A Comparison of Epidemiological Characteristics of Central Nervous System Tumours in China and Globally from 1990 to 2019

Background: Despite their great disease burden, there have been few studies on the epidemiology of central nervous system tumours (CNSTs) in China. We used the latest data updated by GBD to analyse the trends of incidence, mortality, and disability-adjusted life years (DALYs) for CNSTs in China versus globally. Methods: Epidemiological data on CNSTs were extracted from GBD 2019. We used Joinpoint regression analysis to calculate the magnitude and direction of the trends and the age-period-cohort method to analyse the age, period, and cohort effects of the trend. Results: From 1990 to 2019, the 106.52% increase in Chinese incident cases was higher than the global increase (94.35%). The 67.32% increase in cancer deaths and 16.03% increase in DALYs were lower than the global increases (cancer death: 76.36%; DALYs: 40.06%). The age-standardized incidence rates (ASIRs) in China were higher than the global ASIRs, and the increase in China was higher than that globally. Although the age-standardized mortality rates and age-standardized DALY rates in China were higher, their increases in China were less than those globally. Both in China and globally, the number and incidence, mortality, and DALYs by age group showed a bimodal distribution (younger than 5 years and older), and the peak in the older age group showed a backwards trend. The proportion of incident cases, cancer deaths, and DALYs also increased in the older age group. In the age-period-cohort model, the local drifts in the older age group were above zero. Conclusions: The burden of CNSTs is very serious in China, and we should pay attention to the key populations, early diagnosis technology, improvements in medical technology, and ways to reduce medical costs. We believe our results could help policymakers allocate resources efficiently to reduce the burden of CNSTs.

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Central nervous system

Radiotherapy and the Cancers of Children, Teenagers, and Young Adults ◽

10.1093/med/9780198793076.003.0006 ◽

2020 ◽

pp. 107-189

Author(s):

Thankamma Ajithkumar ◽

Tom Boterberg ◽

Edmund Cheesman ◽

Felice D’Arco ◽

Karin Dieckmann ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Brain Tumours ◽

High Grade ◽

Age Group ◽

Germ Cell Tumours ◽

Children And Young People ◽

System P ◽

Central Nervous System Tumours ◽

Embryonal Tumours

Chapter 6 discusses brain tumours, the commonest solid neoplasms of children and young people, which account for about one-quarter of all malignancies in this age group. There are many different varieties: medulloblastomas and other embryonal tumours, and low- and high-grade gliomas, form the commonest categories. Craniopharyngiomas, ependymomas, intracranial germ cell tumours, and other rare types are less frequently encountered. Most brain and spinal tumours are treated with a multimodality schedule comprising surgery, chemotherapy, and radiotherapy. The place of radiotherapy in the management of central nervous system tumours is described in detail.

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Incidence trends in pediatric central nervous system tumors in Canada: a 15 years report from Cancer and Young People in Canada (CYP-C) registry

Neuro-Oncology Advances ◽

10.1093/noajnl/vdaa012 ◽

2020 ◽

Vol 2 (1) ◽

Author(s):

Valérie Larouche ◽

Annie-Kim Toupin ◽

Benoît Lalonde ◽

David Simonyan ◽

Nada Jabado ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Young People ◽

Pediatric Patients ◽

Incidence Rates ◽

Cns Tumors ◽

Benign Tumors ◽

Low Grade ◽

Age Group ◽

Cns Tumor

Abstract Background The aim of this study is to present a national surveillance report on pediatric central nervous system (CNS) tumors in Canada during the period between 2001 and 2015. Methods All pediatric patients with a diagnosis of primary CNS tumors were collected by the Cancer in Young People in Canada (CYP-C) surveillance system that includes every patient less than 15 years of age with a tumor seen in one of the 17 pediatric oncology centres in Canada. This registry included malignant and benign CNS tumors. We calculated the age-adjusted incidence rates (AAIRs) per 100 000 person-years for CNS tumors overall and by age group, major histology subgroups, and geographical distribution over the country. Results Overall, 3306 patients less than 15 years old had been diagnosed with a CNS tumor in Canada in 2001–2015 with a 1.23:1 male to female ratio. The overall AAIR is 3.80. The three most frequent groups of tumors were low-grade gliomas (36.4%), high-grade gliomas (22.3%), and embryonal tumors (18.7%) with incidence rates of 1.41, 0.86, and 0.72 per 100 000 person-years, respectively. The incidence rate of pediatric CNS tumors is stable during the period 2001–2015 in Canada and no significant differences were seen between malignant and benign tumors over the country. Conclusions These data represent all the pediatric patients 0–14 years old with a CNS tumor in the Canadian population. Incidence rates by age group, sex, and subgroups of tumors are similar to those seen in the literature.

