ABO blood group as a potential risk factor for venous thromboembolism in acutely injured patients

2011 ◽  
Vol 105 (01) ◽  
pp. 5-13 ◽  
Author(s):  
Sarah Muellner ◽  
Elliott Haut ◽  
Michael Streiff ◽  
John Holcomb ◽  
Bryan Cotton
Keyword(s):  
Risk Factor ◽  
Venous Thromboembolism ◽  
Blood Group ◽  
Abo Blood Group ◽  
Trauma Patients ◽  
Major Health Problem ◽  
Increase Risk ◽  
Significant Burden ◽  
Injured Patients ◽  
Von Willebrand

SummaryVenous thromboembolism (VTE) is a major health problem that results in a significant burden on hospitals and patients. VTE screening and prophylaxis protocols in trauma patients vary significantly among hospitals and providers. In addition, many patients develop VTE even in the absence of “high-risk” categories. Therefore, more research is needed to better understand and prevent VTE in these patients. ABO blood group has long been recognised as a risk factor for VTE, but its contribution to VTE risk in the trauma setting is poorly studied. This paper reviews the literature describing the link between ABO blood group and VTE risk and the implications for VTE screening and prophylaxis in trauma patients. The effect of ABO blood groups are genotype-dependent – in most populations the A1 allele and the B allele increase risk while A2, O1, and O2 decrease risk of VTE. ABO group is a major determinant of plasma von Willebrand factor (vWF) and factor VIII levels, thereby (partially) mediating the effects of ABO blood group on VTE susceptibility. In addition, ABH antigens alter plasma levels of vWF via clearance mechanisms, which are in turn mediated by ADAMTS13. ABO blood group is a risk factor for VTE that warrants further investigation in trauma patients.

ABO blood group is a potent risk factor for venous thromboembolism in patients with malignant gliomas

Cancer ◽  
2004 ◽  
Vol 100 (8) ◽  
pp. 1717-1723 ◽  
Author(s):  
Michael B. Streiff ◽  
Jodi Segal ◽  
Stuart A. Grossman ◽  
Thomas S. Kickler ◽  
Edward G. Weir
Keyword(s):  
Risk Factor ◽  
Venous Thromboembolism ◽  
Blood Group ◽  
Malignant Gliomas ◽  
Abo Blood Group

scholarly journals Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients

Blood ◽  
2019 ◽  
Vol 134 (11) ◽  
pp. 880-891 ◽  
Author(s):  
Laura L. Swystun ◽  
Kenichi Ogiwara ◽  
Orla Rawley ◽  
Christine Brown ◽  
Ilinca Georgescu ◽  
...  
Keyword(s):  
Blood Group ◽  
Von Willebrand Factor ◽  
Half Life ◽  
Hemophilia A ◽  
Blood Type ◽  
Abo Blood Group ◽  
Genetic Determinants ◽  
Group Status ◽  
Von Willebrand ◽  
Willebrand Factor

Abstract Factor VIII (FVIII) pharmacokinetic (PK) properties show high interpatient variability in hemophilia A patients. Although previous studies have determined that age, body mass index, von Willebrand factor antigen (VWF:Ag) levels, and ABO blood group status can influence FVIII PK, they do not account for all observed variability. In this study, we aim to describe the genetic determinants that modify the FVIII PK profile in a population of 43 pediatric hemophilia A patients. We observed that VWF:Ag and VWF propeptide (VWFpp)/VWF:Ag, but not VWFpp, were associated with FVIII half-life. VWFpp/VWF:Ag negatively correlated with FVIII half-life in patients with non-O blood type, but no correlation was observed for type O patients, suggesting that von Willebrand factor (VWF) half-life, as modified by the ABO blood group, is a strong regulator of FVIII PK. The FVIII-binding activity of VWF positively correlated with FVIII half-life, and the rare or low-frequency nonsynonymous VWF variants p.(Arg826Lys) and p.(Arg852Glu) were identified in patients with reduced VWF:FVIIIB but not VWF:Ag. Common variants at the VWF, CLEC4M, and STAB2 loci, which have been previously associated with plasma levels of VWF and FVIII, were associated with the FVIII PK profile. Together, these studies characterize the mechanistic basis by which VWF clearance and ABO glycosylation modify FVIII PK in a pediatric population. Moreover, this study is the first to identify non-VWF and non-ABO variants that modify FVIII PK in pediatric hemophilia A patients.

ABO Blood Group Genotype and Plasma von Willebrand Factor in Normal Individuals

Vox Sanguinis ◽  
1995 ◽  
Vol 68 (4) ◽  
pp. 236-240 ◽  
Author(s):  
Masayuki Shima ◽  
Yoshihiro Fujimura ◽  
Takayuki Nishiyama ◽  
Tomomi Tsujiuchi ◽  
Nobuhiro Narita ◽  
...  
Keyword(s):  
Blood Group ◽  
Von Willebrand Factor ◽  
Abo Blood Group ◽  
Normal Individuals ◽  
Von Willebrand ◽  
Willebrand Factor

Venous Thromboembolism in Trauma Patients

2007 ◽  
Vol 73 (11) ◽  
pp. 1173-1180 ◽  
Author(s):  
Om P. Sharma ◽  
Michael F. Oswanski ◽  
Rusin J. Joseph ◽  
Peter Tonui ◽  
Libby Westrick Pa-C ◽  
...  
Keyword(s):  
Risk Factor ◽  
Venous Thromboembolism ◽  
Injury Severity Score ◽  
Severity Score ◽  
Injury Severity ◽  
Univariate Analysis ◽  
Trauma Patients ◽  
Vein Thrombosis ◽  
Cord Injury ◽  
Deep Vein

