scholarly journals Smooth muscle glucose metabolism promotes monocyte recruitment and atherosclerosis in a mouse model of metabolic syndrome

JCI Insight ◽  
2018 ◽  
Vol 3 (11) ◽  
Author(s):  
Valerie Z. Wall ◽  
Shelley Barnhart ◽  
Jenny E. Kanter ◽  
Farah Kramer ◽  
Masami Shimizu-Albergine ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Smooth Muscle ◽  
Glucose Metabolism ◽  
Mouse Model ◽  
Monocyte Recruitment

PBI-4547 Improves Glucose Metabolism and Insulin Resistance, and Reduces Liver Damage in a High-Fat Diet Mouse Model of Obesity and Metabolic Syndrome

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1858-P
Author(s):  
MARTIN LEDUC ◽  
BRIGITTE GROUIX ◽  
MIKAËL TREMBLAY ◽  
LIETTE GERVAIS ◽  
FRANÇOIS SARRA-BOURNET ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Glucose Metabolism ◽  
Mouse Model ◽  
Liver Damage ◽  
High Fat Diet ◽  
High Fat

Low IGF-I bioavailability impairs growth and glucose metabolism in a mouse model of human PAPPA2 p.Ala1033Val mutation

2019 ◽  
Author(s):  
Fujimoto M ◽  
Andrew M ◽  
Liao L ◽  
Zhang D ◽  
Yildirim G ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Mouse Model ◽  
Igf I

459-P: Liver-Targeted Mitochondrial Uncoupling by CRMP Improves Whole-Body Insulin Sensitivity and Attenuates Atherosclerosis in A LDLR-/- Mouse Model of Metabolic Syndrome

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 459-P
Author(s):  
LEIGH GOEDEKE ◽  
NOEMI ROTLLAN ◽  
KESHIA TOUSSAINT ◽  
ALI NASIRI ◽  
XINBO ZHANG ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Mouse Model ◽  
Whole Body ◽  
Mitochondrial Uncoupling

scholarly journals Macro- and microtranscriptomic evidence of the monocyte recruitment to regenerating liver after partial hepatectomy in mouse model

2021 ◽  
Vol 138 ◽  
pp. 111516
Author(s):  
Andrey Elchaninov ◽  
Maria Nikitina ◽  
Polina Vishnyakova ◽  
Anastasia Lokhonina ◽  
Andrey Makarov ◽  
...  
Keyword(s):  
Mouse Model ◽  
Partial Hepatectomy ◽  
Regenerating Liver ◽  
Monocyte Recruitment

Decreased Glucose Metabolism and Glutamine Synthesis in the Retina of a Transgenic Mouse Model of Alzheimer’s Disease

2021 ◽  
Author(s):  
Anna Luna Mølgaard Tams ◽  
Berta Sanz-Morello ◽  
Emil Winther Westi ◽  
Zaynab Ahmad Mouhammad ◽  
Jens Velde Andersen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glucose Metabolism ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Glutamine Synthesis

scholarly journals A Multivariate Pattern Analysis of Metabolic Profile in Neurologically Impaired Children and Adolescents

Children ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 186
Author(s):  
Valeria Calcaterra ◽  
Giacomo Biganzoli ◽  
Gloria Pelizzo ◽  
Hellas Cena ◽  
Alessandra Rizzuto ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Glucose Metabolism ◽  
Children And Adolescents ◽  
Metabolic Profile ◽  
Children With Disabilities ◽  
Pattern Analysis ◽  
Multivariate Pattern Analysis ◽  
Neurologically Impaired ◽  
Multivariate Pattern ◽  
Impaired Children

Background: The prevalence of pediatric metabolic syndrome is usually closely linked to overweight and obesity; however, this condition has also been described in children with disabilities. We performed a multivariate pattern analysis of metabolic profiles in neurologically impaired children and adolescents in order to reveal patterns and crucial biomarkers among highly interrelated variables. Patients and methods: We retrospectively reviewed 44 cases of patients (25M/19F, mean age 12.9 ± 8.0) with severe disabilities. Clinical and anthropometric parameters, body composition, blood pressure, and metabolic and endocrinological assessment (fasting blood glucose, insulin, total cholesterol, high-density lipoprotein cholesterol, triglycerides, glutamic oxaloacetic transaminase, glutamate pyruvate transaminase, gamma-glutamyl transpeptidase) were recorded in all patients. As a control group, we evaluated 120 healthy children and adolescents (61M/59F, mean age 12.9 ± 2.7). Results: In the univariate analysis, the children-with-disabilities group showed a more dispersed distribution, thus with higher variability of the features related to glucose metabolism and insulin resistance (IR) compared to the healthy controls. The principal component (PC1), which emerged from the PC analysis conducted on the merged dataset and characterized by these variables, was crucial in describing the differences between the children-with-disabilities group and controls. Conclusion: Children and adolescents with disabilities displayed a different metabolic profile compared to controls. Metabolic syndrome (MetS), particularly glucose metabolism and IR, is a crucial point to consider in the treatment and care of this fragile pediatric population. Early detection of the interrelated variables and intervention on these modifiable risk factors for metabolic disturbances play a central role in pediatric health and life expectancy in patients with a severe disability.

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