Construction of lidocaine transmembrane nano-liposomes and preliminary study on its surface anesthetic effect

2021 ◽  
Vol 11 (11) ◽  
pp. 1826-1832
Author(s):  
Lirong Zhang ◽  
Wei Li ◽  
Qingjun Zhao ◽  
Ruyang Teng
Keyword(s):  
Carboxymethyl Chitosan ◽  
Topical Anesthesia ◽  
Membrane Glycoproteins ◽  
Inhibitory Effects ◽  
New Approach ◽  
Anesthetic Agents ◽  
Performance Requirements ◽  
Topical Analgesics ◽  
The Central Nervous System ◽  
New Type

Lidocaine (Lido) is an amide local anesthetic that has both excitatory and inhibitory effects on the central nervous system, and is one of a group of commonly used local nerve block drugs that are used in the clinic. However, traditional Lido does not meet the transdermal performance requirements of surface anesthetic agents for treating pain in patients. Optimizing the preparation of a Lido transdermal preparation and improving the control of anesthetic depth and efficiency has become a challenge in the field of topical anesthesia. In this study, a new type of Lido nano-transdermal preparation, carboxymethyl chitosan-modified lidocaine liposomes (Lido-CMCSNLP), were constructed based on nano-liposomes. Carboxymethyl chitosan can enhance the permeability of hydrophilic macromolecular pathways by interacting with negatively charged membrane glycoproteins, which is beneficial for the transdermal absorption of Lido. Therefore, Lido-CMCS-NLP provides a new approach for research in clinical topical anesthesia and perioperative topical analgesics.

scholarly journals Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jiang Ouyang ◽  
Ling Zhang ◽  
Leijiao Li ◽  
Wei Chen ◽  
Zhongmin Tang ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Density Functional ◽  
Biomedical Application ◽  
Density Functional Theory Calculations ◽  
Free Electrons ◽  
Functional Theory ◽  
New Approach ◽  
New Type ◽  
Average Size ◽  
Cancer Theranostics

Abstract Stanene (Sn)-based materials have been extensively applied in industrial production and daily life, but their potential biomedical application remains largely unexplored, which is due to the absence of the appropriate and effective methods for fabricating Sn-based biomaterials. Herein, we explored a new approach combining cryogenic exfoliation and liquid-phase exfoliation to successfully manufacture two-dimensional (2D) Sn nanosheets (SnNSs). The obtained SnNSs exhibited a typical sheet-like structure with an average size of ~ 100 nm and a thickness of ~ 5.1 nm. After PEGylation, the resulting PEGylated SnNSs (SnNSs@PEG) exhibited good stability, superior biocompatibility, and excellent photothermal performance, which could serve as robust photothermal agents for multi-modal imaging (fluorescence/photoacoustic/photothermal imaging)-guided photothermal elimination of cancer. Furthermore, we also used first-principles density functional theory calculations to investigate the photothermal mechanism of SnNSs, revealing that the free electrons in upper and lower layers of SnNSs contribute to the conversion of the photo to thermal. This work not only introduces a new approach to fabricate 2D SnNSs but also establishes the SnNSs-based nanomedicines for photonic cancer theranostics. This new type of SnNSs with great potential in the field of nanomedicines may spur a wave of developing Sn-based biological materials to benefit biomedical applications.

scholarly journals Scientia est potentia

2009 ◽  
pp. 43-60
Author(s):  
Ülo Kaevats
Keyword(s):  
Modern Science ◽  
New Approach ◽  
Natural Laws ◽  
Modern Times ◽  
Natural Objects ◽  
Deductive Method ◽  
New Type ◽  
The Subject ◽  
Understanding Of Science ◽  
Object Of Study

