The significances and clinical implications of cholesterol components in human breast cancer

2021 ◽  
Vol 104 (3) ◽  
pp. 003685042110283
Author(s):  
Yanghui Wei ◽  
Yao Huang ◽  
Weiqin Yang ◽  
Qingnan Huang ◽  
Yong Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Malignant Disease ◽  
Strong Association ◽  
Underlying Mechanism ◽  
Clinical Implications ◽  
Human Breast ◽  
Lipid Levels ◽  
Ethnic Population ◽  
The Relationship ◽  
Related Mortality

Breast cancer is one the most common malignancies and leading cause of cancer-related mortality in women. Recent studies suggested that hypercholesterolemia may be the potential modifiable risk factors for breast cancer. Cholesterol was well-known for its strong association with cardiovascular disease for long. Moreover, solid evidence has been provided by different studies to illustrate the correlation between lipid and incidence in multiple cancers. Although the conclusion remains controversial or sometimes contrary, which may be due to the multifactorial nature of the disease and the disparity of ethnic population, it is critical to elucidate the relationship between specific cholesterol components in certain population and the exact underlying mechanism of the lipid-associated signaling pathway in breast cancer. The implications of dysregulated lipoproteins as therapeutic targets or options for breast cancer provide novel strategies for us in combating with this malignant disease, which may be achieved by manipulating lipid levels with pharmacological compounds.

scholarly journals Effect of the LncRNA GAS5-MiR-23a-ATG3 Axis in Regulating Autophagy in Patients with Breast Cancer

2018 ◽  
Vol 48 (1) ◽  
pp. 194-207 ◽  
Author(s):  
Juan Gu ◽  
Yueping Wang ◽  
Xuedong Wang ◽  
Daoping Zhou ◽  
Xinguo Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Tumour Size ◽  
Luciferase Reporter ◽  
Breast Cancer Cell Lines ◽  
Human Breast ◽  
Gene Assay ◽  
Cancer Tissues ◽  
The Relationship ◽  
Lncrna Gas5

Background/Aims: An increasing body of evidence shows that long noncoding RNAs (lncRNAs) are involved in many different cancers. In this study, we aimed to investigate the competing endogenous RNA (ceRNA)-dependent mechanism by which the lncRNA GAS5 contributes to the development of breast cancer. Methods: A total of 68 breast cancer patients were enrolled, and breast cancer and adjacent normal tissues were collected. The human breast cancer cell lines MDA-MB-231, MDA-MB-453, BT549, SK-BR-3 and MCF-7 and human breast cell line MCF10A were utilized in this study. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blotting were performed to detect expression of relative factors. RNA immunoprecipitation (RIP) was used to evaluate the relationship between GAS5 and miR-23a, and a dual luciferase reporter gene assay was employed to assess the relationship between ATG3 and miR-23a. A subcutaneous xenograft nude mouse model was generated to examine the role of GAS5 and its regulatory pathway in autophagy. Results: GAS5 levels were frequently decreased in breast cancer tissues and cell lines, and its relatively low expression was closely related to a larger tumour size, advanced tumour-node-metastasis (TNM) stage and estrogen receptor-negative (ER-) breast cancer tissues. More importantly, we found that GAS5 promoted autophagy, with enhanced autophagosome formation after GAS5 overexpression. GAS5 was found to act as a microRNA sponge in a pathway that included miR-23a and its target gene ATG3. The GAS5-miR-23a-ATG3 axis significantly regulated autophagy in vivo and in vitro. Conclusions: In summary, we report that the GAS5-miR-23a-ATG3 axis can be regarded as a key regulator of autophagy pathways in breast cancer; it may constitute a promising biomarker and therapeutic target in the future.

scholarly journals The relationship between serum p53 autoantibodies and characteristics of human breast cancer

1994 ◽  
Vol 69 (6) ◽  
pp. 1115-1119 ◽  
Author(s):  
B Mudenda ◽  
JA Green ◽  
B Green ◽  
JR Jenkins ◽  
L Robertson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
The Relationship ◽  
Serum P53

scholarly journals Longitudinal effect of emotional processing on psychological symptoms in women under 50 with breast cancer

2019 ◽  
Vol 6 (1) ◽  
pp. 205510291984450 ◽  
Author(s):  
Maria Luisa Martino ◽  
Anna Gargiulo ◽  
Daniela Lemmo ◽  
Pasquale Dolce ◽  
Daniela Barberio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Emotional Processing ◽  
Psychological Symptoms ◽  
Traumatic Event ◽  
Strong Predictor ◽  
Mixed Effects ◽  
Mixed Effects Models ◽  
Traumatic Experiences ◽  
Clinical Implications ◽  
The Relationship

Breast cancer is a potential traumatic event associated with psychological symptoms, but few studies have analysed its impact in under-50 women. Emotional processing is a successful function in integrating traumatic experiences. This work analysed the relationship between emotional processing and psychological symptoms during three phases of treatment (before hospitalization, counselling after surgery and adjuvant therapy) in 50 women under the age of 50 with breast cancer. Mixed-effects models tested statistical differences among phases. There were significant differences in symptoms during the treatments: the levels of anxiety decrease from T1 to T3 (0.046), while those of hostility increase (<0.001). Emotional processing is a strong predictor of all symptoms. Clinical implications are discussed.

scholarly journals The Expression of ERβcx in Human Breast Cancer and the Relationship to Endocrine Therapy and Survival

2004 ◽  
Vol 10 (7) ◽  
pp. 2421-2428 ◽  
Author(s):  
Carlo Palmieri ◽  
Eric W.-F. Lam ◽  
Janine Mansi ◽  
Claire MacDonald ◽  
Sami Shousha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endocrine Therapy ◽  
Human Breast Cancer ◽  
Human Breast ◽  
The Relationship

scholarly journals The evolving role of microRNA subtypes 21, 155 and 10b as oncogenes and biomarkers in breast cancer in a decade: A systematic review article

2021 ◽  
Author(s):  
Mubarak Elnour ◽  
Nagham Eltayeb ◽  
Arwa Esam ◽  
Shiraz Faisal ◽  
Nuha M. Elhassan
Keyword(s):  
Breast Cancer ◽  
Malignant Disease ◽  
Diagnostic Value ◽  
Review Article ◽  
Clinical Implications ◽  
Multiple Gene ◽  
The Past ◽  
Health Burden ◽  
High Incidence

Abstract Breast cancer is a malignant disease with a high incidence worldwide in women-and to less extent in men-, thus remains a health burden. miRNA plays a key role in the development and prognosis of breast cancer; as a single miRNA has the ability to regulate multiple gene targets and adversely alter their expression. In this review, we attempt to systematically analyze the rapidly accumulating body of research regarding the role of miRNAs subtypes particularly as oncogenes and biomarkers in breast cancer, and their clinical implications. A total of 11 pertinent articles in the past 10 years were extracted from high-rank reviews, analyzed, and summarized. Amongst many (eight miRNA subtypes), three subtypes (miR21, 155, and 10b) were selected in order to evaluate the validity of their oncogenicity as well as their diagnostic value as biomarkers.

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