Dissociative-Traumatic Dimension and Triple Network: An EEG Functional Connectivity Study in a Sample of University Students

2021 ◽  
pp. 1-9
Author(s):  
Giuseppe Alessio Carbone ◽  
Claudio Imperatori ◽  
Francesco Saverio Bersani ◽  
Chiara Massullo ◽  
Egle Maria Orlando ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
University Students ◽  
Posterior Parietal Cortex ◽  
Self Report ◽  
Connectivity Pattern ◽  
Eyes Closed ◽  
Dissociative Symptoms ◽  
Trauma Ct ◽  
Eeg Functional Connectivity ◽  
The Right

<b><i>Aims:</i></b> We investigated the association among triple network electroencephalographic (EEG) functional connectivity, dissociative symptoms, and childhood trauma (CT) in a sample of university students. <b><i>Sampling and Methods:</i></b> Seventy-six participants (30 males and 46 females; mean age 22.12 ± 2.35) completed self-report measures investigating dissociative symptoms, CT, and depressive symptoms. Participants also performed an eyes-closed resting-state EEG recording. EEG analyses were conducted through the exact low-resolution electromagnetic tomography (eLORETA) software. <b><i>Results:</i></b> A 2-step cluster analysis revealed 2 groups: participants (<i>N</i> = 23) with high dissociative-traumatic dimension symptoms (DTD+) and participants (<i>N</i> = 53) with low DTD symptoms (DTD−). Compared to DTD− subjects, DTD+ participants showed decreased theta connectivity between the salience network (SN) and central executive network (CEN), specifically between the right anterior insula and the left posterior parietal cortex. No significant correlation was detected between EEG data and clinical variables. <b><i>Conclusion:</i></b> Our results raise the possibility of a dysfunctional connectivity pattern occurring between the SN and CEN in individuals with high DTD symptoms. Such connectivity pattern might reflect the neuropsychophysiological disintegration related to pathological dissociation.

scholarly journals Multivariate Pattern Analysis of fMRI in Breast Cancer Survivors and Healthy Women

2013 ◽  
Vol 20 (4) ◽  
pp. 391-401 ◽  
Author(s):  
S.M. Hadi Hosseini ◽  
Shelli R. Kesler
Keyword(s):  
Breast Cancer ◽  
Functional Connectivity ◽  
Breast Cancer Survivors ◽  
Pattern Analysis ◽  
Brain Connectivity ◽  
Survival Rates ◽  
Connectivity Pattern ◽  
Multivariate Pattern Analysis ◽  
The Right ◽  
Multivariate Pattern

AbstractAdvances in breast cancer (BC) treatments have resulted in significantly improved survival rates. However, BC chemotherapy is often associated with several side effects including cognitive dysfunction. We applied multivariate pattern analysis (MVPA) to functional magnetic resonance imaging (fMRI) to find a brain connectivity pattern that accurately and automatically distinguishes chemotherapy-treated (C+) from non-chemotherapy treated (C−) BC females and healthy female controls (HC). Twenty-seven C+, 29 C−, and 30 HC underwent fMRI during an executive-prefrontal task (Go/Nogo). The pattern of functional connectivity associated with this task discriminated with significant accuracy between C+ and HC groups (72%, p = .006) and between C+ and C− groups (71%, p = .012). However, the accuracy of discrimination between C− and HC was not significant (51%, p = .46). Compared with HC, behavioral performance of the C+ and C− groups during the task was intact. However, the C+ group demonstrated altered functional connectivity in the right frontoparietal and left supplementary motor area networks compared to HC, and in the right middle frontal and left superior frontal gyri networks, compared to C−. Our results provide further evidence that executive function performance may be preserved in some chemotherapy-treated BC survivors through recruitment of additional neural connections. (JINS, 2013, 19, 1–11)

scholarly journals Changes in the temporal variability of the EEG functional connectivity during aging

2015 ◽  
Vol 7 (1) ◽  
pp. 5-15
Author(s):  
Almudena González ◽  
Guzmán Alba ◽  
Julián González
Keyword(s):  
Functional Connectivity ◽  
Cognitive Performance ◽  
Temporal Variability ◽  
Healthy Subjects ◽  
Generalized Synchronization ◽  
Performance Deficits ◽  
Cortical Areas ◽  
Eyes Closed ◽  
Eeg Recordings ◽  
Eeg Functional Connectivity

