scholarly journals Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Study

Dermatology ◽  
2019 ◽  
Vol 235 (3) ◽  
pp. 234-239 ◽  
Author(s):  
Diana Lazarevic ◽  
Egle Ramelyte ◽  
Reinhard Dummer ◽  
Laurence Imhof

Background: Due to the importance of function and cosmetics, periocular skin malignancies represent a therapeutic challenge. Objective: To evaluate the safety and efficacy of radiotherapy (RT) treating periocular skin tumors. Methods: Data of patients with periocular tumors treated with grenz or soft X-rays at the University Hospital Zurich, Switzerland, between 2009 and 2014 were reviewed. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) with associated in situ lesions, cutaneous melanoma, lentigo maligna (LM), cutaneous lymphoma and Kaposi’s sarcoma were included in the analysis. Results: We found 159 periocular lesions in 145 patients. Overall recurrence was highest for actinic keratosis and Bowen’s disease (27%), melanoma (17%) and LM (15%), whereas SCC and BCC showed recurrence in 11 and 10%, respectively. 45% of all recurrences occurred within 12 months after treatment, with a median time to recurrence of 13 months (range 3–73). Conclusion: RT, which provides a good therapeutic response with minimal adverse events, is a therapy option for periocular cutaneous malignancies.

Author(s):  
Rosalba Ciranni ◽  
Donata Pangoli ◽  
Valentina Giuffra ◽  
DAvide Caramella ◽  
Edda Bresciani ◽  
...  

Eighty-five Egyptian mummies belonging to different dynastic periods and collected in a number of Italian museums, have been censed and submitted for paleopathological research. In most cases the presence of bandages required the application of X- rays and computed axial tomography (CAT). Fifty-two mummies have been studied in situ with Xrays; twelve with CAT scanning. Technical problems kept us from investigating eleven of the censed mummies. In a few cases it was possible to perform autopsies, endoscopy, or histological studies. The mummies submitted for X- rays were divided into two groups: The first group thirty-six mummies studied by the team of Paleopathology-Egyptology of the University of Pisa were studied for the first time. The second group was composed of twenty-six mummies studied elsewhere in Italy. Those results also have been included in the Anubi Project database.


2020 ◽  
Vol 11 (2) ◽  
pp. 188-194
Author(s):  
Siniša Kojić ◽  
Zuhra Memić ◽  
Vera Sabljak ◽  
Helena Marić-Kujundžić ◽  
Bojan Kujundžić ◽  
...  

Introduction. Whether it is a classic version of the flap or its modification, the Limberg flap is an appropriate solution for covering small and medium-sized defects, as well as for covering largesized defects where certain localizations are concerned. It represents a local, transposition flap that has proven to be a safe option. Methods. The defect coverage was achieved by marking a defect that was in the form of an equilateral rhombus by means of extending a shorter diagonal by the length of its side and drawing a parallel with the defect side, which created four different flaps. We included 50 patients surgically treated at the Varis Clinic for Plastic and Reconstructive Surgery in Belgrade and the University Hospital in Foca for the period 2018-2020. In all patients, we used the Limberg flap as a method for defect reconstruction. Case presentations. The sample was comprised of up to 50 patients, with an average respondent age of 60.3 years. According to etiology, the most common changes in the skin belonged to Basal cell carcinoma (58%), Squamous cell carcinoma (24%) and melanoma (8%), with the most common predilection sites associated with the face in 22 patients and with the lumbosacral region in 8 patients. A well-planned Limberg flap caused minor complications in terms of mild marginal infection in one patient, and mild marginal infection as an early complication and a stretched scar as a late complication in one patient as well. Other complications in the sample were not recorded. Conclusion. To obtain the best possible functional and esthetic result with minimal disruption of the region, respecting the anatomy and the basic principles in plastic surgery, the Limberg flap is an excellent solution for the reconstruction of defects of different sizes.


1978 ◽  
Vol 22 ◽  
pp. 247-249 ◽  
Author(s):  
C. O. Ruud ◽  
C. S. Barrett

Residual stresses on the inner surface of stainless steel pipe used in nuclear reactors are of exceptional importance. Apparatus for measuring these in situ, in welded lengths of 10-inch diameter austenitic (304) stainless pipe has been developed at the University of Denver Research Institute under the sponsorship of the Electric Power Research Institute.


Folia Medica ◽  
2018 ◽  
Vol 60 (1) ◽  
pp. 164-169
Author(s):  
Valeri Y. Andreev ◽  
Nikolay A. Yanev ◽  
Stefan K. Stanimirov ◽  
Temenuzhka V. Mircheva ◽  
Ivan N. Ivanov ◽  
...  

Abstract As part of a retrospective study on bronchoscopies performed at the Clinic of Pneumonology and Phthisiatry of the University Hospital – Pleven by autofluorescence bronchoscopy we found 3 cases diagnosed with carcinoma in situ. They were treated in different ways – endobronchial electrocoagulation, extraction by forceps biopsy and open surgery, but the result was the same – clinical healing. The paper presents the three clinical cases and the analysis of the treatment.


