scholarly journals Advances in Nanotechnology towards Development of Silver Nanoparticle-Based Wound-Healing Agents

2021 ◽  
Vol 22 (20) ◽  
pp. 11272
Author(s):  
Zimkhitha B. Nqakala ◽  
Nicole R. S. Sibuyi ◽  
Adewale O. Fadaka ◽  
Mervin Meyer ◽  
Martin O. Onani ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Silver Nanoparticle ◽  
Broad Spectrum ◽  
Bacterial Resistance ◽  
Wound Care ◽  
Wound Treatment ◽  
Healing Wound ◽  
As Toxicity

Since antiquity, silver-based therapies have been used in wound healing, wound care and management of infections to provide adequate healing. These therapies are associated with certain limitations, such as toxicity, skin discolouration and bacterial resistance, which have limited their use. As a result, new and innovative wound therapies, or strategies to improve the existing therapies, are sought after. Silver nanoparticles (AgNPs) have shown the potential to circumvent the limitations associated with conventional silver-based therapies as described above. AgNPs are effective against a broad spectrum of microorganisms and are less toxic, effective at lower concentrations and produce no skin discolouration. Furthermore, AgNPs can be decorated or coupled with other healing-promoting materials to provide optimum healing. This review details the history and impact of silver-based therapies leading up to AgNPs and AgNP-based nanoformulations in wound healing. It also highlights the properties of AgNPs that aid in wound healing and that make them superior to conventional silver-based wound treatment therapies.

Temperature-sensitive poly(N-isopropylacrylamide) (PNIPAAm) stabilized size controllable synthesis of silver nanoparticles and its improved antimicrobial activity for wound healing and nursing care after femoral fracture during surgery

2021 ◽  
Vol 11 (1) ◽  
pp. 73-84
Author(s):  
Xiaoyun Wang ◽  
Jing Zhang
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Femoral Fracture ◽  
Bacterial Resistance ◽  
Polymer Nanocomposite ◽  
Temperature Sensitive ◽  
Solution Stability ◽  
Uniform Dispersion ◽  
Significant Temperature ◽  
Thermosensitive Copolymer

In this research, a thermo-sensitive copolymer PNIPAAm-co-MHq was used to successfully synthesize different nano sizes silver nanoparticles in the ranges between 1.5 to 4 nm with uniform dispersion. The polymeric assisted synthesized Ag nanoparticles (AgNPs@PM) exhibited reasonable solution stability and thermalresponsive behaviour. In specific, AgNPs@PM3 (1.59 nm) displayed improved bacterial resistance against clinically approved anti-biotic resistant bacterial pathigens with very low MIC value (4.05 μg/mL). Subsequently, the thermal responsive polymeric molecular structure on AgNPs synthesis has been established that significant temperature dependened anti-bacterial efficiency. It was also observed that the nonparticipants size, temperature responses and proportion of thermosensitive copolymer also influenced the antibacterial efficacy of AgNPs@PM. Resulting thermal sensitive polymer nanocomposite can be extremely beneficial for wound healing treatment after femoral fracture surgery.

scholarly journals EFEKTIFITAS ANTARA PERAWATAN LUKA DENGAN MENGGUNAKAN NaCl 0,9% DAN BETADIN TERHADAP PROSES PENYEMBUHAN LUKA POST OPERASI

2020 ◽  
Vol 7 (1) ◽  
pp. 782-788
Author(s):  
Sri Lestari ◽  
Kunidah Kunidah
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Healing Process ◽  
Care Patient ◽  
Sectio Caesarea ◽  
Wound Healing Process ◽  
P Value ◽  
Purposive Sampling ◽  
Healing Wound ◽  
Post Operation

