scholarly journals Head and Neck Cancer Stem Cells

2011 ◽  
Vol 91 (4) ◽  
pp. 334-340 ◽  
Author(s):  
S. Krishnamurthy ◽  
J.E. Nör
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Self Renewal ◽  
Perivascular Niche

Most cancers contain a small sub-population of cells that are endowed with self-renewal, multipotency, and a unique potential for tumor initiation. These properties are considered hallmarks of cancer stem cells. Here, we provide an overview of the field of cancer stem cells with a focus on head and neck cancers. Cancer stem cells are located in the invasive fronts of head and neck squamous cell carcinomas (HNSCC) close to blood vessels (perivascular niche). Endothelial cell-initiated signaling events are critical for the survival and self-renewal of these stem cells. Markers such as aldehyde dehydrogenase (ALDH), CD133, and CD44 have been successfully used to identify highly tumorigenic cancer stem cells in HNSCC. This review briefly describes the orosphere assay, a method for in vitro culture of undifferentiated head and neck cancer stem cells under low attachment conditions. Notably, recent evidence suggests that cancer stem cells are exquisitely resistant to conventional therapy and are the “drivers” of local recurrence and metastatic spread. The emerging understanding of the role of cancer stem cells in the pathobiology of head and neck squamous cell carcinomas might have a profound impact on the treatment paradigms for this malignancy.

scholarly journals Valproic acid suppresses the self-renewal and proliferation of head and neck cancer stem cells

2015 ◽  
Vol 34 (4) ◽  
pp. 2065-2071 ◽  
Author(s):  
SANG HYUK LEE ◽  
HYO JUNG NAM ◽  
HYUN JUNG KANG ◽  
TINA L. SAMUELS ◽  
NIKKI JOHNSTON ◽  
...  
Keyword(s):  
Stem Cells ◽  
Valproic Acid ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
The Self ◽  
Self Renewal

scholarly journals In vitro Evaluation of Sialyl Lewis X Relationship with Head and Neck Cancer Stem Cells

2013 ◽  
Vol 149 (1) ◽  
pp. 97-104 ◽  
Author(s):  
Michael J. Czerwinski ◽  
Vincenzo Desiderio ◽  
Omar Shkeir ◽  
Petros Papagerakis ◽  
Martian C. Lapadatescu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
Sialyl Lewis X ◽  
Lewis X ◽  
In Vitro Evaluation ◽  
Sialyl Lewis

scholarly journals FGFR signaling regulates resistance of head and neck cancer stem cells to cisplatin

Oncotarget ◽  
2018 ◽  
Vol 9 (38) ◽  
pp. 25148-25165 ◽  
Author(s):  
Sarah C. McDermott ◽  
Christie Rodriguez-Ramirez ◽  
Sean P. McDermott ◽  
Max S. Wicha ◽  
Jacques E. Nör
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
Fgfr Signaling

scholarly journals Cancer stem cells and field cancerization of head and neck cancer - An update

2020 ◽  
Vol 9 (7) ◽  
pp. 3178
Author(s):  
Richa Bansal ◽  
BikashBishwadarshee Nayak ◽  
Shweta Bhardwaj ◽  
CN Vanajakshi ◽  
Pragyan Das ◽  
...  
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
Field Cancerization

Head and Neck Cancer Stem Cells: The Effect of HPV

2012 ◽  
Vol 147 (2_suppl) ◽  
pp. P58-P59
Author(s):  
Alice L. Tang ◽  
John H. Owen ◽  
Samantha Hauff ◽  
Jung J. Park ◽  
Carol R. Bradford ◽  
...  
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer

scholarly journals The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 723 ◽  
Author(s):  
Jarosław Paluszczak
Keyword(s):  
Cell Proliferation ◽  
Head And Neck Cancer ◽  
Wnt Signaling ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Wnt Signaling Pathway ◽  
Squamous Cell Carcinomas ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and neck cancer, the abnormalities in several signaling pathways, which regulate cell proliferation, cell death and stemness, seem to be especially promising with regard to the development of targeted therapies. Canonical Wnt signaling is a pathway engaged in the formation of head and neck tissues, however it is not active in adult somatic mucosal cells. The aim of this review paper is to bring together significant data related to the current knowledge on the mechanisms and functional significance of the dysregulation of the Wnt/β-catenin pathway in head and neck tumors. Research evidence related to the role of Wnt signaling activation in the stimulation of cell proliferation, migration and inhibition of apoptosis in HNSCC is presented. Moreover, its role in promoting stemness traits in head and neck cancer stem-like cells is described. Evidence corroborating the hypothesis that the Wnt signaling pathway is a very promising target of novel therapeutic interventions in HNSCC is also discussed.

scholarly journals Cancer stem cells enrichment with surface markers CD271 and CD44 in human head and neck squamous cell carcinomas

2019 ◽  
Vol 41 (4) ◽  
pp. 458-466 ◽  
Author(s):  
Osama A Elkashty ◽  
Ghada Abu Elghanam ◽  
Xinyun Su ◽  
Younan Liu ◽  
Peter J Chauvin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Cell Lines ◽  
Squamous Cell ◽  
Colony Formation ◽  
Self Renewal ◽  
Tissue Samples ◽  
Hnscc Cell

Abstract Head and neck squamous cell carcinoma (HNSCC) has a poor 5-year survival rate of 50%. One potential reason for treatment failure is the presence of cancer stem cells (CSCs). Several cell markers, particularly CD44, have been used to isolate CSCs. However, isolating a pure population of CSC in HNSCC still remains a challenging task. Recent findings show that normal oral stem cells were isolated using CD271 as a marker. Thus, we investigated the combined use of CD271 and CD44 to isolate an enriched subpopulation of CSCs, followed by their characterization in vitro, in vivo, and in patients’ tissue samples. Fluorescent-activated cell sorting was used to isolate CD44+/CD271+ and CD44+/CD271− from two human HNSCC cell lines. Cell growth and self-renewal were measured with MTT and sphere/colony formation assays. Treatment-resistance was tested against chemotherapy (cisplatin and 5-fluorouracil) and ionizing radiation. Self-renewal, resistance, and stemness-related genes expression were measured with qRT-PCR. In vivo tumorigenicity was tested with an orthotopic immunodeficient mouse model of oral cancer. Finally, we examined the co-localization of CD44+/CD271+ in patients’ tissue samples. We found that CD271+ cells were a subpopulation of CD44+ cells in human HNSCC cell lines and tissues. CD44+/CD271+ cells exhibited higher cell proliferation, sphere/colony formation, chemo- and radio-resistance, upregulation of CSCs-related genes, and in vivo tumorigenicity when compared to CD44+/CD271− or the parental cell line. These cell markers showed increased expression in patients with the increase of the tumor stage. In conclusion, using both CD44 and CD271 allowed the isolation of CSCs from HNSCC. These enriched CSCs will be more relevant in future treatment and HNSCC progression studies.

Abstract 4262: Characterization and regulation of a CXCR4-expressing subpopulation in head and neck cancer stem cells

2010 ◽  
Author(s):  
Alan Kiang ◽  
Eric L. Abhold ◽  
Katherine J. Blair ◽  
Michael A. Yu ◽  
Martin Haas ◽  
...  
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer
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