Abstract MP73: Leisure Time Physical Activity and Cognitive Decline in the Northern Manhattan Study

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Joshua Z Willey ◽  
Hannah Gardener ◽  
Sandino Cespedes ◽  
Charles DeCarli ◽  
Mitsuhiro Yoshita ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cognitive Decline ◽  
Processing Speed ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Domain Specific ◽  
Over Time

Background: Leisure time physical activity (LTPA) has been associated with a lower risk of dementia, but whether the effects are specific to particular cognitive abilities or improvement in functional status remains unclear. We examined LTPA in relation to domain-specific neurocognitive (NC) performance and change over time in a diverse community sample. Methods: Data on LTPA was collected during enrollment (1993-2001) into the Northern Manhattan Study (NOMAS), a prospective cohort study of risk factors for stroke and cognitive decline, using a validated in-person questionnaire, and two waves of NC assessments were done on a subcohort of participants undergoing brain MRI an mean of six and 12 years later (NC1: 2003-2008; NC2: 2008-2014). Baseline LTPA was defined in two manners: (1) maximum intensity of all activities performed categorized as moderate-heavy, light, and none; (2) total summarized as a continuous variable with the metabolic equivalent (MET) score, a composite of total reported intensity and time. Factor analysis-derived construct-relevant cognitive domains, including memory (MEM), executive function (EXEC), processing speed (PS), and language ability (LA), were computed by averaging z-transformed NC test scores. We used multivariable linear regression to examine LTPA in relation to baseline domain-specific NC performance, and change in performance over time, adjusting for socio-demographics, vascular risk factors, and MRI markers of cerebrovascular injury (white matter hyperintensity volume and total cerebral volume, both adjusted for total intracranial volume, and silent brain infarcts). Results: There were 1236 participants (mean age=64 years, 61% women, 67% Latino, 18% black, 15% white) with LTPA and NC data, and 879 with a second NC assessment. Moderate-to-heavy activity was associated with higher baseline LA (p <0.05) and PS (p <0.05), and with a protective effect on change of MEM (p <0.05) and PS (p <0.05); these effects were not attenuated after adjustment for MRI variables. Total MET-score was not associated with baseline NC domain performance. However, participants with greater MET-scores had significantly less decline in processing speed adjusting for age and education. Inclusion of vascular risk factors and MRI markers each attenuated these associations though they remained statistically significant. Conclusions: Leisure time physical activity is independently protective against a decline in processing speed and memory, and was partly mediated by MRI markers. Leisure-time physical activity may protect against dementia through preventing cerebrovascular correlates of brain injury.

Changes in traditional chronic disease risk factors over time and their relationship with leisure-time physical activity in people living with spinal cord injury

2012 ◽  
Vol 37 (6) ◽  
pp. 1072-1079
Author(s):  
Andrea C. Buchholz ◽  
Julie Horrocks ◽  
Kathleen A. Martin Ginis ◽  
Steven R. Bray ◽  
B. Catharine Craven ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Spinal Cord ◽  
Leisure Time ◽  
Iliac Crest ◽  
Disease Risk ◽  
Leisure Time Physical Activity ◽  
Chronic Disease Risk ◽  
Cord Injury ◽  
Over Time

This study examined whether levels of chronic disease risk factors change over time, and whether leisure-time physical activity (LTPA) can explain any of the variation in those risk factors that change, in a sample of community-dwelling people living with spinal cord injury (SCI) in or near Hamilton, Ontario, Canada. LTPA was measured using the Physical Activity Recall Assessment for People with SCI at baseline (n = 76 adults with chronic (≥1 year) paraplegia or tetraplegia), at 6 months (n = 71) and at 18 months (n = 63). Body mass index, waist circumference at the lowest rib (WClowest rib) and iliac crest (WCiliac crest), fat mass, blood pressure, and biochemical data were collected at all 3 time points. Women’s BMI was higher at baseline (least square means (LSM) = 26.2 ± SE = 1.56 kg·m–2, p = 0.0004) and 6 months (25.9 ± 1.6, p = 0.0024) than at 18 months (22.1 ± 1.72). Men’s WClowest ribincreased from baseline (92.1 ± 1.87 cm) to 18 months (93.6 ± 1.87, p = 0.0253). Women who were active vs. inactive at baseline had a lower BMI at 6 months (23.1 ± 2.91 vs. 29.7 ± 2.52, p = 0.0957) and WCiliac crestat 6 months (82.8 ± 6.59 vs. 97.7 ± 5.10, p = 0.0818). Women who were active vs. inactive at 6 months had a lower WCiliac crestat 18 months (73.4 ± 14.3 vs. 102.5 ± 6.41, p = 0.0723). There was little change in traditional risk factors over 18 months. Future studies should extend beyond 18 months in a larger sample, and explore traditional vs. novel risk factors and onset of cardiovascular disease and diabetes in the SCI population.