2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 15530-15530 ◽  
Author(s):  
P. Clement ◽  
J. Verheezen ◽  
S. Nuyts ◽  
V. Vanderpoorten ◽  
R. Sciot

15530 Background: Basosquamous Cell Carcinoma (BSCC) of the larynx, hypopharynx and base of tongue represents 1% of all head and neck tumours. It is considered a more aggressive disease than squamous cell carcinoma, based on higher incidence of advanced stage disease (60% lymph node-involvement and 40% metastases at diagnosis). Therefore, a treatment regimen including chemotherapy is often recommended in addition to surgery and/or radiotherapy in the literature. Methods: We retrospectively analyzed the data of all patients diagnosed with BSCC of the head and neck at the University Hospital of Leuven between 1993 and 2003, and report here the stage at diagnosis, treatment modality, disease evolution, progression free and overall survival. Results: Seven patients where diagnosed with BSCC in the head and neck region. Six patients were male. Three of the tumours were localised in the larynx, two at the base of tongue, and two in the oral cavity. The AJCC stages of disease ranged from I to IVa. Three patients had lymph node involvement at diagnosis. Six patients were treated with surgery in combination with radiotherapy. One patient was treated with cryotherapy before brachytherapy was applied. Five patients have no evidence of disease with a follow up of 4, 5, 6, 10 and 11 years, respectively. One patient died of an unknown cause 18 months after treatment. Only one of the seven patients, developed metastases during follow up. This patient had BSCC of the base of tongue, and was diagnosed with lungmetastases 16 months after surgery and radiotherapy. He was treated with the combination of Doxorubicine, Cisplatin and Fluorouracil. A partial response was confirmed after six cycles. Eight months after the last treatment cycle, there is still no evidence of disease progression. Conclusions: BSCC is a rare tumour of the head and neck. Seven patients were treated at the University hospital of Leuven in the period between 1993 and 2003 with a median progression free and overall survival of more than 5 years. Only one patient developed metastases, and was consequently treated with chemotherapy, inducing a continuing partial remission 8 months after treatment. In contrast to what is reported in the literature we do not confirm a high incidence of metastases at diagnosis nor a high mortality rate. No significant financial relationships to disclose.


2005 ◽  
Vol 11 (5) ◽  
pp. 251-255 ◽  
Author(s):  
Markus Rumpsfeld ◽  
Eli Arild ◽  
Jan Norum ◽  
Elin Breivik

A common workplace was established between the renal unit at the University Hospital of North Norway and two satellite dialysis centres, in Alta and Hammerfest. A 2 Mbit/s ATM network was employed for IP-based videoconferencing. A common electronic medical record system and dialysis monitoring software were used. During an eight-month study period, nine patients were enrolled and 225 videoconferences were performed for daily visits and regular rounds. A bandwidth of 768 kbit/s was required for satisfactory teledialysis. Although technical (28%) and logistical problems (10%) were frequent, five hospitalizations and one-third of the planned visiting rounds were avoided. An economic analysis showed that annual savings amounted to US$46,613, while annual costs were US$79,489. Despite the technical difficulties in about 30% of conferences, the nurses were satisfied with the videoconferencing system. Digital X-rays were communicated without problems. The pilot study indicates that satellite units may be incorporated into the daily management at the central institution by telemedicine.


2016 ◽  
Vol 12 (24) ◽  
pp. 223
Author(s):  
M. Tchaou ◽  
G.N. Gnakadja ◽  
B. N’timon ◽  
L. Sonhaye ◽  
A. Amadou ◽  
...  

Aims: To assess the justification of indications and exposure doses to children during radiographics. Methods: Prospective study of 102 X-ray exams of children collected over a period of 6 months in the Department of Radiology of Kara Teaching Hospital. Objectives: To assess the rationale guidance and exposure doses to children when standard radiographic examinations. Methodology: prospective observational study of 102 standard radiographs (Rx) collected in the radiology department of the University Hospital of Kara on a 6 month period. Results: Male children were predominant with a sex ratio boy / girl of 1.3. The predominant age group was the 5 to 10 years. Chest X-rays were the most practiced exam, with 43%. According to the Guide of well practices of French Society of Radiology (SFR) and the French Society of Biophysics and Nuclear Medicine (SFBMN), 80% of exams were justified. The comparison of our results to diagnostic reference levels (DRLs) shows that 43% and 39% of standard X-rays had dosimetric values exceeds the RDLs respectively the entrance Dose (De) and Dose Surface Product (DSP). Conclusion:Our study reveals that compliance guidance assessments to the proper use of medical imaging examinations guide was not always effective but satisfactory. The study dosimetric constants showed that the dose to children exceeded in a large proportion of the French and Belgian DRLs.


2019 ◽  
Author(s):  
Fredy-Michel Roten ◽  
Richard Steffen ◽  
Maren Kleine-Brueggeney ◽  
Robert Greif ◽  
Marius Wipfli ◽  
...  

Abstract BACKGROUND: The dislocation rate of oral versus nasal airway exchange catheters (AEC) in the postoperative care unit (PACU) are unknown. Our aim was to establish dislocation rates and to assess the usefulness of waveform capnography to detect dislocation. METHODS: In this non-randomized, prospective observational trial at the University Hospital Bern, Switzerland, we included 200 patients admitted to PACU after extubation via AEC, having provided written informed consent. The study was approved by the local ethical committee. AEC position was assessed by nasal fiberoptic endoscopy at beginning of PACU stay and before removal of the AEC. Capnography was continuously recorded via the AEC. Additional measurements included retching and coughing of the patient, and re-intubation, if necessary. RESULTS: Data from 182 patients could be evaluated regarding dislocation. Overall dislocation rate was not different between oral and nasal catheters (7.2% vs. 2.7%, p=0.16). Retching was more often noted in oral catheters (26% vs. 8%, p<0.01). Waveform capnography was unreliable in predicting dislocation (negative predictive value 17%). Re-intubation was successful in all five of the nine re-intubations where an AEC was still in situ. In four patients, the AEC was already removed when re-intubation became necessary, and re-intubation failed once, with a front of neck access as a rescue maneuver. CONCLUSIONS: We found no difference in dislocation rate between nasal and oral position of an airway exchange catheter. However, nasal catheters seemed to be tolerated better. In the future, catheters like the staged extubation catheter may further increase tolerance. TRIAL REGISTRATION: The study was registered in a clinical study registry (ISRCTN 96726807) on 10/06/2010.


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