population of Chinese adults. Gender, age, CVD risk factors and history of cardiovascular/cerebrovascular diseases were significantly associated with ECG abnormalities.

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Prevalences and Associated Factors of Electrocardiographic Abnormalities in Chinese Adults: A Cross-sectional Study

10.21203/rs.3.rs-28222/v4 ◽

2020 ◽

Author(s):

Liping Yu ◽

Xiaojun Ye ◽

Zhaojun Yang ◽

Wenying Yang ◽

Bo Zhang

Keyword(s):

Risk Factors ◽

Large Population ◽

Cerebrovascular Diseases ◽

Cvd Risk Factors ◽

Chinese Adults ◽

Cvd Risk ◽

Bundle Branch Block ◽

St Depression ◽

History Of ◽

Ecg Abnormalities

Abstract Background: Electrocardiogram (ECG) is widely used to screen cardiac diseases. To date, no large population study has provided estimates of the prevalences of ECG findings in China. We aim to investigate the prevalences and associated factors of ECG abnormalities in a general population of Chinese adults.Methods: ECG data were obtained from 34,965 participants in the 2007-2008 China National Diabetes and Metabolic Disorders Study. ECG abnormalities were classified according to the Minnesota coding (MC) criteria. Prevalences of variant ECG abnormalities were calculated. The associations between ECG abnormalities and gender, age and other risk factors for cardiovascular diseases (CVD) were analyzed by multivariate logistic regression test. Results: The prevalences of major arrhythmias were 1.70%, 2.37% and 1.04% in the whole population, men and women, respectively. Atrial fibrillation/flutter was found in 0.35% of men and 0.20% of women. ST depression and T abnormalities accounted for 10.96%, 7.54% and 14.32% in the whole population, men and women, respectively. Independent of gender and other CVD risk factors, older age significantly increased the odds of having atrial fibrillation/flutter, complete left bundle branch block, complete right bundle branch block, sinus tachycardia, atrial/junctional/ventricular premature beats, ST depression and T abnormalities, tall R wave left, left/right atrial hypertrophy, left axis deviation and low voltage. Hypertension, overweight, obesity and hypercholesterolemia all independently increased the odds of having ST depression and T abnormalities. History of cardiovascular/cerebrovascular diseases was positively associated with major arrhythmias, ST depression and T abnormalities and tall R wave left.Conclusions: This study provides estimates of the prevalences of ECG findings in a large population of Chinese adults. Gender, age, CVD risk factors and history of cardiovascular/cerebrovascular diseases were significantly associated with ECG abnormalities.

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New Technologies and Neuropsychological Evaluation of Older Adults

Virtual and Augmented Reality ◽

10.4018/978-1-5225-5469-1.ch083 ◽

2018 ◽

pp. 1762-1779

Author(s):

Stelios Zygouris ◽

Magda Tsolaki

Keyword(s):

Older Adults ◽

Virtual Reality ◽

New Technologies ◽

Cognitive Testing ◽

Computerized Testing ◽

Neuropsychological Evaluation ◽

Speech Recognition Software ◽

Emerging Trends ◽

History Of ◽

Recognition Software

In this chapter the history of computerized cognitive testing for older adults is reviewed critically, challenges are being highlighted and solutions and emerging trends are discussed. Issues such as lack of validation, insufficiently documented psychometric properties and the high cost of computerized instruments are analyzed. At the same time a discussion concerning the lack of integration of computerized testing in healthcare highlights management issues and the need for a paradigm shift. Possible solutions to the issues presented and new avenues of research are identified. Emerging technologies such as adaptive testing, virtual reality (VR) environments, and reliable speech recognition software are presented and their potential is highlighted. At the same time social and scientific trends such as the shift to early detection and the increasing familiarity of older adults with technology are analyzed. The chapter concludes with an outline of the expected future of computerized testing.

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P09.06 Risk factors associated with Meningioma in a Cohort of 2 Million Israeli Adolescents

Neuro-Oncology ◽

10.1093/neuonc/noz126.138 ◽

2019 ◽

Vol 21 (Supplement_3) ◽

pp. iii39-iii40

Author(s):

S Yust-Katz ◽

E Derzane ◽

L Keinan ◽

A Amiel ◽

A Honig ◽

...

Keyword(s):

