Age-specific reference intervals of serum anti-Müllerian hormone in Chinese girls

2021 ◽  
pp. 000456322110028
Author(s):  
Jin Wang ◽  
Ting Yao ◽  
Xinxin Zhang ◽  
Qi Chen ◽  
Shuo Gong ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Luteinizing Hormone ◽  
Body Mass ◽  
Follicle Stimulating Hormone ◽  
Reference Intervals ◽  
Specific Reference ◽  
Hormone Concentration ◽  
Healthy Chinese ◽  
Chinese Girls ◽  
Stimulating Hormone

Background This study aimed to establish anti-Mullerian hormone age-specific reference intervals and determine the correlation between the anti-Mullerian hormone concentration and age, body mass index and concentrations of follicle-stimulating hormones and luteinizing hormone in healthy Chinese girls. Methods Serum anti-Mullerian hormone concentrations of 1702 healthy girls (0−12 years), recruited between March 2018 and December 2019, were determined using the Beckman Access 2 automated chemiluminescence immunoassay. Single-year-specific medians of anti-Mullerian hormone and effects of age, body mass index, follicle-stimulating hormone and luteinizing hormone on anti-Mullerian hormone concentration were analysed. Results The anti-Mullerian hormone median level continued increasing from birth, reached its peak at age 9 at 4.45 ng/mL (interquartile range [IQR] 2.58–6.90) and then gradually decreased. At age 12, the median reached 1.98 ng/mL (IQR 1.05–3.46). Age-specific reference intervals for anti-Mullerian hormone were established in healthy Chinese girls aged 0–12 years. Anti-Mullerian hormone concentrations showed a moderately positive correlation with age (r = 0.33, P < 0.001). In contrast, follicle-stimulating hormone (r = –0.29, P < 0.001) concentrations were weakly negatively correlated with the serum anti-Mullerian hormone concentration. Conclusion We established single-year-specific reference intervals for anti-Mullerian hormone in Chinese girls using the Beckman chemiluminescent platform. This reference range can help clinicians accurately understand anti-Mullerian hormone secretion in healthy girls and promote its clinical use.

Reference intervals for follicle-stimulating hormone, luteinizing hormone and prolactin in children and young adults on the bioMérieux Mini-Vidas system

2007 ◽  
Vol 45 (4) ◽  
Author(s):  
Thu Koskas ◽  
Karamo Souaré ◽  
Tarik Ouahabi ◽  
Dominique Porquet ◽  
Didier Chevenne
Keyword(s):  
Luteinizing Hormone ◽  
Pediatric Population ◽  
Follicle Stimulating Hormone ◽  
Reference Intervals ◽  
Age Group ◽  
Pubertal Stage ◽  
Significant Difference ◽  
Class 1 ◽  
Children And Young Adults ◽  
Stimulating Hormone

AbstractWe measured serum follicle-stimulating hormone (FSH), luteinizing hormone (LH) and prolactin concentrations on a bioMérieux Mini Vidas system in a pediatric population ranging in age from 1 to 19 years. Reference intervals were established separately for females and males, with stratification by age group and by Tanner's pubertal stage. FSH values were higher in females than in males, and were lowest in both sexes of age class 2 (4–8 years), increasing thereafter to the upper limit for stage PIV (females) and stage PV (males). LH values showed a similar pattern of change: concentrations were lowest for class 1 (1–3 years) and class 2 (4–8 years), and highest for stage PII (females) and stage PV (males). No significant difference was observed according to gender. Prolactin values did not differ markedly according to gender or pubertal status.Clin Chem Lab Med 2007;45:541–5.

Processing-independent proANP measurement for low concentrations in plasma: reference intervals and effect of body mass index and plasma glucose

2017 ◽  
Vol 56 (1) ◽  
Author(s):  
Peter D. Mark ◽  
Ingrid Hunter ◽  
Dijana Terzic ◽  
Jens P. Goetze
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Plasma Glucose ◽  
Age Groups ◽  
Radioactive Tracer ◽  
Reference Intervals ◽  
Specific Reference ◽  
Regression Analyses ◽  
Obesity And Diabetes ◽  
Gender Specific

