scholarly journals A Case of Subcutaneous Sarcoidosis Occurring along the Superficial Veins of the Forearms: A Distinctive Cutaneous Manifestation Masquerading Venous Tropic Action in the Underlying Systemic Disease

2017 ◽  
Vol 9 (1) ◽  
pp. 108-113 ◽  
Author(s):  
Haruka Koizumi ◽  
Noritaka Oyama ◽  
Yukinori Hayakawa ◽  
Minoru Hasegawa
Keyword(s):  
Clinical Presentation ◽  
Systemic Disease ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Underlying Disease ◽  
Unknown Etiology ◽  
Multisystem Disease ◽  
Old Japanese ◽  
Skin Nodules ◽  
Systemic Sarcoidosis

Sarcoidosis is a multisystem disease of unknown etiology, developing granulomas in any tissues and organs. Approximately 25% of sarcoidosis patients have cutaneous involvement with various clinical manifestations, which are categorized into specific or nonspecific diseases based on the histopathology; the former represents the typical sarcoid granulomas. Subcutaneous sarcoidosis is one of the specific skin lesions and often affects extremities, to a much lesser extent with other anatomical sites. Herein, we report the case of an 82-year-old Japanese man with subcutaneous sarcoidosis whose skin nodules exclusively overlay the lines of superficial veins on the forearms. This rare clinical presentation was discussed with the literature reported thus far to access the underlying disease pathophysiology from the viewpoint of tropic response to the venous system in systemic sarcoidosis.

scholarly journals Clinical Characteristics of Multicentric Reticulohistiocytosis and Distinguished Features from Rheumatoid Arthritis: A Single-Centre Experience in China

2021 ◽  
Author(s):  
Xiao-juan Zou ◽  
Lin Qiao ◽  
Feng Li ◽  
Hua Chen ◽  
Yun-jiao Yang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Disease ◽  
Clinical Manifestations ◽  
Metacarpophalangeal Joint ◽  
Skin Lesions ◽  
Multicentric Reticulohistiocytosis ◽  
Specific Distribution ◽  
Pathologic Features ◽  
Skin Nodules ◽  
Distal Interphalangeal

Abstract ObjectiveTo investigate the clinical features of multicentric reticulohistiocytosis (MRH). MethodsThe clinical manifestations, laboratory examination results and histologic characteristics of eleven patients with MRH were collected and compared with those of 33 patients with rheumatoid arthritis. ResultsIn total, 72.7% of the MRH patients were women. The median age was 46 years (range: 33-84 years). Diagnosed by specific pathologic features, all MRH patients exhibited cutaneous involvement. The dorsa of the hands, arms, face and auricle were the most commonly affected areas. Nodules were also located on the legs, scalp, trunk, neck, and even the hypoglossis and buccal mucosa. Ten MRH patients (90.9%) had symmetric polyarthritis. Compared with rheumatoid arthritis (RA) patients, MRH patients were more likely to have distal interphalangeal joint (DIP) involvement (63.6% vs 24.2%, P=0.017) and less likely to have elbow (36.4% vs 72.7%, P=0.003), ankle (45.5% vs 93.9%, P<0.001) and metacarpophalangeal joint (MCP) (36.4% vs 78.8%, P=0.009) involvement. The positivity for rheumatoid factor (RF) (36.4% vs 84.6%, P=0.001) and anti-CCP antibody (9.1% vs 81.8%, P=0.000), as well as the median RF titer [43.8 (31.7-61.0) vs 175.4 (21.3-940.3), P = 0.021], in MRH patients was lower than that in RA patients. Elevation of the erythrocyte sedimentation rate (ESR) was also less common in MRH patients than in RA patients (36.4% vs 72.7%, P=0.030). After treatment with median- to large-dose corticosteroids and disease-modifying antirheumatic drugs, 8 patients achieved complete remission, and 2 patients achieved partial remission (skin lesions ameliorated, joint lesions not ameliorated). ConclusionAlways pathologically diagnosed, MRH is a systemic disease involving RA-like erosive polyarthritis and a specific distribution of skin nodules characterized by "coral beads". More DIP involvement and less elbow, ankle and MCP involvement are seen in MRH than in RA. In addition, less positive and lower-titer RF, uncommon presence of anti-CCP antibodies and ESR elevation may be helpful to distinguish MRH from RA.

