Size- and Morphology-Controlled Preparation of Surface-Modified Water-Dispersible Fullerene Nanoparticles for Bioapplications

2020 ◽  
Vol 20 (5) ◽  
pp. 2668-2674
Author(s):  
Hidetoshi Oguma ◽  
Eri Seitoku ◽  
Mami Mutoh ◽  
Saori Yoshizawa ◽  
Ko Nakanishi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Condensation Reaction ◽  
Water Dispersible ◽  
Fullerene Nanoparticles ◽  
Water Dispersibility ◽  
Shape Controlled ◽  
Size And Morphology ◽  
Surface Modified ◽  
Controlled Preparation ◽  
Detection And Quantification

In this study, we investigated water-dispersible surface modification for size- and shape-controlled fullerene nanoparticles (C60P) based on a condensation reaction with di-amino alkane. This modification provided for water dispersibility of C60P and the capability for secondary modification as well. The resultant C60P particles have several useful physical properties: water-dispersibility for ease of injection; fluorescence for detection and quantification; and a characteristic morphology to assist identification. These properties will widely extend the applications of these particles, especially into the biological fields of bioimaging and drug delivery.

scholarly journals Highly Water Dispersible Functionalized Graphene by Thermal Thiol-Ene Click Chemistry

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 2830
Author(s):  
Farzaneh Farivar ◽  
Pei Lay Yap ◽  
Tran Thanh Tung ◽  
Dusan Losic
Keyword(s):  
Click Reaction ◽  
High Water ◽  
Pristine Graphene ◽  
Functionalized Graphene ◽  
Specific Chemical ◽  
Simple Modification ◽  
Water Dispersible ◽  
Chemical Hazards ◽  
Water Dispersibility ◽  
C And N

Functionalization of pristine graphene to achieve high water dispersibility remains as a key obstacle owing to the high hydrophobicity and absence of reactive functional groups on the graphene surface. Herein, a green and simple modification approach to prepare highly dispersible functionalized graphene via thermal thiol-ene click reaction was successfully demonstrated on pristine graphene. Specific chemical functionalities (–COO, –NH2 and –S) on the thiol precursor (L-cysteine ethyl ester) were clicked directly on the sp2 carbon of graphene framework with grafting density of 1 unit L-cysteine per 113 carbon atoms on graphene. This functionalized graphene was confirmed with high atomic content of S (4.79 at % S) as well as the presence of C–S–C and N–H species on the L-cysteine functionalized graphene (FG-CYS). Raman spectroscopy evidently corroborated the modification of graphene to FG-CYS with an increased intensity ratio of D and G band, ID/IG ratio (0.3 to 0.7), full-width at half-maximum of G band, FWHM [G] (20.3 to 35.5) and FWHM [2D] (64.8 to 90.1). The use of ethanol as the reaction solvent instead of common organic solvents minimizes the chemical hazards exposure to humans and the environment. This direct attachment of multifunctional groups on the surface of pristine graphene is highly demanded for graphene ink formulations, coatings, adsorbents, sensors and supercapacitor applications.

Water-dispersible polyphosphate-grafted Fe3O4 nanomagnets for cancer therapy

RSC Advances ◽  
2015 ◽  
Vol 5 (105) ◽  
pp. 86754-86762 ◽  
Author(s):  
Jerina Majeed ◽  
K. C. Barick ◽  
Neena G. Shetake ◽  
B. N. Pandey ◽  
P. A. Hassan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Water Dispersible ◽  
Drug Delivery Applications

Development of water-dispersible polyphosphate-grafted Fe3O4 nanomagnets for hyperthermia and drug delivery applications.

scholarly journals Facile fabrication of water-dispersible nanocomposites based on hexa-peri-hexabenzocoronene and Fe3O4 for dual mode imaging (fluorescent/MR) and drug delivery

RSC Advances ◽  
2018 ◽  
Vol 8 (71) ◽  
pp. 40554-40563 ◽  
Author(s):  
Meng-Meng Song ◽  
Hui-Hui Xiang ◽  
Meng-Yu Fei ◽  
Da-Peng Lu ◽  
Tong-Cui Jiang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dual Mode ◽  
Water Dispersible ◽  
Facile Fabrication

Water-dispersible, stable and biocompatible dandelion-like Fe3O4/HBC@F127 nanocomposites were facilely developed for dual mode imaging (fluorescent/MR) and drug delivery.

