Leukocytoclastic Vasculitis Following COVID-19 Vaccination: A Case Report

2021 ◽  
pp. 001857872110673
Author(s):  
Juny Sebastian ◽  
Merrin Mathew ◽  
Veeranna Sharsty ◽  
Madhan Ramesh
Keyword(s):  
Causality Assessment ◽  
Leukocytoclastic Vasculitis ◽  
Lower Limbs ◽  
Temporal Association ◽  
Causal Association ◽  
Laboratory Findings ◽  
Case Presentation ◽  
The Past ◽  
History Of ◽  
Day By Day

Background: Hypersensitivity or Leukocytoclastic vasculitis (LCV) following the COVID-19 vaccination has been reported rarely all over the world. LCV can be induced by certain factors such as infections, autoimmune disorders, malignancy, or some classes of drugs. Case presentation: A 32-year-old man, who was a known case of seizure disorder from his childhood presented to the department of dermatology with itchy red lesions on extremities and abdomen for the past 1 month. He explains a history of COVID-19 vaccination 1-month back and experienced itching on his lower limbs on the same day at night. A gradual worsening of the condition was observed day by day. He was hospitalized and diagnosed as LCV through clinical and laboratory findings. Conclusion: This case highlights a temporal association with the event of vaccination. The causality assessment showed an indeterminate causal association to LCV with COVID-19 Vaccination.

Aspergillus Spondylodiscitis After Spinal Stenosis Surgery: A Case Report

2020 ◽  
Vol 5 (3 And 4) ◽  
pp. 155-160
Author(s):  
Mohsen Aghapoor ◽  
◽  
Babak Alijani Alijani ◽  
Mahsa Pakseresht-Mogharab ◽  
◽  
...  
Keyword(s):  
Antifungal Drugs ◽  
The Body ◽  
Lower Limbs ◽  
Lumbar Pain ◽  
Case Presentation ◽  
Delay In Diagnosis ◽  
Death Case ◽  
Therapeutic Results ◽  
History Of ◽  
Probable Diagnosis

Background and Importance: Spondylodiscitis is an inflammatory disease of the body of one or more vertebrae and intervertebral disc. The fungal etiology of this disease is rare, particularly in patients without immunodeficiency. Delay in diagnosis and treatment of this disease can lead to complications and even death. Case Presentation: A 63-year-old diabetic female patient, who had a history of spinal surgery and complaining radicular lumbar pain in both lower limbs with a probable diagnosis of spondylodiscitis, underwent partial L2 and complete L3 and L4 corpectomy and fusion. As a result of pathology from tissue biopsy specimen, Aspergillus fungi were observed. There was no evidence of immunodeficiency in the patient. The patient was treated with Itraconazole 100 mg twice a day for two months. Pain, neurological symptom, and laboratory tests improved. Conclusion: The debridement surgery coupled with antifungal drugs can lead to the best therapeutic results.

Psychophysiologic Changes accompanying Oral Contraceptive Use

1970 ◽  
Vol 116 (531) ◽  
pp. 165-167 ◽  
Author(s):  
David B. Marcotte ◽  
Francis J. Kane ◽  
Paul Obrist ◽  
Morris A. Lipton
Keyword(s):  
Oral Contraceptive ◽  
Contraceptive Use ◽  
Emotional Reactions ◽  
Temporal Association ◽  
Double Blind Study ◽  
Double Blind ◽  
Premenstrual Tension ◽  
The Past ◽  
Oral Contraceptive Use ◽  
History Of

There have been many studies (3,15,4) on the effects of oral contraceptive hormonal agents, though relatively few have concerned themselves with the possible adverse emotional reactions accompanying their use. To date, seven women (8, 6, 5, 13) have had psychotic episodes in temporal association with drug use, one patient having reported two such episodes. Four of these seven women had a history of severe postpartum disturbance in the past, and two others had previous psychiatric illness. There have been reports of varying incidence of depression, anxiety, increased or decreased sexual desire and relief of premenstrual tension. We wish to present data from a pilot double blind study of one combination oral contraceptive.