The Spectrum of Cerebrovascular Disease and Associated Cognitive Decline

2019 ◽  
pp. 574-599
Author(s):  
Victoria J. Williams ◽  
Steven E. Arnold ◽  
David H. Salat
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Cerebrovascular Disease ◽  
Cognitive Decline ◽  
Vascular Dementia ◽  
Structure And Function ◽  
Vascular Risk Factors ◽  
Vascular Health ◽  
Vascular Risk ◽  
And Function

Throughout the lifespan, common variations in systemic health and illness contribute to alterations in vasculature structure and function throughout the body, significantly increasing risk for cardiovascular and cerebrovascular disease (CVD). CVD is a prevalent cause of mortality in late life; it also promotes brain alterations, contributing to cognitive decline and, when severe, vascular dementia. Even prior to diseased states, individual variation in CVD risk is associated with structural and functional brain alterations. Yet, how cumulative asymptomatic alterations in vessel structure and function contribute to more subtle changes in brain tissue integrity and function that emerge in late life is unclear. Finally, vascular risk factors are associated with the clinical progression of neurodegenerative diseases such as Alzheimer’s disease (AD); however, recent theory posits that vascular degeneration may serve a contributory role in these conditions. This chapter reviews how lifespan changes in vascular health contribute to degenerative changes in neural tissue and the subsequent development of cognitive impairment and/or vascular dementia. It first discusses associations between vascular risk factors and cognition and also how declining vascular health may lead to cognitive impairment and dementia. Next, it identifies basic aspects of cerebrovascular anatomy and physiology sustaining tissue health and discusses how vulnerabilities of this system contribute to neurodegenerative changes. Finally, it reviews evidence of vascular contributions to AD and presents ideas for future research to better understand the full spectrum of cerebrovascular contributions to brain aging, cognitive decline, and dementia.

Vascular risk factors, alcohol intake, and cognitive decline

2008 ◽  
Vol 12 (6) ◽  
pp. 376-381 ◽  
Author(s):  
F. Panza ◽  
C. Capurso ◽  
A. D’Introno ◽  
A. M. Colacicco ◽  
V. Frisardi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Decline ◽  
Alcohol Intake ◽  
Vascular Risk Factors ◽  
Vascular Risk

Cognitive decline precedes late-life longitudinal changes in vascular risk factors

2010 ◽  
Vol 81 (9) ◽  
pp. 1028-1032 ◽  
Author(s):  
P. van Vliet ◽  
R. G. J. Westendorp ◽  
D. van Heemst ◽  
A. J. M. de Craen ◽  
A. M. Oleksik
Keyword(s):  
Risk Factors ◽  
Cognitive Decline ◽  
Late Life ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Longitudinal Changes

Socioeconomic and Gender Inequalities in Leisure-Time Physical Activity and Access to Public Policies in Brazil From 2013 to 2019

2021 ◽  
pp. 1-8
Author(s):  
Andrea Wendt ◽  
Luiza I.C. Ricardo ◽  
Caroline S. Costa ◽  
Alan G. Knuth ◽  
Maria C.M. Tenório ◽  
...  
Keyword(s):  
Physical Activity ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
National Level ◽  
Public Spaces ◽  
Population Based ◽  
Gender Inequalities ◽  
Public Programs ◽  
Wealth Inequalities ◽  
Over Time

Background: This study aims to describe changes in gender and wealth inequalities in leisure-time physical activity (PA) of Brazilians during a 6-year interval. It also aims to evaluate inequalities regarding PA public programs awareness, participation, and access to public spaces for PA. Methods: Data from 2 population-based surveys conducted in 2013 and 2019 were used. Leisure-time PA prevalence was assessed considering those reporting ≥150 minutes per week. The authors evaluated gender inequalities calculating differences and ratios, and wealth inequalities using the slope index of inequality and the concentration index— assessing changes over time. Results: National levels of leisure-time PA increased from 2013 to 2019, and an increase in inequalities was observed; women and the poorest groups still presented lower prevalence. A decline in socioeconomic inequalities was observed from 2013 to 2019 regarding the availability of public spaces and awareness about public programs. However, outcomes remained more common among the richest group. Inequalities did not vary for participation in public programs. Conclusion: Although leisure-time PA increased from 2013 to 2019 at a national level, there were no improvements in gender inequalities, and wealth inequalities worsened over time. Indicators of public strategies for PA increased for the population, but inequalities remain.

