Abstract P204: Depressive Symptomatology, Anti-depressant Use and Hypertension in Young Adulthood

Objective: While depression symptoms have been associated with cardiovascular disease in adulthood, little is known of the effects of adolescent-onset depression and hypertension in young adulthood. Furthermore, few studies have examined whether use of anti-depressants is associated with hypertension among young adults. Research Design and Methods: We examined the relation between depression symptoms and hypertension in young adulthood in the National Longitudinal Study of Adolescent Health (N=13,722). Adolescents completed the Center for Epidemiologic Studies Depression (CESD)-20 during wave 1 (1994-1995, mean age 16) and the CESD-10 during follow-up wave 4 (2007-2008, mean age 29). Depression symptoms were characterized as a score of 16 or above for the CESD-20 and 11 or above for CESD-10. During follow-up participants were asked to provide to the interviewer all medications they were currently taking or had taken in the previous six months. Antidepressant and antihypertensive medications were identified from all medications provided. Blood pressure was measured during an in-home visit. Hypertension was defined as measured SBP of at least 140mmHg or DBP of at least 90mmHG measured in adulthood, or use of antihypertensive medications. Results: The prevalence of hypertension was 20%. In models adjusting for sociodemographic factors, high depression symptoms in either adolescence or young adulthood were not significantly associated with hypertension in young adulthood. Use of anti-depressants in young adulthood was associated with hypertension (OR 2.89, 95%CI 1.82, 4.56) this association remained even after adjusting for obesity. No interactions by gender were noted. Conclusions: In this nationally representative sample, antidepressant use was associated hypertension in young adulthood. In accordance with a recent AHA Scientific Statement, our findings suggest that young adults with depression should be monitored closely to prevent the development of risk factors, such as hypertension, which may accelerate the development of cardiovascular disease.

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Shared meals among young adults are associated with better diet quality and predicted by family meal patterns during adolescence

Public Health Nutrition ◽

10.1017/s1368980012003539 ◽

2012 ◽

Vol 16 (5) ◽

pp. 883-893 ◽

Cited By ~ 27

Author(s):

Nicole Larson ◽

Jayne Fulkerson ◽

Mary Story ◽

Dianne Neumark-Sztainer

Keyword(s):

Young Adults ◽

Young Adulthood ◽

Sociodemographic Factors ◽

Population Based ◽

Household Composition ◽

Family Meals ◽

Meal Patterns ◽

Food And Beverage ◽

Shared Meals

AbstractObjectiveTo describe shared meal patterns and examine associations with dietary intake among young adults.DesignPopulation-based, longitudinal cohort study (Project EAT: Eating and Activity in Teens and Young Adults).SettingParticipants completed surveys and FFQ in high-school classrooms in Minneapolis/St. Paul, MN, USA in 1998–1999 (mean age = 15·0 years, ‘adolescence’) and follow-up measures online or by mail in 2008–2009 (mean age = 25·3 years, ‘young adulthood’).SubjectsThere were 2052 participants who responded to the 10-year follow-up survey and reported on frequency of having shared meals.ResultsAmong young adults, the frequency of shared meals during the past week was as follows: never (9·9 %), one or two times (24·7 %), three to six times (39·1 %) and seven or more times (26·3 %). Having more frequent family meals during adolescence predicted a higher frequency of shared meals in young adulthood above and beyond other relevant sociodemographic factors such as household composition and parental status. Compared with young adults who never had family meals during adolescence, those young adults who reported seven or more family meals per week during adolescence had an average of one additional shared meal per week. Having more frequent shared meals in young adulthood was associated with greater intake of fruit among males and females, and with higher intakes of vegetables, milk products and some key nutrients among females.ConclusionsNutrition professionals should encourage families of adolescents to share meals often and establish the tradition of eating together, and work with young adults to ensure that healthy food and beverage choices are offered at mealtimes.

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Abstract P107: Serum Urate Trajectories in Young Adulthood and Incident Cardiovascular Disease Events By Middle Age; The Coronary Artery Risk Development in Young Adults (cardia) Study

Circulation ◽

10.1161/circ.141.suppl_1.p107 ◽

2020 ◽

Vol 141 (Suppl_1) ◽

Author(s):

Nagisa Morikawa ◽

Michael P. Bancks ◽

Yuichiro Yano ◽

Masanori Kuwabara ◽

Angelo L. Gaffo ◽

...

