In-Plane Loading in an Elastic Matrix Containing Two Cylindrical Inclusions

1967 ◽  
Vol 1 (4) ◽  
pp. 404-412 ◽  
Author(s):  
James G. Goree
Keyword(s):  
Three Dimensional ◽  
Numerical Results ◽  
Elastic Matrix ◽  
Infinite Length ◽  
Dimensional Problem ◽  
Rigid Spheres ◽  
The Matrix ◽  
Cylindrical Inclusions

A solution is presented for the stresses and displacements in an infinite elastic matrix containing two perfectly bonded rigid circular cylindrical inclusions of different radii, and of infinite length normal to the x-y plane. The matrix is subjected to in-plane stresses Sx and Sy at infinity as well as loading due to radial expan sion of the inclusions. Numerical results are presented and a com parison is made with the associated three dimensional problem of unequal rigid spheres.

Analytical Derivation of Cosserat Moduli via Homogenization of Heterogeneous Elastic Materials

2006 ◽  
Vol 74 (4) ◽  
pp. 741-753 ◽  
Author(s):  
D. Bigoni ◽  
W. J. Drugan
Keyword(s):  
Three Dimensional ◽  
Heterogeneous Material ◽  
Material Response ◽  
Spherical Inclusions ◽  
The Matrix ◽  
Cylindrical Inclusions ◽  
Dilute Suspension ◽  
Experimental Findings ◽  
Do So

Why do experiments detect Cosserat-elastic effects for porous, but not for stiff-particle-reinforced, materials? Does homogenization of a heterogeneous Cauchy-elastic material lead to micropolar (Cosserat) effects, and if so, is this true for every type of heterogeneity? Can homogenization determine micropolar elastic constants? If so, is the homogeneous (effective) Cosserat material determined in this way a more accurate representation of composite material response than the usual effective Cauchy material? Direct answers to these questions are provided in this paper for both two- (2D) and three-dimensional (3D) deformations, wherein we derive closed-form formulae for Cosserat moduli via homogenization of a dilute suspension of elastic spherical inclusions in 3D (and circular cylindrical inclusions in 2D) embedded in an isotropic elastic matrix. It is shown that the characteristic length for a homogeneous Cosserat material that best mimics the heterogeneous Cauchy material can be derived (resulting in surprisingly simple formulae) when the inclusions are less stiff than the matrix, but when these are equal to or stiffer than the matrix, Cosserat effects are shown to be excluded. These analytical results explain published experimental findings, correct, resolve and extend prior contradictory theoretical (mainly numerical and limited to two-dimensional deformations) investigations, and provide both a general methodology and specific results for determination of simple higher-order homogeneous effective materials that more accurately represent heterogeneous material response under general loading conditions. In particular, it is shown that no standard (Cauchy) homogenized material can accurately represent the response of a heterogeneous material subjected to a uniform plus linearly varying applied traction, while a homogenized Cosserat material can do so (when inclusions are less stiff than the matrix).

scholarly journals MODELLING OF A THREE-DIMENSIONAL PROBLEM OF DISTRIBUTION OF HARMFUL IMPURITY IN THE RIVER A RECURRENTLY-OPERATIONAL METHOD

2020 ◽  
Vol 1 (6(75)) ◽  
pp. 8-12
Author(s):  
P. M. Pirniyazova
Keyword(s):  
Three Dimensional ◽  
Numerical Results ◽  
Operational Method ◽  
Dimensional Problem ◽  
Harmful Impurity

In this article the decision of a three-dimensional problem of diffusion is considered by a recurrentlyoperational method which describes process of distribution of harmful impurity along a watercourse. The received numerical results on the COMPUTER where it is possible to define for what time are resulted there is a distribution and river clarification. The received results are illustrated in drawings.

Designing TIMP (tissue inhibitor of metalloproteinases) variants that are selective metalloproteinase inhibitors

2003 ◽  
Vol 70 ◽  
pp. 201-212 ◽  
Author(s):  
Hideaki Nagase ◽  
Keith Brew
Keyword(s):  
Three Dimensional ◽  
Therapeutic Interventions ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Structural Basis ◽  
Structural Elements ◽  
Ridge Structure ◽  
Extracellular Matrix Components ◽  
Metalloproteinase Inhibitors ◽  
The Matrix ◽  
A Disintegrin And Metalloproteinase

The tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of the matrix metalloproteinases (MMPs), enzymes that play central roles in the degradation of extracellular matrix components. The balance between MMPs and TIMPs is important in the maintenance of tissues, and its disruption affects tissue homoeostasis. Four related TIMPs (TIMP-1 to TIMP-4) can each form a complex with MMPs in a 1:1 stoichiometry with high affinity, but their inhibitory activities towards different MMPs are not particularly selective. The three-dimensional structures of TIMP-MMP complexes reveal that TIMPs have an extended ridge structure that slots into the active site of MMPs. Mutation of three separate residues in the ridge, at positions 2, 4 and 68 in the amino acid sequence of the N-terminal inhibitory domain of TIMP-1 (N-TIMP-1), separately and in combination has produced N-TIMP-1 variants with higher binding affinity and specificity for individual MMPs. TIMP-3 is unique in that it inhibits not only MMPs, but also several ADAM (a disintegrin and metalloproteinase) and ADAMTS (ADAM with thrombospondin motifs) metalloproteinases. Inhibition of the latter groups of metalloproteinases, as exemplified with ADAMTS-4 (aggrecanase 1), requires additional structural elements in TIMP-3 that have not yet been identified. Knowledge of the structural basis of the inhibitory action of TIMPs will facilitate the design of selective TIMP variants for investigating the biological roles of specific MMPs and for developing therapeutic interventions for MMP-associated diseases.

Effects of stator splitter blades on aerodynamic performance of a single-stage transonic axial compressor

2020 ◽  
Vol 14 (4) ◽  
pp. 7369-7378
Author(s):  
Ky-Quang Pham ◽  
Xuan-Truong Le ◽  
Cong-Truong Dinh
Keyword(s):  
Stokes Equations ◽  
Three Dimensional ◽  
Axial Compressor ◽  
Aerodynamic Performance ◽  
Numerical Results ◽  
Single Stage ◽  
Navier Stokes ◽  
Navier Stokes Equations ◽  
Operating Stability ◽  
Length Coverage

Splitter blades located between stator blades in a single-stage axial compressor were proposed and investigated in this work to find their effects on aerodynamic performance and operating stability. Aerodynamic performance of the compressor was evaluated using three-dimensional Reynolds-averaged Navier-Stokes equations using the k-e turbulence model with a scalable wall function. The numerical results for the typical performance parameters without stator splitter blades were validated in comparison with experimental data. The numerical results of a parametric study using four geometric parameters (chord length, coverage angle, height and position) of the stator splitter blades showed that the operational stability of the single-stage axial compressor enhances remarkably using the stator splitter blades. The splitters were effective in suppressing flow separation in the stator domain of the compressor at near-stall condition which affects considerably the aerodynamic performance of the compressor.

3D simulation of emulsion flow using the boundary element method on the heterogeneous computational systems

2012 ◽  
Vol 9 (1) ◽  
pp. 142-146
Author(s):  
O.A. Solnyshkina
Keyword(s):  
Boundary Element Method ◽  
Boundary Element ◽  
Three Dimensional ◽  
Reynolds Numbers ◽  
Problem Size ◽  
Low Reynolds Numbers ◽  
Infinite Domains ◽  
The Matrix ◽  
Computational Systems ◽  
Element Method

In this work the 3D dynamics of two immiscible liquids in unbounded domain at low Reynolds numbers is considered. The numerical method is based on the boundary element method, which is very efficient for simulation of the three-dimensional problems in infinite domains. To accelerate calculations and increase the problem size, a heterogeneous approach to parallelization of the computations on the central (CPU) and graphics (GPU) processors is applied. To accelerate the iterative solver (GMRES) and overcome the limitations associated with the size of the memory of the computation system, the software component of the matrix-vector product

scholarly journals Macroporous chitosan/methoxypoly(ethylene glycol) based cryosponges with unique morphology for tissue engineering applications

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pradeep Kumar ◽  
Viness Pillay ◽  
Yahya E. Choonara
Keyword(s):  
Tissue Engineering ◽  
Polymer Network ◽  
Three Dimensional ◽  
Hysteresis Loops ◽  
Interpenetrating Polymer Network ◽  
Morphological Data ◽  
Porous Scaffolds ◽  
Morphological Variations ◽  
Molecular Stability ◽  
The Matrix

AbstractThree-dimensional porous scaffolds are widely employed in tissue engineering and regenerative medicine for their ability to carry bioactives and cells; and for their platform properties to allow for bridging-the-gap within an injured tissue. This study describes the effect of various methoxypolyethylene glycol (mPEG) derivatives (mPEG (-OCH3 functionality), mPEG-aldehyde (mPEG-CHO) and mPEG-acetic acid (mPEG-COOH)) on the morphology and physical properties of chemically crosslinked, semi-interpenetrating polymer network (IPN), chitosan (CHT)/mPEG blend cryosponges. Physicochemical and molecular characterization revealed that the –CHO and –COOH functional groups in mPEG derivatives interacted with the –NH2 functionality of the chitosan chain. The distinguishing feature of the cryosponges was their unique morphological features such as fringe thread-, pebble-, curved quartz crystal-, crystal flower-; and canyon-like structures. The morphological data was well corroborated by the image processing data and physisorption curves corresponding to Type II isotherm with open hysteresis loops. Functionalization of mPEG had no evident influence on the macro-mechanical properties of the cryosponges but increased the matrix strength as determined by the rheomechanical analyses. The cryosponges were able to deliver bioactives (dexamethasone and curcumin) over 10 days, showed varied matrix degradation profiles, and supported neuronal cells on the matrix surface. In addition, in silico simulations confirmed the compatibility and molecular stability of the CHT/mPEG blend compositions. In conclusion, the study confirmed that significant morphological variations may be induced by minimal functionalization and crosslinking of biomaterials.

