Analysis of Genetic Variability and Whole Genome Linkage of Whole-Brain, Subcortical, and Ependymal Hyperintense White Matter Volume

Background We know little about the pathogenesis and diagnosis of retinal detachment. Purpose To assess spontaneous changes in the cerebral cortex of patients with retinal detachment using voxel-based morphometry and to explore the relationship between retinal detachment and clinical behavioral performance. Material and Methods Patients (14 men, 6 women; average age = 49.15 ± 10.32 years) with rhegmatogenous retinal detachment (duration of 24.05 ± 19.61 days) and 20 matched healthy controls were recruited. All participants underwent repeated functional magnetic resonance imaging scans. The original three-dimensional T1 brain images were analyzed using voxel-based morphometry and whole brain white matter volume and whole brain gray matter volume were compared with those of the control group. A receiver operating characteristic (ROC) curve was used to classify the mean gray matter volume values of the patients with retinal detachment compared with the controls. Results Compared with the controls, whole brain gray matter volume was significantly reduced in patients with retinal detachment, as evidenced by changes in the right inferior frontal gyrus, right superior temporal gyrus, right anterior cingulate gyrus, and right cuneus. In addition, the posterior lobe of the cerebellum, left hippocampus, left cingulate gyrus, and left middle temporal gyrus were also obviously atrophied. Furthermore, whole brain white matter volume of the patients with retinal detachment showed a slight reduction. The ROC curve analysis of each brain region showed that the accuracy of the area under the curve was high. Conclusion We proved that patients with retinal detachment had unusual changes in the gray matter volume and white matter volume in vision-related brain regions, which could reveal potential pathological mechanisms of retinal detachment.

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P53 GENETIC VARIABILITY IS ASSOCIATED WITH FRONTAL WHITE MATTER VOLUME IN SCHIZOPHRENIC PATIENTS

Schizophrenia Research ◽

10.1016/j.schres.2010.02.855 ◽

2010 ◽

Vol 117 (2-3) ◽

pp. 458-459

Author(s):

Sergi Papiol ◽

Vicente Molina ◽

Javier Sanz ◽

Araceli Rosa ◽

Bárbara Arias ◽

...

Keyword(s):

White Matter ◽

Genetic Variability ◽

White Matter Volume ◽

Matter Volume ◽

Frontal White Matter ◽

Schizophrenic Patients

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Cardiovascular health in young adulthood and structural brain MRI in midlife

Neurology ◽

10.1212/wnl.0000000000004222 ◽

2017 ◽

Vol 89 (7) ◽

pp. 680-686 ◽

Cited By ~ 7

Author(s):

Michael P. Bancks ◽

Norrina B. Allen ◽

Prachi Dubey ◽

Lenore J. Launer ◽

Donald M. Lloyd-Jones ◽

...

Keyword(s):

White Matter ◽

Cardiovascular Health ◽

Brain Volume ◽

Brain Mri ◽

Average Score ◽

Confidence Limits ◽

White Matter Volume ◽

Whole Brain ◽

Matter Volume ◽

Additional Point

Objective:To examine the association between the American Heart Association (AHA) Life's Simple 7 (LS7) metric and brain structure.Methods:We determined cardiovascular health (CVH) according to the AHA LS7, assigning 0, 1, or 2 points for meeting poor, intermediate, or ideal criteria for the 7 components (range 0–14) at baseline (aged 18–30 years in 1985–1986) and year 25 follow-up examination for 518 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) brain MRI substudy. Visit-based CVH score and average score was assessed in relation to percent of intracranial volume of normal tissue of the whole brain, gray matter, and white matter, and abnormal tissue volume of white matter at year 25 using multivariable linear, logistic, and quantile regression, after adjustment for age, sex, race, field center, educational attainment, and alcohol consumption.Results:Mean percentage of whole brain volume, normal gray matter, and normal white matter was 81.3% (±2.5), 42.9% (±2.0), and 38.4% (±2.0). Greater CVH score at baseline (per each additional point at year 0: 0.1%, 95% confidence limits 0.01–0.3; p < 0.05) and average CVH score were associated with greater percentage of whole brain volume (per each additional point in average score: 0.2%, 95% confidence limits 0.04–0.3; p < 0.05). Visit-based or average CVH score was not significantly associated with normal gray or white matter volume or abnormal white matter volume.Conclusions:Maintaining ideal levels of cardiovascular health, determined by the LS7, in young adulthood is associated with greater whole brain volume in middle age but not regional differences in structure.

