Children with a History of Premature Adrenarche Have Good Health-Related Quality of Life at the Age of 12 Years

2018 ◽  
Vol 89 (3) ◽  
pp. 184-188
Author(s):  
Jani Liimatta ◽  
Harri Sintonen ◽  
Pauliina Utriainen ◽  
Raimo Voutilainen ◽  
Jarmo Jääskeläinen
Keyword(s):  
Quality Of Life ◽  
Psychosocial Development ◽  
Pubertal Development ◽  
Reference Population ◽  
Health Related Quality ◽  
Premature Adrenarche ◽  
Related Quality ◽  
Health Related ◽  
And Control

Background/Aim: Children with premature adrenarche (PA) are taller and more overweight than their healthy peers, and PA girls have a slightly accelerated pubertal development. There is some evidence that early exposure to androgens may have an influence on psychosocial development. The aim of this cross-sectional case-control study was to evaluate health-related quality of life (HRQoL) in PA children at the age of 12 years. Methods: The HRQoL was assessed for 43 PA (36 girls) and 63 control children (52 girls) at the median age of 12.0 years using the standardized 16D instrument, and the scores of the PA children were compared to those of the control children and reference population. Results: The mean overall HRQoL scores did not differ between PA and control girls, PA and control boys, or all PA and control children or the reference population. Independently of PA, overweight girls had a lower mean overall HRQoL score than lean girls, and both overweight girls and boys were on average worse off on the dimension of appearance than their lean peers. Conclusions: PA children have as good self-rated HRQoL as their peers at the age of 12 years. Overweight is associated with a worse HRQoL profile independently of PA.

scholarly journals P139 What impact does JIA have on health-related quality of life over time and by gender?

Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_2) ◽  
Author(s):  
Andrew Smith ◽  
Bishma Saqib ◽  
Rebecca Lee ◽  
Wendy Thomson ◽  
Lis Cordingley
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
Child Health ◽  
Reference Population ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Over Time ◽  
Domain Scores

Abstract Background Juvenile idiopathic arthritis (JIA) is a heterogeneous group of arthritic conditions presenting in children and young people, in which physical limitations and associated complications can have detrimental effects on physical and psychosocial wellbeing. This study aims to investigate the impact of living with JIA on different aspects of health-related quality of life (HRQoL) and to explore how this changes over time, using data from the Childhood Arthritis Prospective Study (CAPS). Methods Longitudinal data collected as part of CAPS were analysed. HRQoL was assessed at baseline, 1 year and 3 years’ post-diagnosis using the Child Health Questionnaire (CHQ), a parent-completed form for children from 5 years of age. The CHQ measures physical, emotional and social components of child health status. Raw domain scores were transformed via algorithm into values ranging from 0-100, with higher scores indicating better health status. Mean (standard deviation) and median (interquartile range) for each domain were determined, both for the full cohort and by gender. Differences between median scores at baseline and 3 years were assessed using the Wilcoxon signed-rank test. Mean scores of each domain were visually compared with a reference population sample of healthy children from the United States. Results 184 participants completed the questionnaire at all 3 time points. At baseline, compared to the reference population, children with JIA scored lower in every domain although scores were closer between the 2 groups at 3 years. Median scores improved over time, the exception being the general health perceptions domain which decreased after baseline. Domains with the greatest improvement were physical functioning,“bodily pain and social-physical. The largest changes occurred from baseline to 1 year. Statistically significant differences between baseline and 3-year scores were found for all domains. Domain scores for male and female participants were very similar at baseline, though scores for male participants indicated slightly better health at 1 and 3 years for both physical and psychosocial domains. Conclusion JIA has significant impact on HRQoL, which improves within 3 years of diagnosis with the greatest improvement occurring within the first year. Physical health domains show greater improvement over time than psychosocial domains, although psychosocial scores were generally higher throughout the study. Male participants tend to score slightly higher than female participants in both physical and psychosocial domains after baseline. Further research should explore measurable patient, age or disease-related drivers of HRQoL. Disclosures A. Smith None. B. Saqib None. R. Lee None. W. Thomson None. L. Cordingley None.

scholarly journals Health-related quality of life among 13–14 year old adolescents with overweight - a mixed methods approach

2019 ◽  
Author(s):  
Turid Kristin Bigum Sundar ◽  
Kirsti Riiser ◽  
Milada Småstuen ◽  
Randi Opheim ◽  
Knut Løndal ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mixed Methods ◽  
Well Being ◽  
Reference Population ◽  
Health Related Quality ◽  
Structured Interviews ◽  
Post Intervention ◽  
Related Quality ◽  
Health Related