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Central nervous system tumours among adolescents and young adults (15–39 years) in Southern and Eastern Europe: Registration improvements reveal higher incidence rates compared to the US

European Journal of Cancer ◽

10.1016/j.ejca.2017.08.030 ◽

2017 ◽

Vol 86 ◽

pp. 46-58 ◽

Cited By ~ 11

Author(s):

Marios K. Georgakis ◽

Paraskevi Panagopoulou ◽

Paraskevi Papathoma ◽

Athanasios Tragiannidis ◽

Anton Ryzhov ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Young Adults ◽

Eastern Europe ◽

Incidence Rates ◽

Adolescents And Young Adults ◽

Central Nervous System Tumours ◽

The Us

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Faculty Opinions recommendation of Molecular pathology of paediatric central nervous system tumours.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726820734.793530284 ◽

2017 ◽

Author(s):

Scott Pomeroy ◽

Soma Sengupta

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Molecular Pathology ◽

Central Nervous System Tumours

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55 Malignant primary brain and other central nervous system tumours diagnosed in the Canadian population from 2009 to 2013

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/cjn.2018.306 ◽

2018 ◽

Vol 45 (S3) ◽

pp. S16-S17

Author(s):

EV Walker ◽

F Davis ◽

Keyword(s):

United States ◽

Central Nervous System ◽

Nervous System ◽

Brain Tumour ◽

Age Distribution ◽

Paediatric Population ◽

The United States ◽

Incidence Rates ◽

Canadian Population ◽

Cns Tumours

The Canadian Brain Tumour Registry (CBTR) project was established in 2016 with the aim of enhancing infrastructure for surveillance and clinical research to improve health outcomes for brain tumour patients in Canada. We present a national surveillance report on malignant primary brain and central nervous system (CNS) tumours diagnosed in the Canadian population from 2009-2013. Patients were identified through the Canadian Cancer Registry (CCR); an administrative dataset that includes cancer incidence data from all provinces/territories in Canada. Cancer diagnoses are coded using the ICD-O3 system. Tumour types were classified by site and histology using The Central Brain Tumour Registry of the United States definitions. Incidence rates (IR) and 95% confidence intervals (CI) were calculated per 100,000 person-years and standardized to the 2011 census population age-distribution. Overall, 12,115 malignant brain and CNS tumours were diagnosed in the Canadian population from 2009-2013 (IR:8.43;95%CI:8.28,8.58). Of these, 6,845 were diagnosed in males (IR:9.72;95%CI:9.49,9.95) and 5,270 in females (IR:7.20;95%CI:7.00,7.39). The most common histology overall was glioblastoma (IR:4.06;95%CI:3.95,4.16). Among those aged 0-19 years, 1,130 malignant brain and CNS tumours were diagnosed from 2009-2013 (IR:3.36;95%CI:3.16,3.56). Of these, 625 were diagnosed in males (IR:3.32;95%CI:3.34,3.92) and 505 in females (IR:3.08;95%CI:2.81,3.36). The most common histology among the paediatric population was pilocytic astrocytoma (IR:0.73;95%CI:0.64,0.83). The presentation will include: IRs for other histologies, the geographic distribution of cases and a comparison between Canada and the United States.

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Histological subtypes of symptomatic central nervous system tumours in Singapore

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp.68.3.372 ◽

2000 ◽

Vol 68 (3) ◽

pp. 372-374 ◽

Cited By ~ 5

Author(s):

A Das

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Histological Subtypes ◽

Central Nervous System Tumours

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Multidisciplinary treatment for central nervous system tumours with nitrosourea compounds

Acta Neurochirurgica ◽

10.1007/bf01811342 ◽

1978 ◽

Vol 41 (4) ◽

pp. 287-299 ◽

Cited By ~ 11

Author(s):

P. Paoletti ◽

G. Robustelli della Cuna ◽

R. Knerich ◽

M. R. Strada

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Multidisciplinary Treatment ◽

Central Nervous System Tumours

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Disability-Adjusted Life Years and Mortality Rate Attributed to Brain and Central Nervous System Cancer in the Middle East and North Africa Countries

Neuroepidemiology ◽

10.1159/000519281 ◽

2021 ◽

pp. 1-13

Author(s):

Hamid Reza Saeidi Borojeni ◽

Farid Najafi ◽

Fatemeh Khosravi Shadmani ◽

Zahra Darabi ◽

Mitra Darbandi ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Mortality Rate ◽

North Africa ◽

Disability Adjusted Life Years ◽

Mena Region ◽

Central Nervous System Cancer ◽

Disability Adjusted Life ◽

Life Years ◽

Nervous System Cancer

Background: Primary brain tumors are among the main causes of death. This study aimed to determine the epidemiological features of the brain and central nervous system cancer in the Middle East and North Africa (MENA) region. Methods: In this study, data of the Global Burden of Disease (GBD) study were used to estimate the incidence, prevalence, deaths, disability-adjusted life years (DALYs), and mortality in 21 countries in the MENA region from 1990 to 2019 based on age and sex. The percentage of the changes of epidemiologic indicators was calculated between 1990 and 2019. Results: Palestine and Turkey had the highest rate of brain and central nervous system cancer in 2019. Saudi Arabia, Oman, Iraq, and Lebanon had the highest percentage of incidence rate changes from 1990 to 2019. The prevalence of brain and central nervous system cancer in the MENA region was increased from 7.51 (95% CI: 4.95–11.01) in 1990 to 16.45 (95% CI: 10.83–19.54) in 2019 (percentage of changes = 54.35%). The standardized age mortality rate in the MENA region was increased by 2.7% in 2019 compared to that in 1990. The rate of standardized age of DALY per 100,000 individuals in the MENA region decreased from 135.09 (95% CI: 92.57–199.92) in 1990 to 128.34 (95% CI: 87.81–151.3) in 2019. Conclusion: The incidence rate, prevalence, and standardized age mortality (per 100,000) had increased significantly in the MENA region in 2019 compared to those in 1990. Focusing on the diversity of the estimates of such indices in different countries of MENA can lead to the identification of important risk factors for brain cancer in future studies.

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