scholarly journals Open your eyes and you will see. Changes in “eyes-open” versus “eyes-closed” small-world properties of EEG functional connectivity in amnesic mild cognitive impairment

2016 ◽  
Vol 127 (2) ◽  
pp. 999-1000 ◽  
Author(s):  
Javier Escudero
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Small World ◽  
Eyes Closed ◽  
Eyes Open ◽  
Eeg Functional Connectivity ◽  
Open Versus ◽  
Amnesic Mild Cognitive Impairment

scholarly journals Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling

2020 ◽  
Author(s):  
Michael J. Firbank ◽  
John T. O’Brien ◽  
Rory Durcan ◽  
Louise M. Allan ◽  
Sally Barker ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Lewy Bodies ◽  
Region Of Interest ◽  
Blood Perfusion ◽  
Arterial Spin Labelling ◽  
Posterior Cingulate ◽  
Eyes Closed ◽  
Eyes Open ◽  
Spin Labelling

Abstract Objective To use arterial spin labelling to investigate differences in perfusion in mild cognitive impairment with Lewy bodies (MCI-LB) compared to Alzheimer type MCI (MCI-AD) and healthy controls. Methods We obtained perfusion images on 32 MCI-LB, 30 MCI-AD and 28 healthy subjects of similar age. Perfusion relative to cerebellum was calculated, and we aimed to examine differences in relative perfusion between MCI-LB and the other groups. This included whole brain voxelwise comparisons, as well as using predefined region-of-interest ratios of medial occipital to medial temporal, and posterior cingulate to precuneus. Differences in occipital perfusion in eyes open vs eyes closed conditions were also examined. Results Compared to controls, the MCI-LB showed reduced perfusion in the precuneus, parietal, occipital and fusiform gyrus regions. In our predefined regions, the ratio of perfusion in occipital/medial temporal was significantly lower, and the posterior cingulate/precuneus ratio was significantly higher in MCI-LB compared to controls. Overall, the occipital perfusion was greater in the eyes open vs closed condition, but this did not differ between groups. Conclusion We found patterns of altered perfusion in MCI-LB which are similar to those seen in dementia with Lewy bodies, with reduction in posterior parietal and occipital regions, but relatively preserved posterior cingulate.

Altered Functional Connectivity of Alpha Rhythm in Obsessive-Compulsive Disorder During Rest

2018 ◽  
Vol 50 (2) ◽  
pp. 88-99 ◽  
Author(s):  
Bo Tan ◽  
Qingxiao Liu ◽  
Chaoyang Wan ◽  
Zhenlan Jin ◽  
Yanchun Yang ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Obsessive Compulsive Disorder ◽  
Alpha Rhythm ◽  
Topological Analysis ◽  
Small World ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Eyes Closed ◽  
Synchronization Likelihood ◽  
Eyes Open

Obsessive-compulsive disorder (OCD) is a common inheritable psychiatric disorder characteristic of repetitive thinking, imagination (obsession), and stereotyped behaviors (compulsive). To explore whether there is an alteration of brain functional connectivity (BFC) in patients with OCD during rest, electroencephalogram (EEG) data of healthy controls (HCs) and patients with OCD were collected during rest in both eyes-closed and eyes-open states. Synchronization likelihood and graph theory were applied to construct and analyze brain functional networks of patients with OCD and HCs. Patients with OCD showed abnormal graph-theoretic parameters and impaired small world features in the alpha and beta bands. In addition, the topological analysis consistently showed that the long-range BFC of alpha rhythm was significantly reduced in the bilateral posterior areas in patients with OCD in comparison with HCs, while the BFC in the beta rhythm was significantly increased only in the eyes-open state. The findings suggest that the BFC of patients with OCD show abnormal small-world features and altered topological structure during rest, mainly in alpha and beta bands, which may provide a new insight for the diagnosis and treatment of OCD.

scholarly journals 1019 Eeg Functional Connectivity During Wakefulness And Rem Sleep In Patients With Mild Cognitive Impairment

SLEEP ◽  
2018 ◽  
Vol 41 (suppl_1) ◽  
pp. A378-A378
Author(s):  
A Lafrenière ◽  
P Brayet ◽  
J Lina ◽  
D Petit ◽  
J Montplaisir ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Rem Sleep ◽  
Eeg Functional Connectivity

scholarly journals The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial

2020 ◽  
Vol 9 (5) ◽  
pp. 1283 ◽  
Author(s):  
Ngeemasara Thapa ◽  
Hye Jin Park ◽  
Ja-Gyeong Yang ◽  
Haeun Son ◽  
Minwoo Jang ◽  
...  
Keyword(s):  
Older Adults ◽  
Virtual Reality ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Resting State ◽  
Intervention Program ◽  
Controlled Trial ◽  
Intervention Group ◽  
Eyes Closed ◽  
Eyes Open