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Application of voxel-based morphometric measurement to brain magnetic resonance imaging in children with non-cyanotic congenital heart disease

10.21203/rs.2.19373/v1 ◽

2019 ◽

Author(s):

Xuan Jia ◽

XIAOHUI MA ◽

JIAWEI LIANG ◽

HAICHUN ZHOU

Keyword(s):

Magnetic Resonance Imaging ◽

White Matter ◽

Gray Matter ◽

Congenital Heart ◽

Healthy Controls ◽

White Matter Volume ◽

Resonance Imaging ◽

Whole Brain ◽

Matter Volume ◽

Central Gyrus

Abstract Background Congenital heart disease（CHD） is a cardiovascular malformation caused by abnormal heart and/or vascular development in the fetus. In children with CHD, abnormalities in the development and function of the nervous system are common. At present, there is a lack of research on the preoperative neurological development and injury of young children with non-cyanotic CHD. The objective of the current study is to determine the changes in white matter, gray matter, and cerebrospinal fluid (CSF) by magnetic resonance imaging (MRI) in children with noncyanotic CHD as compared with healthy controls. MethodsChildren diagnosed with non-cyanotic CHD on ultrasonography (n=54) and healthy control subjects (n=35) aged 1–3 years. Brain MRI was performed prior to surgery for CHD. The SPM v12 software was used to calculate the volumes of the gray matter, white matter, CSF, and the whole brain (sum of the gray-matter, white-matter, and CSF volumes). Volume differences between the two groups were analyzed. Voxelbased morphometry was used to compare specific brain regions with statistically significant atrophy.ResultsCompared with the control group, the study group had significantly reduced whole-brain white-matter volume (P<0.05), but similar whole-brain graymatter, CSF, and whole-brain volumes(P>0.05). As compared with the healthy controls, children with non-cyanotic CHD had mild atrophy in the white matter of the anterior central gyrus, the posterior central gyrus and the pulvinar. ConclusionsChildren with non-cyanotic CHD show decreased white-matter volume before surgery, and this volume reduction is mainly concentrated in the somatosensory and somatic motor nerve regions.

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Cerebral MR Morphometry and Neurodevelopmental Outcome in Children before Fontan Procedure at 2 Years of Age: White Matter Volume Is Smaller after Norwood Procedure

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0036-1571859 ◽

2016 ◽

Vol 64 (S 02) ◽

Author(s):

B. Reich ◽

W. Knirsch ◽

K. Mayer ◽

R. Tuura ◽

I. Scheer ◽

...

Keyword(s):

White Matter ◽

Fontan Procedure ◽

Neurodevelopmental Outcome ◽

Norwood Procedure ◽

White Matter Volume ◽

Matter Volume

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Preliminary Evidence for a Relationship between Elevated Plasma TNFα and Smaller Subcortical White Matter Volume in HCV Infection Irrespective of HIV or AUD Comorbidity

International Journal of Molecular Sciences ◽

10.3390/ijms22094953 ◽

2021 ◽

Vol 22 (9) ◽

pp. 4953

Author(s):

Natalie M. Zahr ◽

Kilian M. Pohl ◽

Allison J. Kwong ◽

Edith V. Sullivan ◽

Adolf Pfefferbaum

Keyword(s):

White Matter ◽

Proinflammatory Cytokines ◽

Soluble Protein ◽

Subcortical White Matter ◽

Control Group ◽

White Matter Volume ◽

Brain Volumes ◽

Protein Levels ◽

Matter Volume ◽

Patient Groups

Classical inflammation in response to bacterial, parasitic, or viral infections such as HIV includes local recruitment of neutrophils and macrophages and the production of proinflammatory cytokines and chemokines. Proposed biomarkers of organ integrity in Alcohol Use Disorders (AUD) include elevations in peripheral plasma levels of proinflammatory proteins. In testing this proposal, previous work included a group of human immunodeficiency virus (HIV)-infected individuals as positive controls and identified elevations in the soluble proteins TNFα and IP10; these cytokines were only elevated in AUD individuals seropositive for hepatitis C infection (HCV). The current observational, cross-sectional study evaluated whether higher levels of these proinflammatory cytokines would be associated with compromised brain integrity. Soluble protein levels were quantified in 86 healthy controls, 132 individuals with AUD, 54 individuals seropositive for HIV, and 49 individuals with AUD and HIV. Among the patient groups, HCV was present in 24 of the individuals with AUD, 13 individuals with HIV, and 20 of the individuals in the comorbid AUD and HIV group. Soluble protein levels were correlated to regional brain volumes as quantified with structural magnetic resonance imaging (MRI). In addition to higher levels of TNFα and IP10 in the 2 HIV groups and the HCV-seropositive AUD group, this study identified lower levels of IL1β in the 3 patient groups relative to the control group. Only TNFα, however, showed a relationship with brain integrity: in HCV or HIV infection, higher peripheral levels of TNFα correlated with smaller subcortical white matter volume. These preliminary results highlight the privileged status of TNFα on brain integrity in the context of infection.

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