Mathematical Theory of Transversally Isotropic Shells of Arbitrary Thickness at Static Load

2019 ◽  
Vol 968 ◽  
pp. 496-510
Author(s):  
Anatoly Grigorievich Zelensky
Keyword(s):  
Mathematical Theory ◽  
Three Dimensional ◽  
Nonlinear Problems ◽  
Theory Of Elasticity ◽  
Elastic Plates ◽  
Dimensional Problem ◽  
Boundary Problems ◽  
Complex Boundary ◽  
Plates And Shells ◽  
Basic Equations

Classical and non-classical refined theories of plates and shells, based on various hypotheses [1-7], for a wide class of boundary problems, can not describe with sufficient accuracy the SSS of plates and shells. These are boundary problems in which the plates and shells undergo local and burst loads, have openings, sharp changes in mechanical and geometric parameters (MGP). The problem also applies to such elements of constructions that have a considerable thickness or large gradient of SSS variations. The above theories in such cases yield results that can differ significantly from those obtained in a three-dimensional formulation. According to the logic in such theories, the accuracy of solving boundary problems is limited by accepted hypotheses and it is impossible to improve the accuracy in principle. SSS components are usually depicted in the form of a small number of members. The systems of differential equations (DE) obtained here have basically a low order. On the other hand, the solution of boundary value problems for non-thin elastic plates and shells in a three-dimensional formulation [8] is associated with great mathematical difficulties. Only in limited cases, the three-dimensional problem of the theory of elasticity for plates and shells provides an opportunity to find an analytical solution. The complexity of the solution in the exact three-dimensional formulation is greatly enhanced if complex boundary conditions or physically nonlinear problems are considered. Theories in which hypotheses are not used, and SSS components are depicted in the form of infinite series in transverse coordinates, will be called mathematical. The approximation of the SSS component can be adopted in the form of various lines [9-16], and the construction of a three-dimensional problem to two-dimensional can be accomplished by various methods: projective [9, 14, 16], variational [12, 13, 15, 17]. The effectiveness and accuracy of one or another variant of mathematical theory (MT) depends on the complex methodology for obtaining the basic equations.

scholarly journals Lymphocyte locomotion and attachment on two-dimensional surfaces and in three-dimensional matrices

1982 ◽  
Vol 92 (3) ◽  
pp. 747-752 ◽  
Author(s):  
WS Haston ◽  
JM Shields ◽  
PC Wilkinson
Keyword(s):  
Three Dimensional ◽  
Two Dimensional ◽  
Collagen Gels ◽  
Peripheral Lymph Node ◽  
Cellulose Esters ◽  
Peripheral Lymph ◽  
The Matrix ◽  
Identical Material ◽  
Variable Morphology ◽  
Collagen Lattices

The adhesion and locomotion of mouse peripheral lymph node lymphocytes on 2-D protein- coated substrata and in 3-D matrices were compared. Lymphocytes did not adhere to, or migrate on, 2-D substrata suck as serum- or fibronectin-coated glass. They did attach to and migrate in hydrated 3-D collagen lattices. When the collagen was dehydrated to form a 2-D surface, lymphocyte attachment to it was reduced. We propose that lymphocytes, which are poorly adhesive, are able to attach to and migrate in 3-D matrices by a nonadhesive mechanism such as the extension and expansion of pseudopodia through gaps in the matrix, which could provide purchase for movement in the absence of discrete intermolecular adhesions. This was supported by studies using serum-coated micropore filters, since lymphocytes attached to and migrated into filters with pore sizes large enough (3 or 8 mum) to allow pseudopod penetration but did not attach to filters made of an identical material (cellulose esters) but of narrow pore size (0.22 or 0.45 mum). Cinematographic studies of lymphocyte locomotion in collagen gels were also consistent with the above hypothesis, since lymphocytes showed a more variable morphology than is typically seen on plane surfaces, with formation of many small pseudopodia expanded to give a marked constriction between the cell and the pseudopod. These extensions often remained fixed with respect to the environment as the lymphocyte moved away from or past them. This suggests that the pseudopodia were inserted into gaps in the gel matrix and acted as anchorage points for locomotion.

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