Associations between EEG functional brain connectivity and a cognitive reserve proxy in healthy older adults

AbstractCognitive reserve is a concept that explains individual differences in vulnerability to cognitive impairment due to age and dementia-related brain changes. Mechanisms underlying the cognitive reserve effect are poorly understood. We investigated associations between a comprehensive cognitive reserve proxy (Lifetime Experiences Questionnaire/LEQ) and functional connectivity of the prefrontal cortex across the whole scalp, covarying for the level of current cognitive functioning (Addenbrookes Cognitive Examination Revised/ACE-R), using multiblock parallel and orthogonalized partial least squares regression. EEG data were collected from 34 healthy older adults (63 to 83 years) in eyes-open and eyes-closed resting-states, and during 0-back and 1-back tasks. Functional connectivity was estimated using imaginary coherence in the theta and alpha frequency bands, as these bands have been heavily implicated in cognitive ageing, attention and executive function. We found three clusters of electrodes where the absolute values of the regression coefficient were above threshold when covarying for ACE-R: (1) a cluster approximating the right frontocentral region during the eyes-open condition in the theta band with seed electrodes approximating the left prefrontal cortex with positive associations of medium effect size; (2) a cluster approximating the right parietotemporal region during the 0-back task in the theta band with seed electrodes approximating the right prefrontal cortex with negative associations of medium to large effect sizes; and (3) a cluster approximating the occipitoparietal region in the eyes-closed condition in the alpha band with seed electrodes approximating the left prefrontal cortex with negative associations of medium effect size. These relationships between a cognitive reserve proxy and functional connectivity, within key networks and frequency bands associated with attention and executive function, may reflect greater neural capacity and efficiency.

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The effect of congenital blindness on resting-state functional connectivity revisited

Scientific Reports ◽

10.1038/s41598-021-91976-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Maria J. S. Guerreiro ◽

Madita Linke ◽

Sunitha Lingareddy ◽

Ramesh Kekunnaya ◽

Brigitte Röder

Keyword(s):

Functional Connectivity ◽

Resting State ◽

Visual Experience ◽

Brain Regions ◽

State Condition ◽

Resting State Functional Connectivity ◽

Congenital Blindness ◽

Eyes Closed ◽

Congenitally Blind ◽

Eyes Open

AbstractLower resting-state functional connectivity (RSFC) between ‘visual’ and non-‘visual’ neural circuits has been reported as a hallmark of congenital blindness. In sighted individuals, RSFC between visual and non-visual brain regions has been shown to increase during rest with eyes closed relative to rest with eyes open. To determine the role of visual experience on the modulation of RSFC by resting state condition—as well as to evaluate the effect of resting state condition on group differences in RSFC—, we compared RSFC between visual and somatosensory/auditory regions in congenitally blind individuals (n = 9) and sighted participants (n = 9) during eyes open and eyes closed conditions. In the sighted group, we replicated the increase of RSFC between visual and non-visual areas during rest with eyes closed relative to rest with eyes open. This was not the case in the congenitally blind group, resulting in a lower RSFC between ‘visual’ and non-‘visual’ circuits relative to sighted controls only in the eyes closed condition. These results indicate that visual experience is necessary for the modulation of RSFC by resting state condition and highlight the importance of considering whether sighted controls should be tested with eyes open or closed in studies of functional brain reorganization as a consequence of blindness.

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Altered Resting-State Frontoparietal Control Network in Children with Attention-Deficit/Hyperactivity Disorder

Journal of the International Neuropsychological Society ◽

10.1017/s135561771500020x ◽

2015 ◽

Vol 21 (4) ◽

pp. 271-284 ◽

Cited By ~ 47

Author(s):

