Forming Tool Use Representations: A Neurophysiological Investigation into Tool Exposure

2011 ◽  
Vol 23 (10) ◽  
pp. 2920-2934 ◽  
Author(s):  
John Christopher Mizelle ◽  
Teresa Tang ◽  
Nikta Pirouz ◽  
Lewis A. Wheaton
Keyword(s):  
Learning Strategies ◽  
Tool Use ◽  
Motor Planning ◽  
Hemispheric Dominance ◽  
Neural Activation ◽  
The Novel ◽  
Beta Band ◽  
Related Information ◽  
Direct Exposure ◽  
Indirect Exposure

Prior work has identified a common left parietofrontal network for storage of tool-related information for various tasks. How these representations become established within this network on the basis of different modes of exposure is unclear. Here, healthy subjects engaged in physical practice (direct exposure) with familiar and unfamiliar tools. A separate group of subjects engaged in video-based observation (indirect exposure) of the same tools to understand how these learning strategies create representations. To assess neural mechanisms engaged for pantomime after different modes of exposure, a pantomime task was performed for both tools while recording neural activation with high-density EEG. Motor planning–related neural activation was evaluated using beta band (13–22 Hz) event-related desynchronization. Hemispheric dominance was assessed, and activation maps were generated to understand topography of activations. Comparison of conditions (effects of tool familiarity and tool exposure) was performed with standardized low-resolution brain electromagnetic tomography. Novel tool pantomime following direct exposure resulted in greater activations of bilateral parietofrontal regions. Activations following indirect training varied by tool familiarity; pantomime of the familiar tool showed greater activations in left parietofrontal areas, whereas the novel tool showed greater activations at right temporoparieto-occipital areas. These findings have relevance to the mechanisms for understanding motor-related behaviors involved in new tools that we have little or no experience with and can extend into advancing theories of tool use motor learning.

scholarly journals Beta-band desynchronization reflects uncertainty in effector selection during motor planning

2021 ◽  
Author(s):  
Milou J.L. van Helvert ◽  
Leonie Oostwoud Wijdenes ◽  
Linda Geerligs ◽  
W. Pieter Medendorp
Keyword(s):  
Time Window ◽  
Brain Activity ◽  
Motor Planning ◽  
Reaction Times ◽  
Motor Preparation ◽  
Motion Artifact ◽  
Theta Band ◽  
Beta Band ◽  
Target Uncertainty ◽  
Band Power

AbstractWhile beta-band activity during motor planning is known to be modulated by uncertainty about where to act, less is known about its modulations to uncertainty about how to act. To investigate this issue, we recorded oscillatory brain activity with EEG while human participants (n = 17) performed a hand choice reaching task. The reaching hand was either predetermined or of participants’ choice, and the target was close to one of the two hands or at about equal distance from both. To measure neural activity in a motion-artifact-free time window, the location of the upcoming target was cued 1000-1500 ms before the presentation of the target, whereby the cue was valid in 50% of trials. As evidence for motor planning during the cueing phase, behavioral observations showed that the cue affected later hand choice. Furthermore, reaction times were longer in the choice than in the predetermined trials, supporting the notion of a competitive process for hand selection. Modulations of beta-band power over central cortical regions, but not alpha-band or theta-band power, were in line with these observations. During the cueing period, reaches in predetermined trials were preceded by larger decreases in beta-band power than reaches in choice trials. Cue direction did not affect reaction times or beta-band power, which may be due to the cue being invalid in 50% of trials, retaining effector uncertainty during motor planning. Our findings suggest that effector uncertainty, similar to target uncertainty, selectively modulates beta-band power during motor planning.New & NoteworthyWhile reach-related beta-band power in central cortical areas is known to modulate with the number of potential targets, here we show, using a cueing paradigm, that the power in this frequency band, but not in the alpha or theta-band, is also modulated by the uncertainty of which hand to use. This finding supports the notion that multiple possible effector-specific actions can be specified in parallel up to the level of motor preparation.