Abstract BackgroundOverweight and obesity are public concerns with risk of adverse health outcomes. Health-related quality of life (HRQoL) is lower in adolescents than children in general. An increase in body mass index (BMI) is associated with a decrease in HRQoL. The purpose of this study was to measure and explore the HRQoL among adolescents with overweight or obesity who had participated in an intervention study with the aim of increasing PA, reducing BMI and promoting HRQoL.Methods Mixed methods, with a convergent design, were used to investigate how different methodological approaches could expand our understanding of the adolescents’ HRQoL. Quantitative post-intervention data on HRQoL were collected among the 84 intervention participants, aged 13–14 years, using the KIDSCREEN 52 questionnaire. The data were compared with a Norwegian reference population of 244 individuals, and analysed using a non-parametric Mann-Whitney test. Qualitative semi-structured interviews were conducted with 21 adolescents from the intervention. A directed approach to content analysis was adopted, using the ten sub-scales from KIDSCREEN 52.ResultsHRQoL in the intervention sample was significantly reduced on the sub-scale of physical well-being compared to the reference population. The reference population scored significantly lower than the intervention sample on the sub-scale of parent relation and home life. No significant differences were found on the other sub-scales. The qualitative data supported the quantitative findings on the sub-scale of physical well-being, but showed that perceptions of fitness, energy level or health could vary. Regarding parent relations, the interviewees extended this to include relationships to other family members as equally important. Most of the interviewees expressed a negative view of their bodies, but not their clothing or accessories. This may explain why no statistically significant differences were found on these aspects in the results from the KIDSCREEN questionnaire. ConclusionThe use of the KIDSCREEN 52 instrument gave important indications about the adolescents’ HRQoL. Combining methods enabled a comprehensive approach to research on HRQoL, indicating better ways of providing help. More research using the benefits of mixed methods approaches is needed to further elucidate these findings.

scholarly journals Long-Term Health-Related Quality of Life of Surgically Treated Pituitary Adenoma Patients: A Descriptive Study

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
A. Raappana ◽  
T. Pirilä ◽  
T. Ebeling ◽  
P. Salmela ◽  
H. Sintonen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Reference Population ◽  
Somatostatin Analog ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
The Mean ◽  
Generic Hrqol Instrument

Context. The literature concerning the health-related quality of life (HRQoL) of patients with surgically treated PA is controversial. Objective. To describe the long-term HRQoL of surgically treated patients in all PA classes. Design and subjects. The 15D, a generic HRQoL instrument producing a 15-dimensional profile and a single 15D index score (a difference ≥0.03 on a 0-1 scale is considered clinically important), was used to assess the HRQoL of a 13-year surgical cohort of PA patients in Northern Finland. Results and Conclusion. Nighty-eight eligible consecutive patients with surgically treated PA were studied at an average of 6.3 years after their latest pituitary operation. The average postoperative 15D profiles in patients with non-functioning PA and in acromegalics without GH-suppressive medical treatment were similar to those of the age-standardized general population. However, after this rather long followup, the mean 15D score and the number of statistically significant 15D dimension impairments, compared with those of their reference population, were 0.11 and 9/15, 0.10 and 3/15, and 0.08 and 7/15 for Cushing’s disease, acromegalics needing somatostatin analog, and prolactinoma patients, respectively. Hypopituitarism with replacement medication was not associated with impaired HRQoL. The somatostatin-analog-associated HRQoL finding warrants further clinical research.

scholarly journals Cognition, Health-Related Quality of Life, and Psychosocial Functioning After GH/GnRHa Treatment in Young Adults Born SGA

2018 ◽  
Vol 103 (11) ◽  
pp. 3931-3938 ◽  
Author(s):  
Wesley Jim Goedegebuure ◽  
Manouk van der Steen ◽  
Justine Lenneke de With ◽  
Anita Hokken-Koelega
Keyword(s):  
Quality Of Life ◽  
Young Adults ◽  
Psychosocial Functioning ◽  
Reference Population ◽  
Study Group ◽  
Health Related Quality ◽  
Self Perception ◽  
Related Quality ◽  
Health Related