scholarly journals Case Report: Migrainous Infarct without Aura

2017 ◽  
Vol 9 (3) ◽  
pp. 241-251
Author(s):  
Kamesh Gupta ◽  
Anurag  Rohatgi ◽  
Shivani Handa
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Case Report ◽  
Rare Case ◽  
Case Presentation ◽  
The Past ◽  
Need To Evaluate ◽  
History Of ◽  
Complicated Migraine ◽  
Full Investigation

Background: Stroke in a migraine with aura has been documented in several cases, even deserving the merit of a classification as complicated migraine. Herein, we present a rare case of migrainous infarct without aura. The diagnosis was challenging due to lack of risk factors. The patient was unique in not having any other comorbidities. Case Presentation: The case is of a 21-year-old female presenting with right-sided hemiplegia and facial drooping. She had had an index presentation of throbbing headaches for the past 2 years, typical of a migraine but not preceded by any aura symptoms. However, in the current episode, the pain became excessively severe and accompanied by right-sided hemiplegia and facial drooping. A full investigation workup using MRI revealed evidence of infarct in the left temporoparietal and basal ganglion region. Conclusion: Our case highlights the need to evaluate silent ischemic stroke in case of prolonged headache with a history of migraine as well as the need for precaution to avoid the use of triptans or opioids in such a case. It also highlights the conditions that need to be excluded before labeling it as a migrainous infarct.

scholarly journals Post-treatment Guillain-Barre Syndrome in a Patient with Brucellosis; A Case Report

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Navid Manouchheri ◽  
Omid Mirmosayyeb ◽  
Majid Ghasemi ◽  
Shervin Badihian ◽  
Vahid Shaygannejad ◽  
...  
Keyword(s):  
Case Report ◽  
Antimicrobial Treatment ◽  
Lower Limbs ◽  
Guillain Barre Syndrome ◽  
Case Presentation ◽  
Brucella Infection ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Guillain Barré ◽  
Uncommon Complication

Introduction: Guillain-Barre Syndrome is an uncommon complication during acute brucellosis. Case presentation: In this study, we present a case of Guillain-Barre Syndrome in a 22-year old male patient with complaints of weakness in his lower limbs. He had a history of acute Brucella infection for four months and received antimicrobial medication. Conclusion: the patients can be affected by GBS after antimicrobial treatment.

Pyruvate carboxylase deficiency type C as a differential diagnosis of diabetic ketoacidosis

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Neslihan Doğulu ◽  
Ümmühan Öncül ◽  
Engin Köse ◽  
Zehra Aycan ◽  
Fatma Tuba Eminoğlu
Keyword(s):  
Diabetic Ketoacidosis ◽  
Pyruvate Carboxylase ◽  
Laboratory Findings ◽  
Case Presentation ◽  
First Case ◽  
Whole Exome ◽  
History Of ◽  
Type C ◽  
Deficiency Type ◽  
Level Analysis

Abstract Objectives Type C pyruvate carboxylase (PC) deficiency is extremely rare, and has been described in only a few patients in literature to date. Herein, we present the case of a four-year-old patient admitted with diabetic ketoacidosis and diagnosed with type C PC deficiency based on clinical and biochemical findings. Case presentation A Turkish girl was referred to the intensive care unit at the age of three-years with a three-day history of vomiting and abdominal pain. Upon physical examination, the patient was found to be experiencing lethargy, dehydration, and Kussmaul breathing. Hyperglycemia, metabolic acidosis, and ketonemia were detected. Clinical and laboratory findings pointed to a prediagnosis of diabetic ketoacidosis. Intravenous fluid, bicarbonate, and insulin treatments were initiated. Elevated alanine and proline levels were recorded in plasma amino acid analysis, while urinary organic acid level analysis revealed increased lactate, pyruvate, 3-OH-butyrate, and acetoacetate levels. Whole exome sequencing revealed homozygous c.584C>T (p.Ala195Val) mutation in the PC gene. Conclusions To date, there have been no reports in literature of type C phenotype patients manifesting with DKA. Our case is the first case with the type C phenotype to be admitted with clinical and laboratory findings of DKA.

scholarly journals Sudden Infant Death Due to Postvaccinal Myocarditis: A Case Report

