Abstract P426: Association of Serum Soy Isoflavones with Metabolic Markers in Japanese Men and Women

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Rhobert W Evans ◽  
Akira Sekikawa ◽  
Takashi Kadowaki ◽  
Abhishek Vishnu ◽  
Sayaka Kadowaki ◽  
...  
Keyword(s):  
Correlation Coefficients ◽  
Population Based ◽  
Japanese Women ◽  
Soy Isoflavones ◽  
Serum Samples ◽  
Japanese Men ◽  
Metabolic Markers ◽  
Men And Women ◽  
Isoflavone Concentration ◽  
Very High

Objectives: Soy isoflavones may have beneficial roles as antioxidants and phytoestrogens. Dietary intake varies widely across populations: very high in Japan but low in North America. We measured the concentrations of daidzein and genistein in the serum of Japanese men and women and evaluated their associations with metabolic markers. Methods: Serum samples were obtained from a population based sample of 94 Japanese men (mean age 45.3), and 142 Japanese women (mean age 66.6; 97% were post-menopausal). Isoflavones were analyzed after extraction and derivatization using GC-MS. Concentrations of daidzein and genistein were summed to obtain total isoflavone concentrations. Results: Isoflavone concentrations were very high among the Japanese. Median values (nM) for men: 558, 452 and 86 and for women 660, 494 and 150 (total isoflavones, genistein and daidzein, respectively). Spearman correlation coefficients for the isoflavones with multiple outcomes among Japanese men and women are shown in the table. No significant (p<0.05) associations were observed among the men but borderline negative associations were observed for total isoflavones (p=0.063) and genistein (p=0.063) with LDLc. Among women there was a significant association between total isoflavones (p=0.041) and daidzein (p=0.006) with HDLc. Borderline significant associations were also observed for total isoflavones (p=0.068) and genistein (p=0.061) with glucose. Discussion: The concentrations of isoflavones are high in the Japanese, approximately 50 times greater than those of N. Americans. Associations between the isoflavones and various outcomes were very weak for the Japanese men. This possibly reflects a plateau of isoflavone concentration has been reached that precludes observing any associations. Although, many correlations were calculated the positive associations of total isoflavones and daidzein with HDLc among women may be real. HDLc concentrations are high in Japanese women which may reflect the estrogenic actions of isoflavones.

Risk factors for falls in a longitudinal population-based cohort study of Japanese men and women: The ROAD Study

Bone ◽  
2013 ◽  
Vol 52 (1) ◽  
pp. 516-523 ◽  
Author(s):  
Shigeyuki Muraki ◽  
Toru Akune ◽  
Yuyu Ishimoto ◽  
Keiji Nagata ◽  
Munehito Yoshida ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Population Based ◽  
Japanese Men ◽  
Men And Women ◽  
The Road ◽  
Risk Factors For Falls ◽  
Road Study

Incidence and risk factors for radiographic knee osteoarthritis and knee pain in Japanese men and women: A longitudinal population-based cohort study

2012 ◽  
Vol 64 (5) ◽  
pp. 1447-1456 ◽  
Author(s):  
Shigeyuki Muraki ◽  
Toru Akune ◽  
Hiroyuki Oka ◽  
Yuyu Ishimoto ◽  
Keiji Nagata ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Population Based ◽  
Japanese Men ◽  
Men And Women ◽  
Radiographic Knee Osteoarthritis

Coffee consumption and mortality in Japanese men and women: A pooled analysis of eight population-based cohort studies in Japan (Japan Cohort Consortium)

2019 ◽  
Vol 123 ◽  
pp. 270-277 ◽  
Author(s):  
Sarah Krull Abe ◽  
Eiko Saito ◽  
Norie Sawada ◽  
Shoichiro Tsugane ◽  
Hidemi Ito ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Coffee Consumption ◽  
Population Based ◽  
Pooled Analysis ◽  
Japanese Men ◽  
Men And Women

Green tea consumption and mortality in Japanese men and women: a pooled analysis of eight population-based cohort studies in Japan

2019 ◽  
Vol 34 (10) ◽  
pp. 917-926 ◽  
Author(s):  
Sarah Krull Abe ◽  
◽  
Eiko Saito ◽  
Norie Sawada ◽  
Shoichiro Tsugane ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Green Tea ◽  
Population Based ◽  
Pooled Analysis ◽  
Tea Consumption ◽  
Japanese Men ◽  
Men And Women

Abstract P388: Which Obesity-related Indicator is Better for Predicting Incident Hypertension? Results from the population-based cohort study of Japan

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Michikazu Nakai ◽  
Makoto Watanabe ◽  
Kunihiro Nishimura ◽  
Misa Takegami ◽  
Yoshihiro Kokubo ◽  
...  
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Proportional Hazard ◽  
Japanese Men ◽  
Men And Women ◽  
Established Risk Factor ◽  
Cox Proportional Hazard ◽  
C Statistic ◽  
Hazard Ratios