Hsiang-Yuan Lin ◽

Wen-Yih Isaac Tseng ◽

Meng-Chuan Lai ◽

Kayako Matsuo ◽

Susan Shur-Fen Gau

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Prefrontal Cortex ◽

Functional Connectivity ◽

Resting State ◽

Control Network ◽

Children With Adhd ◽

Hyperactivity Disorder ◽

Anterior Prefrontal Cortex ◽

The Right ◽

Frontoparietal Control Network

AbstractThe frontoparietal control network, anatomically and functionally interposed between the dorsal attention network and default mode network, underpins executive control functions. Individuals with attention-deficit/hyperactivity disorder (ADHD) commonly exhibit deficits in executive functions, which are mainly mediated by the frontoparietal control network. Involvement of the frontoparietal control network based on the anterior prefrontal cortex in neurobiological mechanisms of ADHD has yet to be tested. We used resting-state functional MRI and seed-based correlation analyses to investigate functional connectivity of the frontoparietal control network in a sample of 25 children with ADHD (7–14 years; mean 9.94±1.77 years; 20 males), and 25 age-, sex-, and performance IQ-matched typically developing (TD) children. All participants had limited in-scanner head motion. Spearman’s rank correlations were used to test the associations between altered patterns of functional connectivity with clinical symptoms and executive functions, measured by the Conners’ Continuous Performance Test and Spatial Span in the Cambridge Neuropsychological Test Automated Battery. Compared with TD children, children with ADHD demonstrated weaker connectivity between the right anterior prefrontal cortex (PFC) and the right ventrolateral PFC, and between the left anterior PFC and the right inferior parietal lobule. Furthermore, this aberrant connectivity of the frontoparietal control network in ADHD was associated with symptoms of impulsivity and opposition-defiance, as well as impaired response inhibition and attentional control. The findings support potential integration of the disconnection model and the executive dysfunction model for ADHD. Atypical frontoparietal control network may play a pivotal role in the pathophysiology of ADHD. (JINS, 2015, 21, 271–284)

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Investigating the Temporal Patterns within and between Intrinsic Connectivity Networks under Eyes-Open and Eyes-Closed Resting States: A Dynamical Functional Connectivity Study Based on Phase Synchronization

PLoS ONE ◽

10.1371/journal.pone.0140300 ◽

2015 ◽

Vol 10 (10) ◽

pp. e0140300 ◽

Cited By ~ 13

Author(s):

Xun-Heng Wang ◽

Lihua Li ◽

Tao Xu ◽

Zhongxiang Ding

Keyword(s):

Functional Connectivity ◽

Phase Synchronization ◽

Temporal Patterns ◽

Eyes Closed ◽

Intrinsic Connectivity ◽

Eyes Open ◽

Intrinsic Connectivity Networks

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Dissociative-Traumatic Dimension and Triple Network: An EEG Functional Connectivity Study in a Sample of University Students

Psychopathology ◽

10.1159/000519563 ◽

2021 ◽

pp. 1-9

Author(s):

Giuseppe Alessio Carbone ◽

Claudio Imperatori ◽

Francesco Saverio Bersani ◽

Chiara Massullo ◽

Egle Maria Orlando ◽

...

Keyword(s):

Functional Connectivity ◽

University Students ◽

Posterior Parietal Cortex ◽

Self Report ◽

Connectivity Pattern ◽

Eyes Closed ◽

Dissociative Symptoms ◽

Trauma Ct ◽

Eeg Functional Connectivity ◽

The Right

Aims: We investigated the association among triple network electroencephalographic (EEG) functional connectivity, dissociative symptoms, and childhood trauma (CT) in a sample of university students. Sampling and Methods: Seventy-six participants (30 males and 46 females; mean age 22.12 ± 2.35) completed self-report measures investigating dissociative symptoms, CT, and depressive symptoms. Participants also performed an eyes-closed resting-state EEG recording. EEG analyses were conducted through the exact low-resolution electromagnetic tomography (eLORETA) software. Results: A 2-step cluster analysis revealed 2 groups: participants (N = 23) with high dissociative-traumatic dimension symptoms (DTD+) and participants (N = 53) with low DTD symptoms (DTD−). Compared to DTD− subjects, DTD+ participants showed decreased theta connectivity between the salience network (SN) and central executive network (CEN), specifically between the right anterior insula and the left posterior parietal cortex. No significant correlation was detected between EEG data and clinical variables. Conclusion: Our results raise the possibility of a dysfunctional connectivity pattern occurring between the SN and CEN in individuals with high DTD symptoms. Such connectivity pattern might reflect the neuropsychophysiological disintegration related to pathological dissociation.

