The Interaction of Parental History of Suicidal Behavior and Exposure to Adoptive Parents' Psychiatric Disorders on Adoptee Suicide Attempt Hospitalizations

Abstract Study Objectives Insomnia is a risk factor for suicidal behavior including attempts and death by suicide. We investigated whether insomnia symptom severity was associated with suicidality and death by suicide in patients with psychiatric disorders. Methods The sample included 180 deceased patients with psychiatric disorders seen at Weber Human Services between 2008 and 2018 who completed the Outpatient Questionnaire-45.2 (OQ) prior to death. Insomnia symptom severity was assessed using item 41 from the OQ. Manner of death was determined by death records and autopsy reports. History of suicidality was determined through electronic medical records. Cases were grouped into 4 lifetime categories: non-suicidal (n=30), suicidal ideation (n=36), suicide attempt (n=95), and death by suicide (n=19). Demographic, medical, and psychiatric features of each group were compared using linear regression. Logistic regression was used to determine whether insomnia symptom severity was associated with lifetime suicidality severity grouping, adjusting for psychiatric disorders commonly linked to suicidality. Results Lifetime suicidality was associated with sleep problems, fatigue, headaches, and psychiatric disorders (i.e., depressive, personality, and trauma-related disorders). Referenced to the non-suicidal group, greater insomnia symptom severity was significantly associated with suicide attempts and death by suicide, with odds ratios (OR) of OR=2.67, p=0.011, and OR=5.53, p=0.002, respectively, even after adjusting important psychiatric diagnoses. Conclusions Results suggest that insomnia symptom severity endorsed during a clinical visit is associated with heightened suicidality, especially suicidal behavior. The presence of insomnia symptoms in patients with psychiatric disorders may indicate risk for suicide and is a target for suicide prevention.

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Predictors of Suicide Behavior Relapse in Pediatric Population

The Spanish Journal of Psychology ◽

10.1017/sjp.2018.7 ◽

2018 ◽

Vol 21 ◽

Author(s):

Francisco Villar ◽

Carmina Castellano-Tejedor ◽

Mireia Verge ◽

Bernardo Sánchez ◽

Tomás Blasco-Blasco

Keyword(s):

Family History ◽

Personality Disorder ◽

Suicide Attempt ◽

Suicidal Behavior ◽

Longitudinal Design ◽

Pediatric Population ◽

Binary Logistic Regression ◽

Binary Logistic Regression Model ◽

Increased Risk ◽

History Of

AbstractIdentifying patients at increased risk of suicide remains a challenge today. It has been reported that 10% of patients committing a suicide attempt end up dying and that both the risk and the severity of clinical symptomatology increase with the number of attempts. Within the framework of selective and indicated prevention, it is essential to identify the group of patients with an increased risk of recurrence. The objective of this study is to identify factors predicting suicide attempt relapse to improve the decision making process in the therapeutic approach to suicidal behavior. The methodology employed was a longitudinal design aimed at identifying factors, in a binary logistic regression model (stepwise), predicting the repetition of suicidal behavior among a sample of 417 participants aged between 8 and 17 years old, at the six months follow-up. A statistically significant model χ2(3, N = 417) = 18.610; p < .001; Nagelkerke R2 = .096 including the following factors was obtained: current diagnosis of personality disorder/maladaptive personality OR = .806, p = .028, 95% CI [1.091, 4.595], personal history of self-injury OR = .728, p = .043, 95% CI [1.023, 4.192], and family history of psychopathological diagnosis OR = .925, p = .021, 95% CI [1.151, 5.530]. Considering these results, having a diagnosis of personality disorder or maladaptive personality traits, presence or history of self-harm and family history of psychopathology draws a predictive profile of autolytic attempt recurrence during the six months after the initial intervention at the emergency room.