scholarly journals Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 118 ◽  
Author(s):  
Reema Narayan ◽  
Usha Nayak ◽  
Ashok Raichur ◽  
Sanjay Garg
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Cost Effective ◽  
Drug Carriers ◽  
Widespread Application ◽  
Distinctive Features ◽  
Potential Benefits ◽  
Size And Morphology

Recent advancements in drug delivery technologies utilizing a variety of carriers have resulted in a path-breaking revolution in the approach towards diagnosis and therapy alike in the current times. Need for materials with high thermal, chemical and mechanical properties have led to the development of mesoporous silica nanoparticles (MSNs). These ordered porous materials have garnered immense attention as drug carriers owing to their distinctive features over the others. They can be synthesized using a relatively simple process, thus making it cost effective. Moreover, by controlling the parameters during the synthesis; the morphology, pore size and volume and particle size can be transformed accordingly. Over the last few years, a rapid increase in research on MSNs as drug carriers for the treatment of various diseases has been observed indicating its potential benefits in drug delivery. Their widespread application for the loading of small molecules as well as macromolecules such as proteins, siRNA and so forth, has made it a versatile carrier. In the recent times, researchers have sorted to several modifications in the framework of MSNs to explore its potential in drug resistant chemotherapy, antimicrobial therapy. In this review, we have discussed the synthesis of these multitalented nanoparticles and the factors influencing the size and morphology of this wonder carrier. The second part of this review emphasizes on the applications and the advances made in the MSNs to broaden the spectrum of its use especially in the field of biomedicine. We have also touched upon the lacunae in the thorough understanding of its interaction with a biological system which poses a major hurdle in the passage of this carrier to the clinical level. In the final part of this review, we have discussed some of the major patents filed in the field of MSNs for therapeutic purpose.

A Recent Update: Solid Lipid Nanoparticles for Effective Drug Delivery

2021 ◽  
Author(s):  
Sonia Pandey ◽  
Farhinbanu Shaikh ◽  
Arti Gupta ◽  
Purnima Tripathi ◽  
Jitendra Singh Yadav
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Biological Drugs ◽  
Characterization Methods ◽  
Solid Lipid ◽  
Future Success ◽  
Research Findings ◽  
Surface Modified

Solid lipid nanoparticles are one of the developed technologies for addressing the bioavailability and targeting issues of drug delivery. In this review article, we attempted to incorporate all the essential details of SLNs like various methods of preparation, different models of SLNs, updated characterization methods, in-vivo behavior (Uptake), their applications, route of administration as well as advancements taken place in the field of delivery of biological drugs like gene vector, new adjuvant for vaccines, protein, and peptide with SLNs. Surface modified SLNs hold excellent potential for targeted and controlled drug delivery which is discussed and summarized. Based on the available data, the future success of SLNs is widened because they could be easily fabricated with various functionalities which would display enormous potential for targeting and diagnosing various diseases. This review would help the budding researchers to find out the unexplored areas of SLNs with the present discussion that reframes the potential of SLNs by gathering the various research findings of SLNs in tabular form along with the approved patent technologies of SLNs.

scholarly journals Doxorobicin as cargo in a redox-responsive drug delivery system capped with water dispersible ZnS nanoparticles

RSC Advances ◽  
2020 ◽  
Vol 10 (27) ◽  
pp. 15825-15835
Author(s):  
Lukáš Žid ◽  
Vladimír Zeleňák ◽  
Vladimír Girman ◽  
Jozef Bednarčík ◽  
Adriana Zeleňáková ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Capping Agent ◽  
Zns Nanoparticles ◽  
Water Dispersible ◽  
Redox Responsive ◽  
Premature Release

Redox-responsive drug delivery system was studied. ZnS nanoparticles served as pore capping agent to prevent premature release of anticancer drug. Such cargo can be monitored by magnetic field which opens possibilities its use in theranostics.

Citrate modified β-cyclodextrin functionalized magnetite nanoparticles: a biocompatible platform for hydrophobic drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (28) ◽  
pp. 22117-22125 ◽  
Author(s):  
Kunnoth N. Jayaprabha ◽  
Pattayil A. Joy
Keyword(s):  
Drug Delivery ◽  
Magnetite Nanoparticles ◽  
Hydrophobic Drug ◽  
Water Dispersible

Water dispersible, β-cyclodextrin functionalized, magnetite nanoparticles are shown to be suitable for the delivery of the hydrophobic drug curcumin, with possible multifunctional applications.

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