Schema cells in the macaque hippocampus

Science ◽  
2019 ◽  
Vol 363 (6427) ◽  
pp. 635-639 ◽  
Author(s):  
P. Baraduc ◽  
J.-R. Duhamel ◽  
S. Wirth
Keyword(s):  
The Novel ◽  
Spatial Concepts ◽  
Surface Features ◽  
Related Information ◽  
Human Hippocampus ◽  
Virtual Maze ◽  
And Task ◽  
Conceptual Schemas

Concept cells in the human hippocampus encode the meaning conveyed by stimuli over their perceptual aspects. Here we investigate whether analogous cells in the macaque can form conceptual schemas of spatial environments. Each day, monkeys were presented with a familiar and a novel virtual maze, sharing a common schema but differing by surface features (landmarks). In both environments, animals searched for a hidden reward goal only defined in relation to landmarks. With learning, many neurons developed a firing map integrating goal-centered and task-related information of the novel maze that matched that for the familiar maze. Thus, these hippocampal cells abstract the spatial concepts from the superficial details of the environment and encode space into a schema-like representation.

scholarly journals Cascading Forgetting in Product Development Challenges and Evaluation

2019 ◽  
Vol 1 (1) ◽  
pp. 2527-2536
Author(s):  
Patricia Kügler ◽  
Claudia Schon ◽  
Benjamin Schleich ◽  
Steffen Staab ◽  
Sandro Wartzack
Keyword(s):  
Product Design ◽  
Information Overload ◽  
Relevant Information ◽  
Knowledge Bases ◽  
Wear Behaviour ◽  
Combustion Engines ◽  
The Novel ◽  
Related Information ◽  
Intentional Forgetting ◽  
Novel Approach

AbstractVast amounts of information and knowledge is produced and stored within product design projects. Especially for reuse and adaptation there exists no suitable method for product designers to handle this information overload. Due to this, the selection of relevant information in a specific development situation is time-consuming and inefficient. To tackle this issue, the novel approach Intentional Forgetting (IF) is applied for product design, which aims to support reuse and adaptation by reducing the vast amount of information to the relevant. Within this contribution an IF-operator called Cascading Forgetting is introduced and evaluated, which was implemented for forgetting related information elements in ontology knowledge bases. For the evaluation the development process of a test-rig for studying friction and wear behaviour of the cam/tappet contact in combustion engines is analysed. Due to the interdisciplinary task of the evaluation and the characteristics of semantic model, challenges are discussed. In conclusion, the focus of the evaluation is to consider how reliable the Cascading Forgetting works and how intuitive ontology-based representations appear to engineers.

Exposure to genocide and the risk of schizophrenia: a population-based study

2015 ◽  
Vol 46 (4) ◽  
pp. 855-863 ◽  
Author(s):  
S. Z. Levine ◽  
I. Levav ◽  
Y. Goldberg ◽  
I. Pugachova ◽  
Y. Becher ◽  
...  
Keyword(s):  
Cox Regression ◽  
Population Based ◽  
In Utero ◽  
Sensitivity Analyses ◽  
Critical Periods ◽  
Population Based Study ◽  
Regression Modelling ◽  
Direct Exposure ◽  
The Holocaust ◽  
Indirect Exposure

BackgroundNo evidence exists on the association between genocide and the incidence of schizophrenia. This study aims to identify critical periods of exposure to genocide on the risk of schizophrenia.MethodThis population-based study comprised of all subjects born in European nations where the Holocaust occurred from 1928 to 1945, who immigrated to Israel by 1965 and were indexed in the Population Register (N = 113 932). Subjects were followed for schizophrenia disorder in the National Psychiatric Case Registry from 1950 to 2014. The population was disaggregated to compare groups that immigrated before (indirect exposure: n = 8886, 7.8%) or after (direct exposure: n = 105 046, 92.2%) the Nazi or fascist era of persecutions began. The latter group was further disaggregated to examine likely initial prenatal or postnatal genocide exposures. Cox regression modelling was computed to compare the risk of schizophrenia between the groups, adjusting for confounders.ResultsThe likely direct group was at a statistically (p < 0.05) greater risk of schizophrenia (hazard ratio = 1.27, 95% confidence interval 1.06–1.51) than the indirect group. Also, the likely combined in utero and postnatal, and late postnatal (over age 2 years) exposure subgroups were statistically at greater risk of schizophrenia than the indirect group (p < 0.05). The likely in utero only and early postnatal (up to age 2 years) exposure subgroups compared with the indirect exposure group did not significantly differ. These results were replicated across three sensitivity analyses.ConclusionsThis study showed that genocide exposure elevated the risk of schizophrenia, and identified in utero and postnatal (combined) and late postnatal (age over 2 years) exposures as critical periods of risk.

