Giant Pleomorphic Adenoma of the Parotid Gland: Case Report and Review of the Literature

1998 ◽  
Vol 77 (8) ◽  
pp. 634-640 ◽  
Author(s):  
John E. Buenting ◽  
Timothy L. Smith ◽  
Douglas K. Holmes
Keyword(s):  
World Literature ◽  
English Language ◽  
Unusual Case ◽  
Malignant Degeneration ◽  
Review Of The Literature ◽  
Mixed Tumor ◽  
Pleomorphic Adenomas ◽  
History Of ◽  
Benign Mixed Tumor ◽  
Mixed Tumors

Pleomorphic adenomas account for the majority of parotid masses, typically arising in the tail of the gland and enlarging slowly over time. The vast majority are 2 to 6 cm in size when resected. We report resection of the largest benign mixed tumor recorded in the modern English language literature. An 85-year-old reclusive woman had a 20-year history of an enlarging right periauricular mass that had begun bleeding several days prior to admission. The patient ultimately underwent resection of the mass, which measured 26 cm in diameter, weighed 6.85 kg, and proved on pathologic examination to be a benign mixed tumor without malignant degeneration. The implications of this unusual case for the management of mixed tumors are discussed, and a review of the world literature on giant pleomorphic adenomas is presented.

scholarly journals Giant Pleomorphic Adenoma of the Parotid Gland

2016 ◽  
Vol 10 (1) ◽  
Author(s):  
Shahzad Alam Shah ◽  
Mohammad Sarfraz
Keyword(s):  
World Literature ◽  
Unusual Case ◽  
Malignant Degeneration ◽  
Parotid Tumor ◽  
The World ◽  
Pleomorphic Adenomas ◽  
History Of ◽  
Benign Mixed Tumor ◽  
Mixed Tumors ◽  
Over Time

Pleomorphic adenomas account for the majority of parotid masses arising mostly in the superficial part of the gland and enlarging slowly over time. The vast majority are 2 to 6 cm in size when resected. We report resection of a huge mixed parotid tumor. A 40 year-old man had a 15-year history of an enlarging right periauricular mass that had developed areas of discoloration of the overlying skin due to underlying necrosis The patient ultimately underwent resection of the mass, which measured 24 cm in diameter, weighed 4.65 kg, and proved on pathologic examination to be a benign mixed tumor without malignant degeneration. The implications of this unusual case for the management of mixed tumors are discussed, and a review of the world literature on giant pleomorphic adenomas is presented.

scholarly journals Giant pleomorphic adenoma of the parotid gland: a case report

2021 ◽  
Vol 14 (3) ◽  
pp. 101-104
Author(s):  
Ernesto Carmona Fernàndez ◽  
Jorje Luis Pineda Izquierdo ◽  
Osiris Suàrez
Keyword(s):  
Parotid Gland ◽  
Unusual Case ◽  
Malignant Degeneration ◽  
Review Of The Literature ◽  
Pathologic Examination ◽  
Mixed Tumour ◽  
Pleomorphic Adenomas ◽  
History Of ◽  
Mixed Tumours ◽  
Left Parotid Gland

Pleomorphic adenomas account for the majority of parotid masses, typically arising in the tail of the gland and enlarging slowly. Most are 2 to 6 cm in size when resected. We report the resection of a benign mixed tumour of the left parotid gland with a history of bleeding. The resected tumour measured 21 cm in diameter, weighed 1.81 kg, and on pathologic examination was a benign mixed tumour without malignant degeneration. The implications of this unusual case for the management of mixed tumours are discussed with a review of the literature.

Pleomorphic Adenoma (benign mixed tumor) of the Breast: An Immunohistochemical, Flow Cytometric, and Ultrastructural Study and Review of the Literature

1990 ◽  
Vol 93 (6) ◽  
pp. 795-801 ◽  
Author(s):  
William A. Ballance ◽  
Jae Y. Ro ◽  
Adel K. El-Naggar ◽  
David J. Grignon ◽  
Alberto G. Ayala ◽  
...  
Keyword(s):  
Pleomorphic Adenoma ◽  
Ultrastructural Study ◽  
Review Of The Literature ◽  
Mixed Tumor ◽  
Flow Cytometric ◽  
Benign Mixed Tumor

scholarly journals An Isolated Phlebolith on the Lip: An Unusual Case and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Gabriela de Morais Gouvêa Lima ◽  
Renata Mendonça Moraes ◽  
Ana Sueli Rodrigues Cavalcante ◽  
Yasmin Rodarte Carvalho ◽  
Ana Lia Anbinder
Keyword(s):  
English Language ◽  
Unusual Case ◽  
Vascular Malformations ◽  
Masticatory Muscles ◽  
Vascular Lesion ◽  
Vascular Lesions ◽  
Common Finding ◽  
Oral Lesions ◽  
Review Of The Literature ◽  
Histological Characteristics