Keyword(s):

Cardiovascular Disease ◽

Young Adults ◽

Young Adulthood ◽

Clinical Characteristics ◽

Middle Age ◽

Serum Urate ◽

Hazard Ratios ◽

Study Participants ◽

Incident Cardiovascular Disease

Introduction: Higher levels of serum urate (UA) obtained on a single occasion have been shown to be associated with a higher risk of cardiovascular disease (CVD) events among middle-aged or older adults. However, little is known regarding UA trajectory patterns during young adulthood and their associations with CVD outcomes by middle age. Hypothesis: We hypothesize that higher UA trajectory is associated with a higher risk for CVD events compared to lower UA trajectories. Methods: We included data from 4845 CARDIA Study participants (mean age at the Year 20 exam 44.8±3.7 (37-55) years; 50.8% African American; 55.6% female). Sex-specific UA trajectories were assessed using group-based trajectory modeling (PROC TRAJ in SAS version 9.4) based on UA levels obtained at baseline (Year 0) and 10, 15, 20 years later. Covariates included age, sex, race, and clinical characteristics at Year 20 (body mass index, diabetes and creatinine). We estimated hazard ratios (HR) for CVD events (coronary heart disease, heart failure, and stroke) from Year 20 (2005-06) through 2017. Results: We identified 3 UA trajectories in men and 3 similar but lower UA trajectories in women, characterized by low-increasing (men: 30%; n=652, mean UA 5.1; women 43%, n=1191, mean UA 3.9), moderate-increasing (men: 52%; n=1290, mean UA 6.4; women 45%, n=1284, mean UA 5.0), and high-increasing UA (men: 17%; n=377, mean UA 8.0; women 12%, n=305, mean UA 6.4) (Figure 1). Sex-specific trajectories were pooled. Over a median follow-up of 10.9 years, 203 incident CVD events occurred. The adjusted HRs for CVD events were 0.98 (95%CI, 0.66-1.45) for the pooled moderate-increasing group and 1.77 (95%CI, 1.10-2.84) for the pooled high-increasing group compared to the pooled low-increasing group. Conclusions: High-increasing UA trajectory during young adulthood was associated with an greater risk of CVD events by middle age. Modeling UA trajectories may help identify young adults at higher risk for CVD events.

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Change in Depression Symptomatology and Cognitive Function in Twins: A 10-Year Follow-Up Study

Twin Research and Human Genetics ◽

10.1017/thg.2016.3 ◽

2016 ◽

Vol 19 (2) ◽

pp. 104-111 ◽

Cited By ~ 5

Author(s):

Inge Petersen ◽

Matt McGue ◽

Qihua Tan ◽

Kaare Christensen ◽

Lene Christiansen

Keyword(s):

Cognitive Decline ◽

Cognitive Abilities ◽

Depressive Symptomatology ◽

Twin Studies ◽

Cognitive Change ◽

Depression Symptoms ◽

Cross Sectional ◽

The Mean ◽

Depression Symptomatology

A complex interrelation exists between change in depression symptomatology and cognitive decline. Studies indicate either that depression is a direct risk factor for cognitive change over time, or vice versa. Longitudinal twin studies provide the possibility to unravel cause and effect of correlated traits. Here, we have applied twin modeling approaches to shed light on the genetic correlation between both level and change of depression symptomatology and cognitive functioning, and to further explore the bidirectionality of any such correlation using assessments of both phenotypes at two occasions 10 years apart. The study included 2,866 Danish twins with a mean age of 56.8 years at intake (range: 45–68 years). Of these, 1,267 were intact pairs. A total number of 1,582 twins (55%), of whom 557 were intact pairs, participated in the follow-up survey. We found stable cross-sectional heritability estimates of approximately 60% for general cognitive abilities and 30% for affective depressive symptoms. There was a considerable decline in the mean cognitive performance over 10 years, whereas the mean affective depression symptoms score was stable and with no genetic contribution to any individual change. Additionally, we saw a small but significant cross-trait correlation at both occasions (-0.11 and -0.09, respectively), but cross-trait cross-occasion analysis revealed no evidence that either of the two traits predicts the other over a 10-year interval. Thus, our study was not able to detect any causal association between change in depressive symptomatology and cognitive decline in middle-aged and elderly people over a 10-year interval.