scholarly journals Repetita iuvant: repetition facilitates online planning of sequential movements

2020 ◽  
Vol 123 (5) ◽  
pp. 1727-1738 ◽  
Author(s):  
Giacomo Ariani ◽  
Young Han Kwon ◽  
Jörn Diedrichsen
Keyword(s):  
Motor Skills ◽  
Motor Planning ◽  
The Novel ◽  
Repetition Effects ◽  
Movement Experience ◽  
Reaching Movement ◽  
Sequential Movements ◽  
Online Planning ◽  
Actual Movement ◽  
Sequence Elements

Even for overlearned motor skills such as reaching, movement repetition improves performance. How brain processes associated with motor planning or execution benefit from repetition, however, remains unclear. We report the novel finding of repetition effects for sequential movements. Our results show that repetition benefits are tied to improved online planning of upcoming sequence elements. We also highlight how actual movement experience appears to be more beneficial than mental rehearsal for observing short-term repetition effects.

scholarly journals Beta-Band Activity during Motor Planning Reflects Response Uncertainty

2010 ◽  
Vol 30 (34) ◽  
pp. 11270-11277 ◽  
Author(s):  
C. Tzagarakis ◽  
N. F. Ince ◽  
A. C. Leuthold ◽  
G. Pellizzer
Keyword(s):  
Motor Planning ◽  
Response Uncertainty ◽  
Beta Band ◽  
Band Activity

scholarly journals Atypical Hemispheric Dominance for Attention: Functional MRI Topography

2005 ◽  
Vol 25 (9) ◽  
pp. 1197-1208 ◽  
Author(s):  
Agnes Flöel ◽  
Andreas Jansen ◽  
Michael Deppe ◽  
Martin Kanowski ◽  
Carsten Konrad ◽  
...  
Keyword(s):  
Spatial Attention ◽  
Right Hemisphere ◽  
Regional Distribution ◽  
Visuospatial Attention ◽  
Hemispheric Dominance ◽  
Neural Activation ◽  
Brain Organization ◽  
Attention Task ◽  
Control Subjects ◽  
The Right

The right hemisphere is predominantly involved in tasks associated with spatial attention. However, left hemispheric dominance for spatial attention can be found in healthy individuals, and both spatial attention and language can be lateralized to the same hemisphere. Little is known about the underlying regional distribution of neural activation in these ‘atypical’ individuals. Previously a large number of healthy subjects were screened for hemispheric dominance of visuospatial attention and language, using functional Doppler ultrasonography. From this group, subjects were chosen who were ‘atypical’ for hemispheric dominance of visuospatial attention and language, and their pattern of brain activation was studied with functional magnetic resonance imaging during a task probing spatial attention. Right-handed subjects with the ‘typical’ pattern of brain organization served as control subjects. It was found that subjects with an inverted lateralization of language and spatial attention (language right, attention left) recruited left-hemispheric areas in the attention task, homotopic to those recruited by control subjects in the right hemisphere. Subjects with lateralization of both language and attention to the right hemisphere activated an attentional network in the right hemisphere that was comparable to control subjects. The present findings suggest that not the hemispheric side, but the intrahemispheric pattern of activation is the distinct feature for the neural processes underlying language and attention.

scholarly journals An Overview of Novel Corona Virus 2019-nCoV and Their Clinical and Immune Responses