Abstract Background Children born small for gestational age (SGA) with a poor adult height (AH) expectation benefit from treatment with GH and additional gonadotropin-releasing hormone analog (GnRHa). Because both SGA birth and GnRHa treatment might negatively influence cognition, health-related quality of life (HRQoL), and psychosocial functioning, we assessed these outcomes at AH. Methods A randomized, dose-response GH study until AH involving 99 adolescents born SGA, of whom 61 children received 2 additional years of GnRHa treatment. At AH, the Wechsler Adult Intelligence Scale and TNO-AZL Adults Quality of Life questionnaire were administered to the study group. Additionally, the study group and 67 adolescents born SGA (19 GnRHa) from a second study group completed the Self-Perception Profile of Adolescents and Child/Adolescent Behavior Checklist at AH. Scores in GH-treated young adults with GnRHa treatment (GH/GnRHa group) were compared with GH-treated adolescents without GnRHa treatment (GH group) and a reference population. Results Mean age (SD) at AH was 17.5 (1.2) and 17.4 (1.4) years in the GH/GnRHa and GH group, respectively. Intelligence quotient scores were similar in GH/GnRHa and GH groups (96.33 vs 92.47). HRQoL was similar between both groups and also when compared with the reference population, but the GH/GnRHa group had a significantly lower perception of cognitive functioning. Self-perception and problem behavior were similar in the GH/GnRHa and GH groups. AH did not correlate with HRQoL, self-perception, or problem behavior. Conclusion Combined GH/GnRHa treatment has no long-term negative effects on cognition, HRQoL, self-perception, and behavior in early adulthood, compared with GH treatment only.

Predictors of health-related quality of life in children with chronic heart disease

2017 ◽  
Vol 27 (8) ◽  
pp. 1455-1464 ◽  
Author(s):  
Mandy Niemitz ◽  
Diana C. M. Gunst ◽  
Hedwig H. Hövels-Gürich ◽  
Michael Hofbeck ◽  
Renate Kaulitz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Disease ◽  
Children And Adolescents ◽  
Psychosocial Development ◽  
Health Related Quality ◽  
Chronic Heart Disease ◽  
Related Quality ◽  
Health Related ◽  
Cardiac Medication

AbstractObjectiveChronic paediatric heart disease is often associated with residual symptoms, persisting functional restrictions, and late sequelae for psychosocial development. It is, therefore, increasingly important to evaluate the health-related quality of life of children and adolescents with chronic heart disease. The aim of this study was to determine medical and socio-demographic variables affecting health-related quality of life in school-aged children and adolescents with chronic heart disease.Patients and methodsThe Pediatric Cardiac Quality of Life Inventory was administered to 375 children and adolescents and 386 parental caregivers. Medical information was obtained from the charts. The socio-demographic information was provided by the patients and caregivers.ResultsGreater disease severity, low school attendance, current cardiac medication, current parental employment, uncertain or limited prognosis, history of connection to a heart–lung machine, number of nights spent in a hospital, and need for treatment in a paediatric aftercare clinic independently contributed to lower health-related quality of life (self-report: R2=0.41; proxy-report: R2=0.46). High correlations between self-reports and parent-proxy reports indicated concordance regarding the evaluation of a child’s health-related quality of life.ConclusionsBeyond medical treatment, integration into school is important to increase health-related quality of life in children and adolescents surviving with chronic heart disease. Regular screening of health-related quality of life is recommended to identify patients with special needs.

scholarly journals Does m-health based exercise (guidance plus education) improve efficacy in patients with chronic low-back pain？A preliminary report on the intervention’s significance

2021 ◽  
Author(s):  
Fuming Zheng ◽  
Shufeng Liu ◽  
Shanshan Zhang ◽  
Qiuhua yu ◽  
Wai Leung Ambrose Lo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Back Pain ◽  
Low Back ◽  
Health Related Quality ◽  
Control Groups ◽  
Related Quality ◽  
Health Related ◽  
And Control

Abstract Objectives: The utilization of mobile health (m-health) has rapidly expanded during the COVID-19 pandemic, and there is still a lack of relevant clinical data pertaining to chronic low-back pain（CLBP）management. This study was designed to compare the effectiveness of m-health based exercise (via guidance plus education) versus exercise (via guidance) during CLBP management.Methods: Participants (n = 40) were randomly assigned to intervention and control groups. The intervention group received m-health based exercise (via guidance plus education), whereas the control group received m-health based exercise (via guidance). The exercise prescription video and educational content were sent to participants by the application (app), Ding Talk. Repeated-measures analysis of variance was used to test the baseline’s intervention effects, 6-week follow-up, and 18-week follow-up. We selected function（Roland and Morris Disability Questionnaire）and pain intensity (current, mean, and most severe Numeric Rating Scale in the last 2 weeks）as the primary outcomes, changes of negative emotion (depression, anxious), and quality of life as the secondary outcomes.Results: Time’s significant effect was found in pain, function, and health-related quality of life in both groups, but time did not show significant interaction effects. Participants were able to use m-based education with their anxiety and depression after treatment, but the relief only lasted until Week 6. No differences were found on the aspect of mental health-related quality of life.Conclusion: M-health based exercise (via guidance) is a convenient and effective method to treat CLBP. Additionally, plus education is more helpful in relieving short-term negative emotions and improving treatment adherence than guidance only. However, at the last follow-up（18-week）, no significant differences were found between the intervention and control groups.

scholarly journals The Effect of Health Education via Mobile Apps in Promoting Asthma Health Related Quality of Life Among Asthmatic School Children in Urban Malaysia.

