Tissue Maturation Correlating to Clinical Manifestations in Juvenile Angiofibroma

2005 ◽  
Vol 114 (9) ◽  
pp. 705-708 ◽  
Author(s):  
Luiz U. Sennes ◽  
Felipe S. G. Fortes ◽  
Ossamu Butugan ◽  
Paulo H. Saldiva ◽  
Fabiola C. Bernardi
Keyword(s):  
Nasal Obstruction ◽  
Benign Tumor ◽  
Clinical Manifestations ◽  
Young Male ◽  
Previous Treatment ◽  
Facial Deformity ◽  
Nasopharyngeal Angiofibroma ◽  
Tumor Number ◽  
Rare Benign Tumor ◽  
Male Patients

Objectives: Juvenile nasopharyngeal angiofibroma is a rare benign tumor that affects young male patients and shows a characteristic development from its origin. It is not a true neoplasm, but shows features of vascular processes, developing into a more fibrous condition. The aim of this study was to correlate the clinical manifestations and the histologic findings of the tumor. Methods: Thirty-six patients without previous treatment were studied. We correlated the incidence and duration of the clinical manifestations (nasal obstruction, epistaxis, nasal and/or pharyngeal tumor, and facial deformity) and morphometric histologic analyses of the central region of the tumor (number, caliber, and presence of muscle cells in the vessel wall, and tissue maturity and cellularity). Results: The duration of nasal obstruction, the presence of nasal and/or pharyngeal tumor, and facial deformity were significantly correlated with the number of vessels, the tissue maturation, and the cellularity of the tumor. Epistaxis showed a strong correlation with the presence of muscle fibers in the vessels. Conclusions: There are correlations between the duration of the clinical manifestations and histologic maturation in the central portion of the tumor.

scholarly journals Ossifying Fibroma of the Ethmoid Sinuses: Rare Scenarios

2011 ◽  
Vol 4 (3) ◽  
pp. 159-162
Author(s):  
Raj Kumar ◽  
Kranti Bhavana ◽  
Amit Keshri ◽  
Sushil Kumar Aggarwal ◽  
Deepika Upadhyay ◽  
...  
Keyword(s):  
Benign Tumor ◽  
Age Groups ◽  
Young Male ◽  
Ossifying Fibroma ◽  
Age Group ◽  
Distinct Entity ◽  
Rare Benign Tumor ◽  
Male Patients ◽  
Ethmoid Sinuses

ABSTRACT Ossifying fibroma (OF) is a rare benign tumor, which is a distinct entity, despite being closely related to fibrous dysplasia, according to WHO classification of 2005.1 It is commonly found in mandible and maxilla but rarely found in ethmoid sinuses, orbit and skull base.2-4 It commonly occurs in age group of 20 to 40 years,5,6 although rarely, it can present in all age groups. OF is more common in females than males.4,7 We describe here two cases of OF involving the ethmoid sinuses in young male patients which presented diagnostic dilemmas for us. We report these cases as the site of involvement, age group and sex of patients and diagnostic and management considerations imparted uniqueness to these cases.

scholarly journals Juvenile Nasopharyngeal Angiofibroma: From Diagnosis to Surgical Approach

2021 ◽  
Vol 2 (7) ◽  
pp. 538-542
Author(s):  
Joana Borges da Costa ◽  
Andre Carcao ◽  
Delfim Duarte ◽  
Miguel Viana
Keyword(s):  
Early Diagnosis ◽  
Surgical Approach ◽  
Benign Tumor ◽  
Surgical Intervention ◽  
Young Male ◽  
Clinical Situation ◽  
Juvenile Nasopharyngeal Angiofibroma ◽  
Nasopharyngeal Angiofibroma ◽  
Rare Benign Tumor ◽  
Benign Nature

Juvenile Nasopharyngeal Angiofibroma (JNA) is a rare benign tumor with primary involvement of the nasopharynx in 98% of cases. It is responsible for 0.5% of tumors of the head and neck, occurring in 1/150,000 individuals. Patients between 14 and 25 years old are particularly affected, with a predominance almost exclusively of males. Despite having a benign nature, AFJ has the potential to grow and involve neighboring structures, which highlights the importance of an attempted diagnosis and therapeutic intervention. This work serves to make a JNA theoretical review and present an endoscopic resection video of a JNA in a young male after a pre-op embolization of the tumour, which was essential for the success of the surgical intervention. JNA is an aggressive and locally invasive tumor that can recur after surgery, so an early diagnosis, adequate staging and the appropriate therapeutic plan are essential for the resolution of the clinical situation.