Serial venous duplex scans (VDS) were done in 507 trauma patients with at least one risk factor (RF) for venous thromboembolism (VTE) during a 2-year study period. Deep vein thrombosis (DVT) was detected in 31 (6.1%) patients. This incidence was 3.1 per cent in low (1–2 RFs), 3.4 per cent in moderate (3–5 RFs), and 7.7 per cent in high (≥6 RFs) VTE scores ( P = 0.172). Incidence was statistically different (3% vs 7.2%, P = 0.048) on reanalyzing patients in two risk categories, low-risk (1–4 RFs) and high-risk (≥5 RFs). Only 4 of 16 RFs had statistically higher incidence of DVT in patients with or without RFs: previous VTE (27.3% vs 5.6%, odds ratio (OR) 6.628, P = 0.024), spinal cord injury (22.6% vs 5%, OR 5.493, P = 0.001), pelvic fractures (11.4% vs 5.1%, OR 2.373, P = 0.042), and head injury with a greater than two Abbreviated Injury Score (10.5% vs 4.2%, OR 2.639, P = 0.014). On reanalyzing patients with ≥5 RFs vs <5RFs, obesity (14.3 vs 6.1%, P = 0.007), malignancy (5.6% vs 0.6%, P = 0.006), coagulopathy (10.8% vs 1.8%, P = 0.000), and previous VTE (3.2% vs 0%, P = 0.019) were significant on univariate analysis. Patients with DVT had 3.70 ± 1.75 RFs and a 9.61 ± 4.93 VTE score, whereas, patients without DVT had 2.66 ± 1.50 RFs and a 6.83 ± 3.91 VTE score ( P = 0.000). DVTs had a direct positive relationship with higher VTE scores, length of stay, and number of VDS (>1 r, P ≤ 0.001). Increasing age was a weak risk factor (0.03 r, P = 0.5). First two VDS diagnosed 77 per cent of DVTs. Patients with injury severity score of ≥15 and 25 had higher DVTs compared with the ones with lower injury severity score levels ( P ≤ 0.05). Pulmonary embolism was silent in 63 per cent and DVTs were asymptomatic in 68 per cent.

scholarly journals Effect of ABO blood group on the collagen-binding assay for von Willebrand factor

2002 ◽  
Vol 71 (3) ◽  
pp. 229-231 ◽  
Author(s):  
Erin Haley ◽  
Nadiya Babar ◽  
Cory Ritter ◽  
Katharine A. Downes ◽  
Deana Green ◽  
...  
Keyword(s):  
Blood Group ◽  
Von Willebrand Factor ◽  
Binding Assay ◽  
Abo Blood Group ◽  
Collagen Binding ◽  
Von Willebrand ◽  
Willebrand Factor

Contact isolation is a risk factor for venous thromboembolism in trauma patients

2015 ◽  
Vol 79 (5) ◽  
pp. 833-837 ◽  
Author(s):  
Christopher R. Reed ◽  
Robert A. Ferguson ◽  
Yiming Peng ◽  
Bryan R. Collier ◽  
Eric H. Bradburn ◽  
...  
Keyword(s):  
Risk Factor ◽  
Venous Thromboembolism ◽  
Trauma Patients ◽  
Contact Isolation

Prothrombotic State Induced by Middle-Distance Endurance Exercise in Middle-Aged Athletes

2018 ◽  
Vol 44 (08) ◽  
pp. 747-755 ◽  
Author(s):  
Gian Salvagno ◽  
Cantor Tarperi ◽  
Matteo Gelati ◽  
Martina Montagnana ◽  
Elisa Danese ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Blood Group ◽  
Thrombin Generation ◽  
Area Under The Curve ◽  
Abo Blood Group ◽  
Middle Aged ◽  
Endurance Running ◽  
Von Willebrand ◽  
The Impact ◽  
D Dimer

AbstractSince the impact of possible prothrombotic factors on blood coagulation resulting from exercise remains elusive, this study investigated the acute effects of middle-distance endurance running on blood coagulation parameters in middle-aged athletes. The study population consisted of 33 male endurance runners who were engaged in a 21.1 km run under competitive conditions. Blood samples were collected before the run, immediately after the run, and 3 hours after run completion. Samples were assessed for activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen, D-dimer, factor VIII (FVIII), von Willebrand factor antigen (VWF:Ag), endogenous thrombin potential (area under the curve of thrombin generation [TGA-AUC]), and peak thrombin generation (TGA-PK). Post-run variations were expressed as delta (Δ). At baseline, APTT was found to be significantly associated with ABO blood group, VWF:Ag, and FVIII; fibrinogen with age; VWF:Ag with BMI, training regimen, and ABO blood group; APTT with FVIII; FVIII with VWF:Ag and ABO blood group; APTT with VWF:Ag; and TGA-PK with ABO blood group, PT, and TGA-AUC. Immediately after the run, statistically significant increases were observed for PT, D-dimer, VWF:Ag, and FVIII, while statistically significant reductions could be observed for APTT, TGA-AUC, and TGA-PK. Fibrinogen values remained unchanged. Significant correlations were observed between Δ VWF:Ag and Δ FVIII, Δ APTT and Δ VWF:Ag, Δ APTT and Δ FVIII, Δ TGA-AUC and Δ TGA-PK, and between Δ D-dimer and Δ TGA-AUC and Δ TGA-PK. No Δ variation was associated with running time. The results of this study seemingly suggest that middle-distance competitive running may evoke several prothrombotic changes in blood coagulation.

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