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Research on serotonin and suicidal behavior: neuroendocrine and molecular approaches

Dialogues in Clinical Neuroscience ◽

10.31887/dcns.2002.4.4/hcorrea ◽

2002 ◽

Vol 4 (4) ◽

pp. 408-416

Keyword(s):

Major Depression ◽

Suicide Attempt ◽

Gene Polymorphism ◽

Psychiatric Disorder ◽

Suicidal Behavior ◽

Suicide Attempts ◽

Healthy Controls ◽

Molecular Approaches ◽

History Of ◽

Serotonergic Function

We carried out two studies to test the hypothesis that altered central serotonergic function, as assessed by lower prolactin (PRL) response to fenfluramine (D-FEN), is more closely associated with suicidal behavior than a particular psychiatric diagnosis. A D-FEN test was performed in 85 major depressed inpatients, 33 schizophrenic inpatients, and 18 healthy controls. We showed that PRL response to D-FEN is a marker of suicidality, regardless of psychiatric disorder. We then examined the association en the serotonin (5-hydroxytryptamine) receptor 5-HT(2A) gene polymorphism (T102C) and suicide in a sample of Brazilian psychiatric inpatients (95 with schizophrenia, 78 with major depression) and 52 healthy controls. No differences were found in genotypic frequencies across patients and controls. Overall, no differences were found between patients with (n=66) and without (n=107) a history of suicide attempt. We also compared patients with a history of severe suicide attempts (lethality>3; n=32) and patients without such a history (n=107), but they did not exhibit different genotypic frequencies either. These results show thai the 5-HT(2A) gene polymorphism (T102C) may not be involved in the genetic susceptibility to suicidal behavior.

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The Relationship Between Prior Suicidal Behavior and Mortality Among Individuals in Community Corrections

Crisis ◽

10.1027/0227-5910/a000207 ◽

2013 ◽

Vol 34 (6) ◽

pp. 428-433 ◽

Cited By ~ 2

Author(s):

C. Brendan Clark ◽

Matthew C. Waesche ◽

Peter S. Hendricks ◽

Cheryl B. McCullumsmith ◽

Nicole Redmond ◽

...

Keyword(s):

Suicide Attempt ◽

Suicidal Behavior ◽

Social Stress ◽

Substance Dependence ◽

Past History ◽

Community Corrections ◽

Multiple Risk Factors ◽

Cox Proportional Hazard ◽

Risk Of Mortality ◽

History Of

Background: Individuals under community corrections have multiple risk factors for mortality including exposure to a criminal environment, drug use, social stress, and a lack of medical care that predispose them to accidents, homicides, medical morbidities, and suicide. The literature suggests that prior suicidal behavior may be a particularly potent risk factor for mortality among individuals in the criminal justice system. Aims: This study looked to extend the link between history of a suicide attempt and future mortality in a community corrections population. Method: Using an archival dataset (N = 18,260) collected from 2002 to 2007 of individuals being monitored under community corrections supervision for an average of 217 days (SD = 268), we examined the association between past history of a suicide attempt and mortality. Results: A Cox Proportional Hazard Model controlling for age, race, gender, and substance dependence indicated that past history of a suicide attempt was independently associated with time to mortality, and demonstrated the second greatest effect after gender. Conclusion: These data suggest the need for a greater focus on screening and preventive services, particularly for individuals with a history of suicidal behavior, so as to reduce the risk of mortality in community corrections populations.

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Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits

Psychological Medicine ◽

10.1017/s0033291721004700 ◽

2021 ◽

pp. 1-9

Author(s):

Ikuo Otsuka ◽

Hanga Galfalvy ◽

Jia Guo ◽

Masato Akiyama ◽

Dan Rujescu ◽

...

Keyword(s):

