scholarly journals Critical Appraisal on the Quality of Reporting on Safety and Efficacy of Transcarotid Artery Stenting With Flow Reversal

Stroke ◽  
2020 ◽  
Vol 51 (9) ◽  
pp. 2863-2871
Author(s):  
Andreia Coelho ◽  
Tossapol Prassaparo ◽  
Armando Mansilha ◽  
Jaap Kappelle ◽  
Ross Naylor ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Critical Appraisal ◽  
Current Evidence ◽  
Quality Of Reporting ◽  
Safety And Efficacy ◽  
Randomized Controlled ◽  
True Value ◽  
Randomized Controlled Studies ◽  
Periprocedural Stroke

Transcarotid revascularization is an alternative to transfemoral carotid artery stenting, designed to avoid aortic arch manipulation and concomitant periprocedural stroke. This article aims to perform a detailed analysis on the quality of the currently available evidence on safety and efficacy of transcarotid artery revascularization. Although current evidence is promising, independent randomized controlled studies comparing transcarotid artery revascularization with carotid endarterectomy in recently symptomatic patients are lacking and will be necessary to establish the true value of transcarotid artery revascularization in carotid artery revascularization.

A randomized controlled clinical trial to evaluate safety and efficacy of a Unani formulation in the management of Kalaf (Melasma)

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ifra Abdul Qaiyyum ◽  
Mohammad Nawab ◽  
Munawwar Husain Kazmi
Keyword(s):  
Quality Of Life ◽  
Test Group ◽  
Control Group ◽  
Safety And Efficacy ◽  
Randomized Controlled ◽  
End Point ◽  
Intergroup Comparison ◽  
And Control ◽  
Change In Mean

Abstract Objectives Kalaf (Melasma) is an acquired facial hypermelanism. It has direct impact on patient’s quality of life and leads to development of various personality disorders. Lack of effective treatment and recurrences have drawn the attention of researcher to find alternative treatment. This study aimed to evaluate safety and efficacy of a topical Unani formulation in the management of melasma. Methods We conducted a prospective randomized controlled clinical study on the participants diagnosed with melasma. The participants (n=72) randomized into test (n=36) and control (n=36) groups. Sixty participants (n=30 in each group) completed the duration of therapy. The participants of the test group were treated with a classical Unani formulation and control group with hydroquinone 4%. The primary end point was change in mean MASI score and secondary end point was improvement in quality of life after eight weeks of treatment. Results The Unani formulation reduced 40.5% mean MASI score (17.31 ± 9.58 to 10.28 ± 5.92) in comparison to 32% reduction in mean MASI score (20.58 ± 9.49 to 13.92 ± 7.38) in the control group after eight weeks of treatment. When comparing with baseline the difference in MASI score was found statistically significant in both groups (p<0.05). On intergroup comparison, the change in MASI score between both groups was not statistically significant (p>0.05). In addition, MQOL and DQLI also improved significantly in both groups. Conclusions This study concluded that the Unani formulation and the control drug were equally effective and safer in the management of melasma.

Quality of reporting in randomized controlled trials of therapeutic cardiovascular medical devices

Surgery ◽  
2019 ◽  
Vol 165 (5) ◽  
pp. 965-969 ◽  
Author(s):  
Wenwen Chen ◽  
Jiajie Yu ◽  
Longhao Zhang ◽  
Guanyue Su ◽  
Wen Wang ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Medical Devices ◽  
Controlled Trials ◽  
Quality Of Reporting ◽  
Randomized Controlled

Quality of reporting of randomized controlled trials published in Intensive Care Medicine from 2001 to 2010

2013 ◽  
Vol 39 (8) ◽  
pp. 1386-1395 ◽  
Author(s):  
Nicola Latronico ◽  
Marta Metelli ◽  
Maddalena Turin ◽  
Simone Piva ◽  
Frank A. Rasulo ◽  
...  
Keyword(s):  
Intensive Care ◽  
Randomized Controlled Trials ◽  
Intensive Care Medicine ◽  
Controlled Trials ◽  
Quality Of Reporting ◽  
Randomized Controlled

scholarly journals Patient-controlled epidural analgesia for labor – a step forward in Ukrainian obstetrics

Pain medicine ◽  
2019 ◽  
Vol 4 (3) ◽  
pp. 67-70
Author(s):  
Yevhenii Grizhimalsky ◽  
Andrii Harha
Keyword(s):  
Patient Satisfaction ◽  
Pain Relief ◽  
Epidural Analgesia ◽  
Local Anesthetics ◽  
Gold Standard ◽  
Severe Pain ◽  
Labour Pain ◽  
Randomized Controlled ◽  
Randomized Controlled Studies