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Dynamic changes of ICA power spectra-derived EEG functional connectivity between eyes open and eyes closed states: Resting state network

Neuroscience Letters ◽

10.1016/j.neulet.2011.05.172 ◽

2011 ◽

Vol 500 ◽

pp. e36

Author(s):

Jean-Lon Chen ◽

Tomas Ros ◽

John Gruzelier

Keyword(s):

Functional Connectivity ◽

Resting State ◽

Power Spectra ◽

Dynamic Changes ◽

Resting State Network ◽

Eyes Closed ◽

Eyes Open ◽

Eeg Functional Connectivity

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Functional Connectivity Analysis from Theta Band of Multi Local Field Potentials on Prefrontal Cortex of Rat during Working Memory Task

2017 9th International Conference on Intelligent Human-Machine Systems and Cybernetics (IHMSC) ◽

10.1109/ihmsc.2017.14 ◽

2017 ◽

Cited By ~ 1

Author(s):

Dexuan Qi ◽

Zhenguo Xiao ◽

Shuo Liu ◽

Yongshu Jiao

Keyword(s):

Working Memory ◽

Prefrontal Cortex ◽

Functional Connectivity ◽

Local Field ◽

Memory Task ◽

Local Field Potentials ◽

Field Potentials ◽

Connectivity Analysis ◽

Theta Band ◽

Functional Connectivity Analysis

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Relation Between Frontal Alpha Asymmetry and Anxiety in Young Patients with Generalized Anxiety Disorder

PRILOZI ◽

10.1515/prilozi-2015-0064 ◽

2015 ◽

Vol 36 (2) ◽

pp. 157-177 ◽

Cited By ~ 2

Author(s):

Aneta Demerdzieva ◽

Nada Pop-Jordanova

Keyword(s):

Anxiety Disorder ◽

Generalized Anxiety Disorder ◽

Frontal Region ◽

Generalized Anxiety ◽

Alpha Power ◽

Alpha Asymmetry ◽

Eyes Closed ◽

Frontal Alpha Asymmetry ◽

Eyes Open ◽

The Right

Abstract Frontal alpha asymmetry (the relative difference in power between two signals in different hemispheres) has been suggested as biomarker for anxiety. The goal of this study was to evaluate alpha asymmetry in the frontal region for young people (7-18 years) with generalized anxiety disorder, diagnosed according to two statistic manuals (DMS-IV-R and ICD-10), the medical history and the neuropsychological assessment. The QEEG recording and analysis of the obtained results from alpha spectra power and log of alpha spectra power are made in four conditions (eyes open, eyes closed, VCPT and ACPT). The obtained results for alpha power in general showed higher cortical activity in the right hemisphere, associated with negative emotions. The calculated alpha asymmetry separate for eyes open, eyes closed, VCPT and ACPT conditions showed the right activation in all four conditions. In addition, the right frontal asymmetry was specific for the Fp1-Fp2 region, while a greater left frontal activation was recorded for the F7-F8 region. The log of alpha power in general was additionally analyzed. The calculated asymmetry score in general (in a way that the left log transformed score was subtracted from the right) confirmed a greater right activation. Testing the power of the whole alpha band (μV2) in general, for all four conditions and for frontal region confirmed the right alpha asymmetries in all participants. The right alpha asymmetry in the frontal region was specific only for the Fp1-Fp2 region (frontopolar region). The only greater left frontal activation was registered between the F7-F8 region. Our findings are supported by many other studies using specific localization methods like fMRI or LORETA source localization.

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Hypoarousal non-stationary ADHD biomarker based on echo-state networks

10.1101/271858 ◽

2018 ◽

Cited By ~ 1

Author(s):

D. Ibanez-Soria ◽

A. Soria-Frisch ◽

J. Garcia-Ojalvo ◽

Jacobo Picardo ◽

Gloria García-Banda ◽

...

