scholarly journals Multiple Sclerosis: Associations Between Physical Disability and Depression Are Not Mediated by Self-Reported Physical Activity

2017 ◽  
Vol 124 (5) ◽  
pp. 974-991 ◽  
Author(s):  
Helene Merkt ◽  
Dena Sadeghi Bahmani ◽  
Pasquale Calabrese ◽  
Yvonne Naegelin ◽  
Markus Gerber ◽  
...  
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Depressive Symptoms ◽  
Physical Disability ◽  
Rating Scales ◽  
Activity Levels ◽  
Expanded Disability Status Scale ◽  
Symptoms Of Depression ◽  
Disability Status ◽  
Physical Activity Levels

This study investigated the interrelatedness of physical disability, physical activity, and depression among patients with multiple sclerosis (MS). We hypothesized that self-reported physical activity would mediate the effect of disability on depressive symptoms. Twenty-seven patients with MS (mean age: 49 years; 44.5% females) completed self-rating scales covering sociodemographic variables, intake of antidepressants, physical activity, and symptoms of depression; disability was measured by the Expanded Disability Status Scale. We found a higher level of disability to be significantly associated with more symptoms of depression. While higher reported physical activity was descriptively associated with lower depression scores and unrelated to Expanded Disability Status Scale, physical activity levels did not mediate the effect of disability on depressive symptoms.

scholarly journals Among Persons With Multiple Sclerosis (MS), Objective Sleep, Psychological Functioning, and Higher Physical Activity Scores Remained Stable Over 2 Years—Results From a Small Study Under Naturalistic Conditions

2020 ◽  
Vol 11 ◽  
Author(s):  
Dena Sadeghi Bahmani ◽  
Roman Gonzenbach ◽  
Jürg Kesselring ◽  
Jens Bansi ◽  
Robert W. Motl ◽  
...  
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Psychological Functioning ◽  
Activity Levels ◽  
Rehabilitation Center ◽  
Sleep Patterns ◽  
Subjective Sleep ◽  
Symptoms Of Depression ◽  
Physical Activity Levels ◽  
Activity Indices

Background: Persons with multiple sclerosis (PwMS) are at increased risk to report poor sleep patterns and lower physical activity indices. To date, data on longitudinal objectively sleep assessment is missing. In the present study, we investigated the pattern of objective sleep and subjective physical activity indices over a period of 13.5 months, under naturalistic conditions.Method: 13.5 months after their first assessment, a total of 16 PwMS (mean age = 49.13 median EDSS score: 5; 11 females) were reassessed on their objective sleep via portable sleep-electroencephalogram (EEG-) devices, along with their subjective sleep patterns (symptoms of insomnia, restless legs syndrome (RLS), and sleep-disordered breathing), physical activity indices, psychological functioning (symptoms of depression, fatigue, daytime sleepiness), and MS-related information (fatigue, EDSS; disease-modifying treatments). While the baseline assessment was performed in a rehabilitation center, the follow-up assessment took place at participants' naturalistic and familiar setting.Results: Statistically, symptoms of depression and fatigue, subjective sleep, and physical activity levels did neither increase, nor decrease over time, although descriptively, both moderate and vigorous physical activity levels decreased, and fatigue and subjective insomnia increased. Time awake after sleep onset statistically significantly decreased, while light sleep duration increased by trend.Conclusions: Among a smaller sample of PwMS, objective sleep in their naturalistic setting remained fairly stable over a mean time lapse of 13.5 months after clinic discharge. Physical activity levels descriptively decreased. The present results are of clinical and practical importance for treatment counseling: PwMS can be reassured that their sleep quality does not deteriorate, once they have left a rehabilitation center. Further, they should be encouraged to keeping their physical activity levels as stable as possible.

scholarly journals Falls and Physical Activity in Persons with Multiple Sclerosis

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
J. J. Sosnoff ◽  
B. M. Sandroff ◽  
J. H. Pula ◽  
S. M. Morrison ◽  
R. W. Motl
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Objective Measure ◽  
Lower Number ◽  
Activity Levels ◽  
Expanded Disability Status Scale ◽  
Community Based ◽  
Significant Difference ◽  
Disability Status ◽  
Neurological Exam

