Development of the Hybrid Rule and the Concept of Justice: The Selection of Subjects in Biomedical Research

2019 ◽  
Vol 27 (6) ◽  
pp. 891-924
Author(s):  
Yoshio Nukaga

As biomedical research with volunteers was expanded in the United States, the rule of subject selection, constituting scientific and ethical criteria, was generated in 1981 to resolve selection bias in research. Few historical studies, however, have investigated the role of this new hybrid rule in institutional review systems. This paper describes how bioethics commissions and federal agencies have created the subject selection rule based on the concept of justice. I argue that the standardization of this rule as temporal measures, linked with risk-benefit assessment, has reformed the review mechanism, specifically investigators’ modification of research plans, thereby developing justice as balancing.


2006 ◽  
Vol 84 (1) ◽  
pp. 49-59 ◽  
Author(s):  
Aaron Y. Lai ◽  
Kathryn G. Todd

The precise role of microglia in stroke and cerebral ischemia has been the subject of debate for a number of years. Microglia are capable of synthesizing numerous soluble and membrane-bound biomolecules, some known to be neuroprotective, some neurotoxic, whereas others have less definitive bioactivities. The molecular mechanisms through which microglia activate these molecules have thus become an important area of ischemia research. Here we provide a survey review that summarizes the key actions of microglial factors in cerebral ischemia including complement proteins, chemokines, pro-inflammatory cytokines, neurotrophic factors, hormones, and proteinases, as well several important messenger molecules that play a part in how these factors respond to extracellular signals during ischemic injuries. We also provide some new perspectives on how microglial intracellular signaling may contribute to the seemingly contradictory roles of several microglial effector molecules.



2016 ◽  
Vol 22 (2) ◽  
pp. 135-140
Author(s):  
Aneta Grodzicka ◽  
Jan Szlązak

Abstract The authors of the current study undertook the subject of the analysis features of the mining rescuer as a member of the ranks of the rescue, with particular emphasis on the following parameters: heart rate, body weight, height, BMI, age and seniority in the mining and rescue. This publication concerns the analysis of the test results of these characteristics rescuer as a potential member of the ranks of the rescue, taking into account its risk appetite, stress resistance, attitude towards life, the role of the team, teamwork, attitude to work, motivation to work and physical fitness.



The Introduction provides an overview of the central questions and the theoretical framework of the book. Since the early 1990s in Europe and the United States many artists critically re-appropriated religious, motifs, themes and images to produce works that cannot qualify as ‘religious,’ but remains in a dialogue with the visual legacy of mostly the Western, and more specifically the Catholic, version of Christianity. Present-day art does not embed religious images to celebrate them, but in order to pose critical questions concerning central aspects of the rules that regulate the status of images, their public significance, the conditions of their production and authorship, and their connection to an origin or tradition, a context or an author that guarantees their value. The motif of the true image or acheiropoietos (not made by a human hand) is related to central set of features that allow distinguishing between regimes or eras of the image. Its transformations provide a conceptual matrix for understanding of the reconfiguring relationships between art and religion. The introduction provides an overview of the theoretical context, the selection of artworks, bibliography on the subject and the chapters of the book.



Author(s):  
Arthur L. Frank

This chapter considers the role and value of the study of the humanities in medical education. Most authors on this subject believe the study of the humanities results in a better physician. However, few papers document this almost universally accepted idea. This chapter cites the available literature on the subject and also considers how the study of the humanities has become more common in countries beyond the United States. The study of the humanities is thought to improve physician communication and to influence ethical behaviors, ultimately improving patient care.



Author(s):  
P. J. Hayward ◽  
Paul H. Harvey

The spatial settlement of marine invertebrate larvae is not a random process. The distribution of the adults of a particular species is influenced by the behavioural responses of the animal to a range of environmental stimuli which, in the case of many sessile invertebrates, result in the display of clear substrate selection. The role of habitat selection in determining the distribution of aquatic invertebrates has been the subject of a review by Meadows & Campbell (1972). The selection of algal substrata by the larvae of various intertidal species of Bryozoa has been demonstrated by Ryland (1959); among these, the ctenostomatous bryozoans Alcyonidium hirsutum and A. polyoum were shown to exhibit a strong preference for fronds of the alga Fucus serratus, an experi-mental result which accorded well with the distribution of the two species on the shore (Ryland, 1962).