Suicide Attempt ◽

Psychiatric Disorders ◽

Suicidal Behavior ◽

Statistical Power ◽

Small Sample ◽

European Ancestry ◽

Risk Scores ◽

Suicide Attempters ◽

Polygenic Risk ◽

Suicide Death

Abstract Background Suicidal behavior is moderately heritable and a consequence of a combination of the diathesis traits for suicidal behavior and suicide-related major psychiatric disorders. Here, we sought to examine shared polygenic effects between various psychiatric disorders/traits and suicidal behavior and to compare the shared polygenic effects of various psychiatric disorders/traits on non-fatal suicide attempt and suicide death. Methods We used our genotyped European ancestry sample of 260 non-fatal suicide attempters, 317 suicide decedents and 874 non-psychiatric controls to test whether polygenic risk scores (PRSs) obtained from large GWASs for 22 suicide-related psychiatric disorders/traits were associated with suicidal behavior. Results were compared between non-fatal suicide attempt and suicide death in a sensitivity analysis. Results PRSs for major depressive disorder, bipolar disorder, schizophrenia, ADHD, alcohol dependence, sensitivity to environmental stress and adversity, educational attainment, cognitive performance, and IQ were associated with suicidal behavior (Bonferroni-corrected p < 2.5 × 10−4). The polygenic effects of all 22 psychiatric disorders/traits had the same direction (p for binomial tests = 4.8 × 10−7) and were correlated (Spearman's ρ = 0.85) between non-fatal suicide attempters and suicide decedents. Conclusions We found that polygenic effects for major psychiatric disorders and diathesis-related traits including stress responsiveness and intellect/cognitive function contributed to suicidal behavior. While we found comparable polygenic architecture between non-fatal suicide attempters and suicide decedents based on correlations with PRSs of suicide-related psychiatric disorders/traits, our analyses are limited by small sample size resulting in low statistical power to detect difference between non-fatal suicide attempt and suicide death.

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Prevalence of and Risk Factors for Suicide Attempts Among Patients With Severe Psychiatric Disorders in Eastern Morocco

Crisis ◽

10.1027/0227-5910/a000825 ◽

2021 ◽

Author(s):

Mohammed Barrimi ◽

Khalid Serraj ◽

Ismail Rammouz ◽

Rachid Alouane ◽

Najoua Messaoudi ◽

...

Keyword(s):

Risk Factors ◽

Family History ◽

Suicide Attempt ◽

Psychiatric Disorders ◽

Suicide Attempts ◽

Personal History ◽

University Hospital ◽

Number Of Patients ◽

History Of ◽

Risk Factors For Suicide

Abstract. Background: Suicide attempts are common in patients with severe psychiatric disorders; however, they are rarely studied in this population. Aims: To investigate the prevalence and risk factors associated with suicide attempts among patients with severe psychiatric disorders. Method: This is a cross-sectional study of patients admitted to the Mohammed VI University Hospital of Psychiatry in Oujda, Morocco. Results: A total of 250 patients with a psychiatric disorder were recruited in this study. Among these, 78 cases (31.2%) had a personal history of suicide attempts. A personal history of suicide attempt was significantly higher among women compared to men (45.5% vs. 27.2%, p = .0099). The most common method of suicide attempts was jumping from heights (31%). Patients with a personal history of suicide attempts had a significantly higher prevalence of alcohol consumption ( p = .0063), family history of psychiatric disorders ( p = .002), family history of suicide attempt ( p = .00004), and family history of suicide ( p = .018) compared to those who had never made suicide attempts. Limitations: As suicidal behavior is highly stigmatized in Morocco, the number of patients who have made a suicide attempt may be underestimated. Conclusion: Our findings justify the need to provide specialized support to psychiatric patients with risk factors for suicide attempts.

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Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts

European Psychiatry ◽

10.1016/j.eurpsy.2018.07.001 ◽

2018 ◽

Vol 54 ◽

pp. 19-26 ◽

Cited By ~ 5

Author(s):

Federico M. Daray ◽

Ángeles R. Arena ◽

Arnaldo R. Armesto ◽

Demián E. Rodante ◽

Soledad Puppo ◽

...

Keyword(s):

Suicide Attempt ◽

Serotonin Transporter ◽

Suicidal Behavior ◽

Suicide Attempts ◽

Age Of Onset ◽

Short Term ◽

History Of ◽

Multicenter Prospective Cohort Study ◽

Adjusted Model

AbstractObjective:The serotonin-transporter-linked polymorphic region (5-HTTLPR) polymorphisms are associated with suicidal behavior; however, prospective studies are scarce. Herein we aim to determine if 5-HTTLPR polymorphisms predict risk of short-term suicide reattempt in a high-risk suicidal sample. We also explore possible mediators or moderators of this relationship.Methods:A multicenter prospective cohort study was designed to compare data obtained form 136 patients admitted to the emergency department for current suicidal ideation or a recent suicide attempt. Subjects were clinically evaluated, genotyped, and monitored for a new suicide attempt for 6 months.Results:At 6 months of follow up, 21% of the subjects had a new suicide attempt. The frequency of L-allele and L-carrier was higher in reattempters when compared with non-reattempters (55.8% vs. 35.4%, p = 0.01 and 76.9% vs. 54.2%, p = 0.04, respectively). Reattempters also differ from non-reattempters patients with respect to age, history of previous suicide attempts, and age of onset of suicidal behavior. The logistic regression model showed that L-carriers had an odds ratio of 2.8 (95% CI: 1.0–7.6) for reattempts when compared to SS genotype. The adjusted model indicates that this association is not mediated or moderated by impulsivity.Conclusion:The 5-HTTLPR polymorphisms predicted short-term risk of suicidal reattempt independently of age and sex. L-carriers have almost three times more risk of relapse when compared with SS carriers.