scholarly journals AB0468 IS THE USE OF INTERLEUKIN 17 INHIBITORS IN SPONDYLOARTHRITIS RELATED TO THE CLINICAL MANIFESTATIONS? 12-MONTH EXPERIENCE OF ONE RHEUMATOLOGY CENTER

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1261.1-1261
Author(s):  
M. Khapsirokova ◽  
Z. Kolkhidova ◽  
S. Erdes
Keyword(s):  
Psoriatic Arthritis ◽  
Biological Therapy ◽  
Clinical Manifestations ◽  
Previous Treatment ◽  
Interleukin 17 ◽  
Disease Modifying Antirheumatic Drugs ◽  
Peripheral Arthritis ◽  
Antirheumatic Drugs ◽  
Male Patients ◽  
Necrosis Factor

Background:Therapy with interleukin 17 (iIL17) inhibitors in Russia is indicated for patients with ankylosing spondylitis (AS) or psoriatic arthritis (PSA). If standard therapy is ineffective in these diseases, both tumor necrosis factor inhibitors (iTNF) and iIL17 can be prescribed as the first biologics.Objectives:To study the clinical features of patients with spondyloarthritis (SPA) who were first prescribed iIL17 in a rheumatology center for 12 months.Methods:During the period from January to December 2019, iIL17 was initiated to 43 SPA patients. To compare the clinical picture, the study additionally included 40 SPA patients who were prescribed iTNF during the same period. The diagnosis of AS was based on the mNY criteria, and psoriatic arthritis was based on the CASPAR criteria. In the combined group of 83 patients, AS was in 52 (62.7%), and PSA – in 31; the age of patients was 39.3±10.8 years, and the duration of the disease was 15.1±8.2 years; men were 47 (56.6%).Results:In the iIL17 group, AS had 23 (53.5%) patients, and PSA – 20 (46.5%), while in the iTNF group, respectively, 29 (72.5%) and 11 (27.5%; χ2=3.2, p=0.76). Among the patients who were prescribed iIL17, men were 29 (67%), and in the iTNF group – 18 (45%; χ2=4.2, p=0.04). In terms of activity indicators (ESR, CRP, BASDAI ASDAS-CRP), patients who were prescribed iIL17 or iTNF did not differ significantly from each other. Peripheral arthritis, dactylitis, and entesitis were observed with almost the same frequency in both groups. In the iIL17 group, there were almost 2 times more patients with psoriasis (53.5% and 25.0%; p<0.05) than in group iTNF and among them, significantly more frequent the patients had previous experience of iTNF treatment (41,9% and 17.5%; p<0.05). Disease-modifying antirheumatic drugs often received patients in iTNF group (80.0% and 48.8%; p<0.05).Conclusion:Thus, in clinical practice iIL17 often prescribed for SPA male patients with psoriasis and previous treatment experience by iTNF. The activity of the disease and the presence of non-axial manifestations practically do not affect the choice of biological therapy.Disclosure of Interests:None declared.

Intraoral lipoma, surgical approach: A Case report

2020 ◽  
Author(s):  
Farnoosh Razmara ◽  
Nima Dehghani ◽  
Xaniar Mahmoudi ◽  
Mohammad Reza Reshadi ◽  
Mahdi Mohammadi
Keyword(s):  
Adipose Tissue ◽  
Buccal Mucosa ◽  
Benign Tumor ◽  
Surgical Techniques ◽  
Surgical Excision ◽  
Occurrence Rate ◽  
Common Region ◽  
Case Presentation ◽  
Rare Benign Tumor ◽  
Male Patients