Objective: Obesity is an established risk factor for hypertension (HT), but it is still controversial which obesity-related indicator is superior in predictability. This study compared the predictability among three indicators, body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WHtR), in the population-based prospective cohort study of Japan, the Suita study. Methods: Participants who had no HT at baseline (1,591 men and 1,973 women) aged 30-84 years were included in this study. The Cox proportional hazard model was used to estimate hazard ratios (HRs) of each indicator for incident HT with the adjustment for age, cigarette smoking and alcohol drinking. Harrell’s C statistics were also estimated for comparison of indicators’ accuracy. Results: During median follow-up of 7.2 years, 1,325 participants (640 men and 685 women) developed HT. HR (95% CI) of BMI, WC and WHtR for incident HT corresponding to a 1 SD increase was 1.25 (1.15-1.35), 1.21 (1.12-1.31) and 1.23 (1.14-1.34) in men while 1.32 (1.22-1.42), 1.27 (1.18-1.37) and 1.32 (1.21-1.44) in women, respectively. Also, C-statistic (95% CI) of BMI, WC and WHtR was 0.64 (0.62-0.66), 0.63 (0.61-0.65) and 0.63 (0.61-0.66) in men while 0.69 (0.67-0.71), 0.69 (0.67-0.71) and 0.69 (0.67-0.71) in women, respectively. Using 95% CI of each C-statistics, there were no statistical differences among three indicators in both men and women. Conclusion: In this study, we showed that all three indicators (BMI, WC and WHtR) were estimated similarly to predict the risk of developing HT in both Japanese men and women.

scholarly journals Isoflavone consumption and subsequent risk of hepatocellular carcinoma in a population-based prospective cohort of Japanese men and women

2009 ◽  
Vol 124 (7) ◽  
pp. 1644-1649 ◽  
Author(s):  
Norie Kurahashi ◽  
Manami Inoue ◽  
Motoki Iwasaki ◽  
Yasuhito Tanaka ◽  
Masashi Mizokami ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prospective Cohort ◽  
Population Based ◽  
Japanese Men ◽  
Men And Women ◽  
Subsequent Risk

Women in charge: Politeness and directives in the speech of Japanese women

1992 ◽  
Vol 21 (1) ◽  
pp. 59-82 ◽  
Author(s):  
Janet S. Smith
Keyword(s):  
General Theory ◽  
Japanese Women ◽  
Culturally Specific ◽  
Japanese Men ◽  
Men And Women ◽  
Women's Speech ◽  
Language And Gender ◽  
Japanese Female ◽  
Female Speech ◽  
And Gender

ABSTRACTThis article explores the linguistic practices of Japanese men and women giving directions to subordinates. Previous research on language and gender across a number of languages has equated the speech of women with powerlessness. The literature on Japanese women's speech would support this notion. It characterizes Japanese female speech as soft, polite, indirect, in sum, as powerless. This presents problems for women who must command. The present study, an extension of my previous work on Japanese female speech (Shibamoto 1985, 1987) centered on women in more typically female roles, examines the directives of women in positions of authority in traditional and nontraditional domains and compares them with the directive forms chosen by men in similar positions. Explanations for the differences found are placed within the frameworks of a general theory of politeness and the culturally specific, gendered strategies for encoding politeness and authority in Japanese. (Sociolinguistics, language and gender, politeness)

Abstract P317: Serum Soy Isoflavones Are Inversely Associated With Coronary Artery Calcification In A Population-based Sample Of 299 Men In Japan

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Akira Sekikawa ◽  
Katsuyuki Miura ◽  
Abhishek Vishnu ◽  
Akira Fujiyoshi ◽  
Rhobert W Evans ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Calcium Score ◽  
Serum Levels ◽  
Population Based ◽  
Soy Isoflavones ◽  
Inverse Association ◽  
Serum Samples ◽  
Cross Sectional

Objectives: Epidemiological studies in Asia where consumption of soy isoflavones (ISF) are regular and high implicated that isoflavones are protective against coronary heart disease (CHD), especially in post-menopausal women. There is a lack of data on the association of isoflavones with atherosclerosis, especially in men. We aim to determine a cross sectional association of serum ISF with coronary artery calcification (CAC) in men in Japan. Methods: A population-based sample of 299 men aged 40-49 years in Japan was examined for CAC and other risk factors in 2002-06. Electron-beam CT was used to evaluate CAC. Stored serum samples were analyzed for ISF (genistein and daidzein). We defined serum ISFs as the sum of genistein and daidzein. Presence of CAC was defined as coronary calcium score ≥ 10. Because the distribution of serum ISF is skewed, we evaluated quartile of serum ISF and analyzed the association of ISF with the presence of CAC using a general linear model. Findings: The median value (interquartile range) of ISF was 517 (195, 1,147) nM/l. Serum ISF had a significant inverse association with CAC in crude analysis. After adjusting for age, LDL-C, smoking, and BMI, each of which had a significant univariate association with CAC, the inverse association of ISF with CAC remained, with littel change in point estimates. After further adjusting for other risk factors as well as serum levels of long-chain n-3 polyunsaturated fatty acids, the inverse association remained. Conclusions: Serum levels of ISF in Japanese men in Japan had an inverse association of CAC, suggesting that ISF at the levels Japanese in Japan regularly consume have anti-atherogenic properties in men.

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