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Maternal Partner Criminality and Cannabis use in Young Adulthood: Prospective Study

Australian & New Zealand Journal of Psychiatry ◽

10.1080/00048670701341897 ◽

2007 ◽

Vol 41 (6) ◽

pp. 546-553 ◽

Cited By ~ 7

Author(s):

Mohammad R. Hayatbakhsh ◽

Stuart A. Kinner ◽

Konrad Jamrozik ◽

Jake M. Najman ◽

Abdullah A. Mamun

Keyword(s):

Young Adults ◽

Young Adulthood ◽

Early Adulthood ◽

Cannabis Use ◽

Birth Cohort Study ◽

Mater Hospital ◽

Frequent Use ◽

Increased Risk ◽

History Of

Objectives: The present study examined whether the experience of the arrest or incarceration of a mother's partner before a child reached 14 years of age was associated with use of cannabis in early adulthood and, if so, whether this association was confounded or mediated by other factors. Method: Data were from the Mater Hospital University of Queensland Study of Pregnancy, a prospective birth cohort study in Brisbane, Australia. The history of partner arrest and incarceration was reported by mothers at the 14 year follow up. Mothers were divided into four groups: mothers whose partner had no history of arrest or incarceration, mothers reporting partner arrest, mothers reporting partner incarceration, and unpartnered mothers. Young adults’ cannabis use was assessed at 21 years. Other covariates were prospectively measured between birth and 14 years. Results: After controlling for potential confounding and mediating factors, frequent use of cannabis at age 21 was more likely among young adults with a history of maternal partner arrest (odds ratio=2.3; 95% confidence interval: 1.4–3.8). There was no significant association between maternal partner incarceration or single motherhood, and cannabis use at age 21. Conclusions: Arrest of the mother's partner before the child is 14 is associated with that child's increased cannabis use at age 21 but this does not appear to be the case for children whose fathers have been imprisoned. It appears that for children whose fathers have been arrested, the father's ongoing presence in the family may result in worse outcomes for the child, including an increased risk of cannabis use in young adulthood.

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Difference in cardiovascular disease incidence by sociodemographic factors in adolescent and young adult (AYA) cancer survivors.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.6565 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. 6565-6565

Author(s):

Theresa Keegan ◽

Lawrence H. Kushi ◽

Qian Li ◽

Ann Brunson ◽

Marcio H. Malogolowkin ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cancer Survivors ◽

Sociodemographic Factors ◽

Cancer Type ◽

Cvd Risk ◽

Risk Of Death ◽

Increased Risk ◽

Race Ethnicity ◽

The Impact

6565 Background: AYA cancer survivors are at increased risk of developing cardiovascular disease (CVD) compared to AYAs without a history of cancer. In AYA cancer survivors, few population-based studies have focused on CVD risk and none have considered whether the occurrence of CVD differs by sociodemographic factors. Methods: Analyses focused on 64,918 patients aged 15-39 y at diagnosis for one of 14 first primary cancers during 1996-2010 and surviving > 2 years after diagnosis, with follow-up through 2013. Data were obtained from the California Cancer Registry and State hospital discharge data. CVD included coronary artery disease, heart failure, and stroke. We estimated the cumulative incidence of developing CVD, accounting for death as a competing risk, stratified by race/ethnicity, neighborhood socioeconomic status (SES) at diagnosis, health insurance status at diagnosis/initial treatment and cancer type. We examined the impact of CVD on mortality using multivariable Cox proportional hazards regression with CVD as a time-dependent covariate. Results: Overall, 2374 (3.7%) patients developed CVD, and 7690 (11.9%) died over the follow-up period. Survivors of acute myeloid leukemia (12.6%), acute lymphoid leukemia (11.1%), central nervous system cancer (9.0%) and non-Hodgkin lymphoma (6.0%) had the highest incidence of CVD at 10-years. Incidence was significantly higher among Blacks (6.7%) at 10-years than non-Hispanic Whites (3.0%), Hispanics (3.7%) and Asian/Pacific Islanders (3.7%) (p < 0.001). AYA survivors with public or no insurance (vs private) had a higher 10-year incidence of CVD (5.8% vs 2.9%; p < 0.001), as did survivors residing in low (vs high) SES neighborhoods (4.1% vs 2.7%; p < 0.001). These sociodemographic differences in CVD incidence were apparent across most cancer sites. The risk of death was increased by five-fold or higher among AYAs who developed CVD. Conclusions: AYA cancer survivors who were uninsured or publicly insured, of Black race/ethnicity, or who resided in lower SES neighborhoods are at increased risk for developing CVD and experiencing higher mortality. The proactive management of CVD risk factors in these subgroups may improve patient outcomes.