Background: Lipoma is a rare benign tumor that overgrows in oral cavity. Its occurrence rate is about 1-4% with predilection for males rather than females. Lipoma is associated with adipose tissue and is usually seen in major salivary glands, buccal mucosa, and vestibule. Fifty percent of lesions are seen in buccal mucosa. The progressive and aggressive growth of these lesions may interfere with speech and mastication owing to the dimensions and location of the tumor. The lesion basically affects the individuals of 4th to 5th decades. Lipoma is managed by surgical excision using scalpel, laser, or electro-cautery. Case Presentation: This study presents two 63 and 18 years old male patients with lipoma in their buccal mucosa along with their improved situation following the treatment. The treatment included surgical excision of the lesion and suturing the surgical area. Conclusions: The incidence of intraoral lipoma is low and buccal mucosa is the most common region for the occurrence of oral lipoma. Most clinicians suggested surgical techniques as a certain treatment.

scholarly journals Angiofibroma Localized in the Sphenoid Sinus

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Alper Yenigun ◽  
Fadlullah Aksoy ◽  
Omer Vural ◽  
Orhan Ozturan
Keyword(s):  
Case Report ◽  
Sphenoid Sinus ◽  
Benign Tumor ◽  
Clinical Signs ◽  
Young Male ◽  
Surgical Excision ◽  
Treatment Method ◽  
Endoscopic Examination ◽  
Male Population ◽  
Nasopharyngeal Angiofibroma

Juvenile nasopharyngeal angiofibroma is the most common benign tumor of the nasopharynx with complaints of unilateral nasal obstruction and recurrent nosebleeds in the young male population. Despite being a benign tumor, it can be aggressively destructive in surrounding tissues and bones by acting locally. The gold standard treatment method is the surgical excision of the tumor. This case report is a case of angiofibroma, a 32-year-old asymptomatic male patient with no evidence of clinical signs and endoscopic examination, which is recognized as a localized vascular mass lesion in the right sphenoid sinus on the cranial MR imaging. We prepared this case report that may represent an angiofibroma localized only within the sphenoid sinus which is very rare in the literature.

scholarly journals Juvenile nasopharyngeal angiofibroma

2020 ◽  
Vol 19 (4) ◽  
pp. 185-197
Author(s):  
A. S. Krasnov ◽  
N. S. Grachev ◽  
I. N. Vorozhtsov ◽  
G. V. Tereschenko
Keyword(s):  
Soft Tissues ◽  
Benign Tumor ◽  
Infratemporal Fossa ◽  
Complex Mixture ◽  
Lateral Spread ◽  
Juvenile Nasopharyngeal Angiofibroma ◽  
Nasopharyngeal Angiofibroma ◽  
Fibrous Stroma ◽  
Male Adolescents ◽  
Rare Benign Tumor

Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor that affects almost exclusively male adolescents. Usually, symptoms of JNA are detected within 15–24 months before seeking medical help. JNA is mainly diagnosed in patients aged 14 to 25 years. Angiofibroma consists of a complex mixture of blood vessels and a fibrous stroma. This feature of their structure determines the property of the tumor to bleed massively even after minimal surgical procedures. The tumor usually grows posteriorly and upward, involving the sphenoid sinus. Under certain circumstances, it can spread anteriorly into the nasal cavity with the involvement of ethmoid cells. With lateral spread, it affects the space of the pterygo-palatine fossa and can also spread into the infratemporal fossa through the expanded pterygo-maxillary fissure, into the region of the chewing muscles and soft tissues of the cheek. In this review, we briefly outline the study history, and current aspects of etiology, pathogenesis, diagnostic and treatment methods of JNA.

An Invasive Hemolymphangioma of the Pancreas in a Young Woman

2019 ◽  
Vol 21 (10) ◽  
pp. 798-800 ◽  
Author(s):  
Zhijun Zhang ◽  
Qinghong Ke ◽  
Weiliang Xia ◽  
Xiuming Zhang ◽  
Yan Shen ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Young Woman ◽  
Benign Tumor ◽  
Abdominal Distension ◽  
Accurate Diagnosis ◽  
Cystic Tumor ◽  
Rare Benign Tumor ◽  
Radical Surgical Resection

Background: Hemolymphangioma is a rare benign tumor. To the best of our knowledge, there were only 10 reports of this tumor of the pancreas until March 2018. Case Report: Here, we reported a large invasive hemolymphangioma of the pancreas in a young woman with a complaint of abdominal distension and an epigastric mass about 3 weeks. She was found to have a huge multilocular cystic tumor at the neck and body of pancreas on computed tomography. She was eventually diagnosed with hemolymphangioma of the pancreas after operation. After 2 years of follow-up, there was no signs of recurrence. Conclusion: From our case and literature, we can conclude that hemolymphangioma of the pancreas is uncommon benign tumor, and it is hard to make an accurate diagnosis preoperatively. Radical surgical resection should be performed whenever possible. The prognosis of this disease seems good.

