Combination of Low and High Molecular Weight Chitosans for the Preparation of Nanoparticles: A Novel Approach Towards Sustained Drug Delivery

2013 ◽  
Vol 1 (4) ◽  
pp. 376-387 ◽  
Author(s):  
Yogesh Choudhari ◽  
Sushant Kulthe ◽  
Nazma Inamdar ◽  
Seema Shirolikar ◽  
Lalit Borde ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
Sustained Drug Delivery ◽  
Novel Approach

scholarly journals Herbal Nanogel Formulation: A Novel Approch

2020 ◽  
pp. 138-146
Keyword(s):  
Drug Delivery ◽  
Patient Compliance ◽  
Drug Delivery Systems ◽  
Polymer Networks ◽  
Herbal Medicines ◽  
Future Generation ◽  
Herbal Drugs ◽  
High Drug ◽  
Sustained Drug Delivery ◽  
Novel Approach

:Increasing research interest has been focused on controlled as well as sustained drug delivery using natural and biocompatible constituents in recent years. Many of them herbal constituents are avoided due to pharmacokinetic and pharmacodynamic issues of herbal constituents. There are many new technological ways and comparisons have been studied to upgrade the herbal discoveries in pharmaceutical market. This review will focus on the nanogel for herbal medicines with high delivery rate, patient compliance and efficiency. A nanoparticles contained hydrogel with cross linked polymer networks called as ‘Nanogel’. Nanogel preferred for herbal medicines due to stability and for the ease. Nanogels in terms of herbal drugs are promising and novel approach which also can be called as future generation drug delivery systems owing to high drug encapsulation capacity, uniformity, minimum toxicity, greater stability.

Modelling transdermal delivery of high molecular weight drugs from microneedle systems

2007 ◽  
Vol 365 (1861) ◽  
pp. 2951-2967 ◽  
Author(s):  
Barrak Al-Qallaf ◽  
Diganta Bhusan Das ◽  
Daisuke Mori ◽  
Zhanfeng Cui
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
Transdermal Delivery ◽  
Drug Transport ◽  
Functional Dependence ◽  
Scaling Analysis ◽  
Drug Permeability ◽  
Transport Behaviour ◽  
Microneedle Arrays

In the past few years, a number of microneedle designs have been proposed for transdermal drug delivery of high molecular weight drugs. However, most of them do not increase the drug permeability in skin significantly. In other cases, designs developed based on certain criteria (e.g. strength of the microneedles) have failed to meet other criteria (e.g. drug permeability in skin, throughputs of the drugs, etc.). It is obvious therefore that in order to determine the ‘optimum’ design of these microneedles, the effect of different factors (e.g. length of the microneedle, surface area of the patch, etc.) along with various transport properties of drug transport behaviour using microneedles should be determined accurately. Appropriate mathematical models for drug transport from these systems into skin have the potential to resolve some of these issues. To address this, a parametric analysis for transdermal delivery of a high molecular weight drug from a microneedle is presented in this paper. The simulations have allowed us to identify the significance of various factors that influence the drug delivery while designing microneedle arrays. A scaling analysis is also done which shows the functional dependence of drug concentration on other variables of skin and microneedle arrays.

Development of simvastatin electrospun fibers: a novel approach for sustained drug delivery

2014 ◽  
Vol 45 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Sudheer Betha ◽  
B. Pamula Reddy ◽  
M. Mohan Varma ◽  
D. Basava Raju ◽  
Venkata Ramana Murthy Kolapalli
Keyword(s):  
Drug Delivery ◽  
Electrospun Fibers ◽  
Sustained Drug Delivery ◽  
Novel Approach

Intracerebral Infusate Distribution by Convection-enhanced Delivery in Humans with Malignant Gliomas: Descriptive Effects of Target Anatomy and Catheter Positioning

2007 ◽  
Vol 60 (suppl_2) ◽  
pp. ONS-89-ONS-99 ◽  
Author(s):  
John H. Sampson ◽  
Martin L. Brady ◽  
Neil A. Petry ◽  
David Croteau ◽  
Allan H. Friedman ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
High Molecular Weight ◽  
Malignant Gliomas ◽  
Critical Parameters ◽  
Convection Enhanced Delivery ◽  
Catheter Position

