scholarly journals The Relationship between Liver Function Tests and Alcohol Intake in Patients Admitted to an Alcoholism Unit

1984 ◽  
Vol 21 (4) ◽  
pp. 261-267 ◽  
Author(s):  
J R Evans ◽  
S Ogston ◽  
Anne Guthrie ◽  
B Johnston ◽  
L McKechnie
Keyword(s):  
Alcohol Intake ◽  
Reference Group ◽  
Reliability And Validity ◽  
Liver Function Tests ◽  
Gamma Glutamyl Transferase ◽  
Dose Response Relationship ◽  
Social Drinkers ◽  
Heavy Drinkers ◽  
Glutamyl Transferase ◽  
The Relationship

Values of various blood plasma tests have been determined in heavy drinkers admitted to an Alcoholism Unit and in a reference group of occasional social drinkers. These tests were total protein, albumin, bilirubin, alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), asparate amino transferase (AST) and amylase. The aim of this study was to assess the reliability and validity of GGT and AST as indices of alcohol intake in heavy drinkers entering an Alcoholism Unit. The data indicate that in the patients group intra-personal variance and analytical variances are relatively small compared with the between-person variance. The data also indicate, however, that in the patients group GGT and AST are not valid group indices of alcohol intake since the between-person variation is large and the correlation with alcohol intake is weak due to large differences in the dose-response relationship between individuals. AST and GGT are poor indicators of alcohol intake in admissions to an Alcoholism Unit.

Biochemical and Haematological Response to Alcohol Intake

1985 ◽  
Vol 22 (1) ◽  
pp. 50-61 ◽  
Author(s):  
A G Shaper ◽  
S J Pocock ◽  
D Ashby ◽  
M Walker ◽  
T P Whitehead
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Intake ◽  
Density Lipoprotein ◽  
Gamma Glutamyl Transferase ◽  
Haematological Response ◽  
Analysis Technique ◽  
Heavy Drinkers ◽  
Mean Corpuscular Haemoglobin ◽  
Glutamyl Transferase ◽  
Single Blood Sample

In a clinical survey of 7735 middle-aged men, alcohol consumption has been related to 25 biochemical and haematological measurements obtained from a single blood sample. Most measurements showed some association with alcohol consumption, gamma-glutamyl transferase (GGT) being the most strongly associated. Lead, mean corpuscular haemoglobin (MCH), mean corpuscular volume, high-density lipoprotein-cholesterol (HDL-C), urate and aspartate transaminase also showed substantial associations with alcohol intake. Using a discriminant analysis technique, a simple score based on five variables (GGT, HDL-C, urate, MCH and lead) provided the best discrimination between heavy drinkers (e.g. more than three pints of beer daily) and occasional drinkers, but still failed to identify more than half of the heavy drinkers. This combined score may prove a useful measure of an individual's biochemical/haematological response to alcohol consumption for use in epidemiological and clinical studies of alcohol-related disorders. The use of such indices should complement but not replace measures of alcohol intake derived from questionnaires.

The Relationship Between the Development of Alcoholic Liver and Pancreatic Diseases and the Induction of Gamma Glutamyl Transferase

1993 ◽  
Vol 28 (Supplement_1B) ◽  
pp. 27-33 ◽  
Author(s):  
Yoshiro Matsuda ◽  
Mutsumi Tsuchishima ◽  
Yasuhiro Ueshima ◽  
Shujiro Takase ◽  
Akira Takada
Keyword(s):  
Gamma Glutamyl Transferase ◽  
Pancreatic Diseases ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase ◽  
The Relationship

scholarly journals A High Percentage of Patients Recovered From COVID-19 but Discharged With Abnormal Liver Function Tests

2021 ◽  
Vol 12 ◽  
Author(s):  
Qinyi Gan ◽  
Beilei Gong ◽  
Manli Sun ◽  
Zhujun Cao ◽  
Yuyan Zheng ◽  
...  
Keyword(s):  
Liver Function ◽  
Oxygenation Index ◽  
Liver Function Tests ◽  
Gamma Glutamyl Transferase ◽  
Function Tests ◽  
Liver Functions ◽  
Global Health Issue ◽  
Treatment Data ◽  
Independent Risk Factors ◽  
Glutamyl Transferase