This work is aimed at investigating changes in the temporal variability of EEG functional connectivity (FC) during agin. The variability in the FC has been linked to cognitive performance. The study was carried out in two groups of healthy subjects: one of 10 adults between 50-65 years old and another of 15 subjects ranging 66-85 years. EEG recordings were made at rest using 16 monopolar channels: under eyes closed (EC) and under hyperventilation (HV). The cortical FC between all EEG channel pairs was estimated from an index (L) of nonlinear generalized synchronization. For each subject and condition, the global connectivity (GC) of each area/channel with the rest of them was calculated, then the GC average and the GC temporal variability (TVC) of such connectivities was computed from the GC mean and standard deviation of successive EEG recordings respectively. The changes with age and condition of GC and TVC of each cortical area were estimated via a MANOVA. We found that the GC does not change with age during OC or HV, but the TVC of all cortical areas is significantly higher (p<0.01) for subjects under 65 and mainly for the central, temporal and parietal areas (p<0.01). It is concluded that TVC decreasing with aging may be related to cognitive performance deficits.

scholarly journals Associations between EEG functional brain connectivity and a cognitive reserve proxy in healthy older adults

2019 ◽  
Author(s):  
Bahar Moezzi ◽  
Louise M. Lavrencic ◽  
Mitchell R. Goldsworthy ◽  
Scott Coussens ◽  
Hannah A.D. Keage
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Cognitive Reserve ◽  
Medium Effect ◽  
Theta Band ◽  
Healthy Older Adults ◽  
Eyes Closed ◽  
Medium Effect Size ◽  
Eyes Open ◽  
The Right

AbstractCognitive reserve is a concept that explains individual differences in vulnerability to cognitive impairment due to age and dementia-related brain changes. Mechanisms underlying the cognitive reserve effect are poorly understood. We investigated associations between a comprehensive cognitive reserve proxy (Lifetime Experiences Questionnaire/LEQ) and functional connectivity of the prefrontal cortex across the whole scalp, covarying for the level of current cognitive functioning (Addenbrookes Cognitive Examination Revised/ACE-R), using multiblock parallel and orthogonalized partial least squares regression. EEG data were collected from 34 healthy older adults (63 to 83 years) in eyes-open and eyes-closed resting-states, and during 0-back and 1-back tasks. Functional connectivity was estimated using imaginary coherence in the theta and alpha frequency bands, as these bands have been heavily implicated in cognitive ageing, attention and executive function. We found three clusters of electrodes where the absolute values of the regression coefficient were above threshold when covarying for ACE-R: (1) a cluster approximating the right frontocentral region during the eyes-open condition in the theta band with seed electrodes approximating the left prefrontal cortex with positive associations of medium effect size; (2) a cluster approximating the right parietotemporal region during the 0-back task in the theta band with seed electrodes approximating the right prefrontal cortex with negative associations of medium to large effect sizes; and (3) a cluster approximating the occipitoparietal region in the eyes-closed condition in the alpha band with seed electrodes approximating the left prefrontal cortex with negative associations of medium effect size. These relationships between a cognitive reserve proxy and functional connectivity, within key networks and frequency bands associated with attention and executive function, may reflect greater neural capacity and efficiency.

Eyes closed or Eyes open? Exploring the alpha desynchronization hypothesis in resting state functional connectivity networks with intracranial EEG

2017 ◽  
Author(s):  
Jaime Gómez-Ramírez ◽  
Shelagh Freedman ◽  
Diego Mateos ◽  
José Luis Pérez-Velázquez ◽  
Taufik Valiante
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Connectivity Pattern ◽  
Cost Calculation ◽  
Resting State Functional Connectivity ◽  
Eyes Closed ◽  
Regional Specificity ◽  
Eyes Open ◽  
First Time ◽  
Intracranial Recordings