2021 ◽  
Vol 11 (3) ◽  
pp. 32227-32227
Author(s):  
Babak Salahshour ◽  
◽  
Sajjad Sadeghi ◽  
Ahmad Sajadianfar ◽  
Kambiz Soltaninejad ◽  
...  
Keyword(s):  
Infant Death ◽  
Causality Assessment ◽  
Histopathological Examination ◽  
Cardiopulmonary Arrest ◽  
Inflammatory Cells ◽  
Sudden Infant Death ◽  
Cardiac Monitoring ◽  
Sudden Infant ◽  
Case Presentation ◽  
History Of

Background: Vaccination is a fundamental strategy in public health for controlling and eradicating infectious diseases. However, the undesirable Adverse Events Following Immunization (AEFI) should be effectively monitored, prevented, and managed in societies. Previously, Sudden Infant Death (SID) has been reported as a serious AEFI. We present a rare case of SID in an 18-month-old girl due to severe myocarditis following vaccination. Case Presentation: An 18-month-old girl presented to the Emergency Department (ED) with a history of the injection of Diphtheria-Tetanus-Whole Cell Pertussis (DTwP); Measles, Mumps, and Rubella (MMR), and oral poliovirus vaccines. She expired one-hour post ED admission after the episodes of vomiting and cardiopulmonary arrest. Postmortem histopathological examination signified marked congestion and the destruction of muscle fibers in the myocardium with inflammatory cells infiltration predominantly eosinophils. Given the postmortem histopathological findings, the cause of death was concluded as severe myocarditis following vaccination. Finally, the causality assessment was performed according to the Naranjo scale; the relevant data revealed a probable association in this regard (Naranjo score 6). Conclusion: Myocarditis is a rare and probable AEFI; thus, cardiac monitoring should be recommended as a diagnostic measure in managing postvaccinal adverse effects.

scholarly journals Leukocytoclastic vasculitis in patients with IL12B or IL12RB1 deficiency: case report and review of the literature

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Niusha Sharifinejad ◽  
Seyed Alireza Mahdaviani ◽  
Mahnaz Jamee ◽  
Zahra Daneshmandi ◽  
Afshin Moniri ◽  
...  
Keyword(s):  
Web Of Science ◽  
Leukocytoclastic Vasculitis ◽  
Slight Reduction ◽  
Case Presentation ◽  
Whole Exome ◽  
History Of ◽  
Ifn Γ ◽  
Weakly Virulent ◽  
Schonlein Purpura ◽  
Experienced Symptom

Abstract Background Mendelian susceptibility to mycobacterial disease (MSMD) is an inborn error of immunity, resulting in susceptibility to weakly virulent mycobacteria and other intramacrophagic pathogens. Rheumatologic manifestations and vasculitis are considered rare manifestations in MSMD patients. Case presentation In this study, we reported a 20-year-old female who was presented with recurrent lymphadenitis following bacillus Calmette-Guérin (BCG) vaccination and a history of recurrent disseminated rash diagnosed as leukocytoclastic vasculitis (LCV). A slight reduction in lymphocyte subsets including CD4+, CD19+, and CD 16 + 56 T-cell count, as well as an elevation in immunoglobulins level (IgG, IgA, IgM, IgE), were observed in the patient. Whole exome sequencing revealed a homozygous Indel-frameshift mutation, c.527_528delCT (p. S176Cfs*12), at the exon 5 of the IL12B gene. She experienced symptom resolution after treatment with anti-mycobacterial agents and subcutaneous IFN-γ. We conducted a manual literature search for MSMD patients reported with vasculitis in PubMed, Web of Science, and Scopus databases. A total of 18 MSMD patients were found to be affected by a variety of vasculitis phenotypes mainly including LCV and Henoch-Schönlein purpura (HSP) with often skin involvement. Patients were all involved with vasculitis at the median age of 6.8 (2.6–7.7) years, nearly 6.1 years after the initial presentations. Sixteen patients (88.9%) had IL12RB1 defects and concurrent Salmonella infection was reported in 15 (88.2%) patients. Conclusion The lack of IL-12 and IL-23 signaling/activity/function and salmonella infection may be triggering factors for the development of leukocytoclastic vasculitis. IL12B or IL12RB1 deficiency and salmonellosis should be considered in MSMD patients with vasculitis.

scholarly journals Albanian Schools in The Framework of The European Education Standards During 1920 - 1939

