Apolipoprotein E polymorphism and ischemic cerebrovascular disease.

The possible association of apolipoprotein E (apoE) DNA polymorphism with ischemic cerebrovascular disease was evaluated in 65 patients who had suffered completed stroke or transient ischemic attack and 330 healthy controls. ApoE genotypes were determined by restriction isotyping/MADGE analysis. Significant difference in apoE genotype frequencies between case and control group was observed (p<0.01). Patients affected by ischemic stroke had higher frequency of E4 allele and lower E2 allele than age-matched control subjects. Compared with persons without E4 allele, carriers of an E4 allele had 2.1 times higher risk of incident stroke. Our results indicate that the apoE gene polymorphism may be a risk factor for the development of ischemic cerebrovascular disease in Serbian population..

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Apolipoprotein E polymorphism in cerebrovascular disease

Acta Neurologica Scandinavica ◽

10.1034/j.1600-0404.2000.90308a.x ◽

2000 ◽

Vol 101 (6) ◽

pp. 399-404 ◽

Cited By ~ 40

Author(s):

A. J. Catto ◽

L. J. McCormack ◽

M. W. Mansfield ◽

A. M. Carter ◽

J. M. Bamford ◽

...

Keyword(s):

Cerebrovascular Disease ◽

Apolipoprotein E ◽

Apolipoprotein E Polymorphism

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Prevalence of apolipoprotein E phenotypes in ischemic cerebrovascular disease. A case-control study.

Stroke ◽

10.1161/01.str.24.5.661 ◽

1993 ◽

Vol 24 (5) ◽

pp. 661-664 ◽

Cited By ~ 94

Author(s):

R Couderc ◽

F Mahieux ◽

S Bailleul ◽

G Fenelon ◽

R Mary ◽

...

Keyword(s):

Cerebrovascular Disease ◽

Apolipoprotein E ◽

Case Control Study ◽

Case Control ◽

Ischemic Cerebrovascular Disease ◽

Control Study

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Platelet Hyperaggregability in Ischemic Cerebrovascular Disease and Effects of Aspirin

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657237 ◽

1982 ◽

Vol 48 (02) ◽

pp. 117-119 ◽

Cited By ~ 6

Author(s):

M Kusunoki ◽

K Kimura ◽

K Nagatsuka ◽

Y Isaka ◽

O Uyama ◽

...

Keyword(s):

Cerebrovascular Disease ◽

Venous Blood ◽

Second Phase ◽

Cerebral Angiogram ◽

Peripheral Venous Blood ◽

Chronic Stage ◽

Ischemic Cerebrovascular Disease ◽

Carotid Arterial ◽

Platelet Hyperaggregability ◽

The Brain

SummaryPlatelet aggregation was studied in 24 patients in the chronic stage of ischemic cerebrovascular disease (CVD), with cerebral affluent and effluent blood, i.e., carotid arterial and internal jugular venous blood, and also with peripheral venous blood. Aggregation tests were performed at various final concentrations of sodium arachidonate (A.A.) and ADP. In 17 patients, not taking aspirin, platelet aggregability in jugular venous blood was significantly accentuated compared with that in arterial and peripheral venous blood. This tendency was more marked in the patients with cerebral artery stenosis and/or occlusion than in those with normal cerebral angiogram. In 7 patients taking 500 mg or more oral aspirin, aggregation differences across the brain were not observed and A.A. aggregation and the second phase of ADP aggregation were completely suppressed. These results suggest that a prophylactic administration of aspirin may be beneficial for patients in chronic stage of CVD.

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