Background. Calcified thrombi are a common finding, especially in the pelvic veins. There are generally multiple thrombi, and they are generally associated with vascular malformations.Design. Herein we report a rare case of a single labial phlebolith, not associated with any other vascular lesion. We aim to alert clinicians to the possibility of the occurrence of vascular thrombi in the mouth and to describe the clinical and histological characteristics of such lesions in order to simplify the diagnosis and treatment. Furthermore, we have reviewed the English-language literature published since 1970 reporting oral (including masticatory muscles) phleboliths.Results. Twenty-nine cases of phleboliths have been reported in the literature since 1970. Only three of the reported phleboliths were solitary and not associated with other vascular lesions, as in the case presented here.Conclusion. Although phleboliths not associated with other vascular lesions are not common, clinicians should be aware of the existence of this pathology and include it as differential diagnosis of oral lesions.

PRIMARY CARCINOMA OF THE LIVER IN INFANCY AND CHILDHOOD

PEDIATRICS ◽  
1960 ◽  
Vol 25 (2) ◽  
pp. 191-203
Author(s):  
Roy G. Shorter ◽  
Archie H. Baggenstoss ◽  
George B. Logan ◽  
George A. Hallenbeck
Keyword(s):  
Previous History ◽  
Primary Carcinoma ◽  
Routine Practice ◽  
Mixed Tumor ◽  
Metastatic Lesions ◽  
Osteoid Tissue ◽  
Primary Hepatic Carcinoma ◽  
Infancy And Childhood ◽  
History Of ◽  
Mixed Tumors

The clinical and pathologic findings in 11 cases of primary hepatic carcinoma occurring in infancy and childhood are presented from the records of the Mayo Clinic from 1905 through 1958. These tumors are rarely encountered in routine practice. All the children were of Caucasian stock and there was no previous history of hepatic disease in 10 cases. In the remaining case the patient had been treated by radiation therapy for hemangioma of the liver 6 years previous to admission to the Clinic. No common factors of possible etiologic significance were present in these patients. Some of the features of previous reports in this field have been described and they are compared and contrasted with the findings in the 11 cases presented. On histologic grounds such tumors of the liver can be divided into two groups: primary carcinomas and mixed tumors. Of the 11 tumors presented seven were considered to be examples of primary carcinomas and four were mixed tumors. The presence of a sarcomatous-like stroma is considered necessary for the diagnosis of a mixed tumor in the absence of osteoid tissue, cartilage, bone or muscle. It is also contended that the presence of osteoid tissue in any amount precludes the diagnosis of primary carcinoma and necessitates a designation of mixed tumor. All the tumors were considered to be malignant and extrahepatic metastasis is described in seven instances. The tumors proved to be fatal within 2 years from the onset of symptoms in 10 cases. In the remaining case, although the child is alive, multiple pulmonary metastatic lesions are present.

Cellular Proliferative and Telomerase Activity in Canine Mammary Gland Tumors

2000 ◽  
Vol 37 (2) ◽  
pp. 177-183 ◽  
Author(s):  
Y. Funakoshi ◽  
H. Nakayama ◽  
K. Uetsuka ◽  
R. Nishimura ◽  
N. Sasaki ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Tumors ◽  
Telomerase Activity ◽  
Benign Tumors ◽  
Tumor Diameter ◽  
Mixed Tumor ◽  
Canine Mammary Tumors ◽  
Benign Mixed Tumor ◽  
The Relationship ◽  
Mixed Tumors