2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Sandhya Ravikumar ◽  
John Ross Crawford

We describe the clinical presentation and clinical course of subacute sclerosing panencephalitis in a 13-year-old previously healthy boy who recently immigrated to the United States from Iraq. He presented with macular retinopathy, followed by progressive myoclonus and encephalopathy. After extensive workup, a diagnosis of subacute sclerosing panencephalitis was suspected by the presence of period epileptiform discharges on electroencephalogram and confirmed by elevated measles titers in the cerebrospinal fluid. Combination immunomodulatory therapy with isoprinosine, ribavirin, and intra-Ommaya interferon alpha did not result in clinical improvement. Within days following the administration of carbamazepine, there was remarkable improvement in the myoclonus and he was able to ambulate independently for a period of 4 months at which time he unfortunately progressed to a vegetative state. This case highlights the importance of carbamazepine as a potential first line symptomatic treatment of subacute sclerosing panencephalitis and provides a review of the literature on the subject.



2002 ◽  
Vol 35 (4) ◽  
pp. 811-833 ◽  
Author(s):  
Roy B. Flemming ◽  
Glen S. Krutz

The expanding public policy role of high courts heightens concerns over whether societal and political inequalities affect the outcomes of litigation. However, comparative research on this question is limited. This article assesses whether status inequalities between parties and differences in the experience and resources of attorneys influence the selection of cases for judicial review in the Supreme Court of Canada. A series of statistical models reveal that governments are more likely than other parties to influence whether leave is granted but that the experience and resources of lawyers, unlike in the United States, have little impact. The decentralized, low volume and high access features of the Canadian process may explain this finding.



Author(s):  
John Charlot

That the Mexican mural renaissance is understudied is clear from the fact than not one of its artists has been the subject of a scholarly biography. Moreover, the movement as a whole has usually been viewed through nationalist prejudices and partisan interpretations. A current reevaluation uses the wedge of several hitherto marginalized artists who figure more prominently in documents and chronology than in popular history. Among them, Jean Charlot can be placed securely at the beginning of several major developments, which were continuations of his work in France. At the open air art school of Coyoacán, he helped the young teachers move from impressionism to a geometry-based postimpressionism more appropriate for mural composition. He introduced woodcut, which he had practiced in France and which became the print medium of choice for generations of Mexican artists. His first mural, The Massacre in the Main Temple, was important for its successful use of fresco—immediately adopted as the preferred medium by other muralists—and its dynamic geometric composition, an alternative to Diego Rivera’s static classicism in Creation. Charlot further broadened the thematic and stylistic options of the movement in a series of small oils and in the first studies of the indigenous nude. He continued to nourish his colleagues with the results of his work as an archeological draughtsman at the Chichen Itza expedition of the Carnegie Institution of Washington, DC. Charlot also participated in the notable collaboration between artists and writers in 1920s Mexico. Along with Manuel Maples Arce, he was on the two-man Direction Committee of the estridentista movement, illustrating books of poetry and joining group exhibitions. His writings are among the earliest discussions of contemporary Mexican art—publicizing the movement in Europe and the United States—and continue to influence interpretation today. His collections of documents and interviews, as well as his personal experience, became the invaluable basis of books like his The Mexican Mural Renaissance, 1920–1925 and numerous articles in several languages. His latest bibliography is 173 pages long. Charlot fulfilled the unique role of insider-outsider, participant-observer, in the Mexican mural renaissance.



Author(s):  
Charles O. Jones

The creative work involved in writing the Constitution of the United States in Philadelphia in 1787 has been interpreted and analysed in political and policy debate ever since. ‘Inventing the Presidency’ considers how the Founders of the United States tried to create unity in a separated system. Why was the title of president selected? What was the role of president going to look like? How long should the single executive serve? Should the person be term-limited? Providing a legislative or law-making role for the president was the subject of considerable debate at the beginning. Inventors solve problems: they tinker until they have a workable device. The creation of the presidency was a process of trial and error.



1950 ◽  
Vol 3 (1) ◽  
pp. 72-87
Author(s):  
Janet Besse ◽  
Harold D. Lasswell

Opinion differs about the role of syndicated columnists in the forming of national opinion and in the decision-making process in the United States. Our columnists have been the subject of pioneering studies, but we have a long way to go before the picture can be called historically complete, scientifically precise, or fully satisfactory for policy-making purposes. What the columnists say is an important chapter in the history of the American public, and history is most useful for critical purposes when written close to the event. The general theory of communication and politics can be refined as the details of the opinion process are more fully known.



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