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Validation of the short Mood and Feelings Questionnaire in young adulthood

10.1101/2021.01.22.21250311 ◽

2021 ◽

Author(s):

Olga Eyre ◽

Rhys Bevan Jones ◽

Sharifah Shameem Agha ◽

Robyn E Wootton ◽

Ajay K Thapar ◽

...

Keyword(s):

Young Adults ◽

Sensitivity And Specificity ◽

Young Adulthood ◽

Early Adulthood ◽

Well Being ◽

The Self ◽

Depression Symptoms ◽

Cut Points ◽

Cut Point ◽

Dsm 5

AbstractBackgroundDepression often onsets in adolescence and is associated with recurrence in adulthood. There is a need to identify and monitor depression symptoms across adolescence and into young adulthood. The short Mood and Feelings Questionnaire (sMFQ) is commonly used to measure depression symptoms in adolescence but has yet to be validated in young adulthood. This study aimed to (1) examine whether the sMFQ is a valid assessment of depression in young adults, and (2) identify cut-points that best capture a DSM-5 diagnosis of depression at age 25.MethodsThe sample included young people who took part in the Avon Longitudinal Study of Parents and Children (ALSPAC) at age 25 (n=4098). Receiver Operating Characteristic analyses were used to examine how well the self-rated sMFQ discriminates between cases and non-cases of DSM-5 Major Depressive Disorder (MDD) classified using the self-rated Development and Well Being Assessment. Sensitivity and specificity values were used to identify cut-points on the sMFQ.ResultsThe sMFQ had high accuracy for discriminating MDD cases from non-cases at age 25. The commonly used cut-point in adolescence (≥12) performed well at this age, best balancing sensitivity and specificity. However, a lower cut-point (≥10) may be appropriate in some contexts, e.g. for screening, when sensitivity is favoured over specificity.LimitationsALSPAC is a longitudinal population cohort that suffers from non-random attrition.ConclusionsThe sMFQ is a valid measure of depression in young adults in the general population. It can be used to screen for and monitor depression across adolescence and early adulthood.

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Multi-Parametric Diagnostic Approach and Potential Markers of Early Onset Subclinical Cardiovascular Disease in a Cohort of Children, Adolescents and Young Adults Vertically Infected with HIV on cART

Journal of Clinical Medicine ◽

10.3390/jcm10225455 ◽

2021 ◽

Vol 10 (22) ◽

pp. 5455

Author(s):

Biagio Castaldi ◽

Gloria Lanzoni ◽

Osvalda Rampon ◽

Daniele Donà ◽

Angela Di Candia ◽

...

Keyword(s):

