The Respiratory Disease Portal At The Rat Genome Database: A Genomic Resource For Asthma, COPD, And Other Respiratory Diseases

2012 ◽  
Author(s):  
Melinda Dwinell ◽  
Stan Laulederkind ◽  
Tom Hayman ◽  
Timothy Lowry ◽  
Rajni Nigam ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Respiratory Diseases ◽  
Genome Database ◽  
Genomic Resource ◽  
Rat Genome

Therapeutic role of vegetables in Respiratory Diseases – A critical review from Ayurvedic classics.

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Dr. Raghavendra Naik ◽  
Shweta Vekariya ◽  
R. N. Acharya ◽  
Sneha D. Borkar
Keyword(s):  
Clinical Practice ◽  
Respiratory Disease ◽  
Respiratory System ◽  
Critical Review ◽  
Critical Analysis ◽  
Respiratory Diseases ◽  
Unique Contribution ◽  
Pharmacological Activities ◽  
The Family

The concept of Pathya (wholesome diet) is an unique contribution of Ayurveda, which plays an important role in prevention and management of many diseases. “Shakavarga”, a category under dietetics in classical texts of Ayurveda enlisted different vegetables with their properties and indications in different disease conditions. These vegetables can be prescribed as Pathya (wholesome diet) in clinical practice. In the present review, plants described under Shakavarga, indicated as Pathya in different diseases related to Pranavaha Srotas (Respiratory system) were compiled from 15 different Ayurvedic classical texts. Critical analysis of the compiled data reveals that out of 332 vegetables described under Shakavarga, 44 are indicated in respiratory disease like Shvasa (Dyspnoea/Asthma), Kasa (Cough), Peenasa (Chronic rhinitis) and Hikka (Hiccup). Among them, botanical identity of 42 classical plants has been established and maximum number of vegetables belongs to the family cucurbitaceae (10) followed by solanaceae (4). Some of these vegetables have been reported for their various pharmacological activities related to prevention and management of diseases related to Pranavaha Srotas (Respiratory system). These vegetables are reported for their anti-inflammatory (16), antioxidant (14), anti-allergic (6) and antitussive (3) activities. The observed result may be helpful in use of vegetables as Pathya (wholesome diet) and planning further scientific studies about the efficacy of these plants on prevention as well as management of respiratory diseases.

Efficacy, Mechanism, and Safety of Herbal Medicine for Respiratory Disease Induced by Particulate Matter: a Protocol for a Scoping Review

2021 ◽  
Author(s):  
Jungtae Leem ◽  
Yohwan Kim ◽  
Kwan-Il Kim
Keyword(s):  
Particulate Matter ◽  
Animal Models ◽  
Respiratory Disease ◽  
Scoping Review ◽  
Respiratory Diseases ◽  
English Language ◽  
Herbal Medicines ◽  
Cochrane Central Register

Abstract Background: Particulate matter (PM) is an important environmental risk factor in the initiation and exacerbation of respiratory disease. Various herbal medicines have exhibited a reduction in symptoms of respiratory diseases induced by PM in animal models; however, their efficacy, mechanism, and safety have not been reviewed. This review will evaluate the efficacy, safety, and mechanism of action of herbal medicines in respiratory diseases caused by PM. Methods:We will follow the scoping review framework developed by Arksey and O’Malley. MEDLINE (via PubMed), EMBASE, and the Cochrane Central Register of Controlled Trials will be searched for relevant English-language publications, and only peer-reviewed, controlled comparative in-vivo/in-vitro studies examining the effects of herbs in animal models of respiratory disease induced by PM will be included. The basic characteristics, research method, possible mechanism, and results will be extracted. The primary outcome will be pulmonary function; secondary outcomes will be inflammatory markers, reactive oxygen species, histology and mechanisms, and adverse events. Two researchers will independently perform the study selection, data extraction, and quality assessment. RevMan software (version 5.3) will be used for the quantitative data synthesis. When appropriate, data will be pooled for meta-analysis using fixed or random effects models; otherwise, evidence will be summarized qualitatively. Ethics and Dissemination: Ethical approval is not required because individual patient data will not be included. The findings will be disseminated through peer-reviewed publications or conference presentations.Registration number: This review protocol has been registered with the Open Science Framework on February 12, 2021 (https://osf.io/s7uvk/)

scholarly journals Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease

Marine Drugs ◽  
2020 ◽  
Vol 18 (11) ◽  
pp. 570
Author(s):  
Kate Summer ◽  
Jessica Browne ◽  
Lei Liu ◽  
Kirsten Benkendorff
Keyword(s):  
Respiratory Disease ◽  
Respiratory Diseases ◽  
Research Priorities ◽  
Evidence Base ◽  
Chemotherapeutic Agents ◽  
Biofilm Inhibition ◽  
Traditional Medicines ◽  
Chemical Structures ◽  
Treatment And Prevention ◽  
Anti Inflammatory