Keyword(s):

Neurodevelopmental Disorder ◽

High Rate ◽

Theta Band ◽

Hyperactivity Disorder ◽

Eyes Closed ◽

Echo State Networks ◽

High Prevalence ◽

Eyes Open ◽

Very High ◽

Better Than

ABSTRACTAttention-Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity and impulsivity. It is one of the most commonly diagnosed neurodevelopmental and psychiatric disorders of childhood and therefore presents a very high prevalence rate. However the high rate of ADHD misdiagnosis makes the discovery of neurophysiological ADHD biomarkers an important clinical challenge. This study proposes a novel non-stationary ADHD biomarker based on Echo State Networks to quantify EEG dynamical changes between low attention/arousal states (resting with eyes closed, or EC) and normal attention/arousal states (resting with eyes open, or EO). Traditionally, EEG biomarkers have revealed an increase in stationary power in the theta band along with a decrease in beta, with these frequencies largely accepted to be altered in the ADHD population. We successfully verify the hypothesis that measured differences between these two conditions are altered in the ADHD population. Statistically significant differences between a group of ADHD subjects and an aged-matched control population were obtained in theta and beta rhythms. Our network discriminates between EO/EC EEG regimes in the ADHDs better than in controls, suggesting that differences in EEG patterns between low and normal arousal/attention states are larger in the ADHD population.

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Functional Connectivity of Nucleus Accumbens and Medial Prefrontal Cortex With Other Brain Regions During Early-Abstinence Is Associated With Alcohol Dependence and Relapse: A Resting-Functional Magnetic Resonance Imaging Study

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.609458 ◽

2021 ◽

Vol 12 ◽

Author(s):

Xia Yang ◽

Ya-jing Meng ◽

Yu-jie Tao ◽

Ren-hao Deng ◽

Hui-yao Wang ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Prefrontal Cortex ◽

Magnetic Resonance ◽

Functional Connectivity ◽

Brain Regions ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Anterior Cortex ◽

The Right

Background: Alcohol dependence (AD) is a chronic recurrent brain disease that causes a heavy disease burden worldwide, partly due to high relapse rates after detoxification. Verified biomarkers are not available for AD and its relapse, although the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) may play important roles in the mechanism of addiction. This study investigated AD- and relapse-associated functional connectivity (FC) of the NAc and mPFC with other brain regions during early abstinence.Methods: Sixty-eight hospitalized early-abstinence AD male patients and 68 age- and education-matched healthy controls (HCs) underwent resting-functional magnetic resonance imaging (r-fMRI). Using the NAc and mPFC as seeds, we calculated changes in FC between the seeds and other brain regions. Over a follow-up period of 6 months, patients were measured with the Alcohol Use Disorder Identification Test (AUDIT) scale to identify relapse outcomes (AUDIT ≥ 8).Results: Thirty-five (52.24%) of the AD patients relapsed during the follow-up period. AD displayed lower FC of the left fusiform, bilateral temporal superior and right postcentral regions with the NAc and lower FC of the right temporal inferior, bilateral temporal superior, and left cingulate anterior regions with the mPFC compared to controls. Among these FC changes, lower FC between the NAc and left fusiform, lower FC between the mPFC and left cingulate anterior cortex, and smoking status were independently associated with AD. Subjects in relapse exhibited lower FC of the right cingulate anterior cortex with NAc and of the left calcarine sulcus with mPFC compared to non-relapsed subjects; both of these reductions in FC independently predicted relapse. Additionally, FC between the mPFC and right frontal superior gyrus, as well as years of education, independently predicted relapse severity.Conclusion: This study found that values of FC between selected seeds (i.e., the NAc and the mPFC) and some other reward- and/or impulse-control-related brain regions were associated with AD and relapse; these FC values could be potential biomarkers of AD or for prediction of relapse. These findings may help to guide further research on the neurobiology of AD and other addictive disorders.

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