Continuous Flow Charts

SIMULATION ◽  
1970 ◽  
Vol 14 (6) ◽  
pp. 281-290
Author(s):  
Louis R. Gieszl ◽  
Frank C. Rieman

The current concept of the flow chart for documenting a computer program seems to be more heavily influenced by its business data processing background than by its mathematically oriented inception. The result of this is a loss of definition which inhibits further developments in program documentation. This paper proceeds from an analysis of the structure of a program and how this structure is represented by a flow chart to derive an extension of this: continuous flow charts. A continuous flow chart, which may be constructed from a conventional flow chart by removing its points of (flow) discontinuity, is shown to be a form of docu mentation ideally suited for large-scale programs that by their nature involve complex logic (such as a war-game simulation). The motivation for continuous flow charting is the pos sibility of dynamic documentation arising from a set of such flow charts. That is, the requirements suggested in this paper for a flow chart to be called continuous pro vide an inductive definition for the members of a set of levels of documentation of a simulation (such that the ease of a user's level to level transition of understanding [the logic depicted] is maintained). Such a set would have, at its highest level, a flow chart picturing the overall logic of the entire simulation, and, at successively lower levels it would contain flow charts describing smaller portions of the program in greater detail. An actual machine-language program would constitute the lowest level of documentation in this set. Since the creation of such a set of continuous flow charts can be started from either the highest level or the lowest level, then this procedure should serve equally well for either developing a complex program from its most basic logical conception, or for documenting such a program as has already been written.

1997 ◽  
Vol 52 (1) ◽  
pp. 110-116
Author(s):  
Michael Gerster ◽  
Martin Maier ◽  
Nils Clausen ◽  
Jens Schewitz ◽  
Ernst Bayer

Sulphurization is a crucial step during synthesis of phosphorothioate oligonucleotides. Insufficient reaction leads to inhomogeneous products with phosphodiester defects and subsequently to destabilization of the oligomers in biological media. To achieve a maximum extent of sulphur incorporation, various sulphurizing agents have been investigated. Solely, the use of Beaucage reagent provided satisfactory results on PS-PEG supports. Based on our investigations in small scale synthesis (1 μmol) with continuous-flow technique, upscaling to the 0.1-0.25 mmolar range has been achieved using a peptide synthesizer. The syntheses were performed in batch mode with standard phosphoramidite chemistry. Additionally, large scale synthesis of a phosphodiester oligonucleotide has been carried out on PS-PEG with optimized protocols and compared to small scale synthesis on different supports. Products were analysed by 31P NMR, capillary gel electrophoresis and electrospray mass spectrometry. An extent of sulphurization of 99% and coupling effiencies of more than 99% were obtained and the products proved to have similar purity compared to small scale syntheses on CPG


1966 ◽  
Vol 12 (8) ◽  
pp. 497-504 ◽  
Author(s):  
Seymour Winsten ◽  
Jeanne Jackson ◽  
Paula Wolf

Abstract Large- scale, microglass bead, continuous- flow electrophoresis was used to separateand collect protein fractions from a single serum sample. These fractions were assayed for a multiplicity of enzyme activities. Relatively good recovery was obtained with lactic acid dehydrogenase, leucine aminopeptidase, and phosphohexoseisomerase. Artifactually high recoveries were observed with aldotase and isocitric acid dehydrogenase. The increase observed in aldolase activity may be due to a pH effect.


1979 ◽  
Vol 9 (3) ◽  
pp. 287-291 ◽  
Author(s):  
Robert Cury

Authors of technical papers have many visual/graphic aids available to them. The most common are: grid graphs, tables, bar charts, flow charts, maps, pie diagrams, and drawings and sketches. Grid graphs are used to show relationships. Tables allow the reader to make comparisons of data. The bar chart is another form of the grid graph and is used for the same purpose. A flow chart gives the reader a visual description of a process. Maps show the location of specific features. Pie diagrams show the proportional breakdown of a topic. Pictures and sketches show the reader exactly what is being talked about in the report. Visual/graphic aids allow the technical writer to condense and present his information in an aesthetically pleasing manner; in addition, these aids serve as psychological white space.


2015 ◽  
Vol 6 (3) ◽  
pp. 1645-1649 ◽  
Author(s):  
Deborah Crawford ◽  
José Casaban ◽  
Robert Haydon ◽  
Nicola Giri ◽  
Tony McNally ◽  
...  

Continuous flow mechanochemical and melt-phase synthesis at kg h−1 rates from solid reagents and either no solvent, or only minimal solvent, is reported.


2019 ◽  
Vol 92 (1) ◽  
pp. 60-72 ◽  
Author(s):  
Sofia Babanova ◽  
Jason Jones ◽  
Sujal Phadke ◽  
Mengqian Lu ◽  
Carlo Angulo ◽  
...  

2020 ◽  
Vol 27 (10) ◽  
pp. 2499-2508 ◽  
Author(s):  
Faissal Aziz ◽  
Mounir El Achaby ◽  
Amina Lissaneddine ◽  
Khalid Aziz ◽  
Naaila Ouazzani ◽  
...  

SIMULATION ◽  
1966 ◽  
Vol 6 (3) ◽  
pp. 160-168 ◽  
Author(s):  
George H. Burgin

The original MIDAS program (MIDAS I, Wright Patterson AFB1) and the enlarged version of MIDAS (MIDAS II, North American Aviation2) proved to be effective tools for the digital solution of comple,, engineering problems. For large problems, however, running times for these programs were excessive and means were sought to improve the run-time efficiency. This is achieved in MIDAS III, which is no longer an interpretive type program as are MIDAS I and II, but rather a pre-compiler generating a FORTRAN program which is then compiled and assembled into an efficient machine language program. The execution times for this program are on the average between four and ten times shorter than in the earlier versions of MIDAS. This ap proach not only reduces computer execution time, it also gives the program more flexibility and expansion capa bility. A fourth order Runge-Kutta Merson integration method with automatic stepsize adjustment is used for the solution of the differential equations. As an application of MIDAS III, a two point boundary value problem is solved.


2014 ◽  
Vol 492 ◽  
pp. 7-12
Author(s):  
Wei Gang Huang ◽  
Jing Ji Li ◽  
Hai Rui Yang

With the increasing pressure on NOx removal in China, a part of CFB boilers have to install the deNOx devices to meet the updated emission regulation. Aiming to the large-scale 300MWe CFB boilers, the existing SCR and SNCR technologies are compared and the SNCR technology using urea as reductant is recommended based on the technical, economic and safety concerns. The design of the SNCR system is also presented. By employing the CFD method, the different urea distributions inside the cyclone are illustrated and the layout of 10 nozzles for each cyclone is optimized to the outer side of cyclone inlet. The technological flow chart of the SNCR system is given to show the whole process of urea storage, transport and injection.


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