scholarly journals Evaluation of pancreatic lipase and gamma-glutamyl transferase in acute pancreatitis

2020 ◽  
Vol 24 (3) ◽  
pp. 401-405
Author(s):  
Ahmed Baban
Keyword(s):  
Acute Pancreatitis ◽  
Pancreatic Lipase ◽  
Digestive Enzymes ◽  
Reference Group ◽  
Gamma Glutamyl Transferase ◽  
Serum Lipase ◽  
Gamma Glutamyl ◽  
Healthy Control ◽  
The Mean ◽  
Glutamyl Transferase

Background and objective: Pancreas is a large organ behind the stomach that produces digestive enzymes and a number of hormones. Pancreatitis is a condition characterized by inflammation of the pancreas. When the digestive enzymes are activated before they are released into the small intestine, they begin attacking the pancreas, and pancreatic damage happens. This study aimed to evaluate the association between pancreatic lipase, gamma-glutamyl transferase, and acute pancreatitis in patients living in Erbil city. Methods: The present study was carried out at the College of Medicine, Hawler Medical University from December 2017 to July 2018. A total of 35 patients with acute pancreatitis and 25 healthy controls were investigated. Examinations of serum pancreatic lipase and gamma glutamyl transferase were carried out spectrophotometrically for both groups using commercial diagnostics kits. Results: The results showed that the mean level of serum pancreatic lipase in patients with pancreatitis was significantly higher (P <0.01)compared to normal healthy control. The mean serum gamma glutamyl transferase was higher in patients with acute pancreatitis when compared to the reference group but not statistically significant. Conclusion: In the frame of this work, we delineate that pancreatic diseases had a significant effect on pancreatic enzymes reflected by a significant increase in serum lipase, whereas the level of gamma glutamyl transferase increased marginally. Keywords: Pancreatitis; Pancreatic lipoprotein lipase; Gamma glutamyl transferase.

STUDY ON EVALUATION OF SERUM GAMMA-GLUTAMYL TRANSFERASE (GGT) LEVELS IN ACUTE CORONARY SYNDROME

2021 ◽  
pp. 39-40
Author(s):  
Avtar Singh Dhanju ◽  
Deepshikha Singla ◽  
Pashaura Singh ◽  
Ajay Chhabra ◽  
Sukhraj Kaur
Keyword(s):  
Acute Coronary Syndrome ◽  
Cross Sectional Study ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
Coronary Syndrome ◽  
Healthy Control ◽  
Group A ◽  
Group B ◽  
Glutamyl Transferase

Aim: The present study was undertaken with the aim to evaluate serum Gamma Glutamyl Transferase (GGT) levels in patients of acute coronary syndrome. Methodology: This cross-sectional study was conducted on 50 cases with acute coronary syndrome (Group A) and 50 healthy control subjects (Group B) meeting inclusion and exclusion criteria. Results: There is signicant rise in serum GGT levels in patients presenting with ACS in Group A as compared to Group B. Conclusion: Higher levels of GGT in ACS patients with risk factors such as hypertension, dyslipidemia and smoking may serve as biomarker to predict the occurrence of ACS.

Development of Radioimmunoassay for Gamma-Glutamyl Transferase Using Pancreatic Enzyme

1983 ◽  
Vol 20 (4) ◽  
pp. 247-250 ◽  
Author(s):  
Masanobu Masuike ◽  
Michio Ogawa ◽  
Takeshi Kitahara ◽  
Atsuo Murata ◽  
Kazuhiko Matsuda ◽  
...  
Keyword(s):  
Enzyme Assay ◽  
Pancreatic Enzyme ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Standard Curve ◽  
Normal Individuals ◽  
The Mean ◽  
Glutamyl Transferase ◽  
Dilution Curves

A radioimmunoassay (RIA) for the determination of gamma-glutamyl transferase (GGT) was developed using human pancreatic enzyme as antigen. The assay allows the determination of GGT in concentrations as low as 80 ng/ml, and it is reproducible and specific. A good parallel relation was demonstrated between the standard curve and dilution curves for serum, urine, bile, and partially purified kidney GGT. In normal individuals, the mean serum concentration of GGT determined by RIA was found to be 3·43 μg/ml (SD ± 1·20). Enzyme activity calculated from the GGT concentration measured by the radioimmunoassay using a regression equation was approximately twice as great as that determined by conventional enzyme assay.

