scholarly journals Patterns of Thyroid Function in Metabolic Syndrome Patients and Its Relationship with Components of Metabolic Syndrome

2021 ◽  
Vol 6 (2) ◽  
pp. 80
Author(s):  
Nazma Akter ◽  
Zafar Ahmed Latif
2017 ◽  
Author(s):  
Bruce Wolffenbuttel ◽  
Hanneke Wouters ◽  
Sandra Slagter ◽  
Waateringe Robert van ◽  
Vliet-Ostaptchouk Jana van ◽  
...  

Author(s):  
Nijole Kazukauskiene ◽  
Aurelija Podlipskyte ◽  
Giedrius Varoneckas ◽  
Narseta Mickuviene

Background: Individuals with insulin resistance (IR) have a high risk of diabetes or metabolic syndrome, and they are more likely to have depression. Furthermore, IR by itself is a major cardiovascular risk factor in healthy persons. Thus, we aimed to investigate IR in association with thyroid function, psychoemotional state, and cardiovascular risk factors among 45–84-year-old citizens of Palanga. Methods: A randomized epidemiological study was performed with 850 subjects. All participants were evaluated for sociodemographic, clinical, and cardiovascular risk factors and biochemical analysis. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR). Results: All study participants were stratified into groups without IR (HOMA-IR ≤ 2.7) and with IR (HOMA-IR > 2.7). The analysis of parameters between the two study groups showed some statistically significant relationships between IR and cardiovascular risk factors. The predictable accuracy was presented using receiver performance characteristic curves for HOMA-IR scores in women and men separately. If the HOMA-IR score is higher than 3.45, individuals are significantly more likely to have type 2 diabetes mellitus (T2DM). Conclusions: An increase of fasting glucose and more frequent incidence of metabolic syndrome, diabetes, and cardiovascular diseases in subjects with IR are associated with the prevalence of cardiovascular risk factors. There was no significant association between thyroid function and HOMA-IR. HOMA-IR cut-offs could predict the presence of T2DM.


2011 ◽  
pp. P2-694-P2-694
Author(s):  
Avantika C Waring ◽  
Nicolas Rodondi ◽  
Stephanie Litwack-Harrison ◽  
Alka Kanaya ◽  
Eleanor Simonsick ◽  
...  

2015 ◽  
Vol 12 (3) ◽  
pp. 85 ◽  
Author(s):  
Manish Gutch ◽  
Pankaj Agarwal ◽  
MohitMohan Singh

2019 ◽  
Vol 274 ◽  
pp. 167-175 ◽  
Author(s):  
Sylwia Kalinowska ◽  
Beata Trześniowska-Drukała ◽  
Krzysztof Safranow ◽  
Justyna Pełka-Wysiecka ◽  
Karolina Kłoda ◽  
...  

2012 ◽  
Vol 16 (6) ◽  
pp. 958 ◽  
Author(s):  
ShantiN Chugh ◽  
Kiran Chugh ◽  
Sandeep Goyal ◽  
Vijay Shankar

2010 ◽  
Vol 163 (2) ◽  
pp. 273-278 ◽  
Author(s):  
Jose de Jesus Garduño-Garcia ◽  
Ulices Alvirde-Garcia ◽  
Guadalupe López-Carrasco ◽  
Ma Elena Padilla Mendoza ◽  
Roopa Mehta ◽  
...  

ObjectiveTo examine the association between thyroid function and the components of the metabolic syndrome and insulin resistance in an Hispanic population.DesignCross-sectional study.MethodsSubjects with no history of thyroid disease or diabetes were included. Thyroid function was stratified as euthyroid or subclinical hypothyroidism (SCH) status and subsequently by free thyroxine (FT4) and TSH tertiles. The association of the metabolic syndrome components (defined by 2004 Adult Treatment Panel III criteria) and insulin resistance with thyroid status, TSH, and FT4 were examined.ResultsA total of 3148 subjects were analyzed. The prevalence of SCH was 8.3%. The prevalence of the metabolic syndrome was similar in euthyroid and SCH patients (31.6 vs 32.06%, P=0.89). Total cholesterol was higher in patients with SCH (5.51±1.19 vs 5.34±1.05 mmol/l, P<0.032). Serum TSH values showed a positive correlation (adjusted for age and sex) with total cholesterol, triglycerides, and waist circumference. In contrast, FT4 showed a positive correlation with high-density lipoprotein cholesterol, and an inverse correlation with waist circumference, insulin, and HOMA-IR.ConclusionSCH is not associated with an increased risk for the metabolic syndrome (as conceived as a diagnostic category defined by the National Cholesterol, Education Program, Adult Treatment Panel III criteria). Despite this, low thyroid function (even in the euthyroid state) predisposes to higher cholesterol, glucose, insulin, and HOMA-IR levels. The combined use of TSH and FT4, compared with the assessment based on only FT4, is a more convenient approach to evaluate the association between thyroid function and metabolic variables.


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