Green and Simple Synthesis of Photoluminescence-Tunable Carbon Dots for Sensing and Cell Imaging Applications

2021 ◽  
Vol 21 (12) ◽  
pp. 6101-6110
Author(s):  
Dong Sun ◽  
Shu-Jun Li ◽  
Chun-Feng Wang ◽  
Tian-Tian Liu ◽  
Guang-Yue Bai ◽  
...  
Keyword(s):  
Boric Acid ◽  
Carbon Dots ◽  
Luminescence Property ◽  
Cell Imaging ◽  
Fluorescence Emission ◽  
Fluorescent Imaging ◽  
Simple Synthesis ◽  
Low Toxicity ◽  
Doped Carbon Dots ◽  
Co Doped

Innovative nitrogen and boron co-doped carbon dots are hydrothermally produced using fructose, urea, and boric acid as precursors. The synthesized carbon dots possess a uniform morphology, and exhibit excellent fluorescence stability, tunable luminescence property, strong resistance to photobleaching, low-toxicity, and excellent biocompatibility. It is also found more dopant urea is conducive to the formation of the carbon dots with more B–N bonds, and shorter wavelength of fluorescence emission. Meanwhile, the synthesized carbon dots are well utilized as a photoluminescent probe for facile Hg2+ determination and fluorescent imaging reagent in cells.

Nitrogen and Sulfur Co-doped Fluorescent Carbon Dots for the Detection of Morin and Cell Imaging

2018 ◽  
Vol 15 (1) ◽  
pp. 47-55
Author(s):  
Xuebing Li ◽  
Haifen Yang ◽  
Ning Wang ◽  
Tijian Sun ◽  
Wei Bian ◽  
...  
Keyword(s):  
Microwave Heating ◽  
Fluorescent Probe ◽  
Fluorescence Intensity ◽  
Carbon Dots ◽  
Cell Imaging ◽  
Water Soluble ◽  
Heating Process ◽  
X Ray ◽  
Doped Carbon Dots ◽  
Co Doped

Background: Morin has many pharmacological functions including antioxidant, anticancer, anti-inflammatory, and antibacterial effects. It is commonly used in the treatment of antiviral infection, gastropathy, coronary heart disease and hepatitis B in clinic. However, researches have shown that morin is likely to show prooxidative effects on the cells when the amount of treatment is at high dose, leading to the decrease of intracellular ATP levels and the increase of necrosis process. Therefore, it is necessary to determine the concentration of morin in biologic samples. Method: Novel water-soluble and green nitrogen and sulfur co-doped carbon dots (NSCDs) were prepared by a microwave heating process with citric acid and L-cysteine. The fluorescence spectra were collected at an excitation wavelength of 350 nm when solutions of NSCDs were mixed with various concentrations of morin. Results: The as-prepared NSCDs were characterized by transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy. The fluorescence intensity of NSCDs decreased significantly with the increase of morin concentration. The fluorescence intensity of NSCDs displayed a linear response to morin in the concentration 0.10-30 μM with a low detection limit of 56 nM. The proposed fluorescent probe was applied to analysis of morin in human body fluids with recoveries of 98.0-102%. Conclusion: NSCDs were prepared by a microwave heating process. The present analytical method is sensitive to morin. The quenching process between NSCDs and morin is attributed to the static quenching. In addition, the cellular toxicity on HeLa cells indicated that the as-prepared NSCDs fluorescent probe does not show obvious cytotoxicity in cell imaging. Our proposed method possibly opens up a rapid and nontoxic way for preparing heteroatom doped carbon dots with a broad application prospect.