scholarly journals Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Nurbanu Gurbuzer ◽  
Eren Gozke ◽  
Zeliha Ayhan Basturk
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Cerebrovascular Risk ◽  
The Mean ◽  
And Gender ◽  
Glutamyl Transferase ◽  
Relationship Of ◽  
The Relationship

Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls who had not cerebrovascular disease were included in the study. The patients were divided into four groups according to the location of the infarct area and evaluated as for GGT levels and the presence of diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL). Results. The frequency of DM, HT, and HL and gender distributions were similar. The mean GGT levels were significantly higher in patients with AIS and those with relatively larger areas of infarction (P<0.05). Increased mean GGT levels were found in the subgroup with hypertension, higher LDL-cholesterol, and triglyceride levels among cases with AIS (P<0.05). Conclusion. Higher GGT levels in AIS patients reinforce the relationship of GGT with inflammation and oxidative stress. The observation of higher GGT levels in patients with relatively larger areas of infarction is indicative of a positive correlation between increases in infarct areas and elevated GGT levels.

scholarly journals METABOLIC SYNDROME

2015 ◽  
Vol 22 (04) ◽  
pp. 414-419
Author(s):  
Tariq Zaffar Shaikh ◽  
Hamid Nawaz Ali Memon ◽  
Nisar Ahmed Shah ◽  
Syed Zulfiquar Ali Shah ◽  
Irfan Murtaza Shahwani
Keyword(s):  
Metabolic Syndrome ◽  
Density Lipoprotein ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Female Population ◽  
Gamma Glutamyltransferase ◽  
Gamma Glutamyl ◽  
The Mean ◽  
One Year ◽  
Glutamyl Transferase

Objective: To determine the role of gamma glutamyltransferase as a biochemicalmarker for the diagnosis of metabolic syndrome. Study Design: Cross sectional descriptivestudy. Period: One year. Setting: Department of Medicine, Liaquat University HospitalHyderabad / Jamshoro. Methods: All the patients with metabolic syndrome visited at OPD /admitted in the ward were further evaluated for serum gamma-glutamyltransferase level. Thedata was analyzed in SPSS 16 and the frequency and percentage was calculated. Results:During one year study period, total one hundred patients (23 males and 77 were females) withmetabolic syndrome were recruited and study for gamma glutamyl transferase level. The meanage ±SD for overall population was 56.84±6.52 whereas it was 48.92±5.82 and 58.61±7.73in male and female population respectively. The mean ± SD of systolic and diastolic bloodpressure (mmHg), triglycerides (mg/dl), high density lipoprotein pressure (mg/dl) and fastingblood sugar (mg/dl) in overall population was 161.20 ± 16.74 and 95.60 ± 8.34, 176.38 ±11.93, 29.44 ± 2.90 and 108.42± 6.25. The mean gamma glutamyl transferase level in overallpopulation was 86.75±7.74 while it was 84.83±5.32 and 89.52±6.84 in male and femalepopulation respectively. The gamma-glutamyltransferase was raised in 75 patients of which13 were males and 62 were females (p=0.02) and majority of patients were 50-59 year agegroup (p <0.01). Conclusions: It is concluded that GGT is a good diagnostic tool in metabolicsyndrome with statistical significant results.

scholarly journals Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

2018 ◽  
Vol 7 (8) ◽  
pp. 3020
Author(s):  
Salih Ezzaldein Salih Elias ◽  
Abdelgadir Eltom ◽  
Ahmed L. Osman ◽  
Asaad MA. Babker
Keyword(s):  
Lactate Dehydrogenase ◽  
Pregnant Women ◽  
Biochemical Markers ◽  
Control Group ◽  
P Value ◽  
Gamma Glutamyl Transferase ◽  
Mean Values ◽  
Gamma Glutamyl ◽  
The Mean ◽  
Glutamyl Transferase

