Abstract P107: Serum Urate Trajectories in Young Adulthood and Incident Cardiovascular Disease Events By Middle Age; The Coronary Artery Risk Development in Young Adults (cardia) Study

Introduction: Higher levels of serum urate (UA) obtained on a single occasion have been shown to be associated with a higher risk of cardiovascular disease (CVD) events among middle-aged or older adults. However, little is known regarding UA trajectory patterns during young adulthood and their associations with CVD outcomes by middle age. Hypothesis: We hypothesize that higher UA trajectory is associated with a higher risk for CVD events compared to lower UA trajectories. Methods: We included data from 4845 CARDIA Study participants (mean age at the Year 20 exam 44.8±3.7 (37-55) years; 50.8% African American; 55.6% female). Sex-specific UA trajectories were assessed using group-based trajectory modeling (PROC TRAJ in SAS version 9.4) based on UA levels obtained at baseline (Year 0) and 10, 15, 20 years later. Covariates included age, sex, race, and clinical characteristics at Year 20 (body mass index, diabetes and creatinine). We estimated hazard ratios (HR) for CVD events (coronary heart disease, heart failure, and stroke) from Year 20 (2005-06) through 2017. Results: We identified 3 UA trajectories in men and 3 similar but lower UA trajectories in women, characterized by low-increasing (men: 30%; n=652, mean UA 5.1; women 43%, n=1191, mean UA 3.9), moderate-increasing (men: 52%; n=1290, mean UA 6.4; women 45%, n=1284, mean UA 5.0), and high-increasing UA (men: 17%; n=377, mean UA 8.0; women 12%, n=305, mean UA 6.4) (Figure 1). Sex-specific trajectories were pooled. Over a median follow-up of 10.9 years, 203 incident CVD events occurred. The adjusted HRs for CVD events were 0.98 (95%CI, 0.66-1.45) for the pooled moderate-increasing group and 1.77 (95%CI, 1.10-2.84) for the pooled high-increasing group compared to the pooled low-increasing group. Conclusions: High-increasing UA trajectory during young adulthood was associated with an greater risk of CVD events by middle age. Modeling UA trajectories may help identify young adults at higher risk for CVD events.

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Serum Urate Trajectory in Young Adulthood and Incident Cardiovascular Disease Events by Middle Age: CARDIA Study

Hypertension ◽

10.1161/hypertensionaha.121.17555 ◽

2021 ◽

Author(s):

Nagisa Morikawa ◽

Michael P. Bancks ◽

Yuichiro Yano ◽

Masanari Kuwabara ◽

Angelo L. Gaffo ◽

...

Keyword(s):

Blood Pressure ◽

Cardiovascular Disease ◽

Young Adulthood ◽

Middle Age ◽

Exposure Period ◽

Serum Urate ◽

Hazard Ratios ◽

Trajectory Group ◽

Incident Cardiovascular Disease

Serum urate levels have been shown to be correlated with risk for incident cardiovascular disease (CVD) events among middle-aged or older adults. However, serum urate trajectory during young adulthood and its association with CVD events has been understudied. Using serum urate measurements collected at baseline and 10, 15, 20 years after baseline from 3563 CARDIA (Coronary Artery Risk Development in Young Adults) participants (mean age 25.1±3.6 [18–30] years at baseline [year 0, 1985–1986]; 46.3% Black; 56.1% female), we determined sex-specific serum urate trajectories using SAS PROC TRAJ. We estimated hazard ratios for incident CVD events (coronary heart disease, heart failure, and stroke) occurring after the year 20 exam through 2017. We identified 3 serum urate trajectories by sex, including low-stable (n=1251), moderate-stable (n=1761), and high-increasing (n=551). Over a median 10.6 years of follow-up, 157 incident CVD events occurred. Participants among the high-increasing trajectory group had 2.89 (95% CI, 1.88–4.43) times greater risk for CVD compared with the low-stable trajectory group. The association was attenuated after adjustment for blood pressure levels during young adulthood. In conclusion, high-increasing serum urate trajectory during young adulthood was associated with incident CVD by middle age, and the association may be explained by blood pressure levels during the exposure period.

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Tea consumption and the risk of atherosclerotic cardiovascular disease and all-cause mortality: The China-PAR project

European Journal of Preventive Cardiology ◽

10.1177/2047487319894685 ◽

2020 ◽

Vol 27 (18) ◽

pp. 1956-1963 ◽

Cited By ~ 2

Author(s):

Xinyan Wang ◽

Fangchao Liu ◽

Jianxin Li ◽

Xueli Yang ◽

Jichun Chen ◽

...