Penyembuhan luka merupakan suatu proses yang kompleks karena berbagai kegiatan bio-seluler, bio-kimia terjadi berkesinambungan. Sifat penyembuhan pada semua luka sama, dengan variasinya bergantung pada lokasi, keparahan, dan luasnya cedera. Tujuan penelitian ini untuk mengetahui efektifitas antara perawatan luka menggunakan NaCl 0,9% dengan betadin terhadap proses penyembuhan luka post operasi pada pasien sectio caesarea. Penelitian ini merupakan jenis penelitian Quaisy Experimen. Dengan populasi seluruh pasien perawatan luka post operasi sectio caesarea yaitu 26, dan menggunakan teknik sampel purposive sampling dengan jumlah 13 responden setiap kelompok. Penelitian ini dilakukan di Rumah Sakit Ciremai Kota Cirebon. Hasil penelitian ini adalah perawatan luka post operasi sectio caesarea menggunakan NaCl 0,9% sebanyak 13 responden dengan proses penyembuhan luka ≤ 3 hari di dapatkan rata-rata 7,07. Dan hasil bivariate menunjukkan bahwa ada perbedaan antara efektifitas proses penyembuhan luka pada perawatan luka pasien post operasi sectio caesarea menggunakan NaCl 0,9% dengan nilai p value = 0,000 < (a=0,05).Kata kunci     : Proses penyembuhan luka, perawatan luka, NaCl 0,9%, Betadin ABSTRACTWound healing is a complex process because of the various activies of bio-chemical, bio-cell occurs continuosly. Wound healing properties on the all the same, with variations depending on the location, saverity, and the extent of the injury. The purpose of this reseach was to determine the effectiveness of wound care using NaCl 0,9 % with using betadin to wound healing process post operation on patients sectio caesarea. This research is a kind of the quaisy experimental. With a population of whole patients wound care post operatition sectio caesarea which is 26, and using the tecnique of purposive sampling with a total of 13 respondents per-group. The research was conducted at the ciremai hospital of cirebon city.The results of this research are wound care post operation sectio caesarea using NaCl 0,9% as much 13 respondents with the healing process of wound ≤ 3 days obtained of average 7,07. Bivariate and result showed the there is between the effectiveness of the process of wound healing in wound care patient post operation sectio caesarea using NaCl 0,9% with a value p = 0,000 < (a=0,05).Keywords      :     The process of wound healing, wound care, NaCl 0,9%, betadin

A moisturizing chitosan-silk fibroin dressing with silver nanoparticles-adsorbed exosomes for repairing infected wounds

2020 ◽  
Vol 8 (32) ◽  
pp. 7197-7212 ◽  
Author(s):  
Zhiyong Qian ◽  
Yating Bai ◽  
Jin Zhou ◽  
Linhao Li ◽  
Jing Na ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Silver Nanoparticles ◽  
Silk Fibroin ◽  
Broad Spectrum ◽  
Electrolyte Balance ◽  
Infected Wounds ◽  
Multifunctional Properties

The CTS-SF/SA/Ag-Exo dressing possessed multifunctional properties including broad-spectrum antimicrobial activity, promoting wound healing, retaining moisture and maintaining electrolyte balance.

scholarly journals Antlerogenic stem cells extract accelerate chronic wound healing: a preliminary study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Janusz Kmiecik ◽  
Michał Jerzy Kulus ◽  
Jarosław Popiel ◽  
Agnieszka Cekiera ◽  
Marek Cegielski
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Wound Care ◽  
Small Population ◽  
Area Ratio ◽  
Wound Treatment ◽  
Ki 67 ◽  
Pressure Therapy

Abstract Background Chronic wounds constitute a significant medical and social problem. Chronic wound treatment may be supported by various techniques, such as negative pressure therapy, phototherapy or stem cells therapy, yet most of those supporting therapies need more evidence to be used for standard wound care. Current study covers the use of sonicated Antlerogenic Stem Cells (ASC) extract on chronic wounds. Methods Study was performed on 20 dermatological patients with venous leg ulcers, divided into two groups – treated with and without ASC extract respectively. The area and circumference of the wounds during the follow-up visits were measured on the wound imprint. Dynamics of wound healing was determined and compared between control and study group; statistics includes changes in absolute values (wound area, circumference), as well as relative (percentage of wound decrease, circumference/area ratio) and their change in time. For the purpose of Ki-67 immunohistochemical staining, sections were sampled from the wound edge at distinct check-points during therapy. Results of both groups were compared with Student test or Mann-Whitney test, depending on results distribution. Results Besides Ki-67 expression, all tested wound healing parameters (including relative and absolute wound decrease and changes in circumference/area ratio) were statistically significant more favorable in experimental group. Conclusion ASC extract significantly supported standard chronic wound treatment. Due to small population of study the results should be considered preliminary, yet promising for further research.

scholarly journals Instillation-TIME (iTIME) as a rationale amendment for TIME conception. Is there enough evidence for the efficiency of negative pressure wound therapy with instillation (iNPWT) to announce a breakthrough idea for wound treatment?