Nitrogen and phosphorus co-doped carbon dots derived from lily bulbs for copper ion sensing and cell imaging

2018 ◽  
Vol 83 ◽  
pp. 272-278 ◽  
Author(s):  
Dan Gu ◽  
Pingbo Zhang ◽  
Lei Zhang ◽  
Hao Liu ◽  
Zhanbin Pu ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Cell Imaging ◽  
Copper Ion ◽  
Nitrogen And Phosphorus ◽  
Ion Sensing ◽  
Doped Carbon Dots ◽  
Co Doped

Facile synthesis of water-soluble and biocompatible fluorescent nitrogen-doped carbon dots for cell imaging

The Analyst ◽  
2014 ◽  
Vol 139 (7) ◽  
pp. 1692-1696 ◽  
Author(s):  
Weiping Wang ◽  
Ya-Chun Lu ◽  
Hong Huang ◽  
Jiu-Ju Feng ◽  
Jian-Rong Chen ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Cell Imaging ◽  
Water Soluble ◽  
Soluble Nitrogen ◽  
Facile Synthesis ◽  
Nitrogen Doped ◽  
Low Toxicity ◽  
Good Biocompatibility ◽  
Doped Carbon Dots ◽  
Nitrogen Doped Carbon

A simple and green hydrothermal method was developed for preparation of water-soluble nitrogen-doped carbon dots (N-CDs) from streptomycin. The prepared N-CDs reveal low toxicity, high stability and good biocompatibility, which can be used as fluorescent probes for cell imaging.

Low temperature synthesis of phosphorous and nitrogen co-doped yellow fluorescent carbon dots for sensing and bioimaging

2015 ◽  
Vol 3 (33) ◽  
pp. 6813-6819 ◽  
Author(s):  
Xiaojuan Gong ◽  
Wenjing Lu ◽  
Yang Liu ◽  
Zengbo Li ◽  
Shaomin Shuang ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Ph Sensing ◽  
Low Temperature Synthesis ◽  
Low Toxicity ◽  
Doped Carbon Dots ◽  
Fluorescent Carbon Dots ◽  
Co Doped ◽  
High Output

A simple and high-output strategy for the fabrication of yellow fluorescent phosphorous and nitrogen co-doped carbon dots (P,N-CDs) is developed. P,N-CDs possess distinctive photoluminescence properties, low toxicity, and biocompatible. P,N-CDs are potentially useful for versatile applications such as pH sensing, in vitro and in vivo imaging.

Facile synthesis of nitrogen and sulfur co-doped carbon dots and application for Fe(III) ions detection and cell imaging

2016 ◽  
Vol 223 ◽  
pp. 689-696 ◽  
Author(s):  
Yanfen Chen ◽  
Yuanya Wu ◽  
Bo Weng ◽  
Bin Wang ◽  
Changming Li
Keyword(s):  
Carbon Dots ◽  
Cell Imaging ◽  
Facile Synthesis ◽  
Doped Carbon Dots ◽  
Co Doped

Nitrogen and phosphorus co-doped carbon dots as a “turn-off-on” fluorescence probe for the detection of Hg2+ and GSH and cell imaging

2019 ◽  
Vol 11 (45) ◽  
pp. 5803-5809 ◽  
Author(s):  
Xuefang Yang ◽  
Mengting Zhang ◽  
Yulu Zhang ◽  
Ning Wang ◽  
Wei Bian ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Cell Imaging ◽  
Fluorescence Probe ◽  
Raw Materials ◽  
Citric Acid Monohydrate ◽  
Hydrogen Phosphate ◽  
Nitrogen And Phosphorus ◽  
Doped Carbon Dots ◽  
Diammonium Hydrogen ◽  
Co Doped

Nitrogen and phosphorus co-doped carbon dots (NPCDs) were synthesized by a microwave method, using citric acid monohydrate and diammonium hydrogen phosphate as raw materials.

One-pot and ultrafast synthesis of nitrogen and phosphorus co-doped carbon dots possessing bright dual wavelength fluorescence emission

Nanoscale ◽  
2015 ◽  
Vol 7 (41) ◽  
pp. 17278-17282 ◽  
Author(s):  
Xiangcheng Sun ◽  
Christian Brückner ◽  
Yu Lei
Keyword(s):  
Carbon Dots ◽  
Fluorescence Emission ◽  
Microwave Assisted Synthesis ◽  
High Quantum Yield ◽  
Green Fluorescence ◽  
Nitrogen And Phosphorus ◽  
One Pot ◽  
Microwave Assisted ◽  
Doped Carbon Dots ◽  
Co Doped

Microwave-assisted synthesis of nitrogen and phosphorus co-doped carbon dots with high quantum yield and dual (blue and green) fluorescence emission.

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