BackgroundCoronavirus disease 2019 (COVID-19) pandemic has become the most severe global health issue. Abnormal liver functions are frequently reported in these patients. However, liver function abnormality was often overlooked during COVID-19 treatment, and data regarding liver functions after cure of COVID-19 is limited. This study aimed to reveal the changes of liver function tests (LFTs) during hospitalization, and its clinical significance in patients with COVID-19.MethodsIn this retrospective, bi-center study, a total of 158 hospitalized patients diagnosed with COVID-19 in China were included from January 22nd, 2020 to February 20th, 2020. Clinical features, laboratory parameters including LFTs, and treatment data were collected and analyzed. LFTs included alanine transaminase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, and total bilirubin. Patients were considered with abnormal LFTs when any value of these tests was higher than upper limit of normal.ResultsOf 158 patients with COVID-19, 67 (42.41%) patients had abnormal LFTs on admission and another 50 (31.65%) patients developed abnormal LFTs during hospitalization. The incidence of LFTs abnormality in severe COVID-19 cases was significantly higher than non-severe cases. All LFTs in COVID-19 patients were correlated with oxygenation index. There was no statistical difference in treatment between the patients with or without liver test abnormalities. By the time of discharge, there were still 64 (40.50%) patients with abnormal LFTs. Logistic regression analysis identified younger age, hypertension and low lymphocyte counts as independent risk factors for persistent abnormal LFTs during hospitalization.ConclusionLiver function tests abnormality was common in COVID-19 patients and was more prevalent in severe cases than in non-severe cases. A substantial percentage of patients still had abnormal LFTs by the time of discharge.

scholarly journals Evaluation of pancreatic lipase and gamma-glutamyl transferase in acute pancreatitis

2020 ◽  
Vol 24 (3) ◽  
pp. 401-405
Author(s):  
Ahmed Baban
Keyword(s):  
Acute Pancreatitis ◽  
Pancreatic Lipase ◽  
Digestive Enzymes ◽  
Reference Group ◽  
Gamma Glutamyl Transferase ◽  
Serum Lipase ◽  
Gamma Glutamyl ◽  
Healthy Control ◽  
The Mean ◽  
Glutamyl Transferase

Background and objective: Pancreas is a large organ behind the stomach that produces digestive enzymes and a number of hormones. Pancreatitis is a condition characterized by inflammation of the pancreas. When the digestive enzymes are activated before they are released into the small intestine, they begin attacking the pancreas, and pancreatic damage happens. This study aimed to evaluate the association between pancreatic lipase, gamma-glutamyl transferase, and acute pancreatitis in patients living in Erbil city. Methods: The present study was carried out at the College of Medicine, Hawler Medical University from December 2017 to July 2018. A total of 35 patients with acute pancreatitis and 25 healthy controls were investigated. Examinations of serum pancreatic lipase and gamma glutamyl transferase were carried out spectrophotometrically for both groups using commercial diagnostics kits. Results: The results showed that the mean level of serum pancreatic lipase in patients with pancreatitis was significantly higher (P <0.01)compared to normal healthy control. The mean serum gamma glutamyl transferase was higher in patients with acute pancreatitis when compared to the reference group but not statistically significant. Conclusion: In the frame of this work, we delineate that pancreatic diseases had a significant effect on pancreatic enzymes reflected by a significant increase in serum lipase, whereas the level of gamma glutamyl transferase increased marginally. Keywords: Pancreatitis; Pancreatic lipoprotein lipase; Gamma glutamyl transferase.

scholarly journals Relationship between Alcohol Consumption and Impaired Liver Function

2020 ◽  
Vol 18 (2) ◽  
pp. 163-170
Author(s):  
Agustina W. Djuma ◽  
Novian A. Yudhaswara ◽  
Suzanne Patricia Dardeau
Keyword(s):  
Alcohol Consumption ◽  
Liver Function ◽  
Gamma Glutamyl Transferase ◽  
Research Subjects ◽  
Impaired Liver Function ◽  
Cross Sectional ◽  
Impaired Liver ◽  
Glutamyl Transferase ◽  
The Impact ◽  
The Relationship

East Nusa Tenggara is a province of high alcohol abuse in Indonesia. Ngada Regency has a prevalence of 38.8%. The high prevalence is inseparable from traditional factors and socio-cultural norms which strongly influence the habit of consuming alcohol, the cold temperature in this area further strengthens this habit. The impact of alcohol consumption is the emergence of various types of diseases, one of which is impaired liver function such as alcoholic liver disease. The objective of this study is to determine the relationship between alcohol consumption and impaired liver function in communities in Bajawa and Golewa Districts, Ngada Regency. This research method is an observational analytic with cross-sectional design. The research subjects were 55 people who consumed alcohol in Golewa and Bajawa Districts, who had met the inclusion criteria. Alcohol consumption was measured by the AUDIT (The Alcohol Use Disorders Identification Test) questionnaire, while the parameter for liver disorders was the level of Gamma Glutamyl Transferase (GGT). The prevalence of liver dysfunction based on GGT examination was 15%. Meanwhile, the relationship between alcohol consumption and impaired liver function was tested with the Spearman correlation with α 0.05, the correlation value was p = 0.413, which means it has a moderate or significant, not too strong relationship. It is recommended that the people of Ngada Regency reduce alcohol consumption so that it can reduce the risk of impaired liver function.

scholarly journals Elevated gamma-glutamyl transferase has a non-linear association with incident non-alcoholic fatty liver disease in the non-obese Chinese population: a secondary retrospective study