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 62-67 ◽  
Author(s):  
Sheetal Devi ◽  
Manish Kumar ◽  
Prabhat Kumar Upadhyay ◽  
Anuj Malik ◽  
Beena Kumari ◽  
...  
Keyword(s):  
Drug Testing ◽  
World Health ◽  
The Novel ◽  
Viral Shedding ◽  
Corona Virus ◽  
Direct Exposure ◽  
Novel Virus ◽  
Polymerase Chain ◽  
Tomography Scan

The novel virus such as corona virus 2019 is the main cause of the disease that is declared by the WHO (World Health Origination). Some other virus similar to this virus were also discovered in initial year of 21th century such as SARS-CoV in 2003, HCoV NL63 in 2004, HKU1 in 2005, MERS-CoV in 2012, and SARS-CoV-2 in 2019. The first few cases of covid-19 were detected from direct contact to the infected animal to human which is also called as animal to human transmission. Due to direct exposure of this virus to infected animals the human to human transmission of the virus is as well possible, which is also likely to be consider and measured as core form of transmission. According to the reports of WHO by 26 February 2020, patients suffering from COVID-19 reduced gradually in China but rapidly increased in countries like Italy, Iran and South Korea. The infection caused by the COVID 19 is detected by looking at the symptoms and it ultimately confirmed by the reverse transcription polymerase chain reaction (rRT-PCR) of infected secretions with 71% sensitivity and computed tomography scan with 98%.  The antimalarial medicate, hydroxychloroquine, is authorized for the chemoprophylaxis and treatment of intestinal sickness and as a disease changing antirheumatic drugs. Pharmacological demonstrating dependent on observed drug absorptions and in vitro drug testing propose that prophylaxis with hydroxychloroquine at affirmed portions could anticipate SARS-CoV-2 contamination and improve viral shedding. Clinical preliminaries of hydroxychloroquine treatment for COVID-19 pneumonia are in progress in China (NCT04261517 and NCT04307693).

An Overview of Novel Corona Virus 2019-nCoV and Their Clinical and Immune Responses

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 62-67
Author(s):  
Sheetal Devi ◽  
Manish Kumar ◽  
Prabhat Kumar Upadhyay ◽  
Anuj Malik ◽  
Beena Kumari ◽  
...  
Keyword(s):  
Drug Testing ◽  
World Health ◽  
The Novel ◽  
Viral Shedding ◽  
Corona Virus ◽  
Direct Exposure ◽  
Novel Virus ◽  
Polymerase Chain ◽  
Tomography Scan

The novel virus such as corona virus 2019 is the main cause of the disease that is declared by the WHO (World Health Origination). Some other virus similar to this virus were also discovered in initial year of 21th century such as SARS-CoV in 2003, HCoV NL63 in 2004, HKU1 in 2005, MERS-CoV in 2012, and SARS-CoV-2 in 2019. The first few cases of covid-19 were detected from direct contact to the infected animal to human which is also called as animal to human transmission. Due to direct exposure of this virus to infected animals the human to human transmission of the virus is as well possible, which is also likely to be consider and measured as core form of transmission. According to the reports of WHO by 26 February 2020, patients suffering from COVID-19 reduced gradually in China but rapidly increased in countries like Italy, Iran and South Korea. The infection caused by the COVID 19 is detected by looking at the symptoms and it ultimately confirmed by the reverse transcription polymerase chain reaction (rRT-PCR) of infected secretions with 71% sensitivity and computed tomography scan with 98%.  The antimalarial medicate, hydroxychloroquine, is authorized for the chemoprophylaxis and treatment of intestinal sickness and as a disease changing antirheumatic drugs. Pharmacological demonstrating dependent on observed drug absorptions and in vitro drug testing propose that prophylaxis with hydroxychloroquine at affirmed portions could anticipate SARS-CoV-2 contamination and improve viral shedding. Clinical preliminaries of hydroxychloroquine treatment for COVID-19 pneumonia are in progress in China (NCT04261517 and NCT04307693).

Sign in / Sign up

Export Citation Format

Share Document