AbstractThis paper addresses a fundamental question, are eyes closed and eyes open resting states equivalent baseline conditions, or do they have consistently different electrophysiological signatures? We compare the functional connectivity patterns in an eyes closed resting state with an eyes open resting state, and show that functional connectivity in the alpha band decreases in the eyes open condition compared to eyes closed. This "alpha desynchronization " or reduction in the number of connections from eyes closed to eyes open, is here, for the first time, studied with intracranial recordings. We provide two calculations of the wiring cost, local and mesoscopic, defined in terms of the distance between the electrodes and the likelihood that they are functionally connected. We find that, in agreement with the "alpha desynchronization" hypothesis, the local wiring cost decreases going from eyes closed to eyes open. However, when the wiring cost calculation takes into account the connectivity pattern, the wiring cost variation from eyes closed to eyes open is not as consistent and shows regional specificity. The wiring cost measure defined here, provides a new avenue for understanding the electrophysiology of resting state.

scholarly journals Brain Network Dynamics Underlying Visuospatial Judgment: An fMRI Connectivity Study

2010 ◽  
Vol 22 (9) ◽  
pp. 2012-2026 ◽  
Author(s):  
Tom A. de Graaf ◽  
Alard Roebroeck ◽  
Rainer Goebel ◽  
Alexander T. Sack
Keyword(s):  
Functional Connectivity ◽  
Posterior Parietal Cortex ◽  
Effective Connectivity ◽  
Inferior Frontal Gyrus ◽  
Brain Network ◽  
Judgment Task ◽  
Connectivity Analysis ◽  
Thalamic Nuclei ◽  
Visuospatial Task ◽  
The Right

Previous functional imaging research has consistently indicated involvement of bilateral fronto-parietal networks during the execution of visuospatial tasks. Studies with TMS have suggested that the right hemispheric network, but not the left, is functionally relevant for visuospatial judgments. However, very little is still known about the interactions within these fronto-parietal networks underlying visuospatial processing. In the current study, we investigated task modulation of functional connectivity (instantaneous correlations of regional time courses), and task-specific effective connectivity (direction of influences), within the right fronto-parietal network activated during visuospatial judgments. Ten healthy volunteers performed a behaviorally controlled visuospatial judgment task (ANGLE) or a control task (COLOR) in an fMRI experiment. Visuospatial task-specific activations were found in posterior parietal cortex (PPC) and middle/inferior frontal gyrus (MFG). Functional connectivity within this network was task-modulated, with significantly higher connectivity between PPC and MFG during ANGLE than during COLOR. Effective connectivity analysis for directed influence revealed that visuospatial task-specific projections within this network were predominantly in a frontal-to-parietal direction. Moreover, ANGLE-specific influences from thalamic nuclei to PPC were identified. Exploratory effective connectivity analysis revealed that closely neighboring clusters, within visuospatial regions, were differentially involved in the network. These neighboring clusters had opposite effective connectivity patterns to other nodes of the fronto-parietal network. Our data thus reveal that visuospatial judgments are supported by massive fronto-parietal backprojections, thalamo-parietal influence, and multiple stages, or loops, of information flow within the visuospatial network. We speculate on possible functional contributions of the various network nodes and informational loops in a neurocognitive model.

scholarly journals Altered local and distant functional connectivity density relate to headache frequency in migraine without aura

2020 ◽  
Author(s):  
Jun Ke ◽  
Yang Yu ◽  
Xiaodong Zhang ◽  
Yunyan Su ◽  
Ximing Wang ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Large Scale ◽  
Parahippocampal Gyrus ◽  
Connectivity Pattern ◽  
Middle Temporal Gyrus ◽  
Functional Connectivity Density ◽  
Whole Brain ◽  
Migraine Frequency ◽  
The Right

Abstract Background Episodic migraine (EM) is associated with alterations in functional connectivity of several regions or resting-state networks, but it is not well known how large-scale functional connectivity pattern of the whole brain is affected in chronic migraine (CM). Methods Fifty-six migraineurs without aura (39 with EM, 17 with CM) and 35 healthy controls (HC) underwent clinical assessment and resting-state functional MRI. Functional connectivity density (FCD) was calculated in a voxel-wise way to examine large-scale brain network property over the whole brain. Results Compared with HC, both migraine groups showed increased local FCD in the left orbital frontal gyrus (OFG), right hippocampus/parahippocampal gyrus (HP/PHG), cerebellum, and decreased local FCD in the bilateral dorsolateral prefrontal cortex. Local FCD of the left OFG increased in CM compared to EM. In comparison with HC, EM showed increased local FCD in the left middle temporal gyrus, and CM exhibited decreased local FCD in the left sensorimotor cortex and bilateral precuneus. Furthermore, relative to HC, EM showed increased distant FCD in the right PHG while CM showed increased distant FCD in the right HP and OFG. Importantly, majority of the observed local and distant FCD alterations were associated with migraine frequency across all migraineurs. Conclusion Patients with higher migraine frequency present more extensive and pronounced functional connectivity dysfunctions in regions involved in pain processing and modulation. FCD, especially local FCD may be a sensitive biomarker for examining the neural mechanism of migraine.