scholarly journals Evaluation of nasal mucociliary clearance in rheumatoid arthritis: a comparative analysis using saccharin test

2017 ◽  
Vol 5 (11) ◽  
pp. 5026 ◽  
Author(s):  
Shelja Deswal ◽  
Jyoti Yadav ◽  
Mohit Deswal ◽  
Harpreet Singh
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Duration ◽  
Mucociliary Clearance ◽  
Systemic Disease ◽  
Unknown Etiology ◽  
Control Group ◽  
Ciliary Activity ◽  
Multisystem Disease ◽  
Organic Particles ◽  
Nasal Mucociliary Clearance

Background: Rheumatoid arthritis (RA) is a chronic multisystem disease of unknown etiology characterized by persistent inflammatory synovitis, usually involving peripheral joints in a symmetric distribution. RA is a systemic disease often associated with cutaneous and organ-specific extra-articular manifestations the mucociliary clearance system protects the lower respiratory system by trapping and removing inhaled pathogenic viruses and bacteria, in addition to nontoxic and toxic particulates (e.g., pollen, ash, mineral dust, mold spores, and organic particles), from the lungs. Effective clearance requires both ciliary activity and the appropriate balance of periciliary fluid and mucus.Methods: This was a case control study conducted in the Department of Physiology, Pt. B.D. Sharma PGIMS, Rohtak in 50 females of age group 30-50 years. Control group comprised of 25 healthy volunteer females while study group comprised of 25 rheumatoid arthritis female patients with disease duration of more than five years. Proven cases of RA (as per 1987 ACR criteria) were taken with disease duration of more than five years from Rheumatology clinic of Pt. B.D. Sharma PGIMS, Rohtak. Nasal mucociliary clearance time was evaluated by saccharin method.Results: The results of our study showed abnormal mucociliary clearance in rheumatoid arthritis patients.Conclusions: The study shows an abnormal mucociliary clearance in rheumatoid arthritis patients. Impairment of mucociliary clearance seems to be the result of qualitative and quantitative alterations in respiratory secretions.

scholarly journals Non Hodgkin T cell lymphoma: an atypical clinical presentation

2013 ◽  
Vol 88 (2) ◽  
pp. 264-267
Author(s):  
Paula Maio ◽  
Diogo Bento ◽  
Raquel Vieira ◽  
Ana Afonso ◽  
Fernanda Sachse ◽  
...  
Keyword(s):  
T Cell ◽  
Clinical Presentation ◽  
Cell Lymphoma ◽  
Systemic Disease ◽  
Skin Lesions ◽  
T Cell Lymphoma ◽  
Lymphocyte Population ◽  
T Cell Lymphomas ◽  
Atypical Clinical Presentation ◽  
New Skin

Cytotoxic lymphomas comprise a spectrum of peripheral T-cell lymphomas that can have a initial or late cutaneous presentation. We describe a 46-year-old man from Cape Verde, with a dermatosis involving his face and trunk, consisting of monomorphic papules with a smooth surface and both motor and sensory polyneuropathy.The hypothesis of leprosy was supported by the clinical and initial hystopathological findings and the patient was referred to our hospital with suspected Hansen's disease. In the new skin and lymph node biopsies a lymphocyte population was identified whose immunohystochemistry study allowed the diagnosis of T-cell lymphoma with expression of cytotoxic markers. The patient was started on chemotherapy with initial remission of the skin lesions but, subsequently, progression of systemic disease.