Abstract Objective: Convection-enhanced delivery (CED) holds tremendous potential for drug delivery to the brain. However, little is known about the volume of distribution achieved within human brain tissue or how target anatomy and catheter positioning influence drug distribution. The primary objective of this study was to quantitatively describe the distribution of a high molecular weight agent by CED relative to target anatomy and catheter position in patients with malignant gliomas. Methods: Seven adult patients with recurrent malignant gliomas underwent intracerebral infusion of the tumor-targeted cytotoxin, cintredekin besudotox, concurrently with 123I-labeled human serum albumin. High-resolution single-photon emission computed tomographic images were obtained at 24 and 48 hours and were coregistered with magnetic resonance imaging scans. The distribution of 123I-labeled human serum albumin relative to target anatomy and catheter position was analyzed. Results: Intracerebral CED infusions were well-tolerated and some resulted in a broad distribution of 123I-labeled human serum albumin, but target anatomy and catheter positioning had a significant influence on infusate distribution even within non-contrastenhancing areas of brain. Intratumoral infusions were anisotropic and resulted in limited coverage of the enhancing tumor area and adjacent peritumoral regions. CONCLUSIONS: CED has the potential to deliver high molecular weight agents into tumorinfiltrated brain parenchyma with volumes of distribution that are clinically relevant. Target tissue anatomy and catheter position are critical parameters in optimizing drug delivery.

Green polymer chemistry: Living oxidative polymerization of dithiols

2012 ◽  
Vol 84 (10) ◽  
pp. 2121-2133 ◽  
Author(s):  
Emily Q. Rosenthal-Kim ◽  
Judit E. Puskas
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
Oxidative Polymerization ◽  
Polymer Chemistry ◽  
Molecular Weights ◽  
Bonded Materials ◽  
Green Polymer ◽  
Oxidative System ◽  
High Molecular Weight Poly

Reduction sensitivity and mild synthetic conditions make disulfide-bonded materials ideal for degradable biomaterial applications. Both the degradation and the synthetic advantages of disulfide-bonded biomaterials have been applied to drug delivery vesicles, protein conjugation, and hydrogel biomaterials, but the synthetic advantages are rarely seen in the creation of biopolymers. A greener and highly efficient oxidative system is presented for the polymerization dithiols to high-molecular-weight poly(disulfide) polymers. The application of this system to 2-[2-(2-sulfanylethoxy)ethoxy]ethanethiol (DODT) produced corresponding degradable poly(disulfide) polymers with molecular weights as high as Mn = 250 000 g/mol and with a polydispersity index (PDI) as low as 1.15.

In vivo characteristics of high, molecular weight copoly(l-lactide/glycolide) with S-type degradation pattern for application in drug delivery systems

Biomaterials ◽  
1991 ◽  
Vol 12 (4) ◽  
pp. 433-437 ◽  
Author(s):  
Hironobu Fukuzaki ◽  
Masaru Yoshida ◽  
Masaharu Asano ◽  
Minoru Kumakura ◽  
Tooru Mashimo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Degradation Pattern

Microtubule motors and other maps

1990 ◽  
Vol 48 (3) ◽  
pp. 1-1
Author(s):  
Richard B. Vallee
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Cytoplasmic Dynein ◽  
Organelle Transport ◽  
Structural Components ◽  
Microtubule Associated Proteins ◽  
Microtubule Motors ◽  
Associated Proteins ◽  
The Subject ◽  
Intracellular Motility

Microtubules are involved in a number of forms of intracellular motility, including mitosis and bidirectional organelle transport. Purified microtubules from brain and other sources contain tubulin and a diversity of microtubule associated proteins (MAPs). Some of the high molecular weight MAPs - MAP 1A, 1B, 2A, and 2B - are long, fibrous molecules that serve as structural components of the cytamatrix. Three MAPs have recently been identified that show microtubule activated ATPase activity and produce force in association with microtubules. These proteins - kinesin, cytoplasmic dynein, and dynamin - are referred to as cytoplasmic motors. The latter two will be the subject of this talk.Cytoplasmic dynein was first identified as one of the high molecular weight brain MAPs, MAP 1C. It was determined to be structurally equivalent to ciliary and flagellar dynein, and to produce force toward the minus ends of microtubules, opposite to kinesin.

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