2021 ◽  
Vol 11 (3) ◽  
pp. 104
Author(s):  
Jani Sota
Keyword(s):  
School System ◽  
The Political ◽  
Education Standards ◽  
The Past ◽  
Look Back ◽  
History Of ◽  
European Education ◽  
Renaissance Man ◽  
Political Economic ◽  
Day By Day

Since the beginning, the first Albanian school had the physiognomy of a school with a contemporary tendency. It is well known that the creators and founders were the Renaissance man, who praised and supported the ideas of the new pedagogy. This mindset set the Albanian school free from the mentality of didactic practices, which were commonly used by the old school. Over the years, Albanian education has tried to follow the footsteps of the European education. The object of this study is to recognize the attitude that Albanian school has held towards new pedagogical theories and developments of Western schools, as well as its tendency to embrace and adapt them to the political, economic, social and cultural situation of Albania. Here, I want to present this important phenomenon of the development of Albanian education and our pedagogical thought during the '20s and '30s of the 20th   century. The purpose of this study is to give a scientific synthesis of the history of the development of education and pedagogical ideas in Albania, from 1920 until 1939. Within the limits allowed in a research paper, the reader can draw certain conclusions and experiences. If we look back and see how this progressive trend, turned into a movement that was becoming more powerful day by day and if we take a look at the past and all the other developments during 1920-1939, it is not difficult to understand that this trend would also appear in the Albanian school system. The basic legitimacy is that all dimensions of time - past, present and future are directly reflected in the fact that during all these years the Albanian education has tried to follow the footsteps of the European education.   Received: 2 February 2021 / Accepted: 19 March 2021 / Published: 10 May 2021

scholarly journals Nevirapine induced Stevens Johnson syndrome

2020 ◽  
Vol 1 (2) ◽  
pp. 35-38
Author(s):  
Himani Prajapati ◽  
Neetu Bala ◽  
Dinesh Kansal
Keyword(s):  
Adverse Effect ◽  
Adverse Event ◽  
Causality Assessment ◽  
Burning Sensation ◽  
The Body ◽  
Stevens Johnson Syndrome ◽  
Case Presentation ◽  
Johnson Syndrome ◽  
Life Threatening ◽  
History Of

Introduction: Severe and life-threatening SJS is more common with nevirapine than with other NNRTIs Case presentation: A 56-year-old male patient presented with a complaint of lesions all over the body with a burning sensation for 4 days. He was on an ART regimen, containing zidovudine, lamivudine, and efavirenz combination for 4 years. But patient accidentally started nevirapine and after 10 days he developed maculopapular lesions which were diagnosed as SJS syndrome. There was a history of rash with nevirapine when ART was started initially in 2012. This incident of an adverse event could be assigned a term "probable" according to the WHO-UMC scale for causality assessment as the re-challenge was found positive. Conclusion: Physicians and patients must be aware of this adverse effect on early diagnosis and treatment.

History of «Ichan Qala» State Museum-Reserve

Infolib ◽  
2021 ◽  
Vol 27 (3) ◽  
pp. 60-64
Author(s):  
Dilmurod Bobojonov ◽  
Keyword(s):  
The Past ◽  
State Museum ◽  
History Of ◽  
The Government ◽  
Day By Day

This article describes the foundation of the Ichan-Kala State Museum Reserve in Khiva in 1920 and the activities of the museum, its staff, exhibitions and events over the past 100 years. The Khiva museum- was opened on April 27, 1920 in Arzkhana (reception hall) of Kunya-Ark in the presence of the participants of the 1st Kurultay (Congress) of national representatives. It was called the People’s Museum. The number of visitors increased day by day. In addition to the exposition itself, introductory lectures were held there and thematic exhibitions were organized on certain dates. Until 1924, the descendants of Allakuli Khan lived in the huge Tash-Khauli palace built in 1831–1839 in the inner fortress of Khiva. Considering it their own possession, they began to sell the property of the palace. The government members, having learnt about this, moved the Khiva museum from Kunya-Ark to Tash-Khauli and included it in the list of state property.13 In August of the same year, the Khiva Museum was supplied with the necessary exhibition equipment delivered from Moscow. 285 unique pieces were exhibited in the imported showcases.

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