Oma algses mitmetähenduslikkuses on see F. Baconi aforism kõige tihendatum tõdemus, mis tõmbab olemusliku eraldusjoone ühelt poolt antiikse ja keskaegse ning teisalt uusaegse arusaama vahele teadusest ja teadusteadmisest. Artiklis püüab autor anda võimaluste piires tervikpildi uusaja teaduse industriaalselt (tehnoloogiliselt) orienteeritud teadmistüübi tekkimisest. Uusaja teaduse kujunemiseks vajaliku pöörde maailmavaateliste eeldustena tuleb käsitleda: (1) põhimõtteliselt uut subjekti ja objekti käsitust; (2) täiesti uut väärtusruumi, uut teaduse ideoloogiat (ilmalikkus, kriitiline vaim, tõesus ja praktiline kasulikkus); (3) tunnetuslaadi muutust — kontemplatsioonilt interventsioonile, kvaliteedi kirjeldamiselt kvantiteedi uurimisele; (4) looduse käsitlemist Kosmose asemel seaduspäraselt korrastatud objektide “väljana”. Uue tunnetusstiili — empiirilise ja teoreetilise tunnetuse kokkuviimine, hüpoteetilis-deduktiivse metodoloogia kujundamine Galilei poolt, abstraktse ja sünteetilis-tekstilise loomuga spekulatsiooni asendumine uurimisobjekti ehituse, korrapära ja põhjuslikkuse objektiivse analüüsiga, universaalsete loodusseaduste doktriini kujunemine jms—kujunemine konstitueeris uut tüüpi teadmise. Teadmise kui nähtava maailma piltkoopia asemele luuakse teadmine kui loodusobjektide seaduspära analüütiline rekonstruktsioon. See on vormiltmatemaatiline, päritolult eksperimentaalne ning loodusobjektide kontrollimisele ja ümbertegemisele suunatud nn valdamisteadmine.This F. Bacon's aphorism in its original ambiguity is the most condensed belief that draws a distinctive essential line between ancient and medieval understanding of science and scientific knowledge on one hand and modern understanding on the other. The author aims at providing, as far as possible, an integral overview of emerging of the industrially (technologically) orientated type of knowledge of modern times. Ideological/philosophical preconditions of the change necessary for emerging of modern science are: (1) a fundamentally new approach to the subject and object; (2) a completely new system of values, a new ideology of science (secularity, critical spirit, trueness and utilitarianism); (3) a change in manner of cognizance - from contemplation to intervention, from describing quality to studying quantity; (4) treating nature as a naturally organised "field" of objects instead of the Cosmos. Emerging of a new style of cognizance - bringing together of empirical and theoretical cognition, the devise of the hypothetical-deductive method by Galilei, replacement of speculations abstract and synthetic-textual in nature with objective study of the structure, regularity and causality of the object of study, establishment of the doctrine of universal natural laws etc - constituted a new type of knowledge. Knowledge as a copy of the visible world is replaced by knowledge as an analytical reconstruction of the regularity of natural objects. It is so-called dispositive knowledge, morphologically mathematical, originally experimental and aimed at control and alteration of natural objects.

A new approach to chemically modified carboxymethyl chitosan and study of its moisture-absorption and moisture-retention abilities

2006 ◽  
Vol 102 (2) ◽  
pp. 1303-1309 ◽  
Author(s):  
Li-Ping Sun ◽  
Yu-Min Du ◽  
Xiao-Wen Shi ◽  
Xiao Chen ◽  
Jian-Hong Yang ◽  
...  
Keyword(s):  
Moisture Absorption ◽  
Carboxymethyl Chitosan ◽  
Moisture Retention ◽  
New Approach ◽  
Chemically Modified

scholarly journals AILU FOR HELMHOLTZ PROBLEMS: A NEW PRECONDITIONER BASED ON THE ANALYTIC PARABOLIC FACTORIZATION

2001 ◽  
Vol 09 (04) ◽  
pp. 1499-1506 ◽  
Author(s):  
MARTIN J. GANDER ◽  
FRÉDÉRIC NATAF
Keyword(s):  
Numerical Experiments ◽  
New Approach ◽  
New Type

We investigate a new type of preconditioner which is based on the analytic factorization of the operator into two parabolic factors. Approximate analytic factorizations lead to new block ILU preconditioners. We analyze the preconditioner at the continuous level where it is possible to optimize its performance. Numerical experiments illustrate the effectiveness of the new approach.

Part Accuracy Management by Topological Mapping of Deviations

2016 ◽  
Vol 859 ◽  
pp. 210-216
Author(s):  
Gabriel Frumuşanu ◽  
Alexandru Epureanu
Keyword(s):  
Geometrical Model ◽  
Synthetic Approach ◽  
Concrete Case ◽  
Topological Map ◽  
New Approach ◽  
Part Geometry ◽  
Real Geometry ◽  
Geometric Deviations ◽  
New Type ◽  
Modern Manufacturing

Despite modern manufacturing processes are characterized by a continuously increasing accuracy, geometric deviations inherently appear on every manufactured part so, for quality-aware companies, it is essential to control and to manage them. This paper introduces a new type of part geometrical model, namely the part topological map, in connection with a new approach in part accuracy management. The part topological map enables a global analytical & synthetic approach of the problems related to tolerancing domain and a generalization of the “part accuracy” concept. The part geometry is seen as a stand-alone ensemble of surfaces dimensionally related, unitary and with its own shape, dimensions and position. The real geometry has also a global, unitary deviation, characterized through deviation features. Each component surface is represented in a particular manner, unrolled, while its deviation features are assessed by using series expansion of the deviations corresponding to a cloud of measured points. A method for effectively realizing the topological map of a part deviation and a numerical exercise to illustrate the method application in a concrete case are also included.