Background: Preeclampsia is a disorder of widespread vascular endothelial malfunction and vasospasm that occurs after 20 weeks' gestation and can present as late as 4-6 weeks post-partum. Pre-eclampsia is a syndrome with multiple aetiologies which has made it difficult to develop adequate screening tests and treatments. Objective of this study to assess the level of gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia in Sudanese pregnant women.Methods: This is a case control hospitalize base study. The study was conducted in preeclamptic pregnant women in Omdurman maternity hospital and medical military hospital in Khartoum state. In this study glutamyl transferase and lactate de-hydrogenase was estimation in 100 Sudanese pregnant women by spectrophotometer method, 50 of them were diagnosed with preeclampsia 27 from this is severe preeclampsia and 23 is mild preeclampsia was matched in aged. Serum samples of all the cases were assayed for GGT and LDH. The data was recorded and analyzed using statistical package for social sciences (SPS –version 16) on programmed computer. The mean standard deviations of variable were calculated for both the test group and the control group and P value for comparison was obtained.Results: The mean values of plasma gamma glutamyl transferase in mild and severe preeclamptic pregnant women were insignificant difference when compared to control P value (0.346 - 0.089) respectively. The mean values of plasma lactate dehydrogenase in mild and severe preeclamptic pregnant women were significant increase when compared to control P value (0.008 - 0.001) respectively.Conclusions: The levels of LDH is raised in Sudanese pregnant women with hypertensive also can be useful biochemical marker that reflects the severity of and the occurrence of complications of pre-eclampsia. GGT levels were normal in Sudanese pregnant women with hypertensive preeclampsia.

scholarly journals GAMMA-GLUTAMYL TRANSFERASE AS AN INDICATOR OF OBESITY: A CROSS-SECTIONAL STUDY

2016 ◽  
Vol 9 (9) ◽  
pp. 240
Author(s):  
Vinodhini V M ◽  
Sudhan Kb
Keyword(s):  
Insulin Resistance ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Hepatic Insulin Resistance ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Elevated Liver Enzymes ◽  
The Mean ◽  
Glutamyl Transferase

ABSTRACTObjective: Obesity, characterized by an increase in excessive fat accumulation, represents a social problem worldwide and has been recognizedas a major underlying factor in the pathogenesis of several diseases. Gamma-glutamyl transferase (GGT) is a cell-surface protein contributing tothe extracellular catabolism of glutathione. Elevated GGT is strongly associated with obesity and excess deposition of fat in the liver, termed nonalcoholicfatty liver disease, which is thought to cause hepatic insulin resistance and contribute to the development of systemic insulin resistanceand hyperinsulinemia. Therefore, we have investigated the serum GGT levels in obese individuals and the correlation of serum GGT with bodymass index (BMI) and waist circumference.Methods: The study was carried out in 100 obese patients and 100 non-obese individuals.Results: Patients with obesity showed a significant increase in GGT levels when compared to the control group. The mean levels of BMI, WC, totalcholesterol, triglycerides, low-density lipoprotein-cholesterol (LDL-c), very LDL-cholesterol, total protein, and aspartate aminotransferase werefound to be significantly elevated in the obese individuals compared to controls. The mean levels of high-density lipoprotein-cholesterol showed asignificant decrease in the obese participants.Conclusion: Elevated liver enzymes, although in normal ranges, especially at upper quartiles as observed in our study, may play a central role inearly diagnosis of fat overflow to the liver. The findings of our study suggest that serum GGT levels may be a simple and reliable marker of visceral fataccumulation.Keywords: Diabetes mellitus, Gamma-glutamyl transferase, Insulin resistance, Metabolic syndrome, Obesity.

scholarly journals Effects of Chronic Kidney Disease on Liver Enzymes Activity During Pre and Post Hemodialysis

2020 ◽  
Vol 9 (1) ◽  
pp. 51-55
Author(s):  
Sanjay Kumar Jha ◽  
Naval Kishor Yadav ◽  
Daya Ram Pokharel
Keyword(s):  
Chronic Kidney Disease ◽  
Alkaline Phosphatase ◽  
Kidney Disease ◽  
Alanine Aminotransferase ◽  
Liver Enzymes ◽  
Gamma Glutamyl Transferase ◽  
Healthy Controls ◽  
Gamma Glutamyl ◽  
Healthy Control ◽  
Glutamyl Transferase

Background: Worldwide chronic kidney disease is one of the primary public health problems. This study aimed to find the activity of liver enzymes alanine aminotransferase, aspartate transaminase, alkaline phosphatase, and Gamma-glutamyl transferase in the patient's serum before and after dialysis in Chronic kidney disease. Materials and Methods: This was a case-control study including 68 cases with chronic kidney disease coming for hemodialysis at dialysis centers and 140 healthy individuals as control. Serum samples were used for the analysis of serum urea and creatinine, liver enzymes aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and gamma-glutamyl transferase using ErbaChem-300 liquid Chemistry autoanalyzer. Pearson’s bivariate correlation analysis and ANOVA were used to correlate variables between the controls and cases. p < 0.05 was considered to be statistically significant. Results: Urea and creatinine levels were significantly higher in both pre and post-hemodialysis as compared to healthy controls with a p-value (p < 0.001). Alanine aminotransferase and aspartate transaminase levels were significantly lower in both pre and post-hemodialysis as compared to healthy controls.  On the other hand, serum alkaline phosphatase levels were significantly higher in pre and post hemodialysis as compared to healthy control. Moreover, serum gamma-glutamyl transferase levels were significantly higher in pre and post hemodialysis as compared to healthy control. Conclusion: The study showed differences in the level of liver enzymes in pre and post hemodialysis in chronic kidney disease.