2021 ◽  
Author(s):  
Abdulaziz Mansoor Al Raimi ◽  
Chan Mei Chong ◽  
Li Yoong Tang ◽  
Yan Piaw Chua ◽  
Latifa Yahya Al Ajeel
Keyword(s):  
Quality Of Life ◽  
Health Education ◽  
Mobile Apps ◽  
Control Group ◽  
Health Related Quality ◽  
Post Intervention ◽  
Related Quality ◽  
Health Related ◽  
And Control

Abstract Objectives: The objective of study to assess the effect of health education via mobile applications in promoting health-related quality of life among schoolchildren with asthma in urban Malaysia. Methods: A Quasi-experimental with two-group pre- and post-intervention design was used in this study involving a total of 214 students. The students were randomly assigned into two groups (intervention group and control group) in a pre and post intervention approach. The control group received face to face education and the experimental group had health education via mobile apps.Results: The findings showed that the total score of health related quality of life has improvement in the mean total score of health-related quality of life from pre-intervention (5.31±1.27) to post-intervention (5.66±1.28) for the control group, compared with the experimental group with a mean total score of HRQoL at pre-intervention (5.01±1.36) and post-intervention (5.85±1.29). A comparison between the experimental and control groups using an independent t-test showed statistically significant differences in the mean HRQoL scores of asthma between the experimental and control groups. The effect of health education via mobile applications showed statistically significant improvement pre and post intervention in HRQoL score [F (1,288) = 57.46, p = <0.01].Conclusion: The use of mobile technology in health education improved HRQoL as compared of traditional method of face-to-face lecture or handbooks among school children with asthma. Thus, educational module using mobile apps improves HRQoL. Trial registration: This study was registered under the Medical Research Committee, University Malaya Medical Centre, Malaysia under Trial MRECID. NO: 2016112-4501, Also, this study is registered with the Australian New Zealand Clinical Trials Registry (ANZCTR) under Trial ID: ACTRN12614300582550

scholarly journals Health-related quality of life in refugee minors from Syria, Iraq and Afghanistan resettled in Sweden: a nation-wide, cross-sectional study

2021 ◽  
Author(s):  
Øivind Solberg ◽  
Mathilde Sengoelge ◽  
Charisse M. Johnson-Singh ◽  
Marjan Vaez ◽  
Anna-Karin Eriksson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Reference Population ◽  
Sociodemographic Factors ◽  
Psychological Wellbeing ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related ◽  
Refugee Minors

Abstract Purpose To examine health-related quality of life (HRQoL) in refugee minors resettled in Sweden and compare results to a European reference population, while exploring associations between sociodemographic factors and HRQoL dimensions. Methods A cross-sectional, nation-wide study was conducted with a stratified sample of refugee minors ages 12–15 and 16–18 from Afghanistan, Iraq and Syria, resettled in Sweden between 2014 and 2018. HRQoL was measured using KIDSCREEN-27. HRQoL dimension scores of the sample were compared to mean scores of European age and gender-matched reference population. Associations between sociodemographic factors and HRQoL dimensions were investigated with independent t tests and ANOVA. A multivariable regression analysis was performed to identify the sociodemographic factors associated with HRQoL. Results The questionnaire was sent to 10,000 potential respondents. The response rate was 26%, yielding n = 2559 refugee minors (boys 55%, girls 45%) in the study sample. Compared to European references, minors in the present study had significantly lower scores of HRQoL within psychological wellbeing and peers and social support, whereas levels for autonomy and parent/guardian relations and school environment were higher. Several sociodemographic factors were significantly associated with all HRQoL dimensions, with those 16–18 years old, having average or poor family economy, and living with an unrelated adult or family reporting lower levels of HRQoL. Minors from Afghanistan had significantly lower scores of HRQoL for all dimensions compared to those from Iraq and Syria. Conclusion Refugee minors had significantly lower levels of HRQoL for psychological wellbeing and peers and social support compared to European references. Future research should further investigate this potential HRQoL gap further.

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