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Vulnerabilidades da população em situação de rua ao comportamento suicida

Revista de Enfermagem UFPE on line ◽

10.5205/1981-8963-v13i2a237023p431-437-2019 ◽

2019 ◽

Vol 13 (2) ◽

pp. 431

Author(s):

Ramon Azevedo Silva de Castro ◽

Éllen Bárbara Padilha ◽

Cássia Maria Dias ◽

Nadja Cristiane Lappann Botti

Keyword(s):

Suicidal Ideation ◽

Suicide Attempt ◽

Suicidal Behavior ◽

Homeless People ◽

Categorical Analysis ◽

Problematic Use ◽

Street People ◽

Analysis Technique ◽

History Of ◽

Qualitative Descriptive

RESUMOObjetivo: compreender as vulnerabilidades de adultos em situação de rua ao comportamento suicida. Método: trata-se de um estudo qualitativo, descritivo, realizado com oito pessoas em situação de rua com história de tentativa de suicídio. Fez-se a coleta de dados por meio de entrevista, e os resultados a partir da técnica de Análise de Conteúdo na modalidade Análise Categorial. Resultados: entende-se que as categorias geradas a partir da análise temática dos dados foram os contextos de vulnerabilidade à ideação suicida, tentativa de suicídio e suicídio para pessoas em situação de rua. Observou-se que os entrevistados acreditam que o comportamento suicida ocorre na população em situação de rua em função da tristeza, sofrimento, desesperança, uso problemático de álcool e/ou outras drogas, doenças e falta de fé. Conclusão: expõem-se os adultos em situação de rua a constantes e diversas situações de vulnerabilidades ao comportamento suicida. Descritores: Pessoas em Situação de Rua; Vulnerabilidade em Saúde; Suicídio; Ideação Suicida; Tentativa de Suicídio; Saúde Mental. ABSTRACT Objective: to understand the vulnerabilities of street adults to suicidal behavior. Method: this is a qualitative, descriptive study carried out with eight street persons with a history of attempted suicide. Data was collected through an interview, and the results were obtained from the Content Analysis technique in the Categorical Analysis modality. Results: it is understood that the categories generated from the thematic analysis of the data were contexts of vulnerability to suicidal ideation, suicide attempt and suicide for street people. It was observed that the interviewees believe that suicidal behavior occurs in the street population due to sadness, suffering, and hopelessness, problematic use of alcohol and / or other drugs, illness and lack of faith. Conclusion: the adults in the street situation are exposed to constant and diverse situations of vulnerability to suicidal behavior. Descriptors: Homeless People; Vulnerability in Health; Suicide; Suicidal Ideation; Suicide attempt; Mental health. RESUMEN Objetivo: comprender las vulnerabilidades de los adultos en situación de calle al comportamiento suicida. Método: se trata de un estudio cualitativo, descriptivo, realizado con ocho personas en situación de calle con historia de intento de suicidio. Se hizo la recolección de datos por medio de entrevista, y los resultados a partir de la técnica de Análisis de Contenido en la modalidad Análisis Categorial. Resultados: se entiende que las categorías generadas a partir del análisis temático de los datos fueron los contextos de vulnerabilidad a la ideación suicida, intento de suicidio y suicidio para personas en situación de calle. Se observó que los entrevistados creen que el comportamiento suicida ocurre en la población en situación de calle en función de la tristeza, sufrimiento, desesperanza, uso problemático de alcohol y / u otras drogas, enfermedades y falta de fe. Conclusión: se exponen los adultos en situación de calle a constantes y diversas situaciones de vulnerabilidades al comportamiento suicida. Descriptores: Personas sin Hogar; Vulnerabilidad em Salud; Suicidio; Ideación Suicida; Intento de Suicidio; Salude Mental.

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