Corrigendum for Multiple Sclerosis: Associations Between Physical Disability and Depression Are Not Mediated by Self-Reported Physical Activity

Abstract The question of the role of physical activity in preventing disability in neurological diseases is the issue which is not in doubt. There is well known that physical activity in Parkinson`s disease and in Multiple Sclerosis patients is less than is the case in the general population. Numerous scientific studies have confirmed the low physical activity of people with PD and MS. Improving physical activity delays the progress of physical disability and has the effect on increasing the quality of life in those two diseases. In this paper an descriptive review of the literature devoted to the effect of physical activity on risk of PD and its impact on disability progression in PD and MS has been presented. The different recommendations for physical activity and different methods of assessment have been described.

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Physical Exercise Moderates the Effects of Disability on Depression in People with Multiple Sclerosis during the Covid-19 Outbreak

Journal of Clinical Medicine ◽

10.3390/jcm10061234 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1234

Author(s):

Antonio Carotenuto ◽

Cristiano Scandurra ◽

Teresa Costabile ◽

Luigi Lavorgna ◽

Giovanna Borriello ◽

...

Keyword(s):

Physical Activity ◽

Multiple Sclerosis ◽

Physical Exercise ◽

Physical Disability ◽

Psychosocial Wellbeing ◽

Interaction Plot ◽

Post Hoc ◽

Moderating Role

Physical disability impacts psychosocial wellbeing in people with multiple sclerosis. However, the role of physical activity in this context is still debated. By taking advantage of a previous survey, conducted online from 22 April to 7 May 2020, we performed a post-hoc analysis with the aim to assess the associations between disability, physical exercise, and mental health in multiple sclerosis. We retrieved the following data: (i) sociodemographic information, (ii) changes in lifestyle (including exercise), (iii) physical disability, as measured with the Patient-Determined Disease Steps scale, and (iv) anxiety feelings and depressive symptoms assessed via the items included in the Quality of Life in Neurological Disorders measurement system. Examination of the interaction plot showed that the effect of disability on depression, but not on anxious symptoms, was significant for all levels of physical exercise (low: b = 1.22, 95% C.I. 0.85, 1.58, p < 0.001; moderate: b = 0.95, 95% C.I. 0.66, 1.24, p < 0.001; and high: b = 0.68, 95% C.I. 0.24, 1.13, p = 0.003). Based on these data, we can conclude that disability significantly impacted depression during the COVID-19 pandemic, with physical activity playing a moderating role. Our results suggest that favoring exercise in multiple sclerosis (MS) would ameliorate psychological wellbeing regardless of the level of physical disability.

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Multiple Sclerosis: Associations Between Physical Disability and Depression Are Not Mediated by Self-Reported Physical Activity

Perceptual and Motor Skills ◽

10.1177/0031512517711851 ◽

2017 ◽

Vol 124 (5) ◽

pp. 974-991 ◽

Cited By ~ 1

Author(s):

Helene Merkt ◽

Dena Sadeghi Bahmani ◽

Pasquale Calabrese ◽

Yvonne Naegelin ◽

Markus Gerber ◽

...

Keyword(s):

Physical Activity ◽

Multiple Sclerosis ◽

Depressive Symptoms ◽

Physical Disability ◽

Rating Scales ◽

Activity Levels ◽

Expanded Disability Status Scale ◽

Symptoms Of Depression ◽

Disability Status ◽

Physical Activity Levels

This study investigated the interrelatedness of physical disability, physical activity, and depression among patients with multiple sclerosis (MS). We hypothesized that self-reported physical activity would mediate the effect of disability on depressive symptoms. Twenty-seven patients with MS (mean age: 49 years; 44.5% females) completed self-rating scales covering sociodemographic variables, intake of antidepressants, physical activity, and symptoms of depression; disability was measured by the Expanded Disability Status Scale. We found a higher level of disability to be significantly associated with more symptoms of depression. While higher reported physical activity was descriptively associated with lower depression scores and unrelated to Expanded Disability Status Scale, physical activity levels did not mediate the effect of disability on depressive symptoms.

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Use of Accelerometers to Measure Real-Life Physical Activity in Ambulatory Individuals with Multiple Sclerosis

International Journal of MS Care ◽

10.7224/1537-2073.2014-037 ◽

2015 ◽

Vol 17 (5) ◽

pp. 215-220 ◽

Cited By ~ 6

Author(s):

Cecilie Fjeldstad ◽

Anette S. Fjeldstad ◽

Gabriel Pardo

Keyword(s):

Physical Activity ◽

Multiple Sclerosis ◽

Physical Disability ◽

Real Life ◽

Study Cohort ◽

Significant Difference ◽

Disability Status ◽

Edss Score ◽

Life Circumstances ◽

Positive Correlations

Background: Multiple sclerosis (MS) may negatively affect individuals' participation in physical activity (PA). We used accelerometers to determine PA level in individuals with MS with varying degrees of disability as measured by the Expanded Disability Status Scale (EDSS) during regular daily activities. Methods: Participants wore an accelerometer from 8 a.m. to 9 p.m. for 7 consecutive days. Activity counts recorded during this period were analyzed in 1-minute epochs and categorized into one of four PA levels: light, moderate, hard, and very hard. Results: The study cohort comprised 13 patients with MS and 12 controls. There were significant negative correlations for minutes spent in PA and EDSS measures on weekdays (r = −0.61), weekend (r = −0.64), and full week (r = −0.61) and number of steps taken on weekdays (r = −0.56), weekend (r = −0.80), and full-week average (r = −0.68). Significant positive correlations were found for minutes spent in light PA and EDSS score (r = 0.69). Significant negative correlations were found for minutes spent in moderate and hard PA and EDSS score. No significant difference was seen between the MS group and controls on any parameters (P > .05). Conclusions: This study showed that accelerometers can be used to objectively quantify PA levels in individuals with MS with different disability levels. This cohort demonstrated that the amount of PA is inversely proportional to the degree of physical disability. Collected data revealed not only the amount but also the intensity of PA performed in real-life circumstances.

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