Testicular fibroma: A case report

2013 ◽  
Vol 21 (3-4) ◽  
pp. 139-140
Author(s):  
Sunita Shere ◽  
Anjali Kulkarni ◽  
Shubhjyoti Pore ◽  
Rajan Bindu
Keyword(s):  
Case Report ◽  
Benign Tumor ◽  
Histopathological Diagnosis ◽  
Testicular Mass ◽  
Rare Benign Tumor ◽  
Testicular Malignancy ◽  
Slow Growing

Testicular fibroma of gonadal stromal origin is a rare benign tumor of testis, which usually presents as a slow growing testicular mass. Intratesticular fibroma of gonadal stromal origin, with or without minor sex cord elements, must be considered, analogous to similar tumors in ovary, as a benign tumor. Until now, only 25 cases of testicular fibroma have been reported in the literature. We reported a case of testicular fibroma in a 20 years male who presented with painless right testicular enlargement since two years. Ultrasonography (USG) showed heterogeneous mass in right scrotum suggestive of testicular malignancy. Right orchidectomy was done. Histopathological diagnosis was testicular fibroma, which was confirmed by immunohistochemistry.

scholarly journals Management of Basal Cell Adenoma of Accessory Parotid Gland Through Transoral Approach: Report of a Rare Case With Review

2021 ◽  
Vol 6 ◽  
pp. 247275122110308
Author(s):  
Charudatta Naik ◽  
Sanjay Joshi ◽  
Bhupendra Mhatre ◽  
Sneha Punamiya
Keyword(s):  
Parotid Gland ◽  
Basal Cell ◽  
Benign Tumor ◽  
Transoral Approach ◽  
Surgical Approaches ◽  
Basal Cell Adenoma ◽  
Diagnostic Dilemma ◽  
Cell Adenoma ◽  
Rare Benign Tumor ◽  
Accessory Parotid Gland

Diagnosis of mid-cheek mass has always been a diagnostic dilemma for clinicians. The incidence of the accessory parotid gland (APG) has been well documented in the literature. However, a diverse spectrum of pathologies can arise from this accessory parotid tissue. Basal cell adenoma is a rare benign tumor that predominantly affects the parotid gland. Its occurrence in the accessory parotid gland has been documented in 9 cases till date. Surgical approaches for the management of such APG lesions have been in debate. This report documents a case of Basal Cell Adenoma arising in accessory parotid tissue in a 55-year-old woman who was treated by transoral excision. This paper also reviews previously documented cases of all APG lesions and attempts to elucidate the rationale for selecting an appropriate surgical approach.

scholarly journals Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications

2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
Stathis Tsiakas ◽  
Chrysanthi Skalioti ◽  
Paraskevi Kotsi ◽  
Ioannis Boletis ◽  
Smaragdi Marinaki
Keyword(s):  
Antiphospholipid Syndrome ◽  
Thrombotic Event ◽  
Renal Involvement ◽  
Clinical Manifestations ◽  
Young Male ◽  
Multiple Organ ◽  
Systemic Autoimmune Disease ◽  
Antiphospholipid Antibody ◽  
Primary Antiphospholipid Syndrome ◽  
Wide Range

ABSTRACT Antiphospholipid syndrome (APS) is a systemic autoimmune disease defined by the presence of antiphospholipid antibodies in association with thrombotic events and/or obstetric complications. Renal involvement is not infrequent in both primary and secondary APS. Kidney manifestations comprise a wide range of clinical features, including hypertension, major renal vessel thrombosis or microvascular endothelial injury, also described as APS nephropathy. In the absence of a thrombotic event, clinical manifestations of APS are often non-specific. We recently encountered a case of primary APS in a young male with newly diagnosed hypertension and renal impairment. The diagnosis of APS was initially suspected by his kidney biopsy findings, when electron microscopy examination showed the features of chronic microangiopathy, and was later confirmed by a triple positive antiphospholipid antibody profile and multiple organ involvement.

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