Objectives. To examine the association between fall history and physical activity using an objective measure of physical activity (i.e., accelerometry) in persons with multiple sclerosis.Design. A community-based sample of 75 ambulatory persons with multiple sclerosis volunteered for the investigation. Participants self-reported fall history in the last year, underwent a neurological exam to determine Expanded Disability Status Scale (EDSS) score, and wore an accelerometer around the waist for 7 consecutive days to determine physical activity.Results. Overall, 37 persons (49.3% of the sample) reported falling in the last year with 28 of the 37 falling more than once. Persons who fell in the last year had a significantly lower number of steps/day than nonfallers (3510 versus 4940 steps/day;P<.05). However, when controlling for disability status there was no statistically significant difference between fallers and nonfallers (4092 versus 4373 steps/day;P>.05).Conclusions. Collectively, the findings suggest that fall history may have little impact on current physical activity levels in persons with multiple sclerosis.

scholarly journals Coping strategies and mood profiles in patients with multiple sclerosis

2014 ◽  
Vol 72 (7) ◽  
pp. 490-495 ◽  
Author(s):  
Aysel Milanlioglu ◽  
Pinar Güzel Özdemir ◽  
Vedat Cilingir ◽  
Tezay Çakin Gülec ◽  
Mehmet Nuri Aydin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Coping Strategies ◽  
Healthy Subjects ◽  
Activity Levels ◽  
Expanded Disability Status Scale ◽  
Secondary Progressive ◽  
Rehabilitation Programs ◽  
Mcdonald Criteria ◽  
Progressive Type ◽  
Disability Status

Objective: The aim of the present study was to investigate the coping strategies, mood characteristics and the association between these aspects in patients diagnosed with multiple sclerosis and healthy subjects. Method: Fifty consecutive patients who were diagnosed with multiple sclerosis according to McDonald criteria and thirty-one healthy subjects were included in the study. In addition to the sociodemographic form, Expanded Disability Status Scale (EDSS), Coping Orientation for Problem Experiences Scale (COPE), and Profile of Mood States (POMS) tests were applied to the participants. Results: Non-functional coping strategies were significantly higher in the secondary-progressive type (p≤0.05). Depression-dejection, fatigue-inertia and total POMS scores were significantly higher in the secondary-progressive type (p≤0.05). Conclusion: The results of our study demonstrate the importance of rehabilitation programs that encourage exercise among patients with multiple sclerosis to increase vigor-activity levels.

scholarly journals Home Confinement in Previously Active Older Adults: A Cross-Sectional Analysis of Physical Fitness and Physical Activity Behavior and Their Relationship With Depressive Symptoms

2021 ◽  
Vol 12 ◽  
Author(s):  
Joana Carvalho ◽  
Flávia Borges-Machado ◽  
Andreia N. Pizarro ◽  
Lucimere Bohn ◽  
Duarte Barros
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Depressive Symptoms ◽  
Physical Fitness ◽  
Exercise Program ◽  
Sitting Time ◽  
Activity Levels ◽  
Cross Sectional ◽  
Depressed Group ◽  
Physical Activity Levels

AimThe aim of our study was to analyze physical activity levels, sitting time, physical fitness, and their relationship with depressive symptoms after home confinement in previously active older adults.MethodsThis cross-sectional study sample comprised 68 older adults (74.24 ± 5.67 years) from a community-based exercise program conducted in Porto, Portugal. After home confinement, participants were assessed in person for lower-body strength (30-s chair stand test), cardiorespiratory fitness (6-min walking test), agility/dynamic balance (8-ft up-and-go test), handgrip strength, and anthropometry. Telephone interviews were performed to evaluate depressive symptoms with the Geriatric Depression Scale – 15 items (GDS-15) and physical activity levels through the International Physical Activity Questionnaire (IPAQ-SV). Individuals were also asked to self-report changes in their physical activity levels and time spent sitting.ResultsNinety percent of older adults self-reported a decrease in overall physical activity levels, and nearly 65% increased daily sitting time during the home confinement. However, previously active older adults still presented high levels of physical fitness (scores above 50th compared with Portuguese normative values) after 11 weeks of home confinement. Overall, 52.9% of participants scored 5 or more points on GDS-15, which is suggestive of depression. Higher levels of moderate-to-vigorous physical activity (MVPA) and cardiorespiratory fitness were found in the non-depressed group compared with the depressed group. Finally, results from multiple regression analysis revealed that MVPA was negatively associated with depression. This model explained 16.4% of the variability seen in depression score, controlled for age, gender, and education.ConclusionEven reporting a decline in physical activity, older adults who previously participated in a formal exercise program, still presented high levels of physical fitness after 11 weeks of home confinement. However, MVPA, but not physical fitness, seems to be an associated depression score in previously active older adults. These results reinforce the importance of older adults to remain physically active, since higher levels of MVPA may have a protective effect on depressive symptoms and, therefore, mitigate the negative impact of home confinement on mental health. Future longitudinal research studies are needed to ascertain these results.

