Lymphadenectomy and Adjuvant Therapy Improve Survival with Uterine Carcinosarcoma: A Large Retrospective Cohort Study

Abstract This is a retrospective cohort study evaluating the safety and effectiveness of biodegradable calcium sulfate antibiotic beads in vascular graft infections compared to standard of care. No differences in acute kidney injury or hypercalcemia were observed between the cohorts. Recurrence of infection did not occur in the 13 patient bead cohort compared to 14 patients that had recurrence in the 45 patient non-bead cohort with a NNT of 4.0.

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Determination of Factors Associated with Critical Weight Loss in Oral Cavity Carcinoma Patients: A Retrospective Cohort Study

International Archives of Otorhinolaryngology ◽

10.1055/s-0038-1641131 ◽

2018 ◽

Vol 22 (04) ◽

pp. 395-399

Author(s):

Haissan Iftikhar ◽

Anwar Suhail ◽

Karim Nathani ◽

Amna Urooba ◽

Noman Shahzad ◽

...

Keyword(s):

Weight Loss ◽

Cohort Study ◽

Adjuvant Therapy ◽

Oral Cavity ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Significant Variable ◽

Complication Rates ◽

Critical Weight ◽

Factors Associated

Introduction Critical weight loss is defined as an unintentional weight loss of ≥ 5% at 1 month or ≥ 10% at 6 months from the start of treatment. Critical weight loss leads to deterioration of the immune function and reduced tolerance to treatment (surgery ± radiochemotherapy) as well as increased complication rates. Objective Critical weight loss, defined as a weight loss of ≥ 5% after 1 month or ≥ 10% after 6 months from the start of treatment, is not uncommon in head and neck cancer patients. We aimed to assess the factors associated with critical weight loss during the treatment of oral cavity squamous cell carcinoma patients. Methods A retrospective cohort study was performed at the Aga Khan University Hospital, in Karachi, Pakistan, on 125 patients. Patients receiving adjuvant therapy were considered exposed, and the outcome was critical weight loss. Results The mean age of presentation was 46.9 ± 12.8 years in patients undergoing surgery and adjuvant therapy, with 119 (79.3%) of them being male and 31 (20.7%) female. One hundred and twelve patients (81.3%) developed critical weight loss at 6 months from the start of treatment, and the only significant variable associated with critical weight loss was the stage of the disease (p = 0.03). Conclusion A large proportion of patients with oral cancer developed critical weight loss requiring a need for intervention. The overall stage of the disease is a significant predictor of critical weight loss in patients undergoing treatment.

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Extent of lymph node dissection and overall survival in patients with uterine carcinosarcoma, papillary serous and endometrioid adenocarcinoma: A retrospective cohort study

International Journal of Surgery ◽

10.1016/j.ijsu.2015.10.006 ◽

2015 ◽

Vol 24 ◽

pp. 9-13 ◽

Cited By ~ 5

Author(s):

Ioannis Alagkiozidis ◽

Jeremy Weedon ◽

Allison Grossman ◽

Pengfei Wang ◽

Benjamin Mize ◽

...

Keyword(s):

Overall Survival ◽

Cohort Study ◽

Lymph Node ◽

Lymph Node Dissection ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Endometrioid Adenocarcinoma ◽

Uterine Carcinosarcoma ◽

Node Dissection

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Intravenous immunoglobulin-based adjuvant therapy for severe COVID-19: a single-center retrospective cohort study

Virology Journal ◽

10.1186/s12985-021-01575-3 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Xiao Hou ◽

Li Tian ◽

Lei Zhou ◽

Xinhua Jia ◽

Li Kong ◽

...

Keyword(s):

Mechanical Ventilation ◽

Cohort Study ◽

Adjuvant Therapy ◽

Hospital Mortality ◽

Hospital Stay ◽

Intravenous Immunoglobulin ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Length Of Hospital Stay ◽

Single Center

Abstract Objective Coronavirus disease 2019 (COVID-19) is a major challenge facing the world. Certain guidelines issued by National Health Commission of the People's Repubilic of China recommend intravenous immunoglobulin (IVIG) for adjuvant treatment of COVID-19. However, there is a lack of clinical evidence to support the use of IVIG. Methods This single-center retrospective cohort study included all adult patients with laboratory-confirmed severe COVID-19 in the Respiratory and Critical Care Unit of Dabie Mountain Regional Medical Center, China. Patient information, including demographic data, laboratory indicators, the use of glucocorticoids and IVIG, hospital mortality, the application of mechanical ventilation, and the length of hospital stay was collected. The primary outcome was the composite end point, including death and the use of mechanical ventilation. The secondary outcome was the length of hospital stay. Results Of the 285 patients with confirmed COVID-19, 113 severely ill patients were included in this study. Compared to the non-IVIG group, more patients in the IVIG group reached the composite end point [12 (25.5%) vs 5 (7.6%), P = 0.008] and had longer hospital stay periods [23.0 (19.0–31.0) vs 16.0 (13.8–22.0), P < 0.001]. After adjusting for confounding factors, differences in primary outcomes between the two groups were not statistically significant (P = 0.167), however, patients in the IVIG group had longer hospital stay periods (P = 0.041). Conclusion Adjuvant therapy with IVIG did not improve in-hospital mortality rates or the need for mechanical ventilation in severe COVID-19 patients. Our study does not support the use of immunoglobulin in patients with severe COVID-19 patients.

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