Systemic Sarcoidosis Revealed by Axillary Electrolysis

2015 ◽  
Vol 19 (4) ◽  
pp. 404-406 ◽  
Author(s):  
Meggie Morand ◽  
Solange Beauregard ◽  
Steve Mathieu
Keyword(s):  
Clinical Manifestations ◽  
Skin Lesions ◽  
Hair Removal ◽  
Granulomatous Disease ◽  
Cutaneous Sarcoidosis ◽  
Systemic Sarcoidosis ◽  
Histopathologic Findings

Background: Sarcoidosis is a noncaseating granulomatous disease that affects a large variety of organs and tissues. Skin sarcoidosis is commonly found in scar and tattooed tissues. Objective: To report this particular case of sarcoidosis following electrolysis hair removal. Method: We report the case of a woman who developed sarcoidosis years after axillary electrolysis hair removal. Results: The diagnosis of cutaneous sarcoidosis was suggested by the clinical manifestations and confirmed by histopathologic findings. Conclusion: Sarcoidosis should be considered during the investigation of skin lesions occurring in scar or traumatized tissue.

Atypical Presentation of Congenital Yellow Nail Syndrome in a 2-Year-Old Female

2013 ◽  
Vol 17 (1) ◽  
pp. 66-68 ◽  
Author(s):  
Michael Cecchini ◽  
Joseph Doumit ◽  
Nordau Kanigsberg
Keyword(s):  
Rare Case ◽  
Pediatric Patients ◽  
Clinical Presentation ◽  
Positive Family History ◽  
Clinical Manifestations ◽  
Clinical Entity ◽  
Unknown Etiology ◽  
Close Monitoring ◽  
Yellow Nail Syndrome ◽  
Atypical Clinical Presentation

Background: Yellow nail syndrome (YNS) is a rare clinical entity of unknown etiology that is characterized by a triad of yellow nails, respiratory manifestations, and lymphedema. The condition appears in the mid- to later years of life and only rarely in childhood. We describe a rare case of YNS with an atypical clinical presentation consisting of only yellow and dystrophic nails in a 2- year-old female since birth. Objective: A case of congenital YNS with only dystrophic and yellow nails is reported. Methods and Results: A 2-year-old female presented with yellow nails since birth. There was no positive family history. Physical examination revealed 20 thickened, dystrophic, yellow nails with onycholysis. There was no evidence of respiratory manifestations or lymphedema. Conclusion: Although rare, YNS can present as a congenital clinical entity and persist after birth. Pediatric patients with YNS show different clinical manifestations than the classic adult patient. The presence of yellow and dystrophic nails in the absence of respiratory and lymphatic manifestations may be the only sign of pathology and warrants close monitoring as progression to more serious complications can occur.

Clinical Manifestations of Scleroderma

1995 ◽  
Vol 16 (2) ◽  
pp. 49-49
Author(s):  
Patricia L. Haber
Keyword(s):  
Systemic Sclerosis ◽  
Connective Tissue ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Localized Scleroderma ◽  
Unknown Etiology ◽  
Collagen Deposition ◽  
Muscle Fibrosis ◽  
Favorable Prognosis ◽  
Organ Systems

Scleroderma is a connective tissue disease of unknown etiology. Its most characteristic feature is thickening of the skin due to increased collagen deposition. However, the disease may involve multiple other organ systems. Two broad categories of scleroderma have been defined: localized and systemic. Although all forms of scleroderma are rare, localized scleroderma occurs more frequently than systemic sclerosis and has a more favorable prognosis. Several types of localized scleroderma exist. Morphea is characterized by the presence of one or more patches of hard, ivory-colored skin lesions. They begin with erythema and progress to nonpitting edema before becoming sclerotic. The margins of active lesions often have a violaceous hue. Underlying muscle fibrosis and atrophy may occur.

Skin and systemic diseases

2010 ◽  
pp. 4715-4723
Author(s):  
Clive B. Archer
Keyword(s):  
Internal Medicine ◽  
Diabetes Mellitus ◽  
Lupus Erythematosus ◽  
Older Patients ◽  
Systemic Disease ◽  
Skin Lesions ◽  
Underlying Disease ◽  
Systemic Diseases ◽  
Systemic Lupus ◽  
General Internal

Dermatology is most interesting where it overlaps with general internal medicine. Skin lesions may be part of a systemic disease (e.g. in sarcoidosis or systemic lupus erythematosus), or they may be a manifestation of an underlying disease or process as in the case of acanthosis nigricans, which can be associated with either an underlying adenocarcinoma in older patients, or with insulin resistance and sometimes overt diabetes mellitus in younger obese patients....