Respiratory diseases place an immense burden on global health and there is a compelling need for the discovery of new compounds for therapeutic development. Here, we identify research priorities by critically reviewing pre-clinical and clinical studies using extracts and compounds derived from molluscs, as well as traditional molluscan medicines, used in the treatment of respiratory diseases. We reviewed 97 biomedical articles demonstrating the anti-inflammatory, antimicrobial, anticancer, and immunomodulatory properties of >320 molluscan extracts/compounds with direct relevance to respiratory disease, in addition to others with promising bioactivities yet to be tested in the respiratory context. Of pertinent interest are compounds demonstrating biofilm inhibition/disruption and antiviral activity, as well as synergism with approved antimicrobial and chemotherapeutic agents. At least 100 traditional medicines, incorporating over 300 different mollusc species, have been used to treat respiratory-related illness in cultures worldwide for thousands of years. These medicines provide useful clues for the discovery of bioactive components that likely underpin their continued use. There is particular incentive for investigations into anti-inflammatory compounds, given the extensive application of molluscan traditional medicines for symptoms of inflammation, and shells, which are the principal molluscan product used in these preparations. Overall, there is a need to target research toward specific respiratory disease-related hypotheses, purify bioactive compounds and elucidate their chemical structures, and develop an evidence base for the integration of quality-controlled traditional medicines.

scholarly journals Quality of Life and Economic Burden of Respiratory Disease in Asia-Pacific—Asia-Pacific Burden of Respiratory Diseases Study

2016 ◽  
Vol 9 ◽  
pp. 72-77 ◽  
Author(s):  
De Yun Wang ◽  
Aloke Gopal Ghoshal ◽  
Abdul Razak Bin Abdul Muttalif ◽  
Horng-Chyuan Lin ◽  
Sanguansak Thanaviratananich ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Respiratory Disease ◽  
Economic Burden ◽  
Respiratory Diseases ◽  
Asia Pacific ◽  
Pacific Asia

scholarly journals The Rat Genome Database 2013--data, tools and users

2013 ◽  
Vol 14 (4) ◽  
pp. 520-526 ◽  
Author(s):  
S. J. F. Laulederkind ◽  
G. T. Hayman ◽  
S.-J. Wang ◽  
J. R. Smith ◽  
T. F. Lowry ◽  
...  
Keyword(s):  
Genome Database ◽  
Rat Genome

scholarly journals Disease pathways at the Rat Genome Database Pathway Portal: genes in context-a network approach to understanding the molecular mechanisms of disease

2014 ◽  
Vol 8 (1) ◽  
Author(s):  
Victoria Petri ◽  
G Thomas Hayman ◽  
Marek Tutaj ◽  
Jennifer R Smith ◽  
Stanley JF Laulederkind ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Network Approach ◽  
Genome Database ◽  
Rat Genome ◽  
Disease Pathways

scholarly journals PhenoMiner: quantitative phenotype curation at the rat genome database

Database ◽  
2013 ◽  
Vol 2013 ◽  
Author(s):  
Stanley J F Laulederkind ◽  
Weisong Liu ◽  
Jennifer R Smith ◽  
G Thomas Hayman ◽  
Shur-Jen Wang ◽  
...  
Keyword(s):  
Biological Information ◽  
Ontology Development ◽  
Rat Strains ◽  
Genome Database ◽  
Quantitative Phenotype ◽  
Phenotype Data ◽  
Disease Associations ◽  
Data Objects ◽  
Cellular Components ◽  
Rat Genome

Abstract The Rat Genome Database (RGD) is the premier repository of rat genomic and genetic data and currently houses >40 000 rat gene records as well as human and mouse orthologs, >2000 rat and 1900 human quantitative trait loci (QTLs) records and >2900 rat strain records. Biological information curated for these data objects includes disease associations, phenotypes, pathways, molecular functions, biological processes and cellular components. Recently, a project was initiated at RGD to incorporate quantitative phenotype data for rat strains, in addition to the currently existing qualitative phenotype data for rat strains, QTLs and genes. A specialized curation tool was designed to generate manual annotations with up to six different ontologies/vocabularies used simultaneously to describe a single experimental value from the literature. Concurrently, three of those ontologies needed extensive addition of new terms to move the curation forward. The curation interface development, as well as ontology development, was an ongoing process during the early stages of the PhenoMiner curation project. Database URL: http://rgd.mcw.edu

scholarly journals Oral Health-Related Quality of Life in Patients With Chronic Respiratory Diseases—Results of a Systematic Review

2022 ◽  
Vol 8 ◽  
Author(s):  
Simin Li ◽  
Wanchen Ning ◽  
Wei Wang ◽  
Dirk Ziebolz ◽  
Aneesha Acharya ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Oral Health ◽  
Respiratory Disease ◽  
Respiratory Diseases ◽  
Health Related Quality ◽  
Chronic Respiratory Diseases ◽  
Related Quality ◽  
Health Related

Background: This systematic review evaluates the oral health-related quality of life (OHRQoL) of patients with chronic respiratory diseases.Methods: A systematic literature search was performed based on the PubMed, Medline, Web of Science, and Scopus, using the search terms: “oral health-related quality of life” and “respiratory disease” or “lung” and “oral health-related quality of life.” Full-text articles published until June 30, 2021 and reporting any OHRQoL measurement in children or adults with a chronic respiratory disease or condition were included and analyzed qualitatively.Results: A total of seven out of 44 studies were included, of which four studies examined adults and three studies investigated children. The respective diseases were chronic obstructive pulmonary disease (COPD) (n = 2), sleep apnea (n = 2), severe asthma (n = 1), cystic fibrosis (n = 1), and lung transplantation (n = 1). Four studies confirmed a worse OHRQoL in the respiratory diseased group compared to healthy controls. The overall OHRQoL was reduced in the included studies. Oral health, health-related quality of life, and disease-related parameters were rarely examined with regard to OHRQoL.Conclusion: Patients with chronic respiratory diseases show a reduced OHRQoL. Oral health should be fostered in these individuals to support their OHRQoL.

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