Preparation of AuNPs/SF Nanofibers and Its Ability to Inhibit Tumor Growth in Breast Cancer-Bearing Animal Models

2021 ◽  
Vol 21 (2) ◽  
pp. 921-927
Author(s):  
Guangning You ◽  
Shuping Xu ◽  
Xingfei Yao ◽  
Huanhuan Wu ◽  
Yingying Shi
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Animal Models ◽  
Tumor Growth ◽  
Gold Nanoparticle ◽  
Silk Fibroin ◽  
Composite System ◽  
Au Nps ◽  
The Stability

Silk fibroin was used as a stabilizer for gold nanoparticles, and a direct silk fibroin-gold nanoparticle composite system was prepared by a direct compounding method in this paper. The stability of Au NPs/SF in phosphate buffer solution with different pH and KCl concentration was studied. The Au NPs/SF system was characterized by UV-visible light spectrum, transmission electron microscope and infrared spectrum. The silk fibroin-gold nanoparticle composite system was prepared by in situ reduction of chloroauric acid with silk fibroin, according to the change of solution color and the change of ultraviolet absorption peak. The effects of exogenous factors on the stability of the silk fibroin-gold nanoparticle in situ composite system were initially discussed, and its inhibition in breast cancer-bearing animal models was studied. In vivo experiments show that in situ injection of Au NPs/SF nanofibers and treatment with light can effectively control tumor growth. Compared with monodisperse gold nanoparticles, silk fibroin-gold nanoparticles can kill tumor cells and inhibit tumor tissue growth more effectively.

scholarly journals Easy and fast in-situ functionalization of exfoliated 2D black phosphorus with gold nanoparticles

2021 ◽  
Author(s):  
Salvatore Moschetto ◽  
Andrea Ienco ◽  
Gabriele Manca ◽  
Manuel Serrano-Ruiz ◽  
Maurizio Peruzzini ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Black Phosphorus ◽  
Au Nps ◽  
In Situ Functionalization

Heterostructures of single- and few-layer black phosphorus (2D bP) functionalized with gold nanoparticles (Au NPs) have been recently reported in the literature, exploiting their intriguing properties and biocompatibility for catalytic,...

Macroscopical monolayer films of ordered arrays of gold nanoparticles as SERS substrates for in-situ quantitative detection in aqueous solutions

Nanoscale ◽  
2021 ◽  
Author(s):  
Lixiang Xing ◽  
Cui Wang ◽  
Yi Cao ◽  
Jihui Zhang ◽  
Haibing Xia
Keyword(s):  
Gold Nanoparticles ◽  
Volume Fraction ◽  
Water Volume ◽  
Quantitative Detection ◽  
Monolayer Films ◽  
Au Nps ◽  
Sers Substrates ◽  
Ordered Arrays ◽  
Water Volume Fraction

In this work, macroscopical monolayer films of ordered arrays of gold nanoparticles (MMF-OA-Au NPs) are successfully prepared at the interfaces of toluene-diethylene glycol (DEG) with a water volume fraction of...

scholarly journals G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer

2020 ◽  
Vol 180 (3) ◽  
pp. 635-646 ◽  
Author(s):  
Kaitlyn J. Andreano ◽  
Suzanne E. Wardell ◽  
Jennifer G. Baker ◽  
Taylor K. Desautels ◽  
Robert Baldi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Animal Models ◽  
Tumor Growth ◽  
Inhibit Tumor Growth

Light-directed on-chip shape transformation of a single gold nanoparticle

2020 ◽  
Vol 8 (45) ◽  
pp. 16198-16203
Author(s):  
Yinfeng Long ◽  
Shuangshuang Wang ◽  
Yunxia Wang ◽  
Yan Qiao ◽  
Tao Ding
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanoparticle ◽  
Surface Plasmons ◽  
Shape Transformation ◽  
Au Nps ◽  
Chip Shape ◽  
On Chip

Surface plasmons enable controllable shape transformation based on the dissolution and re-deposition of gold nanoparticles (Au NPs).

scholarly journals Tandem X-ray absorption spectroscopy and scattering for in situ time-resolved monitoring of gold nanoparticle mechanosynthesis

2020 ◽  
Vol 56 (71) ◽  
pp. 10329-10332 ◽  
Author(s):  
Paulo F. M. de Oliveira ◽  
Adam A. L. Michalchuk ◽  
Ana Guilherme Buzanich ◽  
Ralf Bienert ◽  
Roberto M. Torresi ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanoparticle ◽  
Absorption Spectroscopy ◽  
Mechanochemical Synthesis ◽  
Time Resolved ◽  
X Ray ◽  
X Ray Absorption

A new tandem approach combines XRD and XANES for time-resolved in situ monitoring of the mechanochemical synthesis of gold nanoparticles.