Keyword(s):

Cardiovascular Disease ◽

Disease Incidence ◽

Atherosclerotic Cardiovascular Disease ◽

Tea Consumption ◽

Hazard Ratios ◽

Disease Mortality ◽

All Cause Mortality ◽

Cox Proportional Hazard Regression ◽

Study Participants

Aims The role of tea consumption in the primary prevention of atherosclerotic cardiovascular disease remains unclear in cohort studies. This prospective cohort study aimed to investigate the associations of tea consumption with the risk of atherosclerotic cardiovascular disease and all-cause mortality. Methods We included 100,902 general Chinese adults from the project of Prediction for ASCVD Risk in China (China-PAR) in 15 provinces across China since 1998. Information on tea consumption was collected through standardized questionnaires. Outcomes were identified by interviewing study participants or their proxies, and checking hospital records and/or death certificates. Cox proportional hazard regression models were used to calculate hazard ratios and their corresponding 95% confidence intervals related to tea consumption. Results During a median follow-up of 7.3 years, 3683 atherosclerotic cardiovascular disease events, 1477 atherosclerotic cardiovascular disease deaths, and 5479 all-cause deaths were recorded. Compared with never or non-habitual tea drinkers, the hazard ratio and 95% confidence interval among habitual tea drinkers was 0.80 (0.75–0.87), 0.78 (0.69–0.88), and 0.85 (0.79–0.90) for atherosclerotic cardiovascular disease incidence, atherosclerotic cardiovascular disease mortality, and all-cause mortality, respectively. Habitual tea drinkers had 1.41 years longer of atherosclerotic cardiovascular disease-free years and 1.26 years longer of life expectancy at the index age of 50 years. The observed inverse associations were strengthened among participants who kept the habit during the follow-up period. Conclusion Tea consumption was associated with reduced risks of atherosclerotic cardiovascular disease and all-cause mortality, especially among those consistent habitual tea drinkers.

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Cumulative Lifetime Marijuana Use and Incident Cardiovascular Disease in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

American Journal of Public Health ◽

10.2105/ajph.2017.303654 ◽

2017 ◽

Vol 107 (4) ◽

pp. 601-606 ◽

Cited By ~ 29

Author(s):

Jared P. Reis ◽

Reto Auer ◽

Michael P. Bancks ◽

David C. Goff ◽

Cora E. Lewis ◽

...

Keyword(s):

Cardiovascular Disease ◽

Young Adults ◽

Coronary Artery ◽

Middle Age ◽

Marijuana Use ◽

Incident Cardiovascular Disease

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Abstract P204: Depressive Symptomatology, Anti-depressant Use and Hypertension in Young Adulthood

Circulation ◽

10.1161/circ.133.suppl_1.p204 ◽

2016 ◽

Vol 133 (suppl_1) ◽

Author(s):

Shakira F Suglia ◽

Danielle M Crookes ◽

Katherine M Keyes ◽

Karestan C Koenen

Keyword(s):

Cardiovascular Disease ◽

Young Adults ◽

Young Adulthood ◽

Depressive Symptomatology ◽

Sociodemographic Factors ◽

Epidemiologic Studies ◽

Depression Symptoms ◽

Antihypertensive Medications ◽

Antidepressant Use

Objective: While depression symptoms have been associated with cardiovascular disease in adulthood, little is known of the effects of adolescent-onset depression and hypertension in young adulthood. Furthermore, few studies have examined whether use of anti-depressants is associated with hypertension among young adults. Research Design and Methods: We examined the relation between depression symptoms and hypertension in young adulthood in the National Longitudinal Study of Adolescent Health (N=13,722). Adolescents completed the Center for Epidemiologic Studies Depression (CESD)-20 during wave 1 (1994-1995, mean age 16) and the CESD-10 during follow-up wave 4 (2007-2008, mean age 29). Depression symptoms were characterized as a score of 16 or above for the CESD-20 and 11 or above for CESD-10. During follow-up participants were asked to provide to the interviewer all medications they were currently taking or had taken in the previous six months. Antidepressant and antihypertensive medications were identified from all medications provided. Blood pressure was measured during an in-home visit. Hypertension was defined as measured SBP of at least 140mmHg or DBP of at least 90mmHG measured in adulthood, or use of antihypertensive medications. Results: The prevalence of hypertension was 20%. In models adjusting for sociodemographic factors, high depression symptoms in either adolescence or young adulthood were not significantly associated with hypertension in young adulthood. Use of anti-depressants in young adulthood was associated with hypertension (OR 2.89, 95%CI 1.82, 4.56) this association remained even after adjusting for obesity. No interactions by gender were noted. Conclusions: In this nationally representative sample, antidepressant use was associated hypertension in young adulthood. In accordance with a recent AHA Scientific Statement, our findings suggest that young adults with depression should be monitored closely to prevent the development of risk factors, such as hypertension, which may accelerate the development of cardiovascular disease.

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Serum Urate and Incident Cardiovascular Disease: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

PLoS ONE ◽

10.1371/journal.pone.0138067 ◽

2015 ◽

Vol 10 (9) ◽

pp. e0138067 ◽

Cited By ~ 5

Author(s):

Huifen Wang ◽

David R. Jacobs ◽

Angelo L. Gaffo ◽

Myron D. Gross ◽

David C. Goff ◽

...