This study aimed to investigate the association between a virtual reality (VR) intervention program and cognitive, brain and physical functions in high-risk older adults. In a randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). The MCI diagnosis was based on medical evaluations through a clinical interview conducted by a dementia specialist. Cognitive assessments were performed by neuropsychologists according to standardized methods, including the Mini-Mental State Examination (MMSE) and frontal cognitive function: trail making test (TMT) A & B, and symbol digit substitute test (SDST). Resting state electroencephalogram (EEG) was measured in eyes open and eyes closed conditions for 5 minutes each, with a 19-channel wireless EEG device. The VR intervention program (3 times/week, 100 min each session) comprised four types of VR game-based content to improve the attention, memory and processing speed. Analysis of the subjects for group–time interactions revealed that the intervention group exhibited a significantly improved executive function and brain function at the resting state. Additionally, gait speed and mobility were also significantly improved between and after the follow-up. The VR-based training program improved cognitive and physical function in patients with MCI relative to controls. Encouraging patients to perform VR and game-based training may be beneficial to prevent cognitive decline.

Small World Index in Default Mode Network Predicts Progression from Mild Cognitive Impairment to Dementia

2020 ◽  
Vol 30 (02) ◽  
pp. 2050004 ◽  
Author(s):  
Francesca Miraglia ◽  
Fabrizio Vecchio ◽  
Camillo Marra ◽  
Davide Quaranta ◽  
Francesca Alù ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Default Mode Network ◽  
Resting State ◽  
Cognitive Impairments ◽  
Small World ◽  
Default Mode ◽  
Delta Band ◽  
Eeg Functional Connectivity

Aim of this study was to explore the EEG functional connectivity in amnesic mild cognitive impairments (MCI) subjects with multidomain impairment in order to characterize the Default Mode Network (DMN) in converted MCI (cMCI), which converted to Alzheimer’s disease (AD), compared to stable MCI (sMCI) subjects. A total of 59 MCI subjects were recruited and divided -after appropriate follow-up- into cMCI or sMCI. They were further divided in MCI with linguistic domain (LD) impairment and in MCI with executive domain (ED) impairment. Small World (SW) index was measured as index of balance between integration and segregation brain processes. SW, computed restricting to nodes of DMN regions for all frequency bands, evaluated how they differ between MCI subgroups assessed through clinical and neuropsychological four-years follow-up. In addition, SW evaluated how this pattern differs between MCI with LD and MCI with ED. Results showed that SW index significantly decreased in gamma band in cMCI compared to sMCI. In cMCI with LD impairment, the SW index significantly decreased in delta band, while in cMCI with ED impairment the SW index decreased in delta and gamma bands and increased in alpha1 band. We propose that the DMN functional alterations in cognitive impairment could reflect an abnormal flow of brain information processing during resting state possibly associated to a status of pre-dementia.

scholarly journals EEG-Derived Functional Connectivity Patterns Associated with Mild Cognitive Impairment in Parkinson’s Disease

2021 ◽  
Vol 11 (3) ◽  
pp. 40
Author(s):  
Alejandro Armando Peláez Suárez ◽  
Sheila Berrillo Batista ◽  
Ivonne Pedroso Ibáñez ◽  
Enrique Casabona Fernández ◽  
Marinet Fuentes Campos ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Path Length ◽  
Clustering Coefficient ◽  
Eyes Closed ◽  
The Mean

Objective: To evaluate EEG-derived functional connectivity (FC) patterns associated with mild cognitive impairment (MCI) in Parkinson’s disease (PD). METHODS: A sample of 15 patients without cognitive impairment (PD-WCI), 15 with MCI (PD-MCI), and 26 healthy subjects were studied. The EEG was performed in the waking functional state with eyes closed, for the functional analysis it was used the synchronization likelihood (SL) and graph theory (GT). RESULTS: PD-MCI patients showed decreased FC in frequencies alpha, in posterior regions, and delta with a generalized distribution. Patients, compared to the healthy people, presented a decrease in segregation (lower clustering coefficient in alpha p = 0.003 in PD-MCI patients) and increased integration (shorter mean path length in delta (p = 0.004) and theta (p = 0.002) in PD-MCI patients). There were no significant differences in the network topology between the parkinsonian groups. In PD-MCI patients, executive dysfunction correlated positively with global connectivity in beta (r = 0.47) and negatively with the mean path length at beta (r = −0.45); alterations in working memory were negatively correlated with the mean path length at beta r = −0.45. CONCLUSIONS: PD patients present alterations in the FC in all frequencies, those with MCI show less connectivity in the alpha and delta frequencies. The neural networks of the patients show a random topology, with a similar organization between patients with and without MCI. In PD-MCI patients, alterations in executive function and working memory are related to beta integration.

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