AbstractBackground:Decreased concentrations of pro-atrial-derived natriuretic peptides (proABP) in plasma have been associated with obesity and suggested as a predictor of type 2 diabetes. However, assays for measuring proANP are generally aimed to quantitate higher concentrations of proANP associated with cardiac disease. Therefore, we aimed to measure plasma proANP concentrations in a non-obese Scandinavian reference material and evaluate potential associations of plasma proANP with body mass index (BMI) and plasma glucose, respectively.Methods:We report an optimized processing-independent assay (PIA) for proANP in the lower concentration range. The assay was optimized by raising the amount of radioactive tracer and modifying the mixing ratio of resuspended plasma and buffer. Blood samples from a Scandinavian plasma cohort of 693 healthy subjects were then analyzed and age and gender-specific reference intervals were determined.Results:Simple linear regression analyses of proANP and both BMI and plasma glucose in fasting subjects displayed insignificant associations. Multiple regression analyses supported these findings. However, a higher median plasma concentration of proANP was noted among women <50 years compared to men, whereas no gender-specific differences were seen in other age groups.Conclusions:Our results show that in a healthy non-obese population, BMI and plasma glucose in fasting subjects do not affect plasma proANP concentrations. Our method should be considered for future studies on low proANP concentration studies, e.g. in obesity and diabetes.

Superovulation with urinary human follicle-stimulating hormone: correlations with body mass index and body fat distribution

1996 ◽  
Vol 10 (1) ◽  
pp. 17-21 ◽  
Author(s):  
F. Zullo ◽  
C. Di Carlo ◽  
M. Pellicano ◽  
C. Catizone ◽  
P. Mastrantonio ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Body Fat ◽  
Follicle Stimulating Hormone ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Stimulating Hormone

Luteinizing hormone, follicle-stimulating hormone, testosterone and dihydrotestosterone during testicular descent in the pig fetus

1996 ◽  
Vol 8 (7) ◽  
pp. 1115 ◽  
Author(s):  
JH Visser ◽  
CF Heyns
Keyword(s):  
Luteinizing Hormone ◽  
Body Mass ◽  
Follicle Stimulating Hormone ◽  
Linear Increase ◽  
Testicular Descent ◽  
Serum Concentrations ◽  
Male And Female ◽  
Androgen Synthesis ◽  
Significant Difference ◽  
Stimulating Hormone

To investigate the relationship between gonadotrophins, androgens and testicular descent in the pig fetus, serum concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and serum concentrations and testicular content of testosterone (T) and 5 alpha-dihydrotestosterone (DHT) were determined by radioimmunoassay in 95 fetuses (48 males, 47 females) between Day 60 and Day 90 post coitum (p.c.). The testes were descended in 0% of fetuses at Day 60, 8% of fetuses at Day 70, 40% of fetuses at Day 80 and 87% of fetuses at Day 90 p.c. There was a significant increase in mean serum concentrations of LH in both male and female fetuses from Day 60 to Day 90, with a significant difference in mean serum concentrations of LH between male fetuses with a body mass < 350 g (4% of testes descended) and those with a body mass > 450 g (87% of testes descended), but not between male and female fetuses < 350 g or > 450 g in body mass. There was no significant difference in mean serum concentrations of FSH between male and female fetuses. Mean serum concentrations of T were significantly higher in male fetuses at Day 60 than in those at Days 70-90, with no significant difference in serum concentrations of DHT from Day 60 to Day 90 p.c. Testicular content of T and DHT showed a non-linear increase from Day 60 to Day 90 p.c. Although the serum concentration of T is elevated before, and decreased during, the period of descent, the testicular content of T and DHT increases during the period of descent, indicating that serum concentrations of LH and FSH may have an indirect effect on descent by stimulating testicular androgen synthesis.

scholarly journals Body Mass Index, Follicle-Stimulating Hormone and Their Predictive Value in In Vitro Fertilization

2004 ◽  
Vol 21 (12) ◽  
pp. 431-436 ◽  
Author(s):  
Kathrin Ferlitsch ◽  
Michael O. Sator ◽  
Doris M. Gruber ◽  
Ernst R�cklinger ◽  
Christian J. Gruber ◽  
...  
Keyword(s):  
Body Mass Index ◽  
In Vitro Fertilization ◽  
Body Mass ◽  
Predictive Value ◽  
Follicle Stimulating Hormone ◽  
Vitro Fertilization ◽  
Stimulating Hormone
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