Research on the Sulfate Corrosion-Resistance Admixture for Concrete

2011 ◽  
Vol 250-253 ◽  
pp. 327-330 ◽  
Author(s):  
Ben Ju Yang ◽  
Qiu Yi Li ◽  
Song Gao ◽  
Tao Li
Keyword(s):  
Corrosion Resistance ◽  
Setting Time ◽  
Resistance Coefficient ◽  
Expansion Ratio ◽  
Slag Powder ◽  
Performance Requirements ◽  
Industry Standard ◽  
Invention Patent ◽  
New Type ◽  
And Performance

In this paper, a concrete sulfate corrosion-resistance admixture is developed with anhydrite (CaSO4), super fine slag powder (P800) and anhydrous calcium sulfo-aluminate (C-S-A). It is optimized by means of systematical research on specific surface area, setting time, expansion ratio, compressive strength ratio, corrosion resistance coefficient and expansion coefficient of 20 mixes, which are designed based on the hydration mechanism and performance requirements according to JC/T1011-2006. This new type sulfate corrosion resistance admixture has good performance and completely satisfies the requirements of industry standard JC/T 1011-2006 regarding “Sulfate Corrosion-Resistance Admixture for Concrete”, and has declared Chinese national invention patent (201010256189.2).

scholarly journals Constructive basis for the development of the extreme zones of Siberia and the Russian arctic

2018 ◽  
Vol 7 (2.13) ◽  
pp. 75
Author(s):  
Tat'yana Sarvut
Keyword(s):  
Structural Changes ◽  
Irreversible Process ◽  
World Ocean ◽  
Weather Conditions ◽  
Russian Arctic ◽  
Protective Measures ◽  
New Approach ◽  
The World ◽  
The Face ◽  
New Type

The paper describes the constructive basis for building and structure designing in the difficult regions of Siberia and the Russian Arctic and development of a new approach to the design of buildings and structures in the Russian Arctic in the face of climate change. Severe climate and weather conditions of the northwestern territories of Russia are rapidly changing due to the global warming. The structural changes in development and construction, following this irreversible process, are highlighted and discussed in relation to the foundations and constructive systems. The paper provides an overview of methods and technological approaches to the extreme zone construction. The application of modern methods of design and construction with the involvement of competent "practitioners" increases the pace of construction and reduces its cost; Architectural and constructive solutions should focus on the developing areas of business and tourism. We suggest the possible protective measures against the transgression of the World Ocean and thawing of the permafrost. The term “special Arctic bases”, denoting the new type of settlements in the Russian Arctic, is introduced. The introduction of constructive solutions and the development of planning solutions for the bases will help to ensure a stable activity in the region.  

Nonlinear Dynamic Response of a Thin Plate in a Fractional Viscoelastic Medium under Internal Resonance 1:1:2

2014 ◽  
Vol 518 ◽  
pp. 60-65 ◽  
Author(s):  
Yury Rossikhin ◽  
Marina Shitikova
Keyword(s):  
Nonlinear Equations ◽  
Time Scales ◽  
Viscoelastic Medium ◽  
Equations Of Motion ◽  
Multiple Time Scales ◽  
Multiple Time ◽  
Internal Resonances ◽  
Nonlinear Dynamic Response ◽  
New Approach ◽  
New Type

Dynamic behaviour of a nonlinear plate embedded in a fractional derivative viscoelastic medium and subjected to the conditions of the internal resonances two-to-one has been studied by Rossikhin and Shitikova in [1]. Nonlinear equations, the linear parts of which occur to be coupled, were solved by the method of multiple time scales. A new approach proposed in this paper allows one to uncouple the linear parts of equations of motion of the plate, while the same method, the method of multiple time scales, has been utilized for solving nonlinear equations. The new approach enables one to find a new type of the internal resonanse, i.e., one-to-one-to-two, as well as to solve the problems of vibrations of thin bodies more efficiently.

scholarly journals Land classification based on hydrological landscape units

2011 ◽  
Vol 8 (3) ◽  
pp. 4381-4425
Author(s):  
S. Gharari ◽  
F. Fenicia ◽  
M. Hrachowitz ◽  
H. H. G. Savenije
Keyword(s):  
Conceptual Models ◽  
Overland Flow ◽  
Surface Flow ◽  
Landscape Classification ◽  
Surface Slope ◽  
New Approach ◽  
Digital Elevation ◽  
New Type ◽  
Elevation Model ◽  
Landscape Units

Abstract. This paper presents a new type of hydrological landscape classification based on dominant runoff mechanisms. Three landscape classes are distinguished: wetland, hillslope and plateau, corresponding to three dominant hydrological regimes: saturation excess overland flow, storage excess sub-surface flow, and deep percolation. Topography, geology and land use hold the key to identifying these landscapes. The height above the nearest drain (HAND) and the surface slope, which can be readily obtained from a digital elevation model, appear to be the dominant topographical parameters for hydrological classification. In this paper several indicators for classification are tested as well as their sensitivity to scale and sample size. It appears that the best results are obtained by the simple use of HAND and slope. The results obtained compare well with field observations and the topographical wetness index. The new approach appears to be an efficient method to "read the landscape" on the basis of which conceptual models can be developed.

Sign in / Sign up

Export Citation Format

Share Document