Risk Factors ◽

Autoimmune Diseases ◽

Cancer Registry ◽

Large Population ◽

Univariate Analysis ◽

Hazard Ratios ◽

Increased Risk ◽

Potential Risk Factors ◽

History Of ◽

Cox Proportional Hazard Models

Abstract Background: Meningiomas are the most common primary central nervous system tumors. Risk factors including- obesity, height, history of allergy/atopy or autoimmune diseases, have been assessed with conflicting results. In this study, we reviewed the database of a large cohort of Israeli adolescents in order to assess potential risk factors for the development of meningiomas. Methods: This study analyzed a cohort of 2,035,915 Jewish men and women who underwent compulsory physical examination as part of screening for army drafting between the age of 16 to 19 from 1948 to 1991. Meningioma incidence was identified by linkage to the national cancer registry. Cox proportional hazard models were used to estimate the hazard ratios for meningioma according the several risk factors including sex, BMI, height, history of allergic and autoimmune disease. Results: Linkage of the adolescent military database with the Israeli cancer registry revealed 480 cases of meningioma. The median age at diagnosis of meningioma was 42.1 ± 9.4 (range 17.4–62.6). On univariate analysis, only gender (female) and height were significantly associated with the risk of meningioma for the whole study population (p<0.01 for both variables). When analyzed separately for gender- height was significant only for men. Spline analysis in the men group showed the minimum risk at a height of 1.62 meters and a statistically significant increase in the risk for meningioma at heights taller than 1.85 meters. BMI was not associated with an elevated risk of meningioma even when analyzed separately for gender. Past medical history including asthma, diabetes, and other atopic and autoimmune diseases were not found to be associated with the risk of meningioma. Conclusion: In this large population study, we found that sex and taller height in adolescent males was associated with an increased risk of meningioma.

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Frequency and Types of Red Cell Alloantibodies in Pregnant Females

Proceedings of Shaikh Zayed Medical Complex Lahore - October to December ◽

10.47489/p000s342z7471-5mc ◽

2020 ◽

Vol 34 (2) ◽

pp. 21-25

Author(s):

Asma Munir

Keyword(s):

Risk Factors ◽

Large Population ◽

Antenatal Clinic ◽

Maternal Blood ◽

Population Based ◽

Red Cell ◽

Cross Sectional ◽

Pregnant Females ◽

Peripartum Hemorrhage ◽

History Of

Introduction: Maternal isoimmunization, also called alloimmunization, occurs when immune system of a pregnant female is sensitized to foreign RBC surface antigen producing immune process. This maternal blood when goes to fetal circulation, causes immune reaction and disease in case of maternal and fetal blood group differences. Aims & Objectives: To find out the frequency and types of red cell alloantibodies among females presenting to antenatal care and recognize risk factors for alloimmunization. Place and duration of study: This cross-sectional descriptive study was carried out at Antenatal Clinic of Shaikh Zayed Hospital, Lahore from 1st January 2013 to 31st August 2013. Material & Methods: Pregnant females with at least one previous pregnancy were typed for ABO and Rh antigens. They were screened and typed for red cell alloantibodies. Detailed history was taken to explore for the risk factors. SPSS version 20.0 was used for data analysis, frequencies of different alloantibodies, blood groups and risk factors reported as percentages, age and gravidity in mean±s.d. Results: Out of 200 enrolled cases, 6(3%) had alloantibodies. Of the positive cases, anti-D was found in 3(50%), anti-C in 2(33.33%) and anti-Kell in 1(16.67%). Commonest risk factors were history of peripartum hemorrhage and gynecological procedures. In Rh-negative cases, disparity of spouse Rh group was also main factor. Conclusion: The most common culprit antibody for alloimmunization was anti-D followed by anti-Kell and anti-C. Commonest risk factor for alloimmunization was pregnancy related bleeding and gynecological procedures. Large population-based studies are required to assess true magnitude of the problem.

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EPID-02. HEIGHT AND THE RISK OF MENINGIOMA

Neuro-Oncology ◽

10.1093/neuonc/noz175.302 ◽

2019 ◽

Vol 21 (Supplement_6) ◽

pp. vi74-vi74

Author(s):

Shlomit Yust-Katz ◽

Alexandra Amiel ◽

Ramiz Abu Shkara ◽

Tali Siegal ◽

Gilad Twig

Keyword(s):

Risk Factors ◽

Autoimmune Diseases ◽

Cancer Registry ◽

Large Population ◽

Univariate Analysis ◽

Significant Risk ◽

Female Gender ◽

Total Study Population ◽

Increased Risk ◽

History Of

Abstract BACKGROUND Meningiomas are the most common primary central nervous system tumors. Risk factors for meningiomas including obesity, height, history of allergy/atopy or autoimmune diseases, have been previously assessed with conflicting results. We reviewed a large cohort of Israeli adolescents in order to assess potential risk factors for the development of meningiomas. METHODS This study analyzed a cohort of 2,035,915 Jewish men and women who underwent obligatory physical examination when aged 16 to 19 years, from 1967 to 2011. Meningioma incidence was identified by linkage to the national cancer registry. Cox proportional hazard models were used to estimate the hazard ratios for meningioma according to sex, body mass index (BMI), height, history of allergic and autoimmune disease. RESULTS Linkage of the adolescent military database with the Israeli cancer registry identified 480 cases (152 males and 328 females) of meningioma during a follow up of 40,304,078-person years. The median age at diagnosis of meningioma was 42.1 ± 9.4 (range 17.4–62.6). On univariate analysis, only female gender (p< 0.01) and height (p< 0.01) were associated with risk for meningioma in the total study population. When stratified by gender, height remained a significant risk factor only in men. Spline analysis in the men group showed the minimum risk at a height of 1.62 meters and a statistically significant increase in the risk for meningioma at heights taller than 1.85 meters. BMI, past medical history including asthma, diabetes, and atopic and autoimmune diseases, were not associated with meningioma risk. CONCLUSION in this large population study, we found that sex and taller height in adolescent males was associated with an increased risk of adult meningioma.

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