A facile method to in situ fabricate three dimensional gold nanoparticle micropatterns in a cell-resistant hydrogel

2016 ◽  
Vol 15 (2) ◽  
pp. 181-186
Author(s):  
Ming-Hao Yao ◽  
Jie Yang ◽  
Dong-Hui Zhao ◽  
Rui-Xue Xia ◽  
Rui-Mei Jin ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Gold Nanoparticle ◽  
Three Dimensional ◽  
Photochemical Synthesis ◽  
A Cell

A facile method for in situ fabrication of three-dimensional gold nanoparticles micropatterns throughout a polyethylene glycol hydrogel substrate has been developed by combining photochemical synthesis of gold nanoparticles with photolithography technology.

scholarly journals Novel Copper Photoredox Catalysts for Polymerization: An In Situ Synthesis of Metal Nanoparticles

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2293 ◽  
Author(s):  
Haja Tar ◽  
Tahani I. Kashar ◽  
Noura Kouki ◽  
Reema Aldawas ◽  
Bernadette Graff ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
High Performance ◽  
Gold Chloride ◽  
Au Nps ◽  
Glycol Diacrylate ◽  
Good Production ◽  
Iodonium Salt ◽  
Irradiation Process ◽  
Sem Analyses

The copper II complex (HLCuCl) carrying 2,4 dinitrophenylhydrazone (L) is synthesized and evaluated as a new photoredox catalyst/photoinitiator in combination with triethylamine (TEA) and iodonium salt (Iod) for the radical polymerization of ethylene glycol diacrylate during exposure to visible light using a photoreactor at 419 nm. The copper complex reactivity with TEA/Iod salt/gold chloride showed a good production and stability of gold nanoparticles. Finally, the high performance of Cu (II) complex for radical photopolymerization incorporating gold nanoparticles is provided. The photochemical mechanisms for the production of initiating radicals are studied using cyclic voltammetry. Polymer nanocomposites containing gold nanoparticles (Au NPs) in situ photogenerated during the irradiation process were prepared. The formation of Au NPs inside the polymer matrix was through UV–Vis and EDS/SEM analyses.

In Situ Placement of High-Dose rhBMP-2 within Spine Tumors Slows Tumor Growth and Decreases Onset to Paralysis in a Rat Model of Metastatic Breast Cancer

2011 ◽  
Vol 11 (10) ◽  
pp. S3-S4
Author(s):  
Camilo Molina ◽  
Rachel Sarabia-Estrada ◽  
Ziya Gokaslan ◽  
Jean-Paul Wolinsky ◽  
Ali Bydon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Tumor Growth ◽  
Rat Model ◽  
Metastatic Breast ◽  
High Dose ◽  
Spine Tumors

Synthesis and Radiosynthesis of 17α-[p-(Iodophenylethynyl)]estra-3,17β-diols

2003 ◽  
Vol 58 (8) ◽  
pp. 799-804 ◽  
Author(s):  
Jian Wanga ◽  
Masataka Watanabe ◽  
Shuntaro Mataka ◽  
Thies Thiemann ◽  
Goreti Ribeiro Morais ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Addition Reaction ◽  
Stability Study ◽  
The Stability ◽  
Positive Breast Cancer

Estrones have been subjected to an addition reaction with [(4-ethynylphenyl)azo]pyrrolidine to provide 17 α-{4-[(pyrrolidin-1-yl)-azo]phenylethynyl}estra-3,17 β -diols. A subsequent iodination with iodotrimethylsilane, produced in situ from chlorotrimethylsilane and NaI, leads to 17α-(piodophenylethynyl) estra-3,17 β -diols. This reaction can also be carried out with Na125 I to give radiolabelled estra-3,17 β -diols, which are potentially useful radiodiagnostic agents for the detection of estrogen positive breast cancer. The stability of the radiolabelled compounds is exemplified in a stability study of 3-O-methyl 17 α-(p-[125 I]iodophenylethynyl)estra-1,3,5(10),6-tetraene-17 β -ol in acetonitrile.

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