Greater daily leisure time physical activity is associated with lower chronic disease risk in adults with spinal cord injury

2009 ◽  
Vol 34 (4) ◽  
pp. 640-647 ◽  
Author(s):  
Andrea C. Buchholz ◽  
Kathleen A. Martin Ginis ◽  
Steven R. Bray ◽  
B. Catharine Craven ◽  
Audrey L. Hicks ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Cord Injury

The objective of this study was to examine the relationship between leisure time physical activity (LTPA) and common risk factors for cardiovascular disease (CVD) and type 2 diabetes in community-dwelling adults with chronic spinal cord injury (SCI). LTPA was measured using the Physical Activity Recall Assessment for People with SCI in 76 men and women with chronic (≥1 year) paraplegia or tetraplegia, living in or near Hamilton, Ontario. Body mass index (BMI), waist circumference, body composition (fat mass (FM) and fat-free mass (FFM)), blood pressure, and biochemical data were collected. Thirty-seven percent (n = 28 participants) were inactive, reporting no LTPA whatsoever, and were compared with an equal-sized group consisting of the most active study participants (≥25 min of LTPA per day). After adjusting for significant covariates, BMI (18.7%), %FM (19.4%), and C-reactive protein (143%) were all lower, and %FFM was higher (7.2%), in active participants (all p ≤ 0.05). Ten percent of active participants vs. 33% of inactive participants were insulin resistant (p = 0.03). Waist circumference (17.6%) and systolic blood pressure (15.3%) were lower in active vs. inactive participants with paraplegia (both p ≤ 0.05), but not tetraplegia. In conclusion, greater daily LTPA is associated with lower levels of selected CVD and type 2 diabetes risk factors in individuals living with SCI. Whether this relationship translates into a lower incidence of these chronic diseases has yet to be determined.

scholarly journals Leisure-time physical activity associates with cognitive decline

Neurology ◽  
2016 ◽  
Vol 86 (20) ◽  
pp. 1897-1903 ◽  
Author(s):  
Joshua Z. Willey ◽  
Hannah Gardener ◽  
Michelle R. Caunca ◽  
Yeseon Park Moon ◽  
Chuanhui Dong ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cognitive Decline ◽  
Leisure Time ◽  
Leisure Time Physical Activity

scholarly journals Domain-specific physical activity patterns and cardiorespiratory fitness among the working population: Findings from the cross-sectional German Health Interview and Examination Survey

BMJ Open ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. e034610
Author(s):  
Johannes Zeiher ◽  
Maurice Duch ◽  
Lars E Kroll ◽  
Gert B M Mensink ◽  
Jonas D Finger ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cardiorespiratory Fitness ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Activity Patterns ◽  
Occupational Physical Activity ◽  
Working Population ◽  
Cross Sectional ◽  
Physical Activity Patterns ◽  
Domain Specific

ObjectivesThis study aimed to investigate associations between occupational physical activity patterns (physical work demands linked to job title) and leisure time physical activity (assessed by questionnaire) with cardiorespiratory fitness (assessed by exercise test) among men and women in the German working population.DesignPopulation-based cross-sectional study.SettingTwo-stage cluster-randomised general population sample selected from population registries of 180 nationally distributed sample points. Information was collected from 2008 to 2011.Participants1296 women and 1199 men aged 18–64 from the resident working population.Outcome measureEstimated low maximal oxygen consumption (V˙O2max), defined as first and second sex-specific quintile, assessed by a standardised, submaximal cycle ergometer test.ResultsLow estimatedV˙O2maxwas strongly linked to low leisure time physical activity, but not occupational physical activity. The association of domain-specific physical activity patterns with lowV˙O2maxvaried by sex: women doing no leisure time physical activity with high occupational physical activity levels were more likely to have lowV˙O2max(OR 6.54; 95% CI 2.98 to 14.3) compared with women with ≥2 hours of leisure time physical activity and high occupational physical activity. Men with no leisure time physical activity and low occupational physical activity had the highest odds of lowV˙O2max(OR 4.37; 95% CI 2.02 to 9.47).ConclusionThere was a strong association between patterns of leisure time and occupational physical activity and cardiorespiratory fitness within the adult working population in Germany. Women doing no leisure time physical activity were likely to have poor cardiorespiratory fitness, especially if they worked in physically demanding jobs. However, further investigation is needed to understand the relationships between activity and fitness in different domains. Current guidelines do not distinguish between activity during work and leisure time, so specifying leisure time recommendations by occupational physical activity level should be considered.

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