Keyword(s):

Cardiovascular Disease ◽

Young Adults ◽

Coronary Artery ◽

Serum Urate ◽

Incident Cardiovascular Disease

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Racial Differences in Associations of Blood Pressure Components in Young Adulthood With Incident Cardiovascular Disease by Middle Age

JAMA Cardiology ◽

10.1001/jamacardio.2016.5678 ◽

2017 ◽

Vol 2 (4) ◽

pp. 381 ◽

Cited By ~ 18

Author(s):

Yuichiro Yano ◽

Jared P. Reis ◽

Yacob G. Tedla ◽

David C. Goff ◽

David R. Jacobs ◽

...

Keyword(s):

Blood Pressure ◽

Cardiovascular Disease ◽

Racial Differences ◽

Young Adulthood ◽

Middle Age ◽

Incident Cardiovascular Disease

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Personality, Cardiovascular Disease, and Cancer:

Zeitschrift für Gesundheitspsychologie ◽

10.1026/0943-8149.12.3.102 ◽

2004 ◽

Vol 12 (3) ◽

pp. 102-115 ◽

Cited By ~ 9

Author(s):

Manfred Amelang ◽

Petra Hasselbach ◽

Til Stürmer

Keyword(s):

Cardiovascular Disease ◽

Behavioral Control ◽

Smoking Behavior ◽

Type A Behavior ◽

Incremental Validity ◽

Personality Factors ◽

Emotional Lability ◽

Prevalent Disease ◽

Incident Cardiovascular Disease

Abstract. Ten years ago a sample of N = 5.133 male and female subjects (age 28-74) responded to questionnaires including scales for personality, life style, work stress as well as questions on prevalent disease. We now report on the follow-up regarding self-reported incidence of cardiovascular disease and cancer. During a mean follow-up of 10 years, 257 participants had died. Of those alive, N = 4.010 (82%) participated in the follow-up. Of these, 120 and 180 persons reported incident cardiovascular disease and cancer, respectively. The incidence of cardiovascular disease could be significantly predicted by the personality factors “Emotional Lability”, “Behavioral Control” and “Type-A-Behavior” as well as by the “Rationality/Antemotionality”-scale according to Grossarth-Maticek. After controlling for age, gender and smoking behavior only the significant effect of “Emotional Lability” remained and the predictors according to Grossarth-Maticek had no incremental validity. Cancer could not be predicted by any personality factors.

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Association with Longevity of Phosphatidylinositol 3-Kinase Regulatory Subunit 1 Gene Variants Stems from Protection against Mortality Risk in Men with Cardiovascular Disease

Gerontology ◽

10.1159/000515390 ◽

2021 ◽

pp. 1-9

Author(s):

Timothy A. Donlon ◽

Randi Chen ◽

Kamal H. Masaki ◽

Bradley J. Willcox ◽

Brian J. Morris

Keyword(s):

Cardiovascular Disease ◽

Life Span ◽

Mortality Risk ◽

Regulatory Subunit ◽

Phosphatidylinositol 3 Kinase ◽

Survival Curves ◽

Genotypic Effect ◽

Hazard Ratios ◽

Phosphatidylinositol 3

Introduction: Genetic variation in the phosphatidylinositol 3-kinase reregulatory subunit 1 gene (PIK3R1) is associated with longevity. Objective: The aim of the study was to determine whether cardiovascular disease (CVD) affects this association. Methods: We performed a longitudinal study of longevity-associated PIK3R1 single-nucleotide polymorphism rs7709243 genotype by CVD status in 3,584 elderly American men of Japanese ancestry. Results: At baseline (1991–1993), 2,254 subjects had CVD and 1,314 did not. The follow-up until Dec 31, 2019 found that overall, men with a CVD had higher mortality than men without a CVD (p = 1.7 × 10−5). However, survival curves of CVD subjects differed according to PIK3R1 genotype. Those with longevity-associated PIK3R1 TT/CC had survival curves similar to those of subjects without a CVD (p = 0.11 for TT/CC, and p = 0.054 for TC), whereas survival curves for CVD subjects with the CT genotype were significantly attenuated compared with survival curves of subjects without a CVD (p = 0.0000012 compared with TT/CC, and p = 0.0000028 compared with TC). Men without CVD showed no association of longevity-associated genotype with life span (p = 0.58). Compared to subjects without any CVD, hazard ratios for mortality risk were 1.26 (95% CI, 1.14–1.39; p = 0.0000043) for CT subject with CVD and 1.07 (95% CI 0.99–1.17; p = 0.097) for CC/TT subjects with CVD. There was no genotypic effect on life span for 1,007 subjects with diabetes and 486 with cancer. Conclusion: Our study provides novel insights into the basis for PIK3R1 as a longevity gene. We suggest that the PIK3R1 longevity genotype attenuates mortality risk in at-risk individuals by protection against cellular stress caused by CVD.

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