scholarly journals AMP-Activated Protein Kinase Regulates Endothelial Cell Angiotensin-Converting Enzyme Expression via p53 and the Post-Transcriptional Regulation of microRNA-143/145

2013 ◽  
Vol 112 (8) ◽  
pp. 1150-1158 ◽  
Author(s):  
Karin Kohlstedt ◽  
Caroline Trouvain ◽  
Thomas Boettger ◽  
Lei Shi ◽  
Beate Fisslthaler ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Endothelial Cell ◽  
Protein Kinase ◽  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Enzyme Expression ◽  
Amp Activated Protein Kinase ◽  
Post Transcriptional Regulation

Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421

2014 ◽  
Vol 127 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Daniel W. Lambert ◽  
Louise A. Lambert ◽  
Nicola E. Clarke ◽  
Nigel M. Hooper ◽  
Karen E. Porter ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Transcriptional Regulation ◽  
Angiotensin Converting Enzyme ◽  
Therapeutic Target ◽  
Molecular Mechanisms ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2 ◽  
Post Transcriptional Regulation ◽  
Cardiac Myofibroblasts

The molecular mechanisms controlling the expression of ACE2, a critical regulator of cardiovascular homoeostasis, remain poorly defined. In the present study, we show that miR-421 regulates expression of ACE2 in cardiac myofibroblasts, identifying a possible new therapeutic target in cardiovascular disease.

Vascular Angiotensin-Converting Enzyme Expression Regulates Local Angiotensin II

Hypertension ◽  
1997 ◽  
Vol 29 (1) ◽  
pp. 98-104 ◽  
Author(s):  
Dominik N. Müller ◽  
Jürgen Bohlender ◽  
Karl F. Hilgers ◽  
Duska Dragun ◽  
Olivier Costerousse ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Enzyme Expression
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