Cardiovascular Disease ◽

Young Adults ◽

Cardiovascular Risk ◽

Global Longitudinal Strain ◽

Mean Value ◽

Adolescents And Young Adults ◽

Abdominal Aneurysm ◽

Bilateral Carotid ◽

Subclinical Cardiovascular Disease

Background: HIV infection and lifelong cART are responsible of an increase in cardiovascular risk. The aim of this study was to describe the subclinical cardiovascular disease and to identify early markers of cardiovascular damage in adolescents and young adults vertically infected with HIV on cART, through an innovative multi-parametric approach. Methods: We enrolled 52 patients vertically infected with HIV. Demographic records, traditional cardiovascular risk factors, laboratory findings and echocardiographic measurements were collected in a one-year routine follow up. The echocardiographic examination included measurements of the 2D and 3D ejection fraction (EF), E/A ratio, E/E′ ratio, carotid intima media thickness (cIMT), flow-mediated dilation (FMD) and global longitudinal strain (GLS). Results: At the time of enrolment, all the patients were on cART therapy. The viral load was suppressed in 95% of them. EF was normal in 94.2% of patients (66 ± 7.2%), and GLS (mean value: −20.0 ± 2.5%) was reduced in 29% of patients. The cIMT mean value was higher than the 95th centile for sex and age in 73%, and FMD was impaired in 45% of patients. Clinically evident disease was found in three patients: dilative cardiomyopathy in one, thoracic-abdominal aneurysm Crawford type II with a bilateral carotid dilation in one and carotid plaque with 30% of stenosis in a third patient. Conclusions: This study confirms the presence of clinical and subclinical cardiovascular disease in a very young population vertically infected with HIV, underlining the importance of an early, multi-parametric cardiovascular follow up.

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Associations with kidney transplant survival and eGFR decline in children and young adults in the United Kingdom: a retrospective cohort study

BMC Nephrology ◽

10.1186/s12882-020-02156-2 ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Alexander J. Hamilton ◽

Lucy A. Plumb ◽

Anna Casula ◽

Manish D. Sinha

Keyword(s):

Young Adults ◽

Cohort Study ◽

Young Adulthood ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Graft Loss ◽

Glomerular Diseases ◽

Children And Young Adults ◽

Egfr Decline

Abstract Background Although young adulthood is associated with transplant loss, many studies do not examine eGFR decline. We aimed to establish clinical risk factors to identify where early intervention might prevent subsequent adverse transplant outcomes. Methods Retrospective cohort study using UK Renal Registry and UK Transplant Registry data, including patients aged < 30 years transplanted 1998–2014. Associations with death-censored graft failure were investigated with multivariable Cox proportional hazards. Multivariable linear regression was used to establish associations with eGFR slope gradients calculated over the last 5 years of observation per individual. Results The cohort (n = 5121, of whom n = 371 received another transplant) was 61% male, 80% White and 36% had structural disease. Live donation occurred in 48%. There were 1371 graft failures and 145 deaths with a functioning graft over a 39,541-year risk period. Median follow-up was 7 years. Fifteen-year graft survival was 60.2% (95% CI 58.1, 62.3). Risk associations observed in both graft loss and eGFR decline analyses included female sex, glomerular diseases, Black ethnicity and young adulthood (15–19-year and 20–24-year age groups, compared to 25–29 years). A higher initial eGFR was associated with less risk of graft loss but faster eGFR decline. For each additional 10 mL/min/1.73m2 initial eGFR, the hazard ratio for graft loss was 0.82 (95% CI 0.79, 0.86), p < 0.0001. However, compared to < 60 mL/min/1.73m2, higher initial eGFR was associated with faster eGFR decline (> 90 mL/min/1.73m2; − 3.55 mL/min/1.73m2/year (95% CI -4.37, − 2.72), p < 0.0001). Conclusions In conclusion, young adulthood is a key risk factor for transplant loss and eGFR decline for UK children and young adults. This study has an extended follow-up period and confirms common risk associations for graft loss and eGFR decline, including female sex, Black ethnicity and glomerular diseases. A higher initial eGFR was associated with less risk of graft loss but faster rate of eGFR decline. Identification of children at risk of faster rate of eGFR decline may enable early intervention to prolong graft survival.

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Abstract 13676: Association of Plant-centered Diet Intake With Cardiovascular Disease and All-cause Mortality: Findings From the Coronary Artery Risk Development in Young Adults Study

Circulation ◽

10.1161/circ.142.suppl_3.13676 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Yuni Choi ◽

Nicole Larson ◽

Lyn M Steffen ◽

Pamela J SCHREINER ◽

Daniel D Gallaher ◽

...