Labour pain is recognized by some women as the most severe pain that they have ever felt in their life. Epidural analgesia is an effective method of pain relief in labour and is considered as the gold standard of analgesia for delivery. Traditionally, epidural analgesia in Ukraine is performed without the ability for the patient to control the process of anesthesia. The authors became interested in the delivery of local anesthetics by patient­controlled epidural analgesia instead of the traditional physician methods. In randomized controlled studies there is an evidence that the PCEA method tends to improve the quality of pain relief and increase the patient satisfaction.

scholarly journals Assessing the quality of reporting of harms in randomized controlled trials published in high impact cardiovascular journals

2019 ◽  
Vol 6 (2) ◽  
pp. 177-179
Author(s):  
Muhammad Shahzeb Khan ◽  
Rohan Kumar Ochani ◽  
Asim Shaikh ◽  
Muthiah Vaduganathan ◽  
Safi U Khan ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
High Impact ◽  
Controlled Trials ◽  
Quality Of Reporting ◽  
Randomized Controlled

scholarly journals A New Curcuma Extract (Flexofytol®) in Osteoarthritis: Results from a Belgian Real-Life Experience

2014 ◽  
Vol 8 (1) ◽  
pp. 77-81 ◽  
Author(s):  
Thierry Appelboom ◽  
Nathalie Maes ◽  
Adelin Albert
Keyword(s):  
Quality Of Life ◽  
Patient Satisfaction ◽  
Observational Study ◽  
Life Experience ◽  
Real Life ◽  
Randomized Controlled ◽  
Randomized Controlled Studies ◽  
Patient Pain ◽  
Inflammatory Drugs

This retrospective observational study summarizes the experiences of 820 patients treated with a new Curcuma extract (Flexofytol®, 4-6 capsules per day), for more than 6 months for various forms of painful osteoarthritis. These experiences were reported by 110 Belgian general practitioners via a questionnaire that included quality-of-life parameters for assessing patient experience. Data were submitted to an independent statistician for analysis. Within the first 6 weeks, Flexofytol® improved patient pain, articular mobility, and quality of life. Excellent tolerance was reported, and more than half of these patients were able to discontinue analgaesic and anti-inflammatory drugs. Patient satisfaction was confirmed by their decision to maintain Flexofytol® therapy for more than 6 months. These data must be confirmed with randomized controlled studies. We currently conclude that Flexofytol® which is based on a new preparation of curcumin, is as a potential neutraceutical for the care of patients complaining of joint problems, with excellent tolerance and rapid benefits for articular mobility, pain, and quality of life.

scholarly journals Quality of reporting randomized controlled trials (RCTs) in diabetes in Iran; a systematic review

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Faeze Gohari ◽  
Hamid Reza Baradaran ◽  
Morteza Tabatabaee ◽  
Shabnam Anijidani ◽  
Fatemeh Mohammadpour Touserkani ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Controlled Trials ◽  
Quality Of Reporting ◽  
Randomized Controlled

Reporting of Randomized Controlled Trials in Cleft Lip and Palate: A 10-Year Review

2017 ◽  
Vol 54 (2) ◽  
pp. 142-152 ◽  
Author(s):  
Joseph Hardwicke ◽  
Mohammad Nassimizadeh ◽  
Bruce Richard
Keyword(s):  
Randomized Controlled Trials ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Journal Article ◽  
Controlled Trials ◽  
Jadad Score ◽  
Quality Of Reporting ◽  
Randomized Controlled ◽  
The Mean

Objectives Reviews of the quality of reporting of randomized controlled trials (RCTs) have recently been conducted in different surgical specialties. In this review of RCTs relating to cleft lip, cleft palate, and cleft lip and palate (CL/P), we investigate the quality of reporting against the Consolidated Standards of Reporting Trials (CONSORT) checklist. Design A systematic review of CL/P RCTs published from 2004 to 2013, with the included articles scored against the CONSORT checklist. Patients, Participants The literature search identified 174 articles. Studies were selected for participants with CL/P who were involved in an RCT with prospective data collection and reported in a full journal article. A total of 6352 participants were included from 65 CUP RCTs during the study period. Main Outcome Measures The methodological quality of RCTs was assessed using the CONSORT checklist and Jadad scale. Results The mean CONSORT score was 15.8, and the mean Jadad score was 3.3. There was a significant positive correlation between the CONSORT and Jadad score ( P < .0001, ρ = .47). The only significant correlation showed that with an increasing number of authors, both the CONSORT and the Jadad score increased. Conclusion This analysis has shown that that there are deficiencies in the transparent reporting of factors such as randomization implementation, blinding, and participant flow. Interventions, outcomes, and the interpretation of results are well presented. We would recommend that RCTs are conceived and undertaken using the CONSORT checklist and reported in a clear and reproducible manner.

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