In canine mammary tumors, we examined the telomerase activity, proliferative activity by proliferative cell nuclear antigen (PCNA) immunohistochemistry, and percentage of apoptotic cells by the deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) method. The relationship between these measures and histopathologic malignancy was also investigated. PCNA index was highest in malignant tumors (adenocarcinoma: 27.0%; malignant mixed tumor: 15.7%), followed by benign tumors (adenoma: 4.4%; benign mixed tumor: 5.3%), hyperplasia (2.1%), and normal mammary gland (0.9%). In adenoma and adenocarcinoma, papillary and solid types showing higher cellularity tended to have higher PCNA indices than did cystic and tubular types. Although the TUNEL index was <1% in all cases, the relationship between this measure and histopathologic diagnosis showed the same tendency as observed in PCNA immunostaining. Telomerase activity was detectable in all adenomas, benign mixed tumors, and adenocarcinomas examined. In contrast, all normal mammary glands, hyperplasias, and malignant mixed tumors were negative for telomerase. Relative telomerase activity (RTA) of adenocarcinoma (56.5) was significantly higher than that of adenoma (27.8) and benign mixed tumor (33.9), and a significant positive correlation ( P < 0.001) was noted between RTA and PCNA index. No significant correlations were noted between either PCNA or TUNEL index and clinical features such as metastasis and tumor diameter. PCNA index and telomerase activity may be useful markers for judging malignancy of canine mammary tumors.

scholarly journals Ovarian Cancer Metastasis to the Larynx: A Case Report and Review of the Literature

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Chad Purcell ◽  
Ayham Al Afif ◽  
Martin Bullock ◽  
Martin Corsten
Keyword(s):  
Ovarian Cancer ◽  
Ovarian Carcinoma ◽  
World Literature ◽  
Cancer Metastasis ◽  
High Grade ◽  
Review Of The Literature ◽  
Serous Ovarian Carcinoma ◽  
The World ◽  
History Of ◽  
Progressive Dysphagia

Laryngeal secondary malignancies are rare, and most spread locoregionally from hypopharyngeal or thyroid primaries. Metastasis of ovarian carcinoma to the larynx is extremely rare. A 65-year-old woman with a history of high grade serous ovarian carcinoma was undergoing carboplatin chemotherapy for recurrence. She presented with progressive dysphagia and hoarseness; a computer tomography (CT) scan demonstrated bilateral necrotic lymphadenopathy and hypopharyngeal fullness. A hypopharyngeal mass was confirmed on examination, and operative biopsy identified it as high-grade serous ovarian. To our knowledge, this report describes the second immunohistochemically proven metastatic ovarian cancer detected in the larynx in the world literature.

Carcinoma in Pleomorphic Adenomas of Salivary Glands

1973 ◽  
Vol 82 (5) ◽  
pp. 684-690 ◽  
Author(s):  
Roger Boles ◽  
Michael E. Johns ◽  
John G. Batsakis
Keyword(s):  
Medical Center ◽  
University Of Michigan ◽  
Mixed Tumor ◽  
Total Removal ◽  
Pleomorphic Adenomas ◽  
Malignant Mixed Tumor ◽  
Minimal Treatment ◽  
The University ◽  
Michigan Medical ◽  
Mixed Tumors

Because of the variability of the histological appearance of a given mixed tumor of the salivary gland and because of “recurrences” following less than total removal, biologically benign (not capable of metastasis) mixed tumors have been considered malignant. The true malignant mixed tumor, or more commonly carcinoma, arising from preexisting mixed tumors are unusual and ill-defined in the literature. These tumors make up no more than 5% of the mixed tumor category and occur primarily in the parotid gland. In this report, we present a clinico-pathological appraisal of the malignant mixed tumor based on five cases from the University of Michigan Medical Center and relate our experience to that in the literature. The importance of recognizing the malignant mixed tumor, or “carcinoma ex-mixed tumor,” lies in the accelerated recurrence rate and surprisingly high metastatic rate manifested by this lesion. Minimal treatment is radical total excision. Wide, early excision of the primary “benign” stage of these mixed tumors should reduce the problem of ultimate “malignification.”

scholarly journals Acute Felon as a Complication of Systemic Paclitaxel Therapy: Case Report and Review of the Literature

Hand ◽  
2007 ◽  
Vol 2 (3) ◽  
pp. 101-103 ◽  
Author(s):  
John B. Hijjawi ◽  
David G. Dennison
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Upper Extremity ◽  
Unusual Case ◽  
Review Of The Literature ◽  
Nail Dystrophy ◽  
American Women ◽  
History Of

Breast cancer now affects 1 in 8 American women and the taxane agent paclitaxel (Taxol® Bristol-Myers Squibb) is a major tool in the treatment of many such patients. Hand surgeons are therefore likely to encounter upper extremity complications related to the use of taxane therapy. We present an unusual case of a felon developing in a breast cancer patient on paclitaxel therapy with no antecedent history of trauma. Whereas onycholysis and subungual hemorrhage are reported complications of taxane therapy ( Fig. 1 ), an acute felon with or without associated paronychia is an unusual and more aggressive manifestation of this drug-related nail dystrophy.

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