scholarly journals Clinical observation of generalized sarcoidosis with damage of bones

Pharmacia ◽  
2020 ◽  
Vol 67 (4) ◽  
pp. 193-197
Author(s):  
Nataliia Chaplynska ◽  
Viktoriia Rudnyk ◽  
Liubov Skrypnyk ◽  
Nataliia Matkovska
Keyword(s):  
Bone Lesion ◽  
Clinical Manifestations ◽  
Unknown Etiology ◽  
Multisystem Disease ◽  
Joint System ◽  
X Ray ◽  
Caseous Necrosis ◽  
Dynamic Observation ◽  
Positive Effect

Sarcoidosis is a multisystem disease of unknown etiology, at the basis of which there is an inflammatory granulation epithelioid process without a pronounced exudative reaction and without caseous necrosis. This disease has various manifestations. The aim of the study was to investigate the clinical case of generalized sarcoidosis with bone lesion in a patient M., born in 1987. There were performed X-ray examinations, computed tomography (CT), fibrobronchoscopy, determination of calcium levels, angiotensin converting enzyme (ACE), soluble IL-2 receptor in the blood. Dynamic observation was performed for 10 months. The patient started methylprednisolone therapy at a dose of 20 mg/day. Significant positive effect of this treatment was noted. Thus, when patients complain of the bone and joint system problems, examination plan should include radiological examination of thoracic organs, which will allow us to avoid late diagnosis of sarcoidosis or other multisystem diseases that may have similar clinical manifestations.

scholarly journals Advanced ulcerative tumefactive lesions of the mucocutaneous surface in previously unrecognized Langerhans Cell Histiocytosis

2021 ◽  
Vol 12 (4) ◽  
pp. 419-421
Author(s):  
Fatima Azzahra Elgaitibi ◽  
Soumaya Hamich ◽  
Noureddine Mahiou
Keyword(s):  
Langerhans Cells ◽  
Langerhans Cell Histiocytosis ◽  
Rare Case ◽  
Clinical Presentation ◽  
Histopathological Examination ◽  
Systemic Disease ◽  
Skin Lesions ◽  
Clinical Suspicion ◽  
Langerhans Cell ◽  
Multiple Ulcers

Langerhans cell histiocytosis (LCH) is an uncommon systemic disease characterized by the infiltration of one organ or more by Langerhans cells. Its clinical presentation is heterogeneous and depends on the affected organs. We report the rare case of a 43-year-old female presenting herself with central diabetes insipidus and receiving nasal desmopressin spray. Later, the patient developed multiple papules and pustules progressing to multiple ulcers affecting the retroauricular and axillary folds, as well as the oral and genital mucosas. The skin lesions had been evolving for several months. A histopathological examination of a skin biopsy confirmed the clinical suspicion of LCH.

scholarly journals Oral mucosal lesions in patients with blood disorders

2021 ◽  
Vol 2 (3) ◽  
pp. 18-25
Author(s):  
Irina K. Lutskaya ◽  
◽  
Vladimir S. Kamyshnikov ◽  
Keyword(s):  
Systemic Disease ◽  
Clinical Manifestations ◽  
Disease Diagnosis ◽  
Underlying Disease ◽  
Virus Infections ◽  
Laboratory Examination ◽  
Blood Disorders ◽  
Bodily Fluids ◽  
Oral Mucosal Lesions ◽  
Mucosal Bleeding

Signs of many diseases of body organs and systems are manifested in the oral cavity. Patients with blood disorders are characterized by prominent oral mucosal alterations. One of the most common symptoms includes increased mucosal bleeding, as well as vulnerability and impaired epithelialization of the oral mucosa. The clinical manifestations spectrum depends on the underlying disease severity. Secondary (fungal, herpes virus) infections complicate the diagnosis. Such patients require comprehensive physical and laboratory examination. Blood tests, as well as laboratory tests on other bodily fluids allow dentists to clarify the systemic disease diagnosis, and to provide proper topical treatment.

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