2021 ◽  
Author(s):  
Liling Wu ◽  
Man Zhang ◽  
Haofei Hu ◽  
Qijun Wan
Keyword(s):  
Fatty Liver Disease ◽  
Chinese Population ◽  
Inflection Point ◽  
Cox Regression ◽  
Gamma Glutamyl Transferase ◽  
Alcoholic Fatty Liver ◽  
Non Linear ◽  
Glutamyl Transferase ◽  
The Relationship ◽  
Alcoholic Fatty Liver Disease

Abstract Background Effective and applicable predictors of non-alcoholic fatty liver disease (NAFLD) are needed for the non-obese Chinese population. We investigated whether serum gamma-glutamyl transferase (GGT) was associated with incident NAFLD in the non-obese Chinese population. Methods This was a retrospective cohort study that enrolled a total of 33153 initially NAFLD-free individuals who underwent a health examination in Wenzhou Medical Center of Wenzhou People’s Hospital from January 2010 to December 2014. We determined the relationship between GGT at enrollment and incident NAFLD during follow-up in 11906 persons. The relationship between GGT levels and incident NAFLD was analyzed using Cox regression and generalized additive models after adjustment for demographic and clinical variables. In addition, we also performed a subgroup analysis, which was explored by Cox proportional hazard models. It was stated that the data had been downloaded from the DATADRYAD website. Result Multivariable Cox regression models were used to estimate the hazard ratio (HR) for GGT with incident NAFLD after adjusted demographic and clinical variables. (HR, 1.010; 95% CI, 1.007–1.012; P < 0.001). The incident NAFLD in the highest quartile of GGT levels was 3.653 times as high (95% confidence interval, 2.915 to 4.579) as that in the lowest quartile. A non-linear relationship was firstly detected between GGT and incidence of NAFLD, which had an inflection point of GGT was 26U/L. The effect sizes and the confidence intervals on the left and right sides of the inflection point were 1.104(1.089–1.120)and 1.001༈0.999–1.004༉, respectively. In subgroup analyses, the hazard ratio for incident NAFLD remained consistent across subgroups. Conclusion In conclusion, the GGT level in the non-obese Chinese population was statistically significantly associated with incident NAFLD. The relationship between GGT level and incident NAFLD is non-linear. When GGT level is less than 26 U/L, GGT was strong positively with incident NAFLD.

scholarly journals EBV Infection Unmasking a Choledochal Cyst in an Infant

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Hassan El Khatib ◽  
Batoul Kawtharany ◽  
Diyaa Mohammad ◽  
Mohammad Siblini ◽  
Nahida El-Rifai
Keyword(s):  
Choledochal Cyst ◽  
Stone Formation ◽  
Liver Function Tests ◽  
Gamma Glutamyl Transferase ◽  
Barr Virus ◽  
Ebv Infection ◽  
Hepatic Involvement ◽  
Epstein Barr ◽  
Glutamyl Transferase

Hepatic involvement is common in acute Epstein–Barr virus (EBV) infection in children. It usually manifests as a transitory elevation of transaminases in up to 80% to 90% of patients, and they normalize by 2 to 6 weeks. A cholestatic pattern with elevated gamma-glutamyl transferase (γGT) and alkaline phosphatase (ALP) is common, in up to 60% in young adults. However, jaundice is very rare occurring in only 5% of pediatric patients. We report here an 8-month-old female with EBV infection who developed obstructive jaundice 2 weeks after the initial infection. Radiologic investigations were compatible with choledochal cyst type IVa complicated by stone formation in the common bile duct. In case of clinical exacerbation or nonamelioration of liver function tests in EVB infection, another diagnosis should be addressed. This highlights the importance of close follow-up in these patients in order not to miss a serious underlying condition such as choledochal malformation.

scholarly journals The association of alcohol intake with gamma-glutamyl transferase (GGT) levels: Evidence for correlated genetic effects

2014 ◽  
Vol 134 ◽  
pp. 99-105 ◽  
Author(s):  
Jenny H.D.A. van Beek ◽  
Marleen H.M. de Moor ◽  
Lot M. Geels ◽  
Michel R.T. Sinke ◽  
Eco J.C. de Geus ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Genetic Effects ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Nurbanu Gurbuzer ◽  
Eren Gozke ◽  
Zeliha Ayhan Basturk
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Cerebrovascular Risk ◽  
The Mean ◽  
And Gender ◽  
Glutamyl Transferase ◽  
Relationship Of ◽  
The Relationship

Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls who had not cerebrovascular disease were included in the study. The patients were divided into four groups according to the location of the infarct area and evaluated as for GGT levels and the presence of diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL). Results. The frequency of DM, HT, and HL and gender distributions were similar. The mean GGT levels were significantly higher in patients with AIS and those with relatively larger areas of infarction (P<0.05). Increased mean GGT levels were found in the subgroup with hypertension, higher LDL-cholesterol, and triglyceride levels among cases with AIS (P<0.05). Conclusion. Higher GGT levels in AIS patients reinforce the relationship of GGT with inflammation and oxidative stress. The observation of higher GGT levels in patients with relatively larger areas of infarction is indicative of a positive correlation between increases in infarct areas and elevated GGT levels.

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