Altered cerebellar functional connectivity in remitted bipolar disorder: A resting-state functional magnetic resonance imaging study

2017 ◽  
Vol 52 (10) ◽  
pp. 962-971 ◽  
Author(s):  
Ying Wang ◽  
Shuming Zhong ◽  
Guanmao Chen ◽  
Tao Liu ◽  
Lianping Zhao ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Bipolar Disorder ◽  
Functional Connectivity ◽  
Resting State ◽  
Connectivity Pattern ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Functional Connectivity Strength ◽  
The Right ◽  
Connectivity Strength

Objectives: Several recent studies have reported a strong association between the cerebellar structural and functional abnormalities and psychiatric disorders. However, there are no studies to investigate possible changes in cerebellar functional connectivity in bipolar disorder. This study aimed to examine the whole-brain functional connectivity pattern of patients with remitted bipolar disorder II, in particular in the cerebellum. Methods: A total of 25 patients with remitted bipolar disorder II and 25 controls underwent resting-state functional magnetic resonance imaging and neuropsychological tests. Voxel-wise whole-brain connectivity was analyzed using a graph theory approach: functional connectivity strength. A seed-based resting-state functional connectivity analysis was further performed to investigate abnormal functional connectivity pattern of those regions with changed functional connectivity strength. Results: Remitted bipolar disorder II patients had significantly decreased functional connectivity strength in the bilateral posterior lobes of cerebellum (mainly lobules VIIb/VIIIa). The seed-based functional connectivity analyses revealed decreased functional connectivity between the right posterior cerebellum and the default mode network (i.e. right posterior cingulate cortex/precuneus and right superior temporal gyrus), bilateral hippocampus, right putamen, left paracentral lobule and bilateral posterior cerebellum and decreased functional connectivity between the left posterior cerebellum and the right inferior parietal lobule and bilateral posterior cerebellum in patients with remitted bipolar disorder II. Conclusion: Our results suggest that cerebellar dysconnectivity, in particular distributed cerebellar–cerebral functional connectivity, might be associated with the pathogenesis of bipolar disorder.

scholarly journals Changes in the temporal variability of the EEG functional connectivity during aging

2015 ◽  
Vol 7 (1) ◽  
pp. 5-15
Author(s):  
Almudena González ◽  
Guzmán Alba ◽  
Julián González
Keyword(s):  
Functional Connectivity ◽  
Cognitive Performance ◽  
Temporal Variability ◽  
Healthy Subjects ◽  
Generalized Synchronization ◽  
Performance Deficits ◽  
Cortical Areas ◽  
Eyes Closed ◽  
Eeg Recordings ◽  
Eeg Functional Connectivity

This work is aimed at investigating changes in the temporal variability of EEG functional connectivity (FC) during agin. The variability in the FC has been linked to cognitive performance. The study was carried out in two groups of healthy subjects: one of 10 adults between 50-65 years old and another of 15 subjects ranging 66-85 years. EEG recordings were made at rest using 16 monopolar channels: under eyes closed (EC) and under hyperventilation (HV). The cortical FC between all EEG channel pairs was estimated from an index (L) of nonlinear generalized synchronization. For each subject and condition, the global connectivity (GC) of each area/channel with the rest of them was calculated, then the GC average and the GC temporal variability (TVC) of such connectivities was computed from the GC mean and standard deviation of successive EEG recordings respectively. The changes with age and condition of GC and TVC of each cortical area were estimated via a MANOVA. We found that the GC does not change with age during OC or HV, but the TVC of all cortical areas is significantly higher (p<0.01) for subjects under 65 and mainly for the central, temporal and parietal areas (p<0.01). It is concluded that TVC decreasing with aging may be related to cognitive performance deficits.

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