2019 ◽  
Vol 6 (2) ◽  
pp. 7-8
Author(s):  
Adam Bobkiewicz ◽  
Adam Studniarek ◽  
Łukasz Krokowicz ◽  
Michał Drews ◽  
Tomasz Banasiewicz
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Care Management ◽  
Negative Pressure Wound Therapy ◽  
Chronic Wound ◽  
Wound Care ◽  
Wound Treatment ◽  
Wound Therapy ◽  
Number Of Patients ◽  
Moisture Balance

An increased number of patients developing difficult-to-heal wounds results in billions spending for chronic wound care management. Introduction of TIME conception has been a breakthrough idea for wound healing based on phase-adapted wound therapy that interacts and influence each other and included: T – tissue management, I - infection control, M - moisture balance, E - edge of the wound. Negative pressure wound therapy (NPWT) revolutionized the management of wound healing. Moreover, recently NPWT with instillation (iNPWT) has gained the popularity of optimizing wound healing. In the context of acceleration of wound healing, iNPWT meets the criteria of the TIME conception. All individual components of TIME strategy are found in iNPWT providing “all in one” conception. Such management is easy to apply, monitor and it is well- tolerated by patients. Based on the current studies, iNPWT is found to be an important alternative for other methods of wound healing. It is believed that iNPWT will evolve and gain popularity as an innovative treatment for TIME conception.

scholarly journals Silver nanoparticle – poly (n-isopropylacrylamide) conjugate preparation: biological and chemical characterization studies of the conjugates

2021 ◽  
Vol 23 (09) ◽  
pp. 320-339
Author(s):  
Basil Baby ◽  
◽  
Maya Devi S ◽  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Organic Compounds ◽  
Silver Nanoparticle ◽  
Spectroscopic Analysis ◽  
Chemical Characterization ◽  
Life Saving ◽  
Characterization Studies

Conjugation of nanoparticles with organic compounds are performed to enhance the activity and to increase their stability. This property would aid in developing different life saving biomedical products. Based on this objective, silver nanoparticle – poly (N-isopropylacrylamide) conjugate was developed with the aim of investigating its wound healing ability and biocompatibility in the present study. Chemical characterization of developed silver nanoparticles was also studied using FESEM and UV spectroscopic analysis.

scholarly journals Synthesis of non-toxic, biocompatible, and colloidal stable silver nanoparticle using egg-white protein as capping and reducing agents for sustainable antibacterial application

RSC Advances ◽  
2018 ◽  
Vol 8 (41) ◽  
pp. 23213-23229 ◽  
Author(s):  
Kalaiyarasan Thiyagarajan ◽  
Vijay K. Bharti ◽  
Shruti Tyagi ◽  
Pankaj K. Tyagi ◽  
Anami Ahuja ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Silver Nanoparticle ◽  
Broad Spectrum ◽  
Biomedical Applications ◽  
Egg White ◽  
Reducing Agents ◽  
Egg White Protein

For nearly a decade, silver nanoparticles (AgNPs) have been the most prevalent commercial nanomaterials products widely used in different biomedical applications due to their broad-spectrum antimicrobial activity.

scholarly journals Cutaneous wound healing: Current concepts and advances in wound care

2014 ◽  
Vol 47 (03) ◽  
pp. 303-317 ◽  
Author(s):  
Kenneth C Klein ◽  
Somes Chandra Guha
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Standard Of Care ◽  
Medical Community ◽  
Medical Society ◽  
Cutaneous Wounds ◽  
General Acceptance ◽  
Healing Wound ◽  
The Usa ◽  
Variable Success

ABSTRACTA non-healing wound is defined as showing no measurable signs of healing for at least 30 consecutive treatments with standard wound care.[1] It is a snapshot of a patient’s total health as well as the ongoing battle between noxious factors and the restoration of optimal macro and micro circulation, oxygenation and nutrition. In practice, standard therapies for non-healing cutaneous wounds include application of appropriate dressings, periodic debridement and eliminating causative factors.[2] The vast majority of wounds would heal by such approach with variable degrees of residual morbidity, disability and even mortality. Globally, beyond the above therapies, newer tools of healing are selectively accessible to caregivers, for various logistical or financial reasons. Our review will focus on the use of hyperbaric oxygen therapy (HBOT), as used at our institution (CAMC), and some other modalities that are relatively accessible to patients. HBOT is a relatively safe and technologically simpler way to deliver care worldwide. However, the expense for including HBOT as standard of care for recognized indications per UHMS(Undersea and Hyperbaric Medical Society) may vary widely from country to country and payment system.[3] In the USA, CMS (Centers for Medicare and Medicaid Services) approved indications for HBOT vary from that of the UHMS for logistical reasons.[1] We shall also briefly look into other newer therapies per current clinical usage and general acceptance by the medical community. Admittedly, there would be other novel tools with variable success in wound healing worldwide, but it would be difficult to include all in this treatise.

Sign in / Sign up

Export Citation Format

Share Document