Keyword(s):

Cardiovascular Disease ◽

Young Adults ◽

Coronary Artery ◽

Diet Quality ◽

Lower Risk ◽

Multivariable Analysis ◽

Parental History ◽

Plant Foods ◽

All Cause Mortality

Introduction: There is growing data regarding the potential for plant-centered diets to reduce risk for cardiovascular disease (CVD) and mortality. However, additional investigation is needed to strengthen and address inconsistencies in the existing evidence base. We examined the association between cumulative consumption of a plant-centered diet and a shift toward a more plant-centered diet and onset of CVD and all-cause mortality. Hypothesis: Nutritionally-rich plant-centered diets will be related to decreased risk of CVD and mortality. Methods: We included 4,926 black and white men and women from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort, ages 18-30 years and free of CVD at baseline (1985-1986, exam year [Y0]) and followed until 2018. Diet was assessed through an interviewer-administered diet history at Y0, Y7, and Y20. A Priori Diet Quality Score (APDQS) was used to assess plant-centered diet quality, and high index scores were characterized by higher consumption of nutritionally-rich plant foods with limited consumption of meats and less healthful plant foods. Proportional hazards regression estimated the association of time-varying APDQS, which were cumulatively averaged over follow-up and 13-year change in APDQS (Y7-Y20) with CVD and all-cause mortality. The model was adjusted for sociodemographic factors, energy intake, parental history of CVD, smoking, and physical activity. Results: We documented 289 new CVD cases and 445 all-cause deaths during the median 32-years of follow up. In multivariable analysis, the highest quintile of cumulative APDQS was associated with a 52% lower risk of CVD (hazard ratio [HR]: 0.48, 95% CI: 0.28-0.81) compared with the lowest quintile of cumulative APDQS. Increased APDQS over 13 years was related to a 62% lower subsequent 12-year risk of CVD (95% CI: 0.18-0.78) when comparing extreme quintiles. The association for all-cause mortality was only apparent among high educational groups. Conclusions: Following a plant-centered, high-quality diet staring from young adulthood was associated with a lower risk of developing CVD and death by middle age. Our findings support the concept that a plant-centered diet may help prevent early CVD and death.

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Abstract 16731: Early Onset of Menopause and Premature Cardiovascular Disease: The Coronary Artery Risk Development in Young Adults Study

Circulation ◽

10.1161/circ.142.suppl_3.16731 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Ruth Misha ◽

Laura A Colangelo ◽

Lucia Petito ◽

Cora E Lewis ◽

Pamela Schreiner ◽

...

Keyword(s):

Cardiovascular Disease ◽

Young Adults ◽

Coronary Artery ◽

Black Women ◽

Early Onset ◽

White Women ◽

Proportional Hazards ◽

Cox Proportional Hazards ◽

Age At Menarche

Introduction: Cardiovascular disease (CVD) is the leading cause of death in women and early onset of menopause before the age of 40 years has been identified as a risk enhancer for future CVD events. Quantifying the magnitude of risk for premature CVD among women with early menopause may inform and guide the intensity of sex-specific preventive strategies. Methods: We included all women in the Coronary Artery Risk Development in Young Adults (CARDIA) study who attended a follow-up exam after the age of 40 years, had available data on menopausal status, and had not experienced premature CVD before 40 years. We performed multivariable Cox proportional hazards regression to examine the relationship between early onset of menopause defined as <40 years and incident CVD (coronary heart disease, peripheral arterial disease, stroke, and heart failure) prior to the age of 65 years. We performed Cox proportional hazards models and adjusted for risk factors levels at baseline: age, race, age at menarche, years of education, smoking status, body mass index, diabetes, hypertension, and total cholesterol: high-density lipoprotein ratio. Results: Among 2136 women with mean age of 43.0 (SD 3.0), 9.1% reported premature menopause before the age of 40 years (4.5% in white and 13.9% in black women). Over a median follow-up of 14.0 (IQR 11.5, 16.9) years, 81 premature CVD events occurred. Incidence rate (95% CI) of CVD was 6.46 (2.43, 17.22) and 1.41 (0.92, 2.17) per 1,000 per person-years for white women with and without early onset menopause, respectively; 4.94 (2.66, 9.16) and 3.92 (2.94, 5.24) per 1,000 person-years for black women with and without early onset menopause (FIGURE). Conclusions: In a population-based sample, white women with early onset of menopause had a 3-fold higher rate of premature CVD events, independent of perimenopausal risk factor levels. Interventions to intensify CVD prevention in at-risk women are needed following early onset of menopause.

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