scholarly journals Brain atrophy at onset and physical disability in multiple sclerosis

2012 ◽  
Vol 70 (10) ◽  
pp. 765-768 ◽  
Author(s):  
Juan Ignacio Rojas ◽  
Liliana Patrucco ◽  
Cristina Besada ◽  
Laura Bengolea ◽  
Edgardo Cristiano
Keyword(s):  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Brain Atrophy ◽  
Physical Disability ◽  
Disease Onset ◽  
First Year ◽  
Expanded Disability Status Scale ◽  
Disability Status

The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS: MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categorized in three groups, EDSS=0, EDSS=1 and 2.5 and EDSS>2.5, and used as disability measure. RESULTS: Twenty-six patients were included. Mean atrophy during the first year in patients that reached an EDSS≥3 was -0.76±0.45 %, in patients with an EDSS between 1 and 2.5 was -0.59±0.56, while in patients with an EDSS of 0 it was -0.38±0.42 (p=0.003). DISCUSSION: Brain atrophy rates during the first year of disease were predictive of disease progression in our population.

Outcome measures for multiple sclerosis clinical trials: relative measurement precision of the Expanded Disability Status Scale and Multiple Sclerosis Functional C omposite

2004 ◽  
Vol 10 (1) ◽  
pp. 41-46 ◽  
Author(s):  
J Hobart ◽  
N Kalkers ◽  
F Barkhof ◽  
B Uitdehaag ◽  
C Polman ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Rating Scales ◽  
Total Sample ◽  
Measurement Precision ◽  
Relative Measurement ◽  
Expanded Disability Status Scale ◽  
Paired Samples ◽  
Disability Status ◽  
Mri Scans ◽  
Order Of Magnitude

We compared the relative measurement precision (RMP) of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functio nal C omposite (MSFC) for discriminating between groups of patients known to differ in their extent of multiple sclerosis (MS). A total of 133 patients were rated with the EDSS and MSFC and had magnetic resonance imaging (MRI) scans. Patients were grouped on the basis of MRI appearances (T1- and T2-weighted lesion loads, parenchymal and ventricular fractions - T1LL, T2LL, PF, VF, respectively) and RMP was determined using the method of group differences. For each MRI parameter, the total sample was arranged in ascending order of magnitude and divided into two, three, four and five similar sized groups. For each division (two, three, four or five groups), EDSS and MSFC scores for the groups were compared using parametric (paired samples t-tests, one-way A NOVA) and nonparametric (Wilcoxon’s rank-sum test, Kruskal -Wallis analysis of variance) statistical methods and RMP was estimated. The EDSS and MSFC were correlated substantially (r = -0.64). Relative to the MSFC, the EDSS had inferior measurement precision regardless of the number of groups into which the total sample was divided, or the statistical method. However, the RMP of the EDSS compared with the MSFC varied from 2% to 86%. Results suggest the MSC F is better than the EDSS for detecting differences between groups of patients, defined by these MRI markers of MS. However, the finding that both scales correlated weakly with MRI markers, indicated that they are limited as predicto rs of MS patho logy as defined by MRI. A n explanatio n for this well-established clinical -MRI paradox is that rating scales and MRI measure fundamentally different manifestations of MS.

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