Gamma-glutamyl transferase variability and the risk of hospitalisation for heart failure

Heart ◽  
2020 ◽  
Vol 106 (14) ◽  
pp. 1080-1086 ◽  
Author(s):  
So-hyeon Hong ◽  
Ji Sung Lee ◽  
Jung A Kim ◽  
You-Bin Lee ◽  
Eun Roh ◽  
...  
Keyword(s):  
Heart Failure ◽  
National Health ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Adverse Health Outcomes ◽  
Korean National Health Insurance ◽  
The Mean ◽  
Glutamyl Transferase ◽  
Adjusted Model

ObjectiveGamma-glutamyl transferase (GGT) is associated with oxidative stress, inflammation, cardiovascular disease and mortality. Variability in metabolic parameters has recently emerged as an indicator of adverse health outcomes, including heart failure (HF).MethodsWe investigated whether GGT variability was associated with the incidence of hospitalisation for heart failure (HHF) in a Korean population without previous HF, ischaemic heart disease or liver disease. This longitudinal cohort study analysed 119 201 individuals from the Korean National Health Insurance Service-National Health Screening Cohort. GGT variability was calculated as the coefficient of variation (CV), SD and variability independent of the mean (VIM).ResultsDuring the 8.4 years of follow-up, 1387 cases of HHF (1.16%) developed. In the multivariable-adjusted model, the HR of HHF was 1.22 (95% CI 1.05 to 1.42) in the highest quartile of GGT variability compared with the lowest quartile, as assessed by CV after adjusting for confounding factors, including alcohol consumption and mean GGT levels. Consistent results were obtained using other indices of GGT variability such as SD (HR 1.37, 95% CI 1.16 to 1.62) and VIM (HR 1.29, 95% CI 1.11 to 1.50). In a subgroup analysis stratified by risk factor variables, although a similar relationship was observed, it was more prominent in individuals with dyslipidaemia.ConclusionsThe results of the present study demonstrated that variability in GGT was independently associated with the incidence of HHF. These findings suggest that higher GGT variability may be useful as an indicator of future risk of HF.

scholarly journals Serum gamma-glutamyl transferase level in acute stroke

2019 ◽  
Vol 7 (8) ◽  
pp. 2950
Author(s):  
Lagendra Kumar Singh ◽  
Sourabh Pradhan ◽  
Laxmikanta Dash ◽  
Jagannath Pradhan ◽  
Umakanta Raul ◽  
...  
Keyword(s):  
Standard Deviation ◽  
General Medicine ◽  
First Episode ◽  
P Value ◽  
Gamma Glutamyl Transferase ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
The Mean ◽  
Glutamyl Transferase

Background: Stroke is the second leading cause of death worldwide, causing 6.2 million deaths in 2011. Serum Gamma-Glutamyl Transferase (GGT) has been conventionally considered as a marker of excessive alcohol intake and/or liver dysfunction. There are accumulating evidences suggesting association of raised serum GGT level in stroke. So, this study was conducted to determine the association between the serum GGT level and stroke in population without history of alcohol consumption.Methods: This cross-sectional comparative study was carried out at Department of General medicine, Veer Surendra Sai Institute of Medical Sciences and Research (VIMSAR), Burla from November 2016 to October 2018. 100 cases and 100 controls were included in this study. Cases were the patients admitted to Department of General Medicine, VIMSAR, Burla, presenting within 24 hours of first episode of stroke. Controls were the age (+/-5 years) and sex matched healthy attendants of the patients. Alcoholics or patients suffering from hepatitis, cirrhosis of liver, cholestasis or patients taking drugs like Phenytoin, Valproic acid, Carbamazepine etc or patients with past episode of stroke were excluded from this study. Serum GGT level of both cases and controls were measured and compared.Results: In stroke patients, the mean serum GGT level was 54.95 IU/L with standard deviation of 20.54. In controls, the mean serum GGT level was 32.14 IU/L with standard deviation of 5.07. The p-value was less than 0.0001 i.e. highly significant.Conclusions: Serum